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  1. AU="Hawkyard, Jake"
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  1. Article ; Online: Lymphangioma of the gallbladder.

    Hawkyard, Jake / Pandanaboyana, Sanjay

    Surgery

    2022  Volume 172, Issue 3, Page(s) e33–e34

    MeSH term(s) Abdomen ; Gallbladder Neoplasms/diagnostic imaging ; Gallbladder Neoplasms/surgery ; Humans ; Lymphangioma/diagnostic imaging ; Lymphangioma/surgery
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2022.03.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.129: Show issues Location:
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  2. Article ; Online: Long-term Outcomes following Resection of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasm (A-IPMN) versus Pancreatic Ductal Adenocarcinoma (PDAC): A Propensity-score Matched Analysis.

    Lucocq, James / Halle-Smith, James / Haugk, Beate / Joseph, Nejo / Hawkyard, Jake / Lye, Jonathan / Parkinson, Daniel / White, Steve / Mownah, Omar / Zen, Yoh / Menon, Krishna / Furukawa, Takaki / Inoue, Yosuke / Hirose, Yuki / Sasahira, Naoki / Mittal, Anubhav / Samra, Jas / Sheen, Amy / Feretis, Michael /
    Balakrishnan, Anita / Ceresa, Carlo / Davidson, Brian / Pande, Rupaly / Dasari, Bobby V M / Tanno, Lulu / Karavias, Dimitrios / Helliwell, Jack / Young, Alistair / Marks, Kate / Nunes, Quentin / Urbonas, Tomas / Silva, Michael / Gordon-Weeks, Alex / Barrie, Jenifer / Gomez, Dhanny / van Laarhoven, Stijn / Nawara, Hossam / Doyle, Joseph / Bhogal, Ricky / Harrison, Ewen / Roalso, Marcus / Ciprani, Debora / Aroori, Somaiah / Ratnayake, Bathiya / Koea, Jonathan / Capurso, Gabriele / Bellotti, Ruben / Stättner, Stefan / Alsaoudi, Tareq / Bhardwaj, Neil / Rajesh, Srujan / Jeffery, Fraser / Connor, Saxon / Cameron, Andrew / Jamieson, Nigel / Soreide, Kjetil / Gill, Anthony J / Roberts, Keith / Pandanaboyana, Sanjay

    Annals of surgery

    2024  

    Abstract: Objective: The aim of the present study was to compare long-term post-resection oncological outcomes between A-IPMN and PDAC.: Summary background data: Knowledge of long term oncological outcomes (e.g recurrence and survival data) comparing between ... ...

    Abstract Objective: The aim of the present study was to compare long-term post-resection oncological outcomes between A-IPMN and PDAC.
    Summary background data: Knowledge of long term oncological outcomes (e.g recurrence and survival data) comparing between adenocarcinoma arising from intraductal papillary mucinous neoplasms (A-IPMN) and pancreatic ductal adenocarcinoma (PDAC) is scarce.
    Methods: Patients undergoing pancreatic resection (2010-2020) for A-IPMN were identified retrospectively from 18 academic pancreatic centres and compared with PDAC patients from the same time-period. Propensity-score matching (PSM) was performed and survival and recurrence were compared between A-IPMN and PDAC.
    Results: 459 A-IPMN patients (median age,70; M:F,250:209) were compared with 476 PDAC patients (median age,69; M:F,262:214). A-IPMN patients had lower T-stage, lymphovascular invasion (51.4%vs. 75.6%), perineural invasion (55.8%vs. 71.2%), lymph node positivity (47.3vs. 72.3%) and R1 resection (38.6%vs. 56.3%) compared to PDAC(P<0.001). The median survival and time-to-recurrence for A-IPMN versus PDAC were 39.0 versus19.5months (P<0.001) and 33.1 versus 14.8months (P<0.001), respectively (median follow-up,78 vs.73 months). Ten-year overall survival for A-IPMN was 34.6%(27/78) and PDAC was 9%(6/67). A-IPMN had higher rates of peritoneal (23.0 vs. 9.1%, P<0.001) and lung recurrence (27.8% vs. 15.6%, P<0.001) but lower rates of locoregional recurrence (39.7% vs. 57.8%; P<0.001). Matched analysis demonstrated inferior overall survival (P=0.005), inferior disease-free survival (P=0.003) and higher locoregional recurrence (P<0.001) in PDAC compared to A-IPMN but no significant difference in systemic recurrence rates (P=0.695).
    Conclusions: PDACs have inferior survival and higher recurrence rates compared to A-IPMN in matched cohorts. Locoregional recurrence is higher in PDAC but systemic recurrence rates are comparable and constituted by their own distinctive site-specific recurrence patterns.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study.

    Lucocq, James / Hawkyard, Jake / Haugk, Beate / Mownah, Omar / Menon, Krishna / Furukawa, Takaki / Inoue, Yosuke / Hirose, Yuki / Sasahira, Naoki / Feretis, Michael / Balakrishnan, Anita / Ceresa, Carlo / Davidson, Brian / Pande, Rupaly / Dasari, Bobby / Tanno, Lulu / Karavias, Dimitrios / Helliwell, Jack / Young, Alistair /
    Nunes, Quentin / Urbonas, Tomas / Silva, Michael / Gordon-Weeks, Alex / Barrie, Jenifer / Gomez, Dhanny / Van Laarhoven, Stijn / Robertson, Francis / Nawara, Hossain / Doyle, Joseph / Bhogal, Ricky / Harrison, Ewen / Roalso, Marcus / Ciprani, Debora / Aroori, Somaiah / Ratnayake, Bathiya / Koea, Jonathan / Capurso, Gabriele / Bellotti, Ruben / Stättner, Stefan / Alsaoudi, Tareq / Bhardwaj, Neil / Rajesh, Srujan / Jeffery, Fraser / Connor, Saxon / Cameron, Andrew / Jamieson, Nigel / Sheen, Amy / Mittal, Anubhav / Samra, Jas / Gill, Anthony / Roberts, Keith / Søreide, Kjetil / Pandanaboyana, Sanjay

    The British journal of surgery

    2024  Volume 111, Issue 4

    Abstract: Background: The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemotherapy and ... ...

    Abstract Background: The clinical impact of adjuvant chemotherapy after resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia is unclear. The aim of this study was to identify factors related to receipt of adjuvant chemotherapy and its impact on recurrence and survival.
    Methods: This was a multicentre retrospective study of patients undergoing pancreatic resection for adenocarcinoma arising from intraductal papillary mucinous neoplasia between January 2010 and December 2020 at 18 centres. Recurrence and survival outcomes for patients who did and did not receive adjuvant chemotherapy were compared using propensity score matching.
    Results: Of 459 patients who underwent pancreatic resection, 275 (59.9%) received adjuvant chemotherapy (gemcitabine 51.3%, gemcitabine-capecitabine 21.8%, FOLFIRINOX 8.0%, other 18.9%). Median follow-up was 78 months. The overall recurrence rate was 45.5% and the median time to recurrence was 33 months. In univariable analysis in the matched cohort, adjuvant chemotherapy was not associated with reduced overall (P = 0.713), locoregional (P = 0.283) or systemic (P = 0.592) recurrence, disease-free survival (P = 0.284) or overall survival (P = 0.455). Adjuvant chemotherapy was not associated with reduced site-specific recurrence. In multivariable analysis, there was no association between adjuvant chemotherapy and overall recurrence (HR 0.89, 95% c.i. 0.57 to 1.40), disease-free survival (HR 0.86, 0.59 to 1.30) or overall survival (HR 0.77, 0.50 to 1.20). Adjuvant chemotherapy was not associated with reduced recurrence in any high-risk subgroup (for example, lymph node-positive, higher AJCC stage, poor differentiation). No particular chemotherapy regimen resulted in superior outcomes.
    Conclusion: Chemotherapy following resection of adenocarcinoma arising from intraductal papillary mucinous neoplasia does not appear to influence recurrence rates, recurrence patterns or survival.
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Adenocarcinoma/pathology ; Adenocarcinoma/drug therapy ; Adenocarcinoma/mortality ; Adenocarcinoma/therapy ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/drug therapy ; Adenocarcinoma, Mucinous/therapy ; Adenocarcinoma, Mucinous/mortality ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Capecitabine/administration & dosage ; Capecitabine/therapeutic use ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/mortality ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/therapy ; Carcinoma, Pancreatic Ductal/surgery ; Chemotherapy, Adjuvant ; Gemcitabine ; Neoplasm Recurrence, Local/epidemiology ; Pancreatectomy ; Pancreatic Intraductal Neoplasms/pathology ; Pancreatic Intraductal Neoplasms/therapy ; Pancreatic Intraductal Neoplasms/mortality ; Pancreatic Intraductal Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/therapy ; Pancreatic Neoplasms/surgery ; Propensity Score ; Retrospective Studies
    Chemical Substances Capecitabine (6804DJ8Z9U) ; Gemcitabine
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znae100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.66: Show issues Location:
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  4. Article ; Online: Risk of Recurrence after Surgical Resection for Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasia (IPMN) with Patterns of Distribution and Treatment: An International, Multicentre, Observational Study.

    Lucocq, James / Hawkyard, Jake / Robertson, Francis P / Haugk, Beate / Lye, Jonathan / Parkinson, Daniel / White, Steve / Mownah, Omar / Zen, Yoh / Menon, Krishna / Furukawa, Takaaki / Inoue, Yosuke / Hirose, Yuki / Sasahira, Naoki / Feretis, Michael / Balakrishnan, Anita / Zelga, Piotr / Ceresa, Carlo / Davidson, Brian /
    Pande, Rupaly / Dasari, Bobby / Tanno, Lulu / Karavias, Dimitrios / Helliwell, Jack / Young, Alistair / Nunes, Quentin / Urbonas, Tomas / Silva, Michael / Gordon-Weeks, Alex / Barrie, Jenifer / Gomez, Dhanny / van Laarhoven, Stijn / Doyle, Joseph / Bhogal, Ricky / Harrison, Ewen / Roalso, Marcus / Ciprani, Debora / Aroori, Somaiah / Ratnayake, Bathiya / Koea, Jonathan / Capurso, Gabriele / Bellotti, Ruben / Stättner, Stefan / Alsaoudi, Tareq / Bhardwaj, Neil / Jeffery, Fraser / Connor, Saxon / Cameron, Andrew / Jamieson, Nigel / Sheen, Amy / Mittal, Anubhav / Samra, Jas / Gill, Anthony / Roberts, Keith / Soreide, Kjetil / Pandanaboyana, Sanjay

    Annals of surgery

    2023  

    Abstract: Objective: This international multicentre cohort study aims to identify recurrence patterns and treatment of first and second recurrence in a large cohort of patients after pancreatic resection for adenocarcinoma arising from IPMN.: Summary background ...

    Abstract Objective: This international multicentre cohort study aims to identify recurrence patterns and treatment of first and second recurrence in a large cohort of patients after pancreatic resection for adenocarcinoma arising from IPMN.
    Summary background data: Recurrence patterns and treatment of recurrence post resection of adenocarcinoma arising from IPMN are poorly explored.
    Method: Patients undergoing pancreatic resection for adenocarcinoma from IPMN between January 2010 to December 2020 at 18 pancreatic centres were identified. Survival analysis was performed by the Kaplan-Meier log rank test and multivariable logistic regression by Cox-Proportional Hazards modelling. Endpoints were recurrence (time-to, location, and pattern of recurrence) and survival (overall survival and adjusted for treatment provided).
    Results: Four hundred and fifty-nine patients were included (median, 70 y; IQR, 64-76; male, 54 percent) with a median follow-up of 26.3 months (IQR, 13.0-48.1 mo). Recurrence occurred in 209 patients (45.5 percent; median time to recurrence, 32.8 months, early recurrence [within 1 y], 23.2 percent). Eighty-three (18.1 percent) patients experienced a local regional recurrence and 164 (35.7 percent) patients experienced distant recurrence. Adjuvant chemotherapy was not associated with reduction in recurrence (HR 1.09;P=0.669) One hundred and twenty patients with recurrence received further treatment. The median survival with and without additional treatment was 27.0 and 14.6 months (P<0.001), with no significant difference between treatment modalities. There was no significant difference in survival between location of recurrence (P=0.401).
    Conclusion: Recurrence after pancreatic resection for adenocarcinoma arising from IPMN is frequent with a quarter of patients recurring within 12 months. Treatment of recurrence is associated with improved overall survival and should be considered.
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000006144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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