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  1. Article ; Online: Commentary: Presurgical frailty assessment can predict adverse outcomes in patients undergoing cardiac surgery… but where do we go from here?

    Hay, Jacqueline L / Boreskie, Kevin F / Arora, Rakesh C / Duhamel, Todd A

    JTCVS open

    2022  Volume 10, Page(s) 264–265

    Language English
    Publishing date 2022-02-23
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-2736
    ISSN (online) 2666-2736
    DOI 10.1016/j.xjon.2021.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Frailty-aware care: giving value to frailty assessment across different healthcare settings.

    Boreskie, Kevin F / Hay, Jacqueline L / Boreskie, Patrick E / Arora, Rakesh C / Duhamel, Todd A

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 13

    Abstract: Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at increased risk for adverse health outcomes. ... ...

    Abstract Healthcare systems need to adapt to better serve an aging population with complex presentations. Frailty assessments are a potential means to address this heterogeneity in aging to identify individuals at increased risk for adverse health outcomes. Furthermore, frailty assessments offer an opportunity to optimize patient care in various healthcare settings. While the vast number of frailty assessment tools available can be a source of confusion for clinicians, each tool has features adaptable to the constraints and goals of different healthcare settings. This review discusses and compares barriers, facilitators, and the application of frailty assessments in primary care, the emergency department/intensive care unit and surgical care to cover a breadth of settings with different frailty assessment considerations. The implementation of frailty-aware care across healthcare settings potentiates better healthcare outcomes for older adults.
    MeSH term(s) Aged ; Aging ; Delivery of Health Care ; Emergency Service, Hospital ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Primary Health Care
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-021-02722-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protocol for the WARM Hearts study: examining cardiovascular disease risk in middle-aged and older women - a prospective, observational cohort study.

    Rose, Alexandra V / Boreskie, Kevin F / Hay, Jacqueline L / Thompson, Liam / Arora, Rakesh C / Duhamel, Todd A

    BMJ open

    2021  Volume 11, Issue 5, Page(s) e044227

    Abstract: Introduction: Cardiovascular disease (CVD) is a leading cause of death in women. Novel approaches to detect early signs of elevated CVD risk in women are needed. Enhancement of traditional CVD risk assessment approaches through the addition of ... ...

    Abstract Introduction: Cardiovascular disease (CVD) is a leading cause of death in women. Novel approaches to detect early signs of elevated CVD risk in women are needed. Enhancement of traditional CVD risk assessment approaches through the addition of procedures to assess physical function or frailty as well as novel biomarkers of cardiovascular, gut and muscle health could improve early identification. The Women's Advanced Risk-assessment in Manitoba (WARM) Hearts study will examine the use of novel non-invasive assessments and biomarkers to identify women who are at elevated risk for adverse cardiovascular events.
    Methods and analysis: One thousand women 55 years of age or older will be recruited and screened by the WARM Hearts observational, cohort study. The two screening appointments will include assessments of medical history, gender variables, body composition, cognition, frailty status, functional fitness, physical activity levels, nutritional status, quality of life questionnaires, sleep behaviour, resting blood pressure (BP), BP response to moderate-intensity exercise, a non-invasive measure of arterial stiffness and heart rate variability. Blood sample analysis will be used to assess lipid and novel biomarker profiles and stool samples will support the characterisation of gut microbiota. The incidence of the adverse cardiovascular outcomes will be assessed 5 years after screening to compare WARM Hearts approaches to the Framingham Risk Score, the current clinical standard of assessing CVD risk in Canada.
    Ethics and dissemination: The University of Manitoba Health Research Ethics Board (7 October 2019) and the St Boniface Hospital Research Review Committee (7 October 2019) approved the trial (Ethics Number HS22576 (H2019:063)). Recruitment started 10 October 2020. Data gathered from the WARM Hearts study will be published in peer-reviewed journals and presented at national and international conferences. Knowledge translation strategies will be created to share our findings with stakeholders who are positioned to implement evidence-informed CVD risk assessment programming.
    Trial registration number: NCT03938155.
    MeSH term(s) Aged ; Canada ; Cardiovascular Diseases/epidemiology ; Clinical Trial Protocols as Topic ; Cohort Studies ; Female ; Humans ; Manitoba/epidemiology ; Middle Aged ; Observational Studies as Topic ; Prospective Studies ; Quality of Life ; Risk Assessment
    Language English
    Publishing date 2021-05-25
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-044227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Interindividual variation in cardiometabolic health outcomes following 6 months of endurance training in youth at risk of type 2 diabetes mellitus.

    Hrubeniuk, Travis J / Hay, Jacqueline L / MacIntosh, Andrea C / Wicklow, Brandy / Wittmeier, Kristy / McGavock, Jonathan M / Sénéchal, Martin

    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

    2021  Volume 46, Issue 7, Page(s) 727–734

    Abstract: This study determined the interindividual variation in the cardiometabolic response to 6 months of moderate or vigorous intensity exercise training (ET) among youth at risk for type 2 diabetes mellitus. Youth were randomized to moderate intensity ET (45- ... ...

    Abstract This study determined the interindividual variation in the cardiometabolic response to 6 months of moderate or vigorous intensity exercise training (ET) among youth at risk for type 2 diabetes mellitus. Youth were randomized to moderate intensity ET (45-55% heart rate reserve;
    MeSH term(s) Adolescent ; Body Fat Distribution ; Cardiorespiratory Fitness ; Diabetes Mellitus, Type 2/prevention & control ; Endurance Training ; Exercise Therapy/methods ; Female ; Heart Rate ; Humans ; Individuality ; Insulin/blood ; Intra-Abdominal Fat/anatomy & histology ; Liver/metabolism ; Male ; Overweight/complications ; Overweight/metabolism ; Overweight/therapy ; Pediatric Obesity/complications ; Pediatric Obesity/metabolism ; Pediatric Obesity/therapy ; Risk Factors ; Time Factors ; Triglycerides/metabolism ; Young Adult
    Chemical Substances Insulin ; Triglycerides
    Language English
    Publishing date 2021-02-05
    Publishing country Canada
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2236708-1
    ISSN 1715-5320 ; 1715-5312
    ISSN (online) 1715-5320
    ISSN 1715-5312
    DOI 10.1139/apnm-2020-0707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Interindividual variation in cardiometabolic health outcomes following 6 months of endurance training in youth at risk of type 2 diabetes mellitus

    Hrubeniuk, Travis J. / Hay, Jacqueline L. / MacIntosh, Andrea C. / Wicklow, Brandy / Wittmeier, Kristy / McGavock, Jonathan M. / Sénéchal, Martin

    Applied physiology, nutrition and metabolism. 2021, v. 46, no. 7

    2021  

    Abstract: This study determined the interindividual variation in the cardiometabolic response to 6 months of moderate or vigorous intensity exercise training (ET) among youth at risk for type 2 diabetes mellitus. Youth were randomized to moderate intensity ET (45– ... ...

    Abstract This study determined the interindividual variation in the cardiometabolic response to 6 months of moderate or vigorous intensity exercise training (ET) among youth at risk for type 2 diabetes mellitus. Youth were randomized to moderate intensity ET (45–55% heart rate reserve; n = 31), vigorous intensity ET (70–85% heart rate reserve; n = 37), or control (n = 36). Only those attending ≥70% of ET sessions were included. Cardiometabolic measures included insulin sensitivity, hepatic triglyceride content, visceral adipose area, and cardiorespiratory fitness. The contribution of ET to interindividual variation was determined using the standard deviation of individual responses (SDIR) and considered meaningful if the SDIR surpassed the smallest worthwhile difference (SWD), calculated as 0.2 × the standard deviation of the control group baseline values. ET meaningfully contributed to the interindividual variation among changes in peak oxygen uptake following moderate (SDIR: 2.04) and vigorous (SDIR: 3.43) ET (SWD: 1.17 mL·kg fat free mass⁻¹·min⁻¹), body fat percentage and hepatic triglyceride content following moderate-intensity ET (SDIR: 1.64, SWD: 1.05%; SDIR: 10.08, SWD: 1.06%, respectively), and visceral fat mass following vigorous ET (SDIR: 11.06, SWD: 7.13 cm²). Variation in the changes in insulin sensitivity were not influenced by ET. The contribution of ET to interindividual variation appears to be influenced by the desired outcome and prescribed intensity. Trial registration at ClinicalTrials.gov (identifier no.: NCT00755547). Novelty: The contribution of exercise to interindividual variation following training depends on the outcome and exercise intensity. Increasing exercise intensity does not systematically reduce non-response among youth at risk for type 2 diabetes.
    Keywords cardiorespiratory fitness ; exercise ; heart rate ; insulin resistance ; metabolism ; noninsulin-dependent diabetes mellitus ; nutrition ; peak oxygen uptake ; standard deviation ; triacylglycerols ; visceral fat ; youth ; youth at risk
    Language English
    Size p. 727-734.
    Publishing place NRC Research Press
    Document type Article
    ZDB-ID 2236708-1
    ISSN 1715-5320 ; 1715-5312
    ISSN (online) 1715-5320
    ISSN 1715-5312
    DOI 10.1139/apnm-2020-0707
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: The Association Between Route of Post-menopausal Estrogen Administration and Blood Pressure and Arterial Stiffness in Community-Dwelling Women.

    Kalenga, Cindy Z / Hay, Jacqueline L / Boreskie, Kevin F / Duhamel, Todd A / MacRae, Jennifer M / Metcalfe, Amy / Nerenberg, Kara A / Robert, Magali / Ahmed, Sofia B

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 913609

    Abstract: Background: Postmenopausal hormone therapy (HT) is associated with increased cardiovascular risk. Although the route of estrogen administration may play a role in mediating risk, previous studies have not controlled for concomitant progestin use.: ... ...

    Abstract Background: Postmenopausal hormone therapy (HT) is associated with increased cardiovascular risk. Although the route of estrogen administration may play a role in mediating risk, previous studies have not controlled for concomitant progestin use.
    Objective: To investigate the association between the route of estrogen therapy (oral or non-oral) HT use, without concomitant progestin, and blood pressure and arterial stiffness in postmenopausal women.
    Methods: Systolic blood pressure [SBP], diastolic blood pressure [DBP]), arterial stiffness (aortic pulse wave velocity [aPWV] and augmentation index at 75 beats per minute [AIx]) were measured using a validated automated brachial cuff-based oscillometric approach (Mobil-O-Graph) in a community-dwelling sample of 328 women.
    Results: Fifty-five participants (16.8%) were ever users (current and past use) of estrogen-only HT (oral [
    Conclusion: Ever use of oral estrogen was associated with increased SBP and DBP compared to non-oral estrogen use and no use. Given the cardiovascular risk associated with both menopause and increased blood pressure, further studies are required exploring the potential benefits of non-oral estrogen in postmenopausal women.
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.913609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Self-compassion and responses to health information in middle-aged and older women: An observational cohort study.

    Semenchuk, Brittany N / Boreskie, Kevin F / Hay, Jacqueline L / Miller, Cindy / Duhamel, Todd A / Strachan, Shaelyn M

    Journal of health psychology

    2020  Volume 26, Issue 12, Page(s) 2231–2247

    Abstract: The aim of this study was to determine whether self-compassion-orientation to care for oneself during challenges-helps people at risk of cardiovascular disease deal with emotional reactions and assist with self-regulating health behaviors. This ... ...

    Abstract The aim of this study was to determine whether self-compassion-orientation to care for oneself during challenges-helps people at risk of cardiovascular disease deal with emotional reactions and assist with self-regulating health behaviors. This observational study recruited women (
    MeSH term(s) Adaptation, Psychological ; Aged ; Cohort Studies ; Emotions ; Empathy ; Female ; Health Behavior ; Humans ; Middle Aged
    Language English
    Publishing date 2020-03-07
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2021897-7
    ISSN 1461-7277 ; 1359-1053
    ISSN (online) 1461-7277
    ISSN 1359-1053
    DOI 10.1177/1359105320909860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Myokines as biomarkers of frailty and cardiovascular disease risk in females.

    Boreskie, Kevin F / Oldfield, Christopher J / Hay, Jacqueline L / Moffatt, Teri L / Hiebert, Brett M / Arora, Rakesh C / Duhamel, Todd A

    Experimental gerontology

    2020  Volume 133, Page(s) 110859

    Abstract: Frailty is a risk factor for cardiovascular disease (CVD). Biomarkers have the potential to detect the early stages of frailty, such as pre-frailty. Myokines may act as biomarkers of frailty-related disease progression, as a decline in muscle health is a ...

    Abstract Frailty is a risk factor for cardiovascular disease (CVD). Biomarkers have the potential to detect the early stages of frailty, such as pre-frailty. Myokines may act as biomarkers of frailty-related disease progression, as a decline in muscle health is a hallmark of the frailty phenotype. This study is a secondary analysis of 104 females 55 years of age or older with no previous history of CVD. Differences in systemic myokine concentrations based on frailty status and CVD risk profile were examined using a case-control design. Propensity matching identified two sets of 26 pairs with pre-frailty as the exposure variable in low or elevated CVD risk groups for a total 104 female participants. Frailty was assessed using the Fried Criteria (FC) and CVD risk was assessed using the Framingham Risk Score (FRS). Factorial ANOVA compared the main effects of frailty, CVD risk, and their interaction on the concentrations of 15 myokines. Differences were found when comparing elevated CVD risk status with low for the concentrations of EPO (384.76 ± 1046.07 vs. 206.63 ± 284.61 pg/mL, p = .001), FABP3 (2772.61 ± 3297.86 vs. 1693.31 ± 1019.34 pg/mL, p = .017), FGF21 (193.17 ± 521.09 vs. 70.18 ± 139.51 pg/mL, p = .010), IL-6 (1.73 ± 4.97 vs. 0.52 ± 0.89 pg/mL, p = .023), and IL-15 (2.62 ± 10.56 vs. 0.92 ± 1.25 pg/mL, p = .022). Pre-frail females had lower concentrations of fractalkine compared to robust (27.04 ± 20.60 vs. 103.62 ± 315.45 pg/mL, p = .004). Interaction effects between frailty status and CVD risk for FGF21 and OSM were identified. In elevated CVD risk, pre-frail females, concentrations of FGF21 and OSM were lower than that of elevated CVD risk, robust females (69.10 ± 62.86 vs. 317.24 ± 719.69, p = .011; 1.73 ± 2.32 vs. 24.43 ± 69.21, p = .018, respectively). These data identified specific biomarkers of CVD risk and biomarkers of frailty that are exacerbated with CVD risk.
    MeSH term(s) Aged ; Biomarkers ; Cardiovascular Diseases/epidemiology ; Cross-Sectional Studies ; Female ; Frail Elderly ; Frailty/diagnosis ; Frailty/epidemiology ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-02-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2020.110859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Frailty status and cardiovascular disease risk profile in middle-aged and older females.

    Boreskie, Kevin F / Rose, Alexandra V / Hay, Jacqueline L / Kehler, D Scott / Costa, Eduardo C / Moffatt, Teri L / Arora, Rakesh C / Duhamel, Todd A

    Experimental gerontology

    2020  Volume 140, Page(s) 111061

    Abstract: Objective: Frailty and pre-frailty are known to increase the risk of developing cardiovascular disease (CVD). However, the risk profiles of females are not well characterized. The aim of this study is to characterize the CVD risk profiles of robust, pre- ...

    Abstract Objective: Frailty and pre-frailty are known to increase the risk of developing cardiovascular disease (CVD). However, the risk profiles of females are not well characterized. The aim of this study is to characterize the CVD risk profiles of robust, pre-frail and frail females.
    Methods: Cross-sectional analysis of 985 females ≥55 years with no self-reported history of CVD were recruited. Frailty was assessed using the Fried Criteria with the cut-points standardized to the cohort. Framingham risk scores (FRS), the 4-test Rasmussen Disease Score (RDS), and the CANHEART health index were used to characterize composite CVD risk. Individual measures of CVD risk included blood lipids, artery elasticity assessments, exercise blood pressure response, 6-min walk test (6MWT), sedentary time and PHQ-9 score.
    Results: The cohort comprised of 458 (46.4%) robust, 464 (47.1%) pre-frail and 63 (6.4%) frail females with a mean age of 66 ± 6 (SD) years. Pre-frail females were at increased odds of taking diabetes medications (OR 3.04; 95% CI 1.27-7.27), hypertension medications (OR 2.02; 95% CI 1.44-2.82), having an exaggerated blood pressure response to exercise (OR 1.878; 95% CI 1.39-2.50), mild depression symptoms (OR 2.38; 95% CI 1.68-338), and lower fitness as assessed by 6MWT (OR 5.74; 95% CI 3.18-10.37), even after controlling for age and relevant medications. Pre-frail females were also at increased odds for having CVD risk scores indicating higher risk with the FRS (OR 1.52; 95% CI 1.12-2.05), the RDS (OR 1.60; 95% CI 1.21-2.10) and the CANHEART risk score (OR 3.07; 95% CI 2.04-4.62). These odds were higher when frail females were compared to their robust peers.
    Conclusion: Frailty and pre-frailty were associated with higher odds of presenting with CVD risk factors as compared to robust females, even after controlling for age.
    MeSH term(s) Aged ; Cardiovascular Diseases/epidemiology ; Cross-Sectional Studies ; Female ; Frail Elderly ; Frailty/epidemiology ; Geriatric Assessment ; Humans ; Middle Aged ; Risk Factors
    Language English
    Publishing date 2020-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390992-x
    ISSN 1873-6815 ; 0531-5565
    ISSN (online) 1873-6815
    ISSN 0531-5565
    DOI 10.1016/j.exger.2020.111061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Peer-support interventions for women with cardiovascular disease: protocol for synthesising the literature using an evidence map.

    Parry, Monica / Visintini, Sarah / Johnston, Amy / Colella, Tracey Jf / Kapur, Deeksha / Liblik, Kiera / Gomes, Zoya / Dancey, Sonia / Liu, Shuangbo / Goodenough, Catherine / Hay, Jacqueline L / Noble, Meagan / Adreak, Najah / Robert, Helen / Tang, Natasha / O'Hara, Arland / Wong, Anice / Mullen, Kerri-Anne

    BMJ open

    2022  Volume 12, Issue 10, Page(s) e067812

    Abstract: Introduction: The leading cause of death for women is cardiovascular disease (CVD), including ischaemic heart disease, stroke and heart failure. Previous literature suggests peer support interventions improve self-reported recovery, hope and empowerment ...

    Abstract Introduction: The leading cause of death for women is cardiovascular disease (CVD), including ischaemic heart disease, stroke and heart failure. Previous literature suggests peer support interventions improve self-reported recovery, hope and empowerment in other patient populations, but the evidence for peer support interventions in women with CVD is unknown. The aim of this study is to describe peer support interventions for women with CVD using an evidence map. Specific objectives are to: (1) provide an overview of peer support interventions used in women with ischaemic heart disease, stroke and heart failure, (2) identify gaps in primary studies where new or better studies are needed and (3) describe knowledge gaps where complete systematic reviews are required.
    Methods and analysis: We are building on previous experience and expertise in knowledge synthesis using methods described by the Evidence for Policy and Practice Information (EPPI) and the Coordinating Centre at the Institute of Education. Seven databases will be searched from inception: CINAHL, Embase, MEDLINE, APA PsycINFO, the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials, and Scopus. We will also conduct grey literature searches for registered clinical trials, dissertations and theses, and conference abstracts. Inclusion and exclusion criteria will be kept broad, and studies will be included if they discuss a peer support intervention and include women, independent of the research design. No date or language limits will be applied to the searches. Qualitative findings will be summarised narratively, and quantitative analyses will be performed using R.
    Ethics and dissemination: The University of Toronto's Research Ethics Board granted approval on 28 April 2022 (Protocol #42608). Bubble plots (ie, weighted scatter plots), geographical heat/choropleth maps and infographics will be used to illustrate peer support intervention elements by category of CVD. Knowledge dissemination will include publication, presentation/public forums and social media.
    MeSH term(s) Cardiovascular Diseases/therapy ; Female ; Heart Failure ; Humans ; Myocardial Ischemia ; Research Design ; Stroke ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-10-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-067812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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