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Article ; Online: Relationship between social networks and medication counts: A 1-year follow-up pilot study.

Hasegawa, Sho / Mizokami, Fumihiro / Hayakawa, Yuji / Matsui, Yasumoto

2024 Volume 24, Issue 3, Page(s) 324–326

MeSH term(s)	Humans ; Follow-Up Studies ; Pilot Projects ; Social Networking ; Medication Adherence
Language	English
Publishing date	2024-02-08
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14825
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Article ; Online: Authors' reply to the letter to the editor on "Managing geriatric syndromes: necessity of pharmacists' involvements" by Kojima.

Mizokami, Fumihiro / Hasegawa, Sho / Mizuno, Tomohiro / Yabu, Takeshi / Kameya, Yoshitaka / Hayakawa, Yuji / Arai, Hidenori

Geriatrics & gerontology international

2024 Volume 24, Issue 4, Page(s) 448–450

MeSH term(s)	Humans ; Aged ; Pharmacists ; Syndrome
Language	English
Publishing date	2024-03-11
Publishing country	Japan
Document type	Letter
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14859
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Article: [A case of unresectable gastric cancer treated with triplet combination chemotherapy with itraconazole and conversion surgery].

Sawasaki, Miyuki / Shiba, Toshinari / Hayakawa, Yuji / Kakuno, Ayako / Oosaki, Yukio

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

2022 Volume 119, Issue 2, Page(s) 153–161

Abstract: A 73-year-old woman visited our hospital due to carcinoembryonic antigen (CEA) level elevation (110ng/ml). She underwent an upper gastrointestinal endoscopy (EGD), enhanced computed tomography (CT), and positron emission tomography (PET) -CT. She was ... ...

Abstract	A 73-year-old woman visited our hospital due to carcinoembryonic antigen (CEA) level elevation (110ng/ml). She underwent an upper gastrointestinal endoscopy (EGD), enhanced computed tomography (CT), and positron emission tomography (PET) -CT. She was diagnosed with type 3 esophagogastric junction cancer with paraaortic lymph node (LN) metastases at stage IVA (cT3N4M0). She underwent triplet combination chemotherapy with itraconazole (ITCZ):nab-paclitaxel, oxaliplatin, and S-1 with ITCZ. After six cycles of this regimen, the CEA level was within normal range, and EGD and PET-CT showed no evidence of malignancy. She underwent laparoscopic proximal gastrectomy and lower esophagectomy. The surgical specimen revealed no residual tumor (pathological complete response). Three months later, her CEA level increased to 60.5ng/ml, and she had longitudinal LN recurrence. However, she took S-1 orally for 11 cycles, and the recurrent metastatic LNs improved. She received chemotherapy, including nivolumab followed by ramucirumab and nab-paclitaxel with ITCZ. The CEA level returned to the normal range, and PET-CT showed no evidence of malignancy. Her progression has been stable for 45 months after diagnosis. In summary, we encountered a case of unresectable gastric cancer with conversion surgery after triplet combination chemotherapy with ITCZ.
Language	Japanese
Publishing date	2022-02-12
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	708695-7
ISSN	1349-7693 ; 0446-6586
ISSN (online)	1349-7693
ISSN	0446-6586
DOI	10.11405/nisshoshi.119.153
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Article: Machine learning versus binomial logistic regression analysis for fall risk based on SPPB scores in older adult outpatients.

Hasegawa, Sho / Mizokami, Fumihiro / Kameya, Yoshitaka / Hayakawa, Yuji / Watanabe, Tsuyoshi / Matsui, Yasumoto

Digital health

2023 Volume 9, Page(s) 20552076231219438

Abstract: Objective: To compare the performance of the diagnostic model for fall risk based on the short physical performance battery (SPPB) developed using commercial machine learning software (MLS) and binomial logistic regression analysis (BLRA).: Methods: ... ...

Abstract	Objective: To compare the performance of the diagnostic model for fall risk based on the short physical performance battery (SPPB) developed using commercial machine learning software (MLS) and binomial logistic regression analysis (BLRA). Methods: We enrolled 797 out of 850 outpatients who visited the clinic between March 2016 and November 2021. Patients were categorized into the development ( Results: The participants included 797 outpatients (mean age, 76.3 years; interquartile range, 73.0-81.0; 288 men). The metrics of the current diagnostic model in the commercial MLS were as follows: AUC = 0.78, accuracy = 0.74, precision = 0.46, recall (sensitivity) = 0.81, specificity = 0.71, F-measure = 0.59. The metrics of the current diagnostic model in the BLRA were as follows: AUC = 0.77, accuracy = 0.75, precision = 0.47, recall (sensitivity) = 0.67, specificity = 0.77, F-measure = 0.55. The risk factors for falls in older adult outpatients were handgrip strength, female sex, experience of falls, BMI, and calf circumference in the commercial MLS. Conclusions: The diagnostic model for fall risk based on SPPB scores constructed using commercial MLS is noninferior to BLRA.
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819396-9
ISSN	2055-2076
ISSN	2055-2076
DOI	10.1177/20552076231219438
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Article ; Online: Investigation of geriatric syndromes associated with medication in Japan using insurance claims data.

Hasegawa, Sho / Mizokami, Fumihiro / Mizuno, Tomohiro / Yabu, Takeshi / Kameya, Yoshitaka / Hayakawa, Yuji / Arai, Hidenori

Geriatrics & gerontology international

2023 Volume 24, Issue 1, Page(s) 61–67

Abstract: Aim: Multiple risk factors are involved in geriatric syndrome (GS) occurring in older adults. Although drug therapy often contributes to GS, the specific causes among older adults in Japan remain unclear. In this study, we examined the possible ... ...

Abstract	Aim: Multiple risk factors are involved in geriatric syndrome (GS) occurring in older adults. Although drug therapy often contributes to GS, the specific causes among older adults in Japan remain unclear. In this study, we examined the possible prescribing cascade rate among older outpatients eligible for Late-stage Elderly Health Insurance and elucidated the differences between GS and GS associated with medication (GSAM) trends. Methods: This retrospective study enrolled patients from health insurance claims data in Japan between October 2018 and March 2019; hospitalized patients were excluded. Two groups were identified among the participants with GS: GS (no use of GS-causing medications) and possible-GSAM (p-GSAM; use of GS-causing medications). The collected data were analyzed using the Bell Curve for Excel, and statistical significance was set at P < 0.05. Results: In total, 137 781 outpatients were enrolled. Of the 32 259 outpatients who did not use GS-causing medications, 7342 were classified into the GS group. Among 105 522 outpatients who used GS-causing medications, 8347 were classified as having p-GSAM. The mean number of prescriptions was significantly higher in the p-GSAM group than in the GS group (P < 0.01). Furthermore, all GS symptoms showed significant differences, with impaired appetite being the most prevalent in the p-GSAM group than in the GS group (P < 0.01). A possible prescribing cascade was suspected in 2826 (33.9%) of 8347 outpatients in the p-GSAM group. Conclusion: Impaired appetite in patients taking GS-causing medications might lead to prescribing cascades. Further studies are needed to prevent such prescribing cascades. Geriatr Gerontol Int 2024; 24: 61-67.
MeSH term(s)	Humans ; Aged ; Retrospective Studies ; Japan/epidemiology ; Risk Factors ; Outpatients ; Insurance
Language	English
Publishing date	2023-12-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14755
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Article ; Online: Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study.

Hasegawa, Sho / Mizokami, Fumihiro / Mase, Hiroki / Hayakawa, Yuji / Shimizu, Atsuya / Matsui, Yasumoto

The Journal of international medical research

2022 Volume 50, Issue 10, Page(s) 3000605221130716

Abstract: Objective: To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome.: Methods: This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited ... ...

Abstract	Objective: To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome. Methods: This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited the frailty clinic within this period, outpatients who received antihypertensive drugs at their first visit and were followed-up for about 1 year were enrolled. Participants who discontinued or continued antihypertensive drugs during 1 year of follow-up were classified into a discontinuation group or continuation group, respectively. Each domain in the Kihon checklist (KCL), fall risk score, short physical performance battery (SPPB) score, and skeletal muscle index (SMI) were assessed at the first visit and 1-year follow-up assessment, and were compared between the two groups. Results: Among 498 patients who attended the frailty clinic, 78 were enrolled (discontinuation group, Conclusion: Discontinuation of antihypertensive drugs may positively affect physical performance.
MeSH term(s)	Humans ; Aged ; Frailty/chemically induced ; Antihypertensive Agents/therapeutic use ; Frail Elderly ; Pilot Projects ; Geriatric Assessment ; Outpatients ; Retrospective Studies ; Prospective Studies
Chemical Substances	Antihypertensive Agents
Language	English
Publishing date	2022-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605221130716
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Article ; Online: Machine Learning-Based Prediction of Digoxin Toxicity in Heart Failure: A Multicenter Retrospective Study.

Asai, Yuki / Tashiro, Takumi / Kondo, Yoshihiro / Hayashi, Makoto / Arihara, Hiroki / Omote, Saki / Tanio, Ena / Yamashita, Saena / Higuchi, Takashi / Hashimoto, Ei / Yamada, Momoko / Tsuji, Hinako / Hayakawa, Yuji / Suzuki, Ryohei / Muro, Hiroya / Yamamoto, Yoshiaki

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 4, Page(s) 614–620

Abstract: Digoxin toxicity (plasma digoxin concentration ≥0.9 ng/mL) is associated with worsening heart failure (HF). Decision tree (DT) analysis, a machine learning method, has a flowchart-like model where users can easily predict the risk of adverse drug ... ...

Abstract	Digoxin toxicity (plasma digoxin concentration ≥0.9 ng/mL) is associated with worsening heart failure (HF). Decision tree (DT) analysis, a machine learning method, has a flowchart-like model where users can easily predict the risk of adverse drug reactions. The present study aimed to construct a flowchart using DT analysis that can be used by medical staff to predict digoxin toxicity. We conducted a multicenter retrospective study involving 333 adult patients with HF who received oral digoxin treatment. In this study, we employed a chi-squared automatic interaction detection algorithm to construct DT models. The dependent variable was set as the plasma digoxin concentration (≥ 0.9 ng/mL) in the trough during the steady state, and factors with p < 0.2 in the univariate analysis were set as the explanatory variables. Multivariate logistic regression analysis was conducted to validate the DT model. The accuracy and misclassification rates of the model were evaluated. In the DT analysis, patients with creatinine clearance <32 mL/min, daily digoxin dose ≥1.6 µg/kg, and left ventricular ejection fraction ≥50% showed a high incidence of digoxin toxicity (91.8%; 45/49). Multivariate logistic regression analysis revealed that creatinine clearance <32 mL/min and daily digoxin dose ≥1.6 µg/kg were independent risk factors. The accuracy and misclassification rates of the DT model were 88.2 and 46.2 ± 2.7%, respectively. Although the flowchart created in this study needs further validation, it is straightforward and potentially useful for medical staff in determining the initial dose of digoxin in patients with HF.
MeSH term(s)	Adult ; Humans ; Retrospective Studies ; Stroke Volume ; Creatinine ; Ventricular Function, Left ; Digoxin/adverse effects ; Heart Failure/chemically induced ; Drug-Related Side Effects and Adverse Reactions ; Machine Learning ; Cardiotonic Agents/adverse effects
Chemical Substances	Creatinine (AYI8EX34EU) ; Digoxin (73K4184T59) ; Cardiotonic Agents
Language	English
Publishing date	2023-04-01
Publishing country	Japan
Document type	Multicenter Study ; Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b22-00823
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Zs.A 1474: Show issues

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Article ; Online: Simple and rapid method for routine screening of bovine leukemia virus by loop-mediated isothermal amplification assay.

Okuwa, Yuka / Miyamato-Hayashi, Michiko / Tanaka, Takaichi / Hayakawa, Yuji / Inoshima, Yasuo

The Journal of veterinary medical science

2017 Volume 79, Issue 1, Page(s) 137–140

Abstract: Various techniques for screening and detection of bovine leukemia virus (BLV) were compared to ascertain a rapid and simple technique for routine examination. The performance of real-time PCR, nested PCR and loop-mediated isothermal amplification (LAMP) ... ...

Abstract	Various techniques for screening and detection of bovine leukemia virus (BLV) were compared to ascertain a rapid and simple technique for routine examination. The performance of real-time PCR, nested PCR and loop-mediated isothermal amplification (LAMP) assays was compared using DNA extracted from whole blood instead of white blood cells (WBCs) of 23 cattle. Real-time PCR, LAMP and nested PCR detected 18, 16 and 11 BLV-positive cattle, respectively. These results suggest that LAMP using DNA from whole blood could enable rapid examination, as isolation of WBCs and electrophoresis is time-consuming and could be useful as a simple and rapid method for routine screening of BLV.
MeSH term(s)	Animals ; Cattle ; Enzootic Bovine Leukosis/diagnosis ; Enzootic Bovine Leukosis/virology ; Enzyme-Linked Immunosorbent Assay/veterinary ; Leukemia Virus, Bovine/genetics ; Leukemia Virus, Bovine/isolation & purification ; Nucleic Acid Amplification Techniques/veterinary ; Real-Time Polymerase Chain Reaction/veterinary
Language	English
Publishing date	2017-01-20
Publishing country	Japan
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1071753-5
ISSN	1347-7439 ; 0916-7250
ISSN (online)	1347-7439
ISSN	0916-7250
DOI	10.1292/jvms.16-0328
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Article ; Online: Cutaneous Pseudallescheria boydii/Scedosporium apiospermum Complex (Molecular type: Scedosporium apiospermum [Clade 4]) Infection: A Case Report and Literature Review of Cases from Japan.

Ishii, Satoko / Hiruma, Midori / Hayakawa, Yuji / Sugita, Takashi / Makimura, Koichi / Hiruma, Masataro / Yoshiike, Takashi

Medical mycology journal

2015 Volume 56, Issue 4, Page(s) E25–30

Abstract: We report a case of subcutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection occurring in a 77-year-old Japanese female farmer suffering from interstitial pneumonia. Seven months prior to the current presentation, she noticed nodes ...

Abstract	We report a case of subcutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection occurring in a 77-year-old Japanese female farmer suffering from interstitial pneumonia. Seven months prior to the current presentation, she noticed nodes on her right forearm after pulling up weeds, and the nodes grew larger. Two soft dome-shaped, protruded nodes ( 15 mm and 30 mm in size ) had fused together on the extensor surface of the right forearm. Yellowish-white, rice-grain-sized pustules clustered on the surface. Histopathological examination of the skin specimen showed large and small abscesses surrounded by epithelioid granuloma; separate branching hyphae within the granulation tissue were stained with PAS. No grains were observed. Fungal culture yielded fast-growing, grayish-white, fluffy colonies which were identified as Scedosporium apiospermum (Clade 4) using sequence analysis of the β-tubulin gene. We also reviewed 28 previously reported Japanese cases of P. boydii or S. apiospermum infection presenting with skin manifestations.
MeSH term(s)	Administration, Oral ; Aged ; Asian Continental Ancestry Group ; Cyclosporine/administration & dosage ; Cyclosporine/adverse effects ; Dermatomycoses/diagnosis ; Dermatomycoses/etiology ; Dermatomycoses/microbiology ; Dermatomycoses/pathology ; Female ; Humans ; Idiopathic Interstitial Pneumonias/complications ; Idiopathic Interstitial Pneumonias/drug therapy ; Immunocompromised Host ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Pseudallescheria/isolation & purification ; Scedosporium/isolation & purification
Chemical Substances	Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D)
Language	English
Publishing date	2015
Publishing country	Japan
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2628906-4
ISSN	1882-0476 ; 2186-165X ; 2185-6486 ; 0916-4804
ISSN (online)	1882-0476 ; 2186-165X
ISSN	2185-6486 ; 0916-4804
DOI	10.3314/mmj.56.E25
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Article: [Antiemetic effect of palonosetron in advanced colorectal cancer patients receiving mFOLFOX6 and FOLFIRI: a retrospective survey].

Sato, Yumiko / Hayakawa, Yuji / Tatematsu, Michiko / Muro, Kei / Noma, Hidekazu / Okamoto, Hirokazu

Gan to kagaku ryoho. Cancer & chemotherapy

2012 Volume 39, Issue 8, Page(s) 1215–1219

Abstract: Controlling chemotherapy-induced nausea and vomiting(CINV)is very important for the continuation of chemotherapy. CINV can significantly affect a patient's quality of life, leading to poor compliance with further chemotherapy treatment. In this ... ...

Abstract	Controlling chemotherapy-induced nausea and vomiting(CINV)is very important for the continuation of chemotherapy. CINV can significantly affect a patient's quality of life, leading to poor compliance with further chemotherapy treatment. In this retrospective study, we assessed the efficacy of palonosetron versus granisetron for the incidence of CINV induced by mFOLFOX6 and FOLFIRI in patients with advanced colorectal cancer. Eighty-eight patients were included in the efficacy analyses: 39 patients in the palonosetron group and 49 patients in the granisetron group. The incidence of nausea in the granisetron group(Grade 1: 40. 8%, Grade 2: 10. 2% and Grade 3: 4. 1%)was significantly higher than in the palonosetron group (Grade 1: 25. 6% and Grade 2: 7. 7%, p=0. 0422). The incidence of vomiting and appetite loss in the granisetron group was not significantly higher than in the palonosetron group(p=0. 2419, p=0. 2648, respectively). This suggests that palonosetron exerts better efficacy against chemotherapy-induced nausea than granisetron in patients receiving mFOLFOX6 and FOLFIRI. Information on such analyses is useful to promote the effectiveness of cancer chemotherapy.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antiemetics/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin/adverse effects ; Camptothecin/analogs & derivatives ; Camptothecin/therapeutic use ; Colorectal Neoplasms/drug therapy ; Female ; Fluorouracil/adverse effects ; Fluorouracil/therapeutic use ; Humans ; Isoquinolines/therapeutic use ; Leucovorin/adverse effects ; Leucovorin/therapeutic use ; Male ; Middle Aged ; Nausea/chemically induced ; Nausea/prevention & control ; Organoplatinum Compounds/adverse effects ; Organoplatinum Compounds/therapeutic use ; Quinuclidines/therapeutic use ; Retrospective Studies ; Vomiting/chemically induced ; Vomiting/prevention & control
Chemical Substances	Antiemetics ; Isoquinolines ; Organoplatinum Compounds ; Quinuclidines ; palonosetron (5D06587D6R) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
Language	Japanese
Publishing date	2012-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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