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  1. Article ; Online: Impact of preoperative haemoglobin, albumin, lymphocyte, and platelet score on oral cancer prognosis.

    Ito, Yu / Abe, Atsushi / Hayashi, Hiroki

    Oral diseases

    2024  

    Abstract: Objective: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.: Subjects and methods: Patients (83 men, 32 women; 65.80 ± 11.47 years) ...

    Abstract Objective: To evaluate the preoperative haemoglobin, albumin, lymphocyte, and platelet score as a prognostic indicator in oral squamous cell carcinoma treated by radical surgery.
    Subjects and methods: Patients (83 men, 32 women; 65.80 ± 11.47 years) who underwent radical surgery between 2012 and 2022 were included. Factors affecting overall survival and disease-free survival according to the haemoglobin, albumin, lymphocyte, and platelet score were examined. Patients were categorised into low- and high-score groups using optimal cut-off values obtained from receiver operating characteristic curve analysis.
    Results: The low-score group had poorer overall and disease-free survival (p < 0.001 each). Multivariate analysis identified alcohol consumption (hazard ratio [HR], 3.83; 95% confidence interval [CI]: 1.56-9.41, p = 0.003); vascular invasion (HR, 3.97; 95% CI: 1.60-9.85, p = 0.003); and the haemoglobin, albumin, lymphocyte, and platelet score (HR, 0.39; 95% CI: 0.20-0.78, p = 0.007) as independent prognostic factors for overall survival and vascular (HR, 3.66; 95% CI: 1.79-7.50, p < 0.001) and lymphovascular (HR, 2.44; 95% CI: 1.36-4.41, p = 0.003) invasion as independent prognostic factors for disease-free survival.
    Conclusion: The preoperative haemoglobin, albumin, lymphocyte, and platelet score may be a significant prognostic factor for patients with oral squamous cell carcinoma undergoing radical surgery.
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Toward Ab Initio Reaction Discovery Using the Artificial Force Induced Reaction Method.

    Maeda, Satoshi / Harabuchi, Yu / Hayashi, Hiroki / Mita, Tsuyoshi

    Annual review of physical chemistry

    2023  Volume 74, Page(s) 287–311

    Abstract: Predicting the whole process of a chemical reaction while solving kinetic equations presents an opportunity to realize an on-the-fly kinetic simulation that directly discovers chemical reactions with their product yields. Such a simulation avoids the ... ...

    Abstract Predicting the whole process of a chemical reaction while solving kinetic equations presents an opportunity to realize an on-the-fly kinetic simulation that directly discovers chemical reactions with their product yields. Such a simulation avoids the combinatorial explosion of reaction patterns to be examined by narrowing the search space based on the kinetic analysis of the reaction path network, and would open a new paradigm beyond the conventional two-step approach, which requires a reaction path network prior to performing a kinetic simulation. The authors addressed this issue and developed a practical method by combining the artificial force induced reaction method with the rate constant matrix contraction method. Two algorithms are available for this purpose: a forward mode with reactants as the input and a backward mode with products as the input. This article first numerically verifies these modes for known reactions and then demonstrates their application to the actual reaction discovery. Finally, the challenges of this method and the prospects for ab initio reaction discovery are discussed.
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1470474-2
    ISSN 1545-1593 ; 0066-426X
    ISSN (online) 1545-1593
    ISSN 0066-426X
    DOI 10.1146/annurev-physchem-102822-101025
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  3. Article: Quantum chemical calculations for reaction prediction in the development of synthetic methodologies.

    Hayashi, Hiroki / Maeda, Satoshi / Mita, Tsuyoshi

    Chemical science

    2023  Volume 14, Issue 42, Page(s) 11601–11616

    Abstract: Quantum chemical calculations have been used in the development of synthetic methodologies to analyze the reaction mechanisms of the developed reactions. Their ability to estimate chemical reaction pathways, including transition state energies and ... ...

    Abstract Quantum chemical calculations have been used in the development of synthetic methodologies to analyze the reaction mechanisms of the developed reactions. Their ability to estimate chemical reaction pathways, including transition state energies and connected equilibria, has led researchers to embrace their use in predicting unknown reactions. This perspective highlights strategies that leverage quantum chemical calculations for the prediction of reactions in the discovery of new methodologies. Selected examples demonstrate how computation has driven the development of unknown reactions, catalyst design, and the exploration of synthetic routes to complex molecules prior to often laborious, costly, and time-consuming experimental investigations.
    Language English
    Publishing date 2023-09-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc03319h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A Set of Plasmid-Based Modules for Easy Switching of C-Terminal Epitope Tags in

    Hayashi, Hiroki / Kishi, Tsutomu

    Microorganisms

    2021  Volume 9, Issue 12

    Abstract: Epitope tagging is a powerful strategy for analyzing the functions of targeted proteins. The use of this strategy has become more convenient with the development of the epitope switch, which is another type of epitope tagging designed to convert the ... ...

    Abstract Epitope tagging is a powerful strategy for analyzing the functions of targeted proteins. The use of this strategy has become more convenient with the development of the epitope switch, which is another type of epitope tagging designed to convert the previously tagged epitopes on the chromosome to other epitopes of interest. Various modules for C-terminal epitope switching have been developed and amplified using the one-step polymerase chain reaction (PCR) method before transformation. However, PCR amplification occasionally generates mutations that affect the fidelity of epitope switching. Here, we constructed several plasmids to isolate modules for epitope switching through digestion by restriction enzymes. The isolated modules contained DNA sequences for homologous recombination, various epitopes (13×Myc, 6×HA, GFP, Venus, YFP, mCherry, and CFP), and a transformation marker (
    Language English
    Publishing date 2021-12-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9122505
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  5. Article ; Online: Additional renoprotective effect of the SGLT2 inhibitor dapagliflozin in a patient with ADPKD receiving tolvaptan treatment.

    Minatoguchi, Shun / Hayashi, Hiroki / Umeda, Ryosuke / Koide, Shigehisa / Hasegawa, Midori / Tsuboi, Naotake

    CEN case reports

    2024  

    Abstract: Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of end-stage kidney disease (ESKD). Vasopressin plays a pivotal role in ADPKD progression; therefore, the selective vasopressin V2 receptor antagonist tolvaptan is used as a key drug ... ...

    Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of end-stage kidney disease (ESKD). Vasopressin plays a pivotal role in ADPKD progression; therefore, the selective vasopressin V2 receptor antagonist tolvaptan is used as a key drug in the management of ADPKD. On the other hand, sodium-glucose cotransporter-2 inhibitors (SGLT2i), which may possibly stimulate vasopressin secretion due to the diuretic effect of the drug, have been shown to have both renal and cardioprotective effects in various populations, including those with non-diabetic chronic kidney disease. However, the effect of SGLT2i in patients with ADPKD have not been fully elucidated. Herein, we report the case of a patient with ADPKD on tolvaptan who was administered the SGLT2i dapagliflozin. The patient was a Japanese woman diagnosed with ADPKD at age 30. Despite the treatment with tolvaptan, eGFR was gradually declined from 79.8 to 50 ml/min/1.73 m
    Language English
    Publishing date 2024-03-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-024-00859-1
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  6. Article ; Online: Intrathoracic Needle Migration from the Mediastinum into the Thoracic Cavity.

    Sato, Tomo / Kato, Yasufumi / Kataba, Hiroaki / Yoshida, Koichi / Hayashi, Hiroki / Kakihana, Masatoshi / Ikeda, Norihiko

    Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

    2024  Volume 30, Issue 1

    Abstract: Intrathoracic needles are rarely used in clinical practice. They can migrate within the body, injure large blood vessels and other organs, and cause severe complications. We report an interesting case of intrathoracic needle removal using video-assisted ... ...

    Abstract Intrathoracic needles are rarely used in clinical practice. They can migrate within the body, injure large blood vessels and other organs, and cause severe complications. We report an interesting case of intrathoracic needle removal using video-assisted thoracoscopic surgery. The needle was inserted under the left clavicle, penetrated the mediastinum, and migrated into the right thoracic cavity. Although pneumothorax developed during the disease course, no severe complications were observed. This rare case illustrates the course of needle migration from the mediastinum into the thoracic cavity. Prompt imaging and surgical removal of foreign bodies are necessary in cases of intrathoracic foreign bodies.
    MeSH term(s) Humans ; Mediastinum ; Treatment Outcome ; Thoracic Cavity/surgery ; Foreign Bodies/surgery ; Thoracic Surgery, Video-Assisted/methods ; Foreign-Body Migration/surgery
    Language English
    Publishing date 2024-04-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2019756-1
    ISSN 2186-1005 ; 1341-1098
    ISSN (online) 2186-1005
    ISSN 1341-1098
    DOI 10.5761/atcs.cr.24-00039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5253: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: A Set of Plasmid-Based Modules for Easy Switching of C-Terminal Epitope Tags in Saccharomyces cerevisiae

    Hayashi, Hiroki / Kishi, Tsutomu

    Microorganisms. 2021 Dec. 03, v. 9, no. 12

    2021  

    Abstract: Epitope tagging is a powerful strategy for analyzing the functions of targeted proteins. The use of this strategy has become more convenient with the development of the epitope switch, which is another type of epitope tagging designed to convert the ... ...

    Abstract Epitope tagging is a powerful strategy for analyzing the functions of targeted proteins. The use of this strategy has become more convenient with the development of the epitope switch, which is another type of epitope tagging designed to convert the previously tagged epitopes on the chromosome to other epitopes of interest. Various modules for C-terminal epitope switching have been developed and amplified using the one-step polymerase chain reaction (PCR) method before transformation. However, PCR amplification occasionally generates mutations that affect the fidelity of epitope switching. Here, we constructed several plasmids to isolate modules for epitope switching through digestion by restriction enzymes. The isolated modules contained DNA sequences for homologous recombination, various epitopes (13×Myc, 6×HA, GFP, Venus, YFP, mCherry, and CFP), and a transformation marker (Candida glabrata LEU2). The restriction enzyme-digested plasmids were used to directly transform the cells for epitope switching. We demonstrate the efficient and accurate switching of the MX6 module-based C-terminal tandem affinity purification tags to each aforementioned epitope. We believe that our plasmids can serve as powerful tools for the functional analysis of yeast proteins.
    Keywords Candida glabrata ; Saccharomyces cerevisiae ; chromosomes ; digestion ; epitopes ; homologous recombination ; plasmids ; polymerase chain reaction ; yeasts
    Language English
    Dates of publication 2021-1203
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9122505
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Sick sinus syndrome diagnosed after a sinus arrest during treatment for zygomatic fracture: a case report.

    Hayashi, Hiroki / Abe, Atsushi / Oguma, Tetsushi / Ito, Yu / Nakayama, Atsushi

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 676

    Abstract: Background: Intraoperative sinus arrest is rarely seen during zygomatic fracture treatment. The patient was diagnosed with sick sinus syndrome based on repeated postoperative sinus arrest, which could have resulted in death if diagnosed late, making ... ...

    Abstract Background: Intraoperative sinus arrest is rarely seen during zygomatic fracture treatment. The patient was diagnosed with sick sinus syndrome based on repeated postoperative sinus arrest, which could have resulted in death if diagnosed late, making this case very significant to report.
    Case presentation: Sick sinus syndrome is an arrhythmia associated with reduced automaticity of the sinoatrial node or impaired sinoatrial node conduction. We report the case of a 67-year-old man diagnosed with the syndrome after a sinus arrest that occurred during a zygomatic fracture treatment. The patient had cheek pain and mouth opening disorder, dizziness after fainting and sustaining a facial injury. Preoperative examination determined that the syncope was due to drug-induced arrhythmia, and surgery was authorized after drug withdrawal. During the operation, sinus arrest was observed due to trigeminal vagal reflex, and heart rate was restarted by stopping the operation and chest compressions. After the surgery, the patient showed symptoms of dizziness and palpitations, and sinus arrest following atrial fibrillation and supraventricular tachycardia, which was diagnosed as sick sinus syndrome, and a pacemaker was implanted. Currently, 8 years have passed since the surgery, and there are no symptoms of mouth opening disorder, dizziness, or palpitations.
    Conclusions: In the case of maxillofacial injuries due to syncope, cardiogenic syncope is a possibility, and repeated syncope is a risk for death due to delayed diagnosis. There are no reports of maxillofacial trauma leading to a diagnosis of sick sinus syndrome. The purpose of this case report is to disseminate the importance of diagnosing the cause of syncope as well as injury treatment.
    MeSH term(s) Male ; Humans ; Aged ; Zygomatic Fractures ; Sick Sinus Syndrome/therapy ; Dizziness ; Syncope/etiology ; Atrial Fibrillation
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03413-0
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  9. Book ; Online: Observation of orbital pumping

    Hayashi, Hiroki / Go, Dongwook / Mokrousov, Yuriy / Ando, Kazuya

    2023  

    Abstract: Harnessing spin and orbital angular momentum is a fundamental concept in condensed matter physics, materials science, and quantum-device applications. In particular, the search for new phenomena that generate a flow of spin angular momentum, a spin ... ...

    Abstract Harnessing spin and orbital angular momentum is a fundamental concept in condensed matter physics, materials science, and quantum-device applications. In particular, the search for new phenomena that generate a flow of spin angular momentum, a spin current, has led to the development of spintronics, advancing the understanding of angular momentum dynamics at the nanoscale. In contrast to this success, the generation and detection of orbital currents, the orbital counterpart of spin currents, remains a significant challenge. Here, we report the observation of orbital pumping, a phenomenon in which magnetization dynamics pumps an orbital current, a flow of orbital angular momentum. The orbital pumping is the orbital counterpart of the spin pumping, which is one of the most versatile and powerful mechanisms for spin-current generation. We show that the orbital pumping in Ni/Ti bilayers injects an orbital current into the Ti layer, which is detected through the inverse orbital Hall effect. Our findings provide a promising approach for generating orbital currents and pave the way for exploring the physics of orbital transport in solids.
    Keywords Condensed Matter - Mesoscale and Nanoscale Physics ; Condensed Matter - Materials Science
    Subject code 520
    Publishing date 2023-04-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Oxidation and Reduction Pathways in the Knowles Hydroamination via a Photoredox-Catalyzed Radical Reaction.

    Harabuchi, Yu / Hayashi, Hiroki / Takano, Hideaki / Mita, Tsuyoshi / Maeda, Satoshi

    Angewandte Chemie (International ed. in English)

    2022  , Page(s) e202211936

    Abstract: Systematic reaction path exploration revealed the entire mechanism of Knowles's light-promoted catalytic intramolecular hydroamination. Bond formation/cleavage competes with single electron transfer (SET) between the catalyst and substrate. These ... ...

    Abstract Systematic reaction path exploration revealed the entire mechanism of Knowles's light-promoted catalytic intramolecular hydroamination. Bond formation/cleavage competes with single electron transfer (SET) between the catalyst and substrate. These processes are described by adiabatic processes through transition states in an electronic state and non-radiative transitions through the seam of crossings (SX) between different electronic states. This study determined the energetically favorable SET path by introducing a practical computational model representing SET as non-adiabatic transitions via SXs between substrate's potential energy surfaces for different charge states adjusted based on the catalyst's redox potential. Calculations showed that the reduction and proton shuttle process proceeded concertedly. Also, the relative importance of SET paths (giving the product and leading back to the reactant) varies depending on the catalyst's redox potential, affecting the yield.
    Language English
    Publishing date 2022-11-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202211936
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