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  1. Article: Delayed Pseudoprogression in Glioblastoma Patients Treated With Tumor-Treating Fields.

    Saito, Norihiko / Hirai, Nozomi / Sato, Sho / Hayashi, Morito / Iwabuchi, Satoshi

    Cureus

    2024  Volume 16, Issue 2, Page(s) e55147

    Abstract: Tumor-treating fields (TTFields) is an established treatment modality for glioblastoma. False progression to chemoradiation is a known problem in patients with glioblastoma multiforme (GBM), with most cases occurring within three months of radiation ... ...

    Abstract Tumor-treating fields (TTFields) is an established treatment modality for glioblastoma. False progression to chemoradiation is a known problem in patients with glioblastoma multiforme (GBM), with most cases occurring within three months of radiation therapy. In this report, we present two cases of delayed pseudoprogression caused by TTFields. Two patients with GBM who received TTFields showed signs of radiographic progression six months after the completion of radiation therapy. Patient 1 was a 37-year-old female with a glioblastoma in the right temporal lobe. Patient 2 was a 70-year-old male with glioblastoma in the left temporal lobe. Both patients received radiation therapy, followed by temozolomide (TMZ) maintenance therapy and TTFields. Patient 1 underwent a second resection; however, the pathology revealed only a treatment effect, and the final diagnosis was a pseudoprogression. In Case 2, the disease resolved with steroid therapy alone. In both patients, the lesions appeared later than during the typical pseudoprogression period. A recent study reported that TTFields increase the permeability of the plasma cell membrane, which may result in further leakage of gadolinium into the extracellular lumen. Further studies are needed to better characterize delayed pseudoprogression and improve treatment outcomes.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.55147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Predictive Value of Acute Neurological Progression Using Bayesian CT Perfusion for Acute Ischemic Stroke with Large or Median Vessel Occlusion.

    Yoshii, Shinya / Fujita, Satoshi / Hiramoto, Yu / Hayashi, Morito / Iwabuchi, Satoshi

    Journal of neuroendovascular therapy

    2023  Volume 18, Issue 1, Page(s) 1–9

    Abstract: Objective: Since the efficacy of mechanical thrombectomy (MT) for acute cerebral infarction due to large vessel occlusion has been proven, the time available for treatment has gradually increased. Currently, under certain conditions, treatment is ... ...

    Abstract Objective: Since the efficacy of mechanical thrombectomy (MT) for acute cerebral infarction due to large vessel occlusion has been proven, the time available for treatment has gradually increased. Currently, under certain conditions, treatment is indicated up to 24 h from onset. Based on neurological signs and imaging diagnosis, Stroke Treatment Guideline 2021 recommends initiation of MT within 6-24 h from onset. Herein, we retrospectively investigated the relationship between cerebral perfusion imaging evaluation and prognosis in patients with acute cerebral infarction due to large or median vessel occlusion.
    Methods: Fifty-one patients diagnosed with acute cerebral infarction due to large or median vessel occlusions in anterior circulation between November 2019 and December 2021 were divided into medical care and reconstructive therapy (including tissue plasminogen activator [t-PA] therapy and MT) groups. The primary outcome was changes in the National Institutes of Health Stroke Scale (NIHSS) at admission and 1 week after onset. Patients in the medical care group were divided into those whose NIHSS did not worsen and those whose NIHSS worsened. Those in the reconstructive therapy group were divided into those whose NIHSS improved and those whose NIHSS did not improve. We evaluated the relationship between improvement factors in acute neurological symptoms and penumbral and core volumes from computed tomography perfusion performed at admission.
    Results: Of 45 eligible patients, 10 received medical care without t-PA or MT and 35 underwent reconstructive therapy, including t-PA and MT. Among the 10 patients in the medical care group, 3 had worsening symptoms and 7 did not. The mean and median (interquartile range [IQR]) penumbra volumes were significantly higher in patients with worsening symptoms than in those without. The receiver operating characteristic (ROC) curve showed a threshold value of 28.6 mL with an area under the curve (AUC) of 0.952. Among the 35 patients in the reconstructive therapy group, symptoms improved for 29 but did not improve for 6. The mean and median (IQR) core volumes were significantly higher in patients whose symptoms did not improve than in those whose symptoms improved. The ROC curve showed a threshold value of 25 mL and an AUC of 0.632.
    Conclusion: Evaluation of penumbra volumes could detect cases with worsening symptoms in cases where medical care was performed, and evaluation of core volumes may detect cases with non-improved symptoms in cases that received reconstructive therapy.
    Language English
    Publishing date 2023-11-22
    Publishing country Japan
    Document type Journal Article
    ISSN 2186-2494
    ISSN (online) 2186-2494
    DOI 10.5797/jnet.oa.2023-0046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of Treatment Strategies for Male Prolactin-Secreting Pituitary Neuroendocrine Tumors.

    Saito, Norihiko / Hirai, Nozomi / Koyahara, Yuki / Sato, Sho / Hiramoto, Yu / Fujita, Satoshi / Nakayama, Haruo / Hayashi, Morito / Iwabuchi, Satoshi

    Cureus

    2024  Volume 16, Issue 2, Page(s) e54503

    Abstract: Prolactin-secreting pituitary neuroendocrine tumors (PitNETs) are more common in women. Male patients may also have few symptoms and have macroadenomas extending outside the sella turcica. This study aimed to report the results of cabergoline treatment ... ...

    Abstract Prolactin-secreting pituitary neuroendocrine tumors (PitNETs) are more common in women. Male patients may also have few symptoms and have macroadenomas extending outside the sella turcica. This study aimed to report the results of cabergoline treatment in male patients with prolactin-secreting PitNET. The study included nine male patients aged 26-65 years (median, 46 years) diagnosed with prolactin-secreting PitNETs. The age at onset, prolactin values, tumor size, symptoms, and treatment were assessed. The mean prolactin value at the initial presentation was 2734.6 ng/mL, and the mean maximum tumor diameter was 40.4 mm. Visual field disturbance was the most common symptom (44.4%), followed by headaches (33.3%), asymptomatic symptoms (11.1%), and galactorrhea (11.1%). Eight patients responded to cabergoline treatment with normalization of prolactin levels and tumor shrinkage. One patient did not respond to the cabergoline treatment and required surgical intervention. There were no cases of cerebrospinal fluid leakage. Cabergoline was found to be an effective treatment for male prolactin-secreting PitNETs.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Comparative Study of Postmortem MRI and Pathological Findings in Malignant Brain Tumors.

    Saito, Norihiko / Hirai, Nozomi / Koyahara, Yuki / Sato, Sho / Hiramoto, Yu / Fujita, Satoshi / Nakayama, Haruo / Hayashi, Morito / Ito, Keisuke / Iwabuchi, Satoshi

    Cureus

    2024  Volume 16, Issue 3, Page(s) e56241

    Abstract: This study compared magnetic resonance imaging (MRI) findings of postmortem brain specimens with neuropathological findings to evaluate the value of postmortem MRI. Postmortem MRI was performed on five formalin-fixed whole brains with malignant tumors. ... ...

    Abstract This study compared magnetic resonance imaging (MRI) findings of postmortem brain specimens with neuropathological findings to evaluate the value of postmortem MRI. Postmortem MRI was performed on five formalin-fixed whole brains with malignant tumors. Postmortem T2-weighted images detected all neuropathological abnormalities as high-signal regions but also showed histological tumor invasion in areas without edema. Tumor lesions with high necrosis and edema showed high signal intensity on T2-weighted images; in three cases, lesion enlargement was detected on the final prenatal imaging and postmortem MRI. Disease progression immediately before death may have contributed to this difference. In conclusion, the correlation between MRI and neuropathological findings facilitates understanding of the mechanisms responsible for MRI abnormalities. Increased free water due to edema, necrosis, and brain tissue injury can explain the increased signal intensity observed on T2-weighted images. Postmortem MRI may contribute to effective pathology by identifying subtle abnormalities prior to brain dissection.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.56241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: [Subcortical calcification on CT in Borden type III intracranial dural arteriovenous fistula].

    Saito, Kazuyuki / Hino, Taro / Fujita, Satoshi / Hayashi, Morito / Kubodera, Takayuki / Wada, Yoshiaki

    Rinsho shinkeigaku = Clinical neurology

    2019  Volume 59, Issue 2, Page(s) 93–97

    Abstract: We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. ... ...

    Abstract We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. Electroencephalography indicated diffuse spike and slow wave complex, so non-convulsive status epilepticus was diagnosed. Cerebral angiography revealed several feeder arteries with retrograde leptomeningeal venous drainage. We diagnosed her with Borden type III cerebral dural arteriovenous fistulas. Trans-arterial embolization with n-butyl-2-cyanoacrylate was performed, and she has experienced no epileptic attacks for at least ten months. Calcification changes are sometimes seen in Borden type II dural arteriovenous fistulas but not in aggressive types, such as Borden type III. It is important to suspect dural arteriovenous fistulas when we encounter patients with progressive dementia or/and epilepsy with cerebral calcification lesions, as this may be a treatable disease condition.
    MeSH term(s) Aged ; Brain/blood supply ; Brain/pathology ; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; Calcinosis/diagnostic imaging ; Calcinosis/pathology ; Central Nervous System Vascular Malformations/classification ; Central Nervous System Vascular Malformations/diagnostic imaging ; Central Nervous System Vascular Malformations/pathology ; Central Nervous System Vascular Malformations/surgery ; Cerebral Angiography ; Dementia ; Disease Progression ; Embolization, Therapeutic ; Enbucrilate/administration & dosage ; Endovascular Procedures ; Female ; Humans ; Status Epilepticus ; Tomography, X-Ray Computed
    Chemical Substances Enbucrilate (F8CEP82QNP)
    Language Japanese
    Publishing date 2019-01-31
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.cn-001200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 223: Show issues

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  6. Article: The Oncogene Addiction Switch from NOTCH to PI3K Requires Simultaneous Targeting of NOTCH and PI3K Pathway Inhibition in Glioblastoma.

    Saito, Norihiko / Hirai, Nozomi / Aoki, Kazuya / Suzuki, Ryo / Fujita, Satoshi / Nakayama, Haruo / Hayashi, Morito / Ito, Keisuke / Sakurai, Takatoshi / Iwabuchi, Satoshi

    Cancers

    2019  Volume 11, Issue 1

    Abstract: The NOTCH pathway regulates neural stem cells and glioma initiating cells (GICs). However, blocking NOTCH activity with γ-secretase inhibitors (GSIs) fails to alter the growth of GICs, as GSIs seem to be active in only a fraction of GICs lines with ... ...

    Abstract The NOTCH pathway regulates neural stem cells and glioma initiating cells (GICs). However, blocking NOTCH activity with γ-secretase inhibitors (GSIs) fails to alter the growth of GICs, as GSIs seem to be active in only a fraction of GICs lines with constitutive NOTCH activity. Here we report loss of
    Language English
    Publishing date 2019-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11010121
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  7. Article ; Online: Sail or sink: novel behavioural adaptations on water in aerially dispersing species.

    Hayashi, Morito / Bakkali, Mohammed / Hyde, Alexander / Goodacre, Sara L

    BMC evolutionary biology

    2015  Volume 15, Page(s) 118

    Abstract: Background: Long-distance dispersal events have the potential to shape species distributions and ecosystem diversity over large spatial scales, and to influence processes such as population persistence and the pace and scale of invasion. How such ... ...

    Abstract Background: Long-distance dispersal events have the potential to shape species distributions and ecosystem diversity over large spatial scales, and to influence processes such as population persistence and the pace and scale of invasion. How such dispersal strategies have evolved and are maintained within species is, however, often unclear. We have studied long-distance dispersal in a range of pest-controlling terrestrial spiders that are important predators within agricultural ecosystems. These species persist in heterogeneous environments through their ability to re-colonise vacant habitat by repeated long-distance aerial dispersal ("ballooning") using spun silk lines. Individuals are strictly terrestrial, are not thought to tolerate landing on water, and have no control over where they land once airborne. Their tendency to spread via aerial dispersal has thus been thought to be limited by the costs of encountering water, which is a frequent hazard in the landscape.
    Results: In our study we find that ballooning in a subset of individuals from two groups of widely-distributed and phylogenetically distinct terrestrial spiders (linyphiids and one tetragnathid) is associated with a hitherto undescribed ability of those same individuals to survive encounters with both fresh and marine water. Individuals that showed a high tendency to adopt 'ballooning' behaviour adopted elaborate postures to seemingly take advantage of the wind current whilst on the water surface.
    Conclusions: The ability of individuals capable of long-distance aerial dispersal to survive encounters with water allows them to disperse repeatedly, thereby increasing the pace and spatial scale over which they can spread and subsequently exert an influence on the ecosystems into which they migrate. The potential for genetic connectivity between populations, which can influence the rate of localized adaptation, thus exists over much larger geographic scales than previously thought. Newly available habitat may be particularly influenced given the degree of ecosystem disturbance that is known to follow new predator introductions.
    MeSH term(s) Adaptation, Physiological ; Animal Migration ; Animals ; Ecosystem ; Phylogeny ; Spiders/classification ; Spiders/genetics ; Spiders/physiology ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2015-07-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2148
    ISSN (online) 1471-2148
    DOI 10.1186/s12862-015-0402-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum to: Sail or sink: novel behavioural adaptations on water in aerially dispersing species.

    Hayashi, Morito / Bakkali, Mohammed / Hyde, Alexander / Goodacre, Sara L

    BMC evolutionary biology

    2015  Volume 15, Page(s) 228

    Language English
    Publishing date 2015-10-20
    Publishing country England
    Document type Published Erratum
    ISSN 1471-2148
    ISSN (online) 1471-2148
    DOI 10.1186/s12862-015-0500-4
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  9. Article: Corrigendum to "Relationship between the Direction of Ophthalmic Artery Blood Flow and Ocular Microcirculation before and after Carotid Artery Stenting".

    Ishii, Masashi / Hayashi, Morito / Yagi, Fumihiko / Sato, Kenichiro / Tomita, Goji / Iwabuchi, Satoshi

    Journal of ophthalmology

    2017  Volume 2017, Page(s) 7861491

    Abstract: This corrects the article DOI: 10.1155/2016/2530914.]. ...

    Abstract [This corrects the article DOI: 10.1155/2016/2530914.].
    Language English
    Publishing date 2017-11-12
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2017/7861491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Relationship between the Direction of Ophthalmic Artery Blood Flow and Ocular Microcirculation before and after Carotid Artery Stenting.

    Ishii, Masashi / Hayashi, Morito / Yagi, Fumihiko / Sato, Kenichiro / Tomita, Goji / Iwabuchi, Satoshi

    Journal of ophthalmology

    2016  Volume 2016, Page(s) 2530914

    Abstract: When internal carotid artery stenosis is accompanied by ocular ischemic syndrome, intervention is recommended to prevent irreversible visual loss. In this study, we used laser speckle flowgraphy to measure the ocular microcirculation in the optic nerve ... ...

    Abstract When internal carotid artery stenosis is accompanied by ocular ischemic syndrome, intervention is recommended to prevent irreversible visual loss. In this study, we used laser speckle flowgraphy to measure the ocular microcirculation in the optic nerve head before and after carotid artery stenting (CAS) of 40 advanced internal carotid stenosis lesions from 37 patients. The aim was to investigate the relationship between ocular microcirculation and the direction of ophthalmic artery blood flow obtained by angiography. We found that there was a significant increase in blood flow after CAS (
    Language English
    Publishing date 2016-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2546525-9
    ISSN 2090-0058 ; 2090-004X
    ISSN (online) 2090-0058
    ISSN 2090-004X
    DOI 10.1155/2016/2530914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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