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  1. Article ; Online: Diary of a Family Physician.

    Hayashi, Seiji

    American family physician

    2024  Volume 108, Issue 6, Page(s) 623

    MeSH term(s) Humans ; Physicians, Family ; Surveys and Questionnaires ; Family
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  2. Article ; Online: Diary of a Family Physician.

    Hayashi, Seiji

    American family physician

    2022  Volume 106, Issue 4, Page(s) 458

    MeSH term(s) Humans ; Physicians, Family ; Surveys and Questionnaires
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  3. Article ; Online: Diary of a Family Physician.

    Hayashi, Seiji

    American family physician

    2021  Volume 104, Issue 6, Page(s) 644

    MeSH term(s) Diaries as Topic ; Humans ; Male ; Middle Aged ; Physicians, Family/psychology ; Physicians, Family/trends
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  4. Article ; Online: Diary of a Family Physician.

    Hayashi, Seiji

    American family physician

    2021  Volume 103, Issue 4, Page(s) 240

    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  5. Article ; Online: Lasing in Low-Dimensional Crystals of a Fumaronitrile-Based Luminogen.

    Matsuo, Takumi / Hayashi, Shotaro

    The journal of physical chemistry letters

    2024  Volume 15, Issue 14, Page(s) 3968–3974

    Abstract: Low-dimensional structures are ideal for organic laser media because of their efficient waveguide, photon confinement, and stimulated emission. Control of the structure and alignment of luminescent molecules is very important for realizing laser media. ... ...

    Abstract Low-dimensional structures are ideal for organic laser media because of their efficient waveguide, photon confinement, and stimulated emission. Control of the structure and alignment of luminescent molecules is very important for realizing laser media. Here, we fabricate low-dimensional crystals of bis(biphenyl)fumaronitrile (BPFN), which is an aggregation-induced emission luminogen. The BPFN molecule contains fumaronitrile, which displays solid-state luminescence, and biphenyl, which forms low-dimensional structures through dipole-dipole interactions. Solvent diffusion yielded two-dimensional platelet crystals of BPFN with strong dipole-dipole CH-π interactions. The high photoluminescence quantum efficiency of 0.46 and uniaxially aligned molecular π-electronic transition dipole moment in the two-dimensional crystals of BPFN resulted in optically pumped lasing even when using an optical excitation source with a long pulse duration (∼5 ns). One-dimensional BPFN crystals obtained via epitaxial growth on the cleaved surface of a KBr single crystal also displayed lasing behavior.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c03401
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  6. Article ; Online: High-resolution mass spectrometry imaging reveals skin lipid changes and the cholesterol sulphate cycle during keratinization.

    Tokoro, S / Ogawa, T / Hayashi, S / Igawa, K

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  

    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19621
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    Zs.A 3492: Show issues Location:
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    Zs.MO 413: Show issues

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  7. Article ; Online: [Unraveling the Pathogenesis of Inflammatory Bowel Disease and Search for New Therapeutic Medicines].

    Hayashi, Shusaku

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2020  Volume 140, Issue 2, Page(s) 123–128

    Abstract: The breakdown of the intestinal mucosal barrier has been shown to play a key role in the pathogenesis of intestinal immune-related disorders such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disorder with intermittent episodes of ... ...

    Abstract The breakdown of the intestinal mucosal barrier has been shown to play a key role in the pathogenesis of intestinal immune-related disorders such as inflammatory bowel disease (IBD). IBD is a chronic inflammatory disorder with intermittent episodes of remission and relapse, and the incidence of IBD in Japan has risen dramatically in recent decades. Although sustained clinical remission has recently been recognized as an important goal of IBD therapy, there are not many treatment options to maintain long-term remission. Intestinal macrophages play pivotal roles in the regulation of immune homeostasis and inflammation in the intestine. Resident intestinal macrophages can regulate themselves and other immune cells, primarily through the spontaneous secretion of interleukin-10 (IL-10). We reported that the enhancement of IL-10 production by intestinal macrophages has the potential to be a novel therapeutic mechanism for maintaining the remission of IBD. Thus, to develop new therapeutic medicines for IBD, we screened the Wakanyaku Library derived from medicinal herbs for the ability to enhance IL-10 production by intestinal macrophages. Some compounds were identified with the potential to enhance IL-10 production by intestinal macrophages and thereby maintain long-term remission in IBD. This review focuses on our recent findings on the role of intestinal macrophages in the pathogenesis of IBD and developing a novel therapeutic strategy aimed at maintaining remission in IBD.
    MeSH term(s) Drug Development ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/immunology ; Interleukin-10/immunology ; Interleukin-10/metabolism ; Intestinal Mucosa/immunology ; Macrophages/immunology
    Chemical Substances Interleukin-10 (130068-27-8)
    Language Japanese
    Publishing date 2020-01-23
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.19-00164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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  8. Article ; Online: Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila.

    Yoshida, Kentaro / Hayashi, Shigeo

    Development (Cambridge, England)

    2023  Volume 150, Issue 5

    Abstract: Dying cells in the epithelia communicate with neighboring cells to initiate coordinated cell removal to maintain epithelial integrity. Naturally occurring apoptotic cells are mostly extruded basally and engulfed by macrophages. Here, we have investigated ...

    Abstract Dying cells in the epithelia communicate with neighboring cells to initiate coordinated cell removal to maintain epithelial integrity. Naturally occurring apoptotic cells are mostly extruded basally and engulfed by macrophages. Here, we have investigated the role of Epidermal growth factor (EGF) receptor (EGFR) signaling in the maintenance of epithelial homeostasis. In Drosophila embryos, epithelial tissues undergoing groove formation preferentially enhanced extracellular signal-regulated kinase (ERK) signaling. In EGFR mutant embryos at stage 11, sporadic apical cell extrusion in the head initiates a cascade of apical extrusions of apoptotic and non-apoptotic cells that sweeps the entire ventral body wall. Here, we show that this process is apoptosis dependent, and clustered apoptosis, groove formation, and wounding sensitize EGFR mutant epithelia to initiate massive tissue disintegration. We further show that tissue detachment from the vitelline membrane, which frequently occurs during morphogenetic processes, is a key trigger for the EGFR mutant phenotype. These findings indicate that, in addition to cell survival, EGFR plays a role in maintaining epithelial integrity, which is essential for protecting tissues from transient instability caused by morphogenetic movement and damage.
    MeSH term(s) Animals ; Drosophila/metabolism ; Epidermal Growth Factor/metabolism ; Epithelium/metabolism ; ErbB Receptors/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Phosphorylation ; Signal Transduction
    Chemical Substances Epidermal Growth Factor (62229-50-9) ; ErbB Receptors (EC 2.7.10.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Egfr protein, Drosophila (EC 2.7.10.1)
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.201231
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    Ub I Zs.183: Show issues Location:
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  9. Article ; Online: High-Density Formation of Ir/MoO

    Hayashi, Shun / Shishido, Tetsuya

    ACS organic & inorganic Au

    2023  Volume 3, Issue 5, Page(s) 283–290

    Abstract: To form high-density metal/oxide interfacial active sites, we developed a catalyst preparation method based on hybrid clustering. An iridium-molybdenum (Ir-Mo) hybrid clustering catalyst was prepared by using the hybrid cluster [(IrCp*) ...

    Abstract To form high-density metal/oxide interfacial active sites, we developed a catalyst preparation method based on hybrid clustering. An iridium-molybdenum (Ir-Mo) hybrid clustering catalyst was prepared by using the hybrid cluster [(IrCp*)
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ISSN 2694-247X
    ISSN (online) 2694-247X
    DOI 10.1021/acsorginorgau.3c00017
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  10. Article ; Online: Gasless laparoendoscopic single-site assisted extracorporeal ovarian cystectomy through the umbilicus for the management of ovarian torsion at 33 weeks of gestation: A case report with literature review.

    Takeda, Akihiro / Hayashi, Shotaro

    Case reports in women's health

    2023  Volume 38, Page(s) e00517

    Abstract: Ovarian torsion in the third trimester of pregnancy is a rare but potentially dangerous non-obstetric complication for both mother and fetus and presents a diagnostic and therapeutic challenge for the treating physicians. A 39-year-old woman (gravida 2, ... ...

    Abstract Ovarian torsion in the third trimester of pregnancy is a rare but potentially dangerous non-obstetric complication for both mother and fetus and presents a diagnostic and therapeutic challenge for the treating physicians. A 39-year-old woman (gravida 2, para 1) presented at 7 weeks of gestation. Asymptomatic bilateral small ovarian cysts were diagnosed at the initial presentation. Progesterone was intramuscularly administered every 2 weeks after 28 weeks of gestation because of uterine cervical length shortening. Sudden onset of right lateral abdominal pain was reported at 33 weeks and 2 days of gestation. Emergency laparoendoscopic single-site (LESS) surgery was performed through the umbilicus under strong suspicion of right adnexal torsion with ovarian cyst, as indicated by magnetic resonance imaging a day after admission. Isolated right ovarian torsion without fallopian tube involvement was identified under laparoscopic view. The contents of the right ovarian cyst were aspirated after confirming resumption of color tone of the right ovary after detorsion. Then, the right adnexal tissue was grasped through the umbilicus, followed by a successful ovarian cystectomy under direct vision. Tocolysis was postoperatively attempted by intravenous ritodorine hydrochloride and magnesium sulfate administration, which was continued through to 36 weeks and 4 days of gestation, because of increased uterine contraction frequency. The next day, spontaneous labor occurred, followed by the vaginal delivery of a healthy 2108-g female infant. The postnatal course was uneventful. Transumbilical LESS-assisted extracorporeal ovarian cystectomy is a feasible and minimally invasive option for ovarian torsion management in the third trimester of pregnancy.
    Language English
    Publishing date 2023-06-02
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2023.e00517
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