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  1. Book ; Online: Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy : The JACIE Guide

    Aljurf, Mahmoud / Snowden, John A. / Hayden, Patrick / Orchard, Kim H. / McGrath, Eoin

    2021  

    Keywords Haematology ; Oncology ; Hematology ; Blood Transfusion Medicine ; Internal Medicine ; outcome analysis ; structural indicators ; process indicators ; Hematopoietic Stem Cell Transplantation ; Quality Management ; Audits ; Qualification and Validation ; Personnel Requirements ; Performance Measurement ; Tracking and Traceability ; Adverse Events ; Quality Management Plan ; Accreditation ; Data Management ; Training ; Risk Management ; JACIE
    Size 1 electronic resource (181 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021048350
    ISBN 9783030644925 ; 3030644928
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy

    Aljurf, Mahmoud / Snowden, John A. / Hayden, Patrick / Orchard, Kim H. / McGrath, Eoin

    The JACIE Guide

    2021  

    Author's details edited by Mahmoud Aljurf, John A. Snowden, Patrick Hayden, Kim H. Orchard, Eoin McGrath
    Keywords Hematology ; Oncology   ; Blood transfusion
    Subject code 616.15
    Language English
    Size 1 Online-Ressource (X, 181 p. 42 illus., 34 illus. in color)
    Edition 1st ed. 2021
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT020861941
    ISBN 978-3-030-64492-5 ; 9783030644918 ; 9783030644932 ; 9783030644949 ; 3-030-64492-8 ; 303064491X ; 3030644936 ; 3030644944
    DOI 10.1007/978-3-030-64492-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Recognition and Global Politics

    Schick, Kate / Hayden, Patrick

    2016  

    Abstract: The notion of recognition, drawing on the philosophy of Hegel, has become increasingly central to international debates in recent years, yet there have been few attempts to critically examine new theoretical positions and empirical analyses of its ... ...

    Abstract The notion of recognition, drawing on the philosophy of Hegel, has become increasingly central to international debates in recent years, yet there have been few attempts to critically examine new theoretical positions and empirical analyses of its possible meanings, limits and manifestations. Recognition and global politics examines the potential and limitations of the discourse of recognition as a strategy for reframing justice and injustice within contemporary world affairs. Drawing on resources from social and political theory and international relations theory as well as other areas including feminist theory, postcolonial studies and social psychology, this ambitious collection explores a range of political struggles, social movements and sites of opposition that have shaped certain practices and informed contentious debates in the language of recognition. How have recognition-based claims been deployed in relation to international, transnational and global politics?The contributors speak to central issues in current debates about cosmopolitanism, genocide, human rights, global capitalism, multiculturalism, rebellion and the environment. This innovative volume will push the boundaries of the debate on recognition into new areas, opening up provocative lines of inquiry and critique
    Keywords International relations ; Ethics
    Size 1 electronic resource (264 p.)
    Publisher Manchester University Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091887
    ISBN 9781526101037 ; 1526101033
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Sequence not salvage.

    Sborov, Douglas W / Fortuna, Gliceida Galarza / Hayden, Patrick J

    British journal of haematology

    2024  Volume 204, Issue 5, Page(s) 1590–1592

    Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of multiple myeloma (MM) has fundamentally changed the relapsed and refractory therapeutic landscape, but the disease remains incurable. Two CAR-T products, idecabtagene vicleucel (ide- ... ...

    Abstract Chimeric antigen receptor T-cell (CAR-T) therapy for the treatment of multiple myeloma (MM) has fundamentally changed the relapsed and refractory therapeutic landscape, but the disease remains incurable. Two CAR-T products, idecabtagene vicleucel (ide-cel; Abecma) and ciltacabtagene autoleucel (cilta-cel, Carvykti), have been FDA- and EMA-approved for the treatment of relapsed/refractory MM (RRMM); both target B-cell maturation antigen (BCMA), a surface glycoprotein highly expressed on MM cells. Despite deep and durable responses following CAR-T therapy, most patients will need subsequent treatment, and the optimal next-line therapy is presently unclear. Commentary on: Liu et al. Outcomes in patients with multiple myeloma receiving salvage treatment after BCMA-specific CAR-T therapy: A retrospective analysis of LEGEND-2. Br J Haematol 2024;204:1780-1789.
    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Immunotherapy, Adoptive/methods ; Salvage Therapy/methods ; B-Cell Maturation Antigen ; Receptors, Chimeric Antigen/therapeutic use
    Chemical Substances B-Cell Maturation Antigen ; Receptors, Chimeric Antigen ; idecabtagene vicleucel (8PX1X7UG4D)
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Upfront autologous transplantation still improving outcomes in patients with multiple myeloma.

    Beksac, Meral / Hayden, Patrick

    The Lancet. Haematology

    2022  Volume 10, Issue 2, Page(s) e80–e82

    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Transplantation, Autologous ; Hematopoietic Stem Cell Transplantation/adverse effects ; Antineoplastic Combined Chemotherapy Protocols ; Patients
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(22)00360-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development.

    Kandarova, Helena / Hayden, Patrick J

    Handbook of experimental pharmacology

    2021  Volume 265, Page(s) 57–71

    Abstract: Three-dimensional (3D) reconstructed human skin (RhS) models featuring fully-differentiated characteristics of in vivo human epidermis have been known for almost 40 years. In this chapter, the topic of commercial in vitro tissue models is described, ... ...

    Abstract Three-dimensional (3D) reconstructed human skin (RhS) models featuring fully-differentiated characteristics of in vivo human epidermis have been known for almost 40 years. In this chapter, the topic of commercial in vitro tissue models is described, taking RhS models as an example. The need for highly standardised models is evident for regulatory testing purposes, e.g. the classification and labelling of chemicals and formulations, as well as for pharmacology-oriented research and drug development. Following the standardisation of RhS model production by commercial developers, international validation studies and regulatory acceptance, 3D RhS models are now used globally in both industrial and academic research laboratories. Industrial production of standardised 3D RhS models involves GMP-compliant processes together with ISO 9001 documentation in order to control and ensure reproducibility and quality. Key biological, functional, and performance features that are addressed in industrial production include barrier properties, histological and immunohistochemical characterisation, lipid profile characterisation, and tissue viability before and after transport. An up-to-date survey of commercial RhS tissue producers and the regulatory acceptance status of major safety, hazard, and efficacy assays currently available to chemical and pharmaceutical industries is presented in this chapter. Safety and ethical concerns related to the use of human tissue in the industrial production of RhS models are discussed. Finally, innovative approaches to the production of standardised 3D RhS models including automated production, development of more representative 3D RhS models using advanced additive manufacturing tools, microfluidics technologies, and bioprinting are presented. The future outlook for 3D RhS models includes a prevalence of high-quality models which will be fabricated by end-users rather than commercial producers. These will overcome problems with shipments and customs clearance that many users still face when buying RhS from overseas commercial suppliers. Open-source technologies and commercial components for "do-it-yourself" RhS will significantly change the skin model market as well as regulatory acceptance of open-source models during the next decade. All of these developments and improvements will together allow more widespread use of in vitro RhS models for broader application as animal replacements in areas ranging from industrial and regulatory toxicology and pharmacology, to drug development and personalised medicine.
    MeSH term(s) Animals ; Humans ; Reproducibility of Results ; Skin
    Language English
    Publishing date 2021-01-06
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2020_417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

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  7. Article ; Online: The role of maintenance therapy following autologous stem cell transplantation in newly diagnosed multiple myeloma: Considerations on behalf of the Chronic Malignancies Working Party of the EBMT.

    Hwang, Angela / Hayden, Patrick / Pawlyn, Charlotte / McLornan, Donal / Garderet, Laurent

    British journal of haematology

    2024  Volume 204, Issue 4, Page(s) 1159–1175

    Abstract: Recent treatment advancements in multiple myeloma have led to significant improvements in patient outcomes. Maintenance therapy following autologous haematopoietic stem cell transplantation (AHCT) is now standard of care and has been demonstrated to ... ...

    Abstract Recent treatment advancements in multiple myeloma have led to significant improvements in patient outcomes. Maintenance therapy following autologous haematopoietic stem cell transplantation (AHCT) is now standard of care and has been demonstrated to prolong and deepen treatment responses. Currently, lenalidomide remains the single agent that has been approved for maintenance post-AHCT in Europe and the USA which, if tolerated, is continued until disease progression. The treatment landscape is rapidly expanding however, and the optimal personalised maintenance approach for a patient is becoming more complex. Treatment outcomes for patients with high-risk disease remain poor and choice of maintenance in this population also remains unclear. This review article evaluates up-to-date literature regarding established maintenance approaches. It further analyses ongoing studies exploring maintenance regimens using combination and novel agents, approaches to maintenance in patients with cytogenetic high-risk disease and minimal residual disease response-adapted strategies that reflect the current evolving treatment paradigm.
    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Transplantation, Autologous ; Lenalidomide ; Treatment Outcome ; Antineoplastic Combined Chemotherapy Protocols ; Stem Cell Transplantation
    Chemical Substances Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Special review series on 3D organotypic culture models: Introduction and historical perspective.

    Hayden, Patrick J / Harbell, John W

    In vitro cellular & developmental biology. Animal

    2020  Volume 57, Issue 2, Page(s) 95–103

    Abstract: Three dimensional (3D) organ-like (organotypic) culture models are a rapidly advancing area of in vitro biological science. In contrast to monolayer cell culture methods which were developed to achieve proliferation of animal cells in the beginning of in ...

    Abstract Three dimensional (3D) organ-like (organotypic) culture models are a rapidly advancing area of in vitro biological science. In contrast to monolayer cell culture methods which were developed to achieve proliferation of animal cells in the beginning of in vitro biology, the advancements in 3D culture methods are designed to promote cellular differentiation, and to achieve in vivo-like 3D structure and organotypic functions. This project was conceived through the Society for In Vitro Biology to draw on the expertise of individual scientists with special expertise in organotypic cultures of selected tissues or associated interrogation methods to prepare individual-focused reviews in this series. This introductory manuscript will review the early achievements of animal cell culture in monolayer culture and the limitations of that approach to reproduce functioning organ systems. Among these are the nature and 3D architecture of the substrate on which or in which the cells are grown, physical and mechanical clues from the substrate, cell-cell interactions, and defined biochemical factors that trigger the induction of the 3D organotypic differentiation. The organoid culture requires a source of cells with proliferative capacity (ranging from tissue-derived stem or immortalized cells to the iPSC cultures), a suitable substrate or matrix with the mechanical and stimulatory properties appropriate for the organotypic construct and the necessary stimulation of the culture to drive differentiation of the cell population to form the functioning organotypic construct. Details for each type of organotypic construct will be provided in the following papers.
    MeSH term(s) Animals ; Bioprinting ; Cell Culture Techniques/history ; Cell Culture Techniques/methods ; History, 20th Century ; Humans ; Models, Biological
    Language English
    Publishing date 2020-11-25
    Publishing country Germany
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 1077810-x
    ISSN 1543-706X ; 0883-8364 ; 1071-2690
    ISSN (online) 1543-706X
    ISSN 0883-8364 ; 1071-2690
    DOI 10.1007/s11626-020-00500-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 851: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article: Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma Treated with Radiation Therapy: A Case Report and Review of the Literature.

    Armstrong, Paul / Hayden, Patrick / Jeffers, Michael / Fitzpatrick, Lisa / Mcknight, Aoife / Armstrong, John

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 1528–1535

    Abstract: Introduction: Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma or MALToma) is a prevalent type of primary pulmonary lymphoma. Typically, the primary therapeutic approaches involve surgery or chemotherapy, although there have been instances of ... ...

    Abstract Introduction: Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma or MALToma) is a prevalent type of primary pulmonary lymphoma. Typically, the primary therapeutic approaches involve surgery or chemotherapy, although there have been instances of radiation therapy being employed.
    Case report: We present a case of pulmonary MALToma that exhibited progression despite rituximab therapy. Subsequently, the patient demonstrated a positive response to radiation therapy.
    Conclusion: This case highlights the potential efficacy of radiation therapy as a treatment option for pulmonary MALToma, especially in cases where other conventional treatments like rituximab have proven ineffective. Further research and studies are warranted to better understand the role of radiation therapy in managing pulmonary MALToma and to determine optimal treatment strategies for patients with this condition.
    Language English
    Publishing date 2023-12-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000534802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Special review series on 3D organotypic culture models: Introduction and historical perspective

    Hayden, Patrick J / Harbell, John W

    In vitro cellular & developmental biology. 2021 Feb., v. 57, no. 2

    2021  

    Abstract: Three dimensional (3D) organ-like (organotypic) culture models are a rapidly advancing area of in vitro biological science. In contrast to monolayer cell culture methods which were developed to achieve proliferation of animal cells in the beginning of in ...

    Abstract Three dimensional (3D) organ-like (organotypic) culture models are a rapidly advancing area of in vitro biological science. In contrast to monolayer cell culture methods which were developed to achieve proliferation of animal cells in the beginning of in vitro biology, the advancements in 3D culture methods are designed to promote cellular differentiation, and to achieve in vivo–like 3D structure and organotypic functions. This project was conceived through the Society for In Vitro Biology to draw on the expertise of individual scientists with special expertise in organotypic cultures of selected tissues or associated interrogation methods to prepare individual-focused reviews in this series. This introductory manuscript will review the early achievements of animal cell culture in monolayer culture and the limitations of that approach to reproduce functioning organ systems. Among these are the nature and 3D architecture of the substrate on which or in which the cells are grown, physical and mechanical clues from the substrate, cell-cell interactions, and defined biochemical factors that trigger the induction of the 3D organotypic differentiation. The organoid culture requires a source of cells with proliferative capacity (ranging from tissue-derived stem or immortalized cells to the iPSC cultures), a suitable substrate or matrix with the mechanical and stimulatory properties appropriate for the organotypic construct and the necessary stimulation of the culture to drive differentiation of the cell population to form the functioning organotypic construct. Details for each type of organotypic construct will be provided in the following papers.
    Keywords cell culture ; cell differentiation ; organoids
    Language English
    Dates of publication 2021-02
    Size p. 95-103.
    Publishing place Springer US
    Document type Article
    Note NAL-AP-2-clean ; Review
    ISSN 1071-2690
    DOI 10.1007/s11626-020-00500-2
    Database NAL-Catalogue (AGRICOLA)

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