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  1. Article ; Online: Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation.

    Theobald, H / Bejarano, D A / Katzmarski, N / Haub, J / Schulte-Schrepping, J / Yu, J / Bassler, K / Ament, A L / Osei-Sarpong, C / Piattini, F / Vornholz, L / T'Jonck, W / Györfi, A H / Hayer, H / Yu, X / Sheoran, S / Al Jawazneh, A / Chakarov, S / Haendler, K /
    Brown, G D / Williams, D L / Bosurgi, L / Distler, J H W / Ginhoux, F / Ruland, J / Beyer, M D / Greter, M / Bain, C C / Vazquez-Armendariz, A I / Kopf, M / Schultze, J L / Schlitzer, A

    Nature immunology

    2024  

    Abstract: The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and developmental adaptation remain ... ...

    Abstract The lung is constantly exposed to the outside world and optimal adaptation of immune responses is crucial for efficient pathogen clearance. However, mechanisms that lead to lung-associated macrophages' functional and developmental adaptation remain elusive. To reveal such mechanisms, we developed a reductionist model of environmental intranasal β-glucan exposure, allowing for the detailed interrogation of molecular mechanisms of pulmonary macrophage adaptation. Employing single-cell transcriptomics, high-dimensional imaging and flow cytometric characterization paired with in vivo and ex vivo challenge models, we reveal that pulmonary low-grade inflammation results in the development of apolipoprotein E (ApoE)-dependent monocyte-derived alveolar macrophages (ApoE
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-024-01830-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  2. Article ; Online: Chromatin accessibility profiling of targeted cell populations with laser capture microdissection coupled to ATAC-seq.

    Carraro, Caterina / Bonaguro, Lorenzo / Srinivasa, Rachana / van Uelft, Martina / Isakzai, Victoria / Schulte-Schrepping, Jonas / Gambhir, Prerna / Elmzzahi, Tarek / Montgomery, Jessica V / Hayer, Hannah / Li, Yuanfang / Theis, Heidi / Kraut, Michael / Mahbubani, Krishnaa T / Aschenbrenner, Anna C / König, Ireen / Fava, Eugenio / Fried, Hans-Ulrich / De Domenico, Elena /
    Beyer, Marc / Saglam, Adem / Schultze, Joachim L

    Cell reports methods

    2023  Volume 3, Issue 10, Page(s) 100598

    Abstract: Spatially resolved omics technologies reveal context-dependent cellular regulatory networks in tissues of interest. Beyond transcriptome analysis, information on epigenetic traits and chromatin accessibility can provide further insights on gene ... ...

    Abstract Spatially resolved omics technologies reveal context-dependent cellular regulatory networks in tissues of interest. Beyond transcriptome analysis, information on epigenetic traits and chromatin accessibility can provide further insights on gene regulation in health and disease. Nevertheless, compared to the enormous advancements in spatial transcriptomics technologies, the field of spatial epigenomics is much younger and still underexplored. In this study, we report laser capture microdissection coupled to ATAC-seq (LCM-ATAC-seq) applied to fresh frozen samples for the spatial characterization of chromatin accessibility. We first demonstrate the efficient use of LCM coupled to in situ tagmentation and evaluate its performance as a function of cell number, microdissected areas, and tissue type. Further, we demonstrate its use for the targeted chromatin accessibility analysis of discrete contiguous or scattered cell populations in tissues via single-nuclei capture based on immunostaining for specific cellular markers.
    MeSH term(s) Chromatin/genetics ; Chromatin Immunoprecipitation Sequencing ; Laser Capture Microdissection ; Gene Expression Profiling ; Freezing
    Chemical Substances Chromatin
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 2667-2375
    ISSN (online) 2667-2375
    DOI 10.1016/j.crmeth.2023.100598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: verfahren zur herstellung von nativem kasein, kaseinat loeslich, bakteriologische pharmaqualitaet

    Hayer, H

    1982  

    Language German
    Publishing place brd
    Document type Book
    Database Max Rubner-Institute, Federal Research Institute of Nutrition and Food

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  4. Book: verfahren zur herstellung von molkeproteinkonzentrate, die nicht durch hitze denaturiert sind

    Hayer, H

    1982  

    Language German
    Publishing place brd
    Document type Book
    Database Max Rubner-Institute, Federal Research Institute of Nutrition and Food

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  9. Book: verfahren und vorrichtung zur herstellung von mit protein angereicherten fluessigkeiten

    Damerow, G / Hayer, H

    1975  

    Publishing place brd
    Document type Book
    Database Max Rubner-Institute, Federal Research Institute of Nutrition and Food

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Die hungendurchblutung bei der isolierten kinksherzbelastung in Säuglingsalter.

    Hayer, H W / Wolf, G / Pokorny, W

    Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin

    1974  Volume 120, Issue 3, Page(s) 268–274

    Title translation Pulmonary vasularisation in isolated left heart syndromes in neonates (author's transl).
    MeSH term(s) Angiography ; Aortic Coarctation/physiopathology ; Aortic Valve Stenosis/physiopathology ; Diagnosis, Differential ; Female ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/physiopathology ; Humans ; Infant ; Infant, Newborn ; Lung/physiopathology ; Lung Diseases/diagnosis ; Male ; Pulmonary Circulation ; Regional Blood Flow
    Language German
    Publishing date 1974-03
    Publishing country Germany
    Document type Journal Article
    ISSN 0015-8151
    ISSN 0015-8151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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