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  1. Article ; Online: Drug-induced syndrome of inappropriate diuresis or of antidiuretic hormone secretion?

    Haymann, Jean-Philippe

    Annales d'endocrinologie

    2023  Volume 84, Issue 3, Page(s) 388–390

    Abstract: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (Bartter and Schwartz, 1967) is defined as low effective plasma osmolality due to impaired renal water dilution together with impaired thirst center regulation once effective ... ...

    Abstract The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (Bartter and Schwartz, 1967) is defined as low effective plasma osmolality due to impaired renal water dilution together with impaired thirst center regulation once effective hypovolemia and corticotropin deficiency are ruled out (Robertson, 2006). Impaired water dilution is encountered following stimulation of voloreceptors triggering ADH (i.e., vasopressin) secretion through brain circumventricular organ stimulation [including notably the subfornical organ (SFO)] (Bichet, 2019). This condition is reversed as soon as volemia is restored: hyponatremia is corrected within hours, unlike withdrawal of drugs inducing SIADH, in which optimal water dilution recovery usually takes several days or weeks. Therefore, diuretics will be beyond the scope of this review.
    MeSH term(s) Humans ; Inappropriate ADH Syndrome/chemically induced ; Hyponatremia/chemically induced ; Hyponatremia/therapy ; Diuresis ; Thirst ; Water
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2023-03-23
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 299-9
    ISSN 2213-3941 ; 0003-4266
    ISSN (online) 2213-3941
    ISSN 0003-4266
    DOI 10.1016/j.ando.2023.03.010
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  2. Article ; Online: Sulfamethoxazole-induced crystal nephropathy: characterization and prognosis in a case series.

    Azencot, Ruben / Saint-Jacques, Camille / Haymann, Jean-Philippe / Frochot, Vincent / Daudon, Michel / Letavernier, Emmanuel

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6078

    Abstract: Cotrimoxazole (Trimethoprim/Sulfamethoxazole-SMX) is frequently used in critically ill and immunocompromised patients. SMX is converted to N-acetyl-sulfamethoxazole (NASM) and excreted by the kidneys. NASM may form crystals in urine, especially in acid ... ...

    Abstract Cotrimoxazole (Trimethoprim/Sulfamethoxazole-SMX) is frequently used in critically ill and immunocompromised patients. SMX is converted to N-acetyl-sulfamethoxazole (NASM) and excreted by the kidneys. NASM may form crystals in urine, especially in acid urine, that may induce a crystalline nephropathy. However, the imputability of crystals in acute kidney injury (AKI) has not been proven. We aimed to assess whether NASM crystals may promote AKI and to investigate risk factors associated with NASM crystalline nephropathy. Patients from Ile-de-France, France who developed AKI under SMX treatment introduced during hospitalization and had a crystalluria positive for NASM crystals were selected. Patients with excessive preanalytical delay for crystalluria or missing data regarding SMX treatment were excluded. We used the Naranjo score to assess the causal relationship between SMX and the development of AKI in patients with positive NASM crystalluria. Fourteen patients were included. SMX was the probable cause of AKI for 11 patients and a possible cause for 3 patients according to Naranjo score. Patients were exposed to high doses of SMX (but within recommended ranges), and most of them had a preexisting chronic kidney disease and were hypoalbuminemic. Urine pH was mildly acid (median 5.9). AKI occured more rapidly than expected after introduction of SMX (median 4 days) and recovered rapidly after drug discontinuation in most, but not all, cases. SMX is a probable cause of crystalline nephropathy. Monitoring of crystalluria in patients exposed to SMX may be of interest to prevent the development of crystalline nephropathy. Approval number of the study: BPD-2018-DIAG-008.
    MeSH term(s) Humans ; Crystalluria ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use ; Prognosis ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Risk Factors ; Retrospective Studies
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56322-9
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  3. Article ; Online: Metabolic disorders: stones as first clinical manifestation of significant diseases.

    Haymann, Jean-Philippe

    World journal of urology

    2014  Volume 33, Issue 2, Page(s) 187–192

    Abstract: Introduction: Metabolic syndrome, type 2 diabetes, and primary hyperparathyroidism are metabolic disorders that should deserve a special focus in renal stone patients as a pathogenic link is established with some stone components. Indeed, an acidic ... ...

    Abstract Introduction: Metabolic syndrome, type 2 diabetes, and primary hyperparathyroidism are metabolic disorders that should deserve a special focus in renal stone patients as a pathogenic link is established with some stone components. Indeed, an acidic urinary pH due to a decreased ammonium bioavailability explains the high prevalence of uric acid stones in patients with metabolic syndrome or diabetes and, primary hyperparathyroidism induced hypercalciuria increases the risk of calcium phosphate stones.
    Materials and methods: We report here four clinical cases of renal stone patients with metabolic disorders encountered in a daily practice. Clinical and metabolic findings altogether with stone analysis components presented here, illustrate relevant pathophysiological links.
    Conclusion: 24 hours urine evaluation and stone analysis which includes both morphological typing and infrared spectroscopy, are key diagnostic steps for early recognition of metabolic disorders. Metabolic screening allows diet related stone identification, points out stone risk factors and identifies patients'comorbidity. The occurrence of nephrocalcinosis with or without chronic renal failure should require a more detailed metabolic evaluation in order to identify uncommon etiologies such as renal tubular acidosis.
    MeSH term(s) Adult ; Female ; Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/diagnosis ; Male ; Metabolic Diseases/complications ; Metabolic Diseases/diagnosis ; Middle Aged ; Urinary Calculi/diagnosis ; Urinary Calculi/etiology ; Urolithiasis/diagnosis ; Urolithiasis/etiology
    Language English
    Publishing date 2014-09-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-014-1391-5
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  4. Article ; Online: In Reply to 'Urinary Concentration Capacity, GFR, and Mortality in the General American Population'.

    Tabibzadeh, Nahid / Stengel, Bénédicte / Haymann, Jean-Philippe

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2019  Volume 74, Issue 4, Page(s) 572

    MeSH term(s) Fasting ; Glomerular Filtration Rate ; Humans ; Osmolar Concentration ; Prospective Studies ; Renal Insufficiency, Chronic ; United States
    Language English
    Publishing date 2019-08-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2019.04.027
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    Zs.MO 468: Show issues

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  5. Article: Experimental models of renal calcium stones in rodents.

    Bilbault, Héloïse / Haymann, Jean-Philippe

    World journal of nephrology

    2016  Volume 5, Issue 2, Page(s) 189–194

    Abstract: In human nephrolithiasis, most stones are containing calcium and are located within urinary cavities; they may contain monohydrate calcium oxalate, dihydrate calcium oxalate and/or calcium phosphates in various proportion. Nephrolithiasis may also be ... ...

    Abstract In human nephrolithiasis, most stones are containing calcium and are located within urinary cavities; they may contain monohydrate calcium oxalate, dihydrate calcium oxalate and/or calcium phosphates in various proportion. Nephrolithiasis may also be associated with nephrocalcinosis, i.e., crystal depositions in tubular lumen and/or interstitium, an entity which suggests specific pathological processes. Several rodents models have been developed in order to study the pathophysiology of intrarenal crystal formation. We review here calcium rodent models classified upon the presence of nephrolithiasis and/or nephrocalcinosis. As rodents are not prone to nephrolithiasis, models require the induction of a long standing hypercalciuria or hyperoxaluria (thus explaining the very few studies reported), conversely to nephrocalcinosis which may occur within hours or days. Whereas a nephrotoxicity leading to tubular injury and regeneration appears as a critical event for crystal retention in nephrocalcinosis models, surprisingly very little is known about the physiopathology of crystal attachment to urothelium in nephrolithiasis. Creating new models of nephrolithiasis especially in different genetic mice strains appears an important challenge in order to unravel the early mechanisms of urinary stone formation in papilla and fornices.
    Language English
    Publishing date 2016-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2220-6124
    ISSN 2220-6124
    DOI 10.5527/wjn.v5.i2.189
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  6. Article ; Online: Hypercalcemia and Acute Renal Failure Indicating Peritoneal Sarcoidosis.

    Bachmeyer, Claude / Belaube, Nicolas / Loi, Valeria / Wendum, Dominique / Gauthé, Mathieu / Haymann, Jean Philippe

    The American journal of medicine

    2021  Volume 134, Issue 12, Page(s) e571–e572

    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Aged, 80 and over ; Calcium-Regulating Hormones and Agents/therapeutic use ; Cinacalcet/therapeutic use ; Diagnosis, Differential ; Glucocorticoids/therapeutic use ; Humans ; Hypercalcemia/diagnosis ; Hypercalcemia/drug therapy ; Hypercalcemia/etiology ; Laparoscopy ; Lymphadenopathy ; Male ; Peritoneal Diseases/complications ; Peritoneal Diseases/diagnosis ; Peritoneal Diseases/drug therapy ; Peritonitis, Tuberculous/diagnosis ; Positron Emission Tomography Computed Tomography ; Prednisone/therapeutic use ; Renal Insufficiency, Chronic/complications ; Sarcoidosis/complications ; Sarcoidosis/diagnosis ; Sarcoidosis/drug therapy ; Tomography, X-Ray Computed
    Chemical Substances Calcium-Regulating Hormones and Agents ; Glucocorticoids ; Cinacalcet (UAZ6V7728S) ; Prednisone (VB0R961HZT)
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.06.023
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    Ua VI Zs.289: Show issues Location:
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  7. Article ; Online: Metabolic Evaluation: Place of the Calcium Load Test: How, When, For Whom, and Why?

    Keller, Etienne Xavier / De Coninck, Vincent / Pietropaolo, Amelia / Somani, Bhaskar / Haymann, Jean-Philippe / Daudon, Michel

    European urology focus

    2021  Volume 7, Issue 1, Page(s) 26–30

    Abstract: Most human urinary stones are calcium-based and are often associated with hypercalciuria. A simple test described in 1975 by Pak et al allows for pathogenic classification of hypercalciuria: the calcium load test (CLT). The CLT explores calcium ... ...

    Abstract Most human urinary stones are calcium-based and are often associated with hypercalciuria. A simple test described in 1975 by Pak et al allows for pathogenic classification of hypercalciuria: the calcium load test (CLT). The CLT explores calcium homeostasis after a low-calcium diet and then a calcium load (typically oral administration of 1 g of elemental calcium). Only simple laboratory equipment is required. Inadequate calcium excretion after a calcium-free diet or a calcium load is suggestive of resorptive or absorptive hypercalciuria, respectively. The CLT is particularly valuable in diagnosing primary hyperparathyroidism, even in most early stages of this disease. PATIENT SUMMARY: Kidney stone formation can be linked to calcium metabolism. When high calcium levels are found in urine despite adequate diet changes, a calcium load test may help to understand the underlying mechanisms. Urine and blood levels are explored during a low-calcium diet phase, and after a calcium load phase in the test. The calcium load test is particularly advantageous for revealing abnormally high function of the parathyroid gland, which is called hyperparathyroidism.
    MeSH term(s) Calcium/metabolism ; Humans ; Hypercalciuria/diagnosis ; Hyperparathyroidism/diagnosis ; Kidney Calculi/diagnosis ; Kidney Calculi/etiology ; Urinary Calculi
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-01-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2020.12.019
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  8. Article ; Online: Effect of parathyroidectomy on renal stone recurrence.

    Charles, Pierre-Yves / Letavernier, Emmanuel / Périé, Sophie / Gauthé, Mathieu / Daudon, Michel / Haymann, Jean-Philippe

    Urolithiasis

    2021  Volume 49, Issue 4, Page(s) 327–334

    Abstract: Parathyroidectomy (PTX) is routinely performed in hypercalciuric renal stone patients with primary hyperparathyroidism (PHPT). However, some data indicate a persistent stone activity following PTX, raising the issue of the link between PHPT and stone ... ...

    Abstract Parathyroidectomy (PTX) is routinely performed in hypercalciuric renal stone patients with primary hyperparathyroidism (PHPT). However, some data indicate a persistent stone activity following PTX, raising the issue of the link between PHPT and stone disease. We performed an observational study on 30 renal stone patients diagnosed with PHPT. Patients were selected among 1448 hypercalciuric patients referred in our department for a diagnostic evaluation. Patients with no parathyroid surgery or any biological follow-up were excluded. Clinical and biological data (including 24-h urine collection and a calcium load test) were collected before and within 12 months following surgery. Stone recurrence was evaluated by direct phone contact (median 43 months). Comparison of biological data before and after surgery showed a significant decrease of ionized calcium and serum parathyroid hormone after PTX. All stones contained calcium-dependent species such as carbapatite, brushite or dihydrate calcium oxalate. Urine saturation indexes and calciuria significantly decreased after surgery (from 9.9 to 5.9 mmol/d, p < 0.0001), but a persistent hypercalciuria was detected in 47% of patients. The other stone risk factors including diuresis stayed similar. Stone activity that was increasing (from 0.20-0.30 to 0.50-0.75/year) the 2 years before PTX, significantly decreased after surgery [0.05-0.15/year (p < 0.001)]. PTX in calcium-dependent renal stone formers with PHPT significantly decreases both stone recurrence and urine saturation indexes. However, PTX unmasked an underlying renal stone disease related to idiopathic hypercalciuria in half of patients with a remaining stone activity, testifying the need for patient's follow-up to prevent stone recurrence.
    MeSH term(s) Adult ; Female ; Humans ; Hyperparathyroidism, Primary/complications ; Hyperparathyroidism, Primary/surgery ; Kidney Calculi/complications ; Male ; Middle Aged ; Parathyroidectomy ; Recurrence
    Language English
    Publishing date 2021-01-09
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-020-01239-x
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    Zs.A 928: Show issues Location:
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  9. Article ; Online: The Case | An 80-year-old man with obstructive uropathy.

    Saint-Jacques, Camille / Uzan, Audrey / Marechal, Elise / Frochot, Vincent / Haymann, Jean-Philippe / Traxer, Olivier / Daudon, Michel / Letavernier, Emmanuel

    Kidney international

    2022  Volume 102, Issue 5, Page(s) 1197–1198

    MeSH term(s) Male ; Humans ; Aged, 80 and over ; Urethral Diseases ; Ureteral Obstruction/diagnostic imaging ; Ureteral Obstruction/etiology
    Language English
    Publishing date 2022-10-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.03.018
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    Zs.A 797: Show issues Location:
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  10. Article ; Online: Les pathologies cristallines humaines : les premières étapes de la pathogénèse.

    Bazin, Dominique / Letavernier, Emmanuel / Haymann, Jean-Philippe / Frochot, Vincent / Daudon, Michel

    Annales de biologie clinique

    2020  Volume 78, Issue 4, Page(s) 349–362

    Abstract: The prevalence of crystalline pathologies including urolithiasis, gallstones, vascular calcifications and crystalline arthritis, is very high in the general population beyond 60 years old. Characterization of microcrystals in tissue at the micrometer and ...

    Title translation Crystalline pathologies in the human body: first steps of pathogenesis.
    Abstract The prevalence of crystalline pathologies including urolithiasis, gallstones, vascular calcifications and crystalline arthritis, is very high in the general population beyond 60 years old. Characterization of microcrystals in tissue at the micrometer and at the nanometer scale through physico-chemical techniques constitutes a new opportunity for the physician to decipher the early stage of the pathogenesis of these biological entities. In this review, such description indicates a wide variety of the chemical process associated to the nucleation process directly from supersaturated solution or from organic support such as DNA or elastin. We will also discuss the case of vesicles which play a major role in the case of ectopic calcification situated in kidney tissue, namely the Randall's plaque. All this research focused on the very first steps of the genesis of pathological calcifications constitute a major step to develop specific therapy able to avoid the formation of these abnormal deposits in tissues. As already underlined, crystals may be the consequence of various pathologies, but they are also involved in the dysfunction of the tissues.
    MeSH term(s) Calcinosis/etiology ; Calcinosis/metabolism ; Calcinosis/pathology ; Crystallization ; Humans ; Kidney Calculi/etiology ; Kidney Calculi/metabolism ; Kidney Calculi/pathology ; Lithiasis/etiology ; Lithiasis/metabolism ; Lithiasis/pathology ; Urolithiasis/etiology ; Urolithiasis/metabolism ; Urolithiasis/pathology ; Vascular Calcification/etiology ; Vascular Calcification/metabolism ; Vascular Calcification/pathology
    Language French
    Publishing date 2020-05-27
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2020.1557
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