LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 74

Search options

  1. Book: Coordinating organismal physiology through the unfolded protein response

    Wiseman, R. Luke / Haynes, Cole M.

    (Current topics in microbiology and immunology ; volume 414 ; Biomedicine)

    2018  

    Author's details R. Luke Wiseman, Cole M. Haynes, editors
    Series title Current topics in microbiology and immunology ; volume 414
    Biomedicine
    Collection
    Keywords endoplasmic reticulum stress ; unfolded protein response signaling ; secretory proteostasis ; neurodegenerative disease ; stress-sensing proteins ; lipid homeostasis ; calcium regulation ; organellar morphology
    Subject code 610
    Language English
    Size vii, 213 Seiten, Illustrationen, 23.5 cm x 15.5 cm
    Publisher Springer
    Publishing place Cham, Switzerland
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019688407
    ISBN 978-3-319-78529-5 ; 3-319-78529-X ; 9783319785301 ; 3319785303
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -414- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Online ; E-Book: Coordinating organismal physiology through the unfolded protein response

    Wiseman, R. Luke / Haynes, Cole M.

    (Current topics in microbiology and immunology ; 414)

    2018  

    Author's details R. Luke Wiseman, Cole M. Haynes editors
    Series title Current topics in microbiology and immunology ; 414
    Collection
    Language English
    Size 1 Online-Ressource (vii, 213 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019704727
    ISBN 978-3-319-78530-1 ; 9783319785295 ; 3-319-78530-3 ; 331978529X
    DOI 10.1007/978-3-319-78530-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Regulation of proteostasis and innate immunity via mitochondria-nuclear communication.

    Kim, Sookyung / Ramalho, Theresa R / Haynes, Cole M

    The Journal of cell biology

    2024  Volume 223, Issue 3

    Abstract: Mitochondria are perhaps best known as the "powerhouse of the cell" for their role in ATP production required for numerous cellular activities. Mitochondria have emerged as an important signaling organelle. Here, we first focus on signaling pathways ... ...

    Abstract Mitochondria are perhaps best known as the "powerhouse of the cell" for their role in ATP production required for numerous cellular activities. Mitochondria have emerged as an important signaling organelle. Here, we first focus on signaling pathways mediated by mitochondria-nuclear communication that promote protein homeostasis (proteostasis). We examine the mitochondrial unfolded protein response (UPRmt) in C. elegans, which is regulated by a transcription factor harboring both a mitochondrial- and nuclear-targeting sequence, the integrated stress response in mammals, as well as the regulation of chromatin by mitochondrial metabolites. In the second section, we explore the role of mitochondria-to-nuclear communication in the regulation of innate immunity and inflammation. Perhaps related to their prokaryotic origin, mitochondria harbor molecules also found in viruses and bacteria. If these molecules accumulate in the cytosol, they elicit the same innate immune responses as viral or bacterial infection.
    MeSH term(s) Animals ; Caenorhabditis elegans/genetics ; Immunity, Innate ; Mammals ; Mitochondria/metabolism ; Proteostasis ; Cell Nucleus/metabolism ; Unfolded Protein Response ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; Inflammasomes ; DNA, Mitochondrial
    Chemical Substances Chromatin ; Inflammasomes ; DNA, Mitochondrial
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202310005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Mitochondrial dysfunction, aging, and the mitochondrial unfolded protein response in Caenorhabditis elegans.

    Haynes, Cole M / Hekimi, Siegfried

    Genetics

    2022  Volume 222, Issue 4

    Abstract: We review the findings that establish that perturbations of various aspects of mitochondrial function, including oxidative phosphorylation, can promote lifespan extension, with different types of perturbations acting sometimes independently and ... ...

    Abstract We review the findings that establish that perturbations of various aspects of mitochondrial function, including oxidative phosphorylation, can promote lifespan extension, with different types of perturbations acting sometimes independently and additively on extending lifespan. We also review the great variety of processes and mechanisms that together form the mitochondrial unfolded protein response. We then explore the relationships between different types of mitochondrial dysfunction-dependent lifespan extension and the mitochondrial unfolded protein response. We conclude that, although several ways that induce extended lifespan through mitochondrial dysfunction require a functional mitochondrial unfolded protein response, there is no clear indication that activation of the mitochondrial unfolded protein response is sufficient to extend lifespan, despite the fact that the mitochondrial unfolded protein response impacts almost every aspect of mitochondrial function. In fact, in some contexts, mitochondrial unfolded protein response activation is deleterious. To explain this pattern, we hypothesize that, although triggered by mitochondrial dysfunction, the lifespan extension observed might not be the result of a change in mitochondrial function.
    MeSH term(s) Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Unfolded Protein Response ; Longevity/genetics ; Aging/genetics ; Aging/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism
    Chemical Substances Caenorhabditis elegans Proteins
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyac160
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 767: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Breaks in mitochondrial DNA rig the immune response.

    Naresh, Nandhitha Uma / Haynes, Cole M

    Nature

    2021  Volume 591, Issue 7850, Page(s) 372–373

    MeSH term(s) DNA, Mitochondrial/genetics ; Immunity ; Mitochondria/genetics ; Tripartite Motif Proteins
    Chemical Substances DNA, Mitochondrial ; Tripartite Motif Proteins
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-021-00429-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Mitochondrial distress call moves to the cytosol to trigger a response to stress.

    Tremblay, Bradford P / Haynes, Cole M

    Nature

    2020  Volume 579, Issue 7799, Page(s) 348–349

    MeSH term(s) Cytosol ; Mitochondria ; Mitochondrial Proteins
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2020-03-14
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-00552-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan.

    Ali, Levi / Haynes, Cole M

    The Journal of cell biology

    2020  Volume 219, Issue 6

    Abstract: In this issue, Liu et al. (2019. J. Cell. Biol.https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the ... ...

    Abstract In this issue, Liu et al. (2019. J. Cell. Biol.https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the transcription factor HLH-30, which promotes lysosomal biogenesis.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Longevity ; Lysosomes ; Mitochondrial Dynamics
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Caenorhabditis elegans Proteins ; HLH-30 protein, C elegans
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202005084
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.190: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Folding the Mitochondrial UPR into the Integrated Stress Response.

    Anderson, Nadine S / Haynes, Cole M

    Trends in cell biology

    2020  Volume 30, Issue 6, Page(s) 428–439

    Abstract: Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response ( ... ...

    Abstract Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to overcome environmental insults and respond to physiological cues. The mitochondrial unfolded protein response (UPR
    MeSH term(s) Animals ; Humans ; Mitochondria/metabolism ; Protein Biosynthesis ; Signal Transduction ; Stress, Physiological ; Unfolded Protein Response
    Language English
    Publishing date 2020-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 30122-x
    ISSN 1879-3088 ; 0962-8924
    ISSN (online) 1879-3088
    ISSN 0962-8924
    DOI 10.1016/j.tcb.2020.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MG 25: Show issues
    Zs.MO 113: Show issues
    Zs.A 3410: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Cell biology: Surviving import failure.

    Haynes, Cole M

    Nature

    2015  Volume 524, Issue 7566, Page(s) 419–420

    MeSH term(s) Cytosol/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Proteins/metabolism ; Protein Precursors/metabolism ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances Mitochondrial Proteins ; Protein Precursors ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2015-08-27
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature14644
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Signaling and Regulation of the Mitochondrial Unfolded Protein Response.

    Naresh, Nandhitha Uma / Haynes, Cole M

    Cold Spring Harbor perspectives in biology

    2019  Volume 11, Issue 6

    Abstract: The mitochondrial proteome encompasses more than a thousand proteins, which are encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding ... ...

    Abstract The mitochondrial proteome encompasses more than a thousand proteins, which are encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding environment. Cell-extrinsic or -intrinsic stressors that challenge mitochondrial proteostasis negatively affect organellar function. During conditions of stress, cells use impaired protein import as a sensor for mitochondrial dysfunction to activate a stress response called the mitochondrial unfolded protein response (UPR
    MeSH term(s) Animals ; Humans ; Mitochondrial Diseases/metabolism ; Mitochondrial Proteins/metabolism ; Neurodegenerative Diseases/metabolism ; Organelle Biogenesis ; Signal Transduction ; Unfolded Protein Response
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a033944
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top