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Article: A Comparison of Clinical, Demographic and Treatment Characteristics of Pediatric-Onset and Adult-Onset Patients Diagnosed With Localized Scleroderma.

Akbaş, Ayşe / Kılınç, Fadime / Hayran, Yıldız

2024 Volume 14, Issue 1

Abstract: Introduction: Morphea localized scleroderma (LS) is a rare skin disease with unknown pathogenesis, which causes sclerosis of the dermis and subcutaneous tissue.: Objectives: It was aimed to compare the characteristics of patients with pediatric and ... ...

Abstract	Introduction: Morphea localized scleroderma (LS) is a rare skin disease with unknown pathogenesis, which causes sclerosis of the dermis and subcutaneous tissue. Objectives: It was aimed to compare the characteristics of patients with pediatric and adult-onset morphea. Methods: A retrospective analysis was performed on the records of 183 adult morphea patients. The demographics, clinical and laboratory characteristics, and treatment options of the patients were recorded. Adult patients with morphea over the age of 18 were divided into two groups according to the age of onset and compared. Results: Twenty-two percent (N = 41) of the patients had pediatric-onset morphea (POLS) and 77.6% (n=142) had adult-onset morphea (AOLS). While POLS had a higher head-neck involvement, AOLS had a higher breast involvement (P < 0.001 and P = 0.043). Patients with linear morphea were younger, and more frequently had at least one laboratory anomaly (P = 0.016 versus 0.024). Anti-dsDNA positivity and low hemoglobin (Hb) were observed more frequently in patients with breast involvement. Patients with inguinal involvement, on the other hand, had lower Hb and a higher rate of diabetes, and those patients were older (P = 0.042, 0.040, and 0.012, respectively). Conclusions: Clinical characteristics and accompanying laboratory anomalies of the patients with morphea depend on the age of onset, involvement areas and the types of morphea, having such data readily available should guide the holistic approach for, and the monitoring process of, the disease.
Language	English
Publishing date	2024-01-01
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2685397-8
ISSN	2160-9381
ISSN	2160-9381
DOI	10.5826/dpc.1401a23
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Article ; Online: Vitamin D levels in patients with seborrheic dermatitis.

Akbaş, Ayşe / Kılınç, Fadime / Şener, Sertaç / Hayran, Yıldız

Revista da Associacao Medica Brasileira (1992)

2023 Volume 69, Issue 7, Page(s) e20230022

Abstract: Objective: Seborrheic dermatitis is a common papulosquamous skin disease with unknown pathogenesis. The aim of our study was to determine the serum level of 25-hydroxy vitamin D in patients with seborrheic dermatitis SD.: Methods: A total of 53 ... ...

Abstract	Objective: Seborrheic dermatitis is a common papulosquamous skin disease with unknown pathogenesis. The aim of our study was to determine the serum level of 25-hydroxy vitamin D in patients with seborrheic dermatitis SD. Methods: A total of 53 patients and 60 healthy controls were included in the study. Serum vitamin D, calcium, phosphorus, and parathormone levels were measured in the patient and control groups, and a comparison was made between the two groups regarding these parameters. Results: Severe vitamin D deficiency was more frequent among patients with seborrheic dermatitisSD compared to controls (52.8 vs. 25.8%, p=0.003). In patients with severe vitamin D deficiency, seborrheic dermatitis SD was detected more frequently at an early age (p=0048) and in women (p=0.015). No correlation was found between the seborrheic dermatitis skin involvement site and vitamin D level. Conclusion: The fact that vitamin D levels decreased in patients with seborrheic dermatitis SD and patients with severe vitamin D deficiency develop seborrheic dermatitis SD earlier suggests that the low levels of vitamin D are related to seborrheic dermatitis.
MeSH term(s)	Humans ; Female ; Dermatitis, Seborrheic/pathology ; Skin/pathology ; Vitamin D ; Vitamins ; Vitamin D Deficiency/complications
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-07-17
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20230022
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Article ; Online: Systemic Immune-Inflammation Index (SII) Correlates with Disease Severity in Hidradenitis Suppurativa Patients.

Hayran, Yıldız / Şen, Orhan / Aktaş, Akın

Indian journal of dermatology

2023 Volume 68, Issue 2, Page(s) 208–209

Language	English
Publishing date	2023-04-14
Publishing country	India
Document type	Journal Article
ZDB-ID	416069-1
ISSN	1998-3611 ; 0019-5154
ISSN (online)	1998-3611
ISSN	0019-5154
DOI	10.4103/ijd.ijd_532_22
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Article ; Online: Isotretinoin-Induced Acne Fulminans.

Yorulmaz, Ahu / Hayran, Yildiz

Journal of cutaneous medicine and surgery

2021 Volume 26, Issue 4, Page(s) 435

MeSH term(s)	Acne Vulgaris/chemically induced ; Acne Vulgaris/drug therapy ; Humans ; Isotretinoin/adverse effects
Chemical Substances	Isotretinoin (EH28UP18IF)
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1361720-5
ISSN	1615-7109 ; 1203-4754
ISSN (online)	1615-7109
ISSN	1203-4754
DOI	10.1177/12034754211045379
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Zs.A 4987: Show issues

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Article ; Online: Investigation of the relationship between seborrheic dermatitis and metabolic syndrome parameters.

Akbaş, Ayşe / Kılınç, Fadime / Şener, Sertaç / Hayran, Yıldız

Journal of cosmetic dermatology

2022

Abstract: Background: Seborrheic dermatitis (SD) is a common, chronic inflammatory disease with relapses and remissions.: Objectives: So we planned to investigate the relationship between SD and metabolic syndrome (Mets).: Methods: 54 patients over 18 years ...

Abstract	Background: Seborrheic dermatitis (SD) is a common, chronic inflammatory disease with relapses and remissions. Objectives: So we planned to investigate the relationship between SD and metabolic syndrome (Mets). Methods: 54 patients over 18 years of age without known diabetes mellitus, hypertension, coronary artery disease who were clinically diagnosed with SD in our clinic and 47 healthy controls were included in the study. Body mass index (BMI) was calculated of all participants. Complete blood count, fasting blood sugar (FBG), triglyceride (TG), total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were examined. The relationship between the presence of MetS, disease severity, and duration was investigated. Results: Average age of patients was 35.4 (sd: 12). Average age of controls was 32.9 (sd: 10.7). MetS was detected in 35.2% (n = 19) of the patient group and 10.6% (n = 5) of the control group. The presence of MetS was higher in SD patients than in the control group (p = 0.004). The rate of people with high TG was significantly higher in the SD group than the controls (p = 0.015). HDL level was significantly lower in the patient group (p = 0.050). Systolic and diastolic blood pressure were high in patients (p = 0.016, p = 0.029). Conclusions: Seborrheic dermatitis should be considered as a MetS marker and the presence of MetS should be examined in this group of patients. This can be helpful for the early diagnosis of a systemic disease complex with numerous complications. Also, treatment of MetS can also improve SD lesions.
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.15121
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Article ; Online: Smoking habits amongst patients with psoriasis and the effect of smoking on clinical and treatment-associated characteristics: A cross-sectional study.

Hayran, Yıldız / Yalçın, Başak

International journal of clinical practice

2020 Volume 75, Issue 2, Page(s) e13751

Abstract: Background: Psoriasis is a multifactorial, chronic inflammatory skin disease where genetic and environmental factors play a role in the pathogenesis. Smoking is one of the critical environmental factors triggering psoriasis.: Objective: The purpose ... ...

Abstract	Background: Psoriasis is a multifactorial, chronic inflammatory skin disease where genetic and environmental factors play a role in the pathogenesis. Smoking is one of the critical environmental factors triggering psoriasis. Objective: The purpose of the present study was to analyse the smoking habits of patients with psoriasis and the effect of smoking on disease characteristics. Methods: One hundred and thirty-three patients who applied to the department of Dermatological and Venereal Diseases, Ankara Numune Education and Research Hospital, between May 2018 and May 2019 and were diagnosed with psoriasis participated in the study. Clinical, demographical, and treatment-related characteristics, and smoking habits of patients were recorded. Results: Sixty-seven point six percent of psoriasis patients were smokers. The presence of moderate to severe psoriasis (P = .028), nail involvement (P = .004), administration of systemic treatment (P = .024) and additional cardiovascular disease (P = .038) frequencies was higher in smokers compared to non-smokers. Besides, a positive correlation was observed between the amount of smoking and psoriasis area and severity index (PASI) (P = .003; r = .32). Conclusions: Smoking has many negative effects on patients with psoriasis including higher PASI levels, increased frequency of nail involvement, and cardiovascular diseases. Questioning cigarette smoking in psoriatic patients and supporting smoking cessation may contribute to reducing the adverse impact of smoking on psoriasis.
MeSH term(s)	Chronic Disease ; Cross-Sectional Studies ; Humans ; Psoriasis/epidemiology ; Severity of Illness Index ; Smoking/adverse effects
Language	English
Publishing date	2020-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.13751
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Article: Investigation of the PD-1/PD-L1 Expression in the Lesional Skins of Patients With Psoriasis.

Emre, Selma / Süngü, Nuran / Hayran, Yıldız / Demirseren, D Deniz / Aktas, Akın / Duman, Tuce Özkara

Dermatology practical & conceptual

2023 Volume 13, Issue 2

Abstract: Introduction: Psoriasis is an immune-mediated, chronic and inflammatory disease whose pathogenesis is affected by the interactions of several immune cells and cytokines. PD-1 is an inhibitor receptor that is expressed to a large extent in T lymphocytes ... ...

Abstract	Introduction: Psoriasis is an immune-mediated, chronic and inflammatory disease whose pathogenesis is affected by the interactions of several immune cells and cytokines. PD-1 is an inhibitor receptor that is expressed to a large extent in T lymphocytes and responsible for regulating autoimmunity and self-tolerance. Objectives: In this study, we aimed to investigate the expression of PD-1/PD-L molecules in the lesioned skins of psoriasis patients. Methods: The study included 30 psoriasis patients, and 15 healthy volunteers as the control group. Anti PD-1 and PD-L1 antibodies were applied to the skin biopsy samples that were collected from the patient and control groups. Cytoplasmic and membranous staining of PD-1 and PD-L1 were considered positive. The number of stained immune cells that was examined for each case. Results: The percentage of the tissues with high PD-1 (+) and PDL-1 (+) immune cell counts were significantly higher in the psoriasis patients compared to healthy controls (P values = 0.004 and 0.002, respectively). A negative and statistically significant correlation was detected between PDL-1(+) immune cell numbers and PASI scores (P = 0.033, r=-0.57). Conclusions: In the lesioned skin samples of psoriasis patients, the PD-1 and PD-L1 expressions were significantly higher in immune cells than that in the skin samples of the healthy controls. This study was the first investigation of the expression of PD-1/PD-L molecules in the immune cells in found the lesioned skins of psoriasis patients.
Language	English
Publishing date	2023-04-01
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2685397-8
ISSN	2160-9381
ISSN	2160-9381
DOI	10.5826/dpc.1302a134
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Article ; Online: Thiol-Disulphide Homeostasis, Ischemia-Modified Albumin, Trace Elements and Vitamins in Vitiligo Patients.

Oğuz, Esra Firat / Hayran, Yildiz / Yücel, Çiğdem / Eren, Funda / Kizilgün, Murat / Erel, Özcan

Indian journal of dermatology

2023 Volume 68, Issue 4, Page(s) 487

Abstract: Background: Vitiligo, a multifactorial, depigmented skin disease, is characterised by selective loss of functional melanocytes leading to pigment reduction in the affected areas of the skin.: Aim: We aimed to examine thiol-disulphide homeostasis, IMA, ...

Abstract	Background: Vitiligo, a multifactorial, depigmented skin disease, is characterised by selective loss of functional melanocytes leading to pigment reduction in the affected areas of the skin. Aim: We aimed to examine thiol-disulphide homeostasis, IMA, copper, zinc, selenium, vitamin A and vitamin C levels in vitiligo patients. Materials and methods: The study included 83 vitiligo patients and 72 healthy controls. Copper, zinc, and selenium levels were measured by atomic absorption spectrophotometer; vitamin A and E levels were measured by high-performance liquid chromatography. Ischemia-modified albumin and native/total thiol levels were measured by colourimetric method. Results: Serum native and total thiol levels were significantly lower in vitiligo patients ( Conclusions: All thiol-disulphide homeostasis parameters (the most important antioxidant-oxidant system in circulation), trace elements, and vitamins together were evaluated in the present study in vitiligo patients. It can be concluded that vitiligo patients have increased oxidative stress status, and also the increase in the dissemination of the disease also increases the oxidative stress in the body.
Language	English
Publishing date	2023-10-09
Publishing country	India
Document type	Journal Article
ZDB-ID	416069-1
ISSN	1998-3611 ; 0019-5154
ISSN (online)	1998-3611
ISSN	0019-5154
DOI	10.4103/ijd.ijd_169_23
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Article ; Online: Different hair loss patterns in two pediatric patients with COVID-19-associated multisystem inflammatory syndrome in children.

Hayran, Yıldız / Yorulmaz, Ahu / Gür, Güneş / Aktaş, Akın

Dermatologic therapy

2021 Volume 34, Issue 2, Page(s) e14820

MeSH term(s)	Alopecia/chemically induced ; Alopecia/diagnosis ; Alopecia/drug therapy ; COVID-19 ; Child ; Humans ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2021-02-07
Publishing country	United States
Document type	Letter
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/dth.14820
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Article ; Online: The relationship between non-segmental Vitiligo, HLA genotype and oxidative stress.

Hayran, Yıldız / Özge Ergen, Gül / Özmen, Füsun

International journal of clinical practice

2021 Volume 75, Issue 3, Page(s) e14024

Abstract: Background: Vitiligo is an autoimmune disease characterised by acquired loss of melanocytes. Although the pathogenesis of vitiligo remains unknown, oxidative stress and autoimmune dysregulations are considered to play a role.: Objective: The aim of ... ...

Abstract	Background: Vitiligo is an autoimmune disease characterised by acquired loss of melanocytes. Although the pathogenesis of vitiligo remains unknown, oxidative stress and autoimmune dysregulations are considered to play a role. Objective: The aim of this study was to evaluate the HLA profile and total antioxidant capacity (TAC) and their relationship to clinical characteristic of vitiligo patients. Methods: Ninety-one vitiligo patients and 100 healthy controls were included in the study. We analysed HLA allele frequencies using sequence-specific oligonucleotide Prob (SSOP) method. Serum total antioxidant capacity (TAC) levels were measured and compared between vitiligo patients and controls. Results: HLA-A02 allele frequency was increased (OR = 1.6, CI = 1.12-2.24, P = .009), HLA-A11 (OR = 0.46, CI = 0.32-0.91, P = .019) and HLA-DRB101 (OR = 0.39, CI = 0.16-0.92, P = .029) frequencies were decreased in vitiligo patients. HLA-A02 allele especially increased the risk of late onset (Vitiligo onset >30 years of age) vitiligo (OR:3.67, 95% CI: 1.63-8.26, P = .002). Serum TAC levels were similar between vitiligo patients and healthy controls but TAC levels were significantly lower in patients who did not have an HLA-DRB101 allele (1.52 vs 1.61, P = .033). Conclusion:* Our study showed that HLA-A02 increases, HLA-A11 and HLA-DRB1*01 decreases vitiligo susceptibility in Turkish patients as well as a possible relationship between HLA and TAC.
MeSH term(s)	Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; HLA-DRB1 Chains/genetics ; Humans ; Oxidative Stress/genetics ; Vitiligo/genetics
Chemical Substances	HLA-DRB1 Chains
Language	English
Publishing date	2021-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14024
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