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  1. Article ; Online: Unraveling von Willebrand factor deficiency.

    Hayward, Catherine P M

    Blood

    2021  Volume 137, Issue 23, Page(s) 3160–3161

    MeSH term(s) Blood Coagulation Factors ; Humans ; von Willebrand Diseases ; von Willebrand Factor/genetics
    Chemical Substances Blood Coagulation Factors ; von Willebrand Factor
    Language English
    Publishing date 2021-06-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021010942
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    Zs.MO 364: Show issues

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  2. Article ; Online: Update on major activities of the International Society for Laboratory Hematology.

    Hayward, Catherine P M

    International journal of laboratory hematology

    2020  Volume 42 Suppl 1, Page(s) 4–5

    MeSH term(s) Hematology ; Humans ; Laboratories, Hospital ; Periodicals as Topic ; Societies, Medical
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Editorial
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13171
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    Zs.A 1499: Show issues Location:
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  3. Article ; Online: Rare inherited coagulation and fibrinolytic defects that challenge diagnostic laboratories.

    Mathews, Natalie / Tasneem, Subia / Hayward, Catherine P M

    International journal of laboratory hematology

    2023  Volume 45 Suppl 2, Page(s) 30–43

    Abstract: Background: Coagulation factors, anticoagulants, and fibrinolytic proteins are important for hemostasis, and mutations affecting these proteins causes some rare inherited bleeding disorders that are particularly challenging to diagnose.: Aims: This ... ...

    Abstract Background: Coagulation factors, anticoagulants, and fibrinolytic proteins are important for hemostasis, and mutations affecting these proteins causes some rare inherited bleeding disorders that are particularly challenging to diagnose.
    Aims: This review provides current information on rare inherited bleeding disorders that are difficult to diagnose.
    Material & methods: A review of the literature was conducted for up to date information on rare and difficult to diagnose bleeding disorders.
    Results: Some rare bleeding disorders cause an inherited deficiency of multiple coagulation factors (F), such as combined FV and FVIII deficiency and familial vitamin K-dependent clotting factor deficiency. Additionally, congenital disorders of glycosylation can affect a variety of procoagulant and anticoagulant proteins and also platelets. Some bleeding disorders reflect mutations with unique impairments in the procoagulant/anticoagulant balance, including those caused by F5 mutations that secondarily increase the plasma levels of tissue factor pathway inhibitor as well as THBD mutations that increase functional thrombomodulin in plasma or cause a consumptive coagulopathy due to thrombomodulin deficiency. Some bleeding disorders accelerate fibrinolysis due to loss-of-function mutations in SERPINE1 and SERPINF2 or in the case of Quebec platelet disorder, a duplication mutation that rewires PLAU and selectively increases expression in megakaryocytes, resulting in a unique platelet-dependent gain-of-function defect in fibrinolysis.
    Discussion: Current information on rare and difficult to diagnose bleeding disorders indicates they have unique clinical and laboratory features, and pathogenic characteristics to consider for diagnostic evaluation.
    Conclusion: Laboratories and clinicians should consider rare inherited disorders, and difficult to diagnose conditions, in their strategy for diagnosing bleeding disorders.
    MeSH term(s) Humans ; Thrombomodulin ; Laboratories ; Hemorrhagic Disorders/diagnosis ; Blood Coagulation Factors ; Anticoagulants
    Chemical Substances Thrombomodulin ; Blood Coagulation Factors ; Anticoagulants
    Language English
    Publishing date 2023-05-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.14084
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  4. Article ; Online: Update from the President of the International Society for Laboratory Hematology on major activities of our society.

    Hayward, Catherine P M

    International journal of laboratory hematology

    2019  Volume 41 Suppl 1, Page(s) 6–7

    MeSH term(s) Hematology ; Societies, Medical/organization & administration
    Language English
    Publishing date 2019-05-25
    Publishing country England
    Document type Editorial
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13003
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    Zs.A 1499: Show issues Location:
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  5. Article ; Online: Update on platelet procoagulant mechanisms in health and in bleeding disorders.

    Bourguignon, Alex / Tasneem, Subia / Hayward, Catherine P M

    International journal of laboratory hematology

    2022  Volume 44 Suppl 1, Page(s) 89–100

    Abstract: Platelet procoagulant mechanisms are emerging to be complex and important to achieving haemostasis. The mechanisms include the release of procoagulant molecules from platelet storage granules, and strong agonist-induced expression of procoagulant ... ...

    Abstract Platelet procoagulant mechanisms are emerging to be complex and important to achieving haemostasis. The mechanisms include the release of procoagulant molecules from platelet storage granules, and strong agonist-induced expression of procoagulant phospholipids on the outer platelet membrane for tenase and prothrombinase assembly. The release of dense granule polyphosphate is important to platelet procoagulant function as it promotes the activation of factors XII, XI and V, inhibits tissue factor pathway inhibitor and fibrinolysis, and strengthens fibrin clots. Platelet procoagulant function also involves the release of partially activated factor V from platelets. Scott syndrome has provided important insights on the mechanisms that regulate procoagulant phospholipids expression on the external platelet membrane, which require strong agonist stimulation that increase cystolic calcium levels, mitochondrial calcium uptake, the loss of flippase function and activation of the transmembrane scramblase protein anoctamin 6. There have been advances in the methods used to directly and indirectly assess platelet procoagulant function in health and disease. Assessments of thrombin generation with platelet rich plasma samples has provided new insights on how platelet procoagulant function is altered in inherited platelet disorders, and how platelets influence the bleeding phenotype of a number of severe coagulation factor deficiencies. Several therapies, including desmopressin and recombinant factor VIIa, improve thrombin generation by platelets. There is growing interest in targeting platelet procoagulant function for therapeutic benefit. This review highlights recent advances in our understanding of platelet-dependent procoagulant mechanisms in health and in bleeding disorders.
    MeSH term(s) Blood Coagulation Disorders ; Blood Platelets/metabolism ; Calcium/metabolism ; Hemorrhagic Disorders ; Humans ; Phospholipids/metabolism ; Platelet Activation ; Thrombin/metabolism
    Chemical Substances Phospholipids ; Thrombin (EC 3.4.21.5) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13866
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  6. Article ; Online: Improved platelet counts during prolonged tranexamic therapy for Quebec platelet disorder implicate the underlying fibrinolytic defect as the cause of lower platelet counts.

    Hayward, Catherine P M / Tasneem, Subia / Rivard, Georges E

    International journal of laboratory hematology

    2020  Volume 42, Issue 6, Page(s) e274–e276

    MeSH term(s) Antifibrinolytic Agents/pharmacology ; Antifibrinolytic Agents/therapeutic use ; Blood Coagulation Disorders/blood ; Blood Coagulation Disorders/genetics ; Blood Platelets/drug effects ; Factor V Deficiency/blood ; Factor V Deficiency/complications ; Factor V Deficiency/drug therapy ; Factor V Deficiency/genetics ; Fibrinolysin/biosynthesis ; Fibrinolysis/drug effects ; Hemarthrosis/drug therapy ; Hemarthrosis/etiology ; Hematoma/drug therapy ; Hematoma/etiology ; Hemorrhage/prevention & control ; Humans ; Male ; Membrane Proteins/genetics ; Middle Aged ; Platelet Count ; Postoperative Hemorrhage/etiology ; Postoperative Hemorrhage/prevention & control ; Prospective Studies ; Tranexamic Acid/pharmacology ; Tranexamic Acid/therapeutic use ; Wound Healing/drug effects
    Chemical Substances Antifibrinolytic Agents ; Membrane Proteins ; PLAU protein, human ; Tranexamic Acid (6T84R30KC1) ; Fibrinolysin (EC 3.4.21.7)
    Language English
    Publishing date 2020-08-09
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13311
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    Zs.A 1499: Show issues Location:
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  7. Article ; Online: Evaluation of a diagnostic platelet aggregation test strategy for platelet rich plasma samples with low platelet counts.

    Altahan, Rahaf Mahmoud / Mathews, Natalie / Bourguignon, Alex / Tasneem, Subia / Arnold, Donald M / Lim, Wendy / Hayward, Catherine P M

    International journal of laboratory hematology

    2023  Volume 46, Issue 2, Page(s) 362–374

    Abstract: Introduction: Light transmission aggregometry (LTA) is important for diagnosing platelet function disorders (PFD) and von Willebrand disease (VWD) affecting ristocetin-induced platelet aggregation (RIPA). Nonetheless, data is lacking on the utility of ... ...

    Abstract Introduction: Light transmission aggregometry (LTA) is important for diagnosing platelet function disorders (PFD) and von Willebrand disease (VWD) affecting ristocetin-induced platelet aggregation (RIPA). Nonetheless, data is lacking on the utility of LTA for investigating thrombocytopenic patients and platelet rich plasma samples with low platelet counts (L-PRP). Previously, we developed a strategy for diagnostic LTA assessment of L-PRP that included: (1) acceptance of referrals/samples, regardless of thrombocytopenia severity, (2) tailored agonist selection, based on which are informative for L-PRP with mildly or severely low platelet counts, and (3) interpretation of maximal aggregation (MA) using regression-derived 95% confidence intervals, determined for diluted control L-PRP (C-L-PRP).
    Methods: To further evaluate the L-PRP LTA strategy, we evaluated findings for a subsequent patient cohort.
    Results: Between 2008 and 2021, the L-PRP strategy was applied to 211 samples (11.7% of all LTA samples) from 192 unique patients, whose platelet counts (median [range] × 10
    Conclusion: Diagnostic LTA with L-PRP, using a strategy that considers thrombocytopenia severity, is feasible and informative.
    MeSH term(s) Humans ; Platelet Count ; Platelet Aggregation ; Platelet Function Tests ; Blood Platelets/pathology ; von Willebrand Diseases/diagnosis ; Thrombocytopenia/diagnosis ; Thrombocytopenia/pathology ; Blood Platelet Disorders/diagnosis ; Platelet-Rich Plasma
    Language English
    Publishing date 2023-12-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.14216
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  8. Article ; Online: Erratum: Quebec Platelet Disorder: Update on Pathogenesis, Diagnosis, and Treatment.

    Hayward, Catherine P M / Rivard, Georges E

    Seminars in thrombosis and hemostasis

    2019  Volume 45, Issue 1, Page(s) 121–122

    Language English
    Publishing date 2019-01-14
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0038-1625972
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    Zs.A 1259: Show issues Location:
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  9. Article ; Online: Management of a Left Atrial Appendage Thrombus Due to Atrial Fibrillation Complicating Québec Platelet Disorder.

    Goodliffe, Laura / Ainsworth, Craig / Whitlock, Richard P / Chan, Noel C / Wong, Jorge A / Rivard, Georges-Étienne / Hayward, Catherine P M

    The Canadian journal of cardiology

    2022  Volume 38, Issue 9, Page(s) 1464–1466

    MeSH term(s) Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Echocardiography, Transesophageal ; Factor V Deficiency ; Heart Diseases/etiology ; Humans ; Thrombosis/complications ; Thrombosis/etiology
    Language English
    Publishing date 2022-04-15
    Publishing country England
    Document type Case Reports
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2022.04.010
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  10. Article ; Online: Patient advocacy and its importance to laboratory medicine practice.

    Hayward, Catherine P M / George, Tracy I / Van Cott, Elizabeth M / Smock, Kristi J

    International journal of laboratory hematology

    2020  Volume 42 Suppl 1, Page(s) 21–22

    MeSH term(s) Blood Coagulation Disorders/diagnosis ; Clinical Laboratory Techniques ; Humans ; Patient Advocacy
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13193
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