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Book ; Online: Analyzing Transatlantic Network Traffic over Scientific Data Caches

Deng, Z. / Sim, A. / Wu, K. / Guok, C. / Hazen, D. / Monga, I. / Andrijauskas, F. / Wuerthwein, F. / Weitzel, D.

2023

Abstract: Large scientific collaborations often share huge volumes of data around the world. Consequently a significant amount of network bandwidth is needed for data replication and data access. Users in the same region may possibly share resources as well as ... ...

Abstract	Large scientific collaborations often share huge volumes of data around the world. Consequently a significant amount of network bandwidth is needed for data replication and data access. Users in the same region may possibly share resources as well as data, especially when they are working on related topics with similar datasets. In this work, we study the network traffic patterns and resource utilization for scientific data caches connecting European networks to the US. We explore the efficiency of resource utilization, especially for network traffic which consists mostly of transatlantic data transfers, and the potential for having more caching node deployments. Our study shows that these data caches reduced network traffic volume by 97% during the study period. This demonstrates that such caching nodes are effective in reducing wide-area network traffic.
Keywords	Computer Science - Networking and Internet Architecture ; Computer Science - Distributed ; Parallel ; and Cluster Computing
Subject code	303
Publishing date	2023-05-01
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Candida auris outbreak at a tertiary care hospital during the COVID-19 pandemic.

Dbeibo, Lana / Beeler, Cole / Clark, Lauren / Zondor, Megan / Sartino, Catherine / Relich, Ryan F / Hazen, Dana / Lyons, Kathy / Kelley, Kristen / Webb, Douglas / Saysana, Michele / Kara, Areeba

American journal of infection control

2024

Abstract: Background: Candida auris (C auris) is a fungal pathogen that has the potential for environmental persistence leading to outbreaks in health care settings. There has been a worldwide surge in C auris outbreaks during the COVID-19 pandemic. In this ... ...

Abstract	Background: Candida auris (C auris) is a fungal pathogen that has the potential for environmental persistence leading to outbreaks in health care settings. There has been a worldwide surge in C auris outbreaks during the COVID-19 pandemic. In this report, we describe an outbreak of C auris, its control, patient outcomes, and lessons learned. Methods: The outbreak occurred in a 600-bed adult academic tertiary care hospital. Contact tracing was initiated immediately after identification of the index case and surveillance testing for C auris was obtained from patients who were exposed to the index case. Infection prevention measures were closely followed. Results: A total of 560 cultures were performed on 453 unique patients between August 2021 and December 2021. Of those, 31 cultures (5.5%) were positive for C auris; 27 (87.1%) were colonized with C auris, while 4 patients developed a clinical infection (12.9%). The secondary attack rate was 6.8% (31/453). The 30-day all-cause mortality rate for all patients who tested positive for C auris was 9.7%. Discussion: C auris can cause protracted outbreaks that result in colonization and invasive infections. Multidisciplinary work to improve adherence to infection prevention measures as well as targeted admission screening are essential to limit outbreaks.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2024.03.012
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Article ; Online: Double magnetic tunnel junctions with a switchable assistance layer for improved spin transfer torque magnetic memory performance.

Sanchez Hazen, Daniel / Auffret, Stéphane / Joumard, Isabelle / Vila, Laurent / Buda-Prejbeanu, Liliana D / Sousa, Ricardo C / Prejbeanu, Lucian / Dieny, Bernard

Nanoscale

2021 Volume 13, Issue 33, Page(s) 14096–14109

Abstract: This paper reports the first experimental demonstration of a new concept of double magnetic tunnel junctions comprising a magnetically switchable assistance layer. These double junctions are used as memory cells in spin transfer torque magnetic random ... ...

Abstract	This paper reports the first experimental demonstration of a new concept of double magnetic tunnel junctions comprising a magnetically switchable assistance layer. These double junctions are used as memory cells in spin transfer torque magnetic random access memory (STT-MRAM) devices. Their working principle, fabrication and electrical characterization are described and their performances are compared to those of reference devices without an assistance layer. We show that thanks to the assistance layer, the figure of merit of STT-MRAM cells can be increased by a factor of 4 as compared to that of STT-MRAM based on conventional stacks without the assistance layer. A detailed discussion of the results is given supported by numerical simulations. The simulations also provide guidelines on how to optimize the properties of the assistance layer to get the full benefit from this concept.
Language	English
Publishing date	2021-08-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d1nr01656c
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Book ; Online: Unleashing In-network Computing on Scientific Workloads

Kim, Daehyeok / Jain, Ankush / Liu, Zaoxing / Amvrosiadis, George / Hazen, Damian / Settlemyer, Bradley / Sekar, Vyas

2020

Abstract: Many recent efforts have shown that in-network computing can benefit various datacenter applications. In this paper, we explore a relatively less-explored domain which we argue can benefit from in-network computing: scientific workloads in high- ... ...

Abstract	Many recent efforts have shown that in-network computing can benefit various datacenter applications. In this paper, we explore a relatively less-explored domain which we argue can benefit from in-network computing: scientific workloads in high-performance computing. By analyzing canonical examples of HPC applications, we observe unique opportunities and challenges for exploiting in-network computing to accelerate scientific workloads. In particular, we find that the dynamic and demanding nature of scientific workloads is the major obstacle to the adoption of in-network approaches which are mostly open-loop and lack runtime feedback. In this paper, we present NSinC (Network-accelerated ScIeNtific Computing), an architecture for fully unleashing the potential benefits of in-network computing for scientific workloads by providing closed-loop runtime feedback to in-network acceleration services. We outline key challenges in realizing this vision and a preliminary design to enable acceleration for scientific applications. Comment: 8 pages, 3 figures
Keywords	Computer Science - Networking and Internet Architecture ; Computer Science - Distributed ; Parallel ; and Cluster Computing
Subject code	303
Publishing date	2020-09-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Changing the culture of urine culturing: Utilizing Agile Implementation to improve diagnostic stewardship in the ICU.

Page, Shannon / Hazen, Dana / Kelley, Kristen / Singh, Ranjeet / Rodgers, Richard B / Brewer, Brian / Sadowski, Joshua / Desai, Armisha / Beeler, Cole / Webb, Douglas / Azar, Jose / Dbeibo, Lana

American journal of infection control

2020 Volume 48, Issue 11, Page(s) 1375–1380

Abstract: Over diagnosis of catheter-associated urinary tract infection (CAUTI) contributes to unnecessary and excessive antibiotic use, selection for resistant organisms, increased risk for Clostridiodes difficile infections, as well as a false elevation in CAUTI ...

Abstract	Over diagnosis of catheter-associated urinary tract infection (CAUTI) contributes to unnecessary and excessive antibiotic use, selection for resistant organisms, increased risk for Clostridiodes difficile infections, as well as a false elevation in CAUTI rates. Utilizing agile implementation to implement a urine culture algorithm achieved statistically significant reduction in CAUTI rates in a critical care unit resulting in sustainment and spread throughout the system.
MeSH term(s)	Anti-Bacterial Agents ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/prevention & control ; Humans ; Intensive Care Units ; Urinary Tract Infections/diagnosis
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2020-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2020.01.022
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Article ; Online: Strategies for the successful implementation of disinfecting port protectors to reduce CLABSI in a large tertiary care teaching hospital.

Beeler, Cole / Kerley, Denise / Davis, Carmen / Hazen, Dana / Snyderman, William / Lyons, Kathy / Sadowski, Josh / Sweeney, Jennifer / Dbeibo, Lana / Kelley, Kristen / Webb, Douglas H

American journal of infection control

2019 Volume 47, Issue 12, Page(s) 1505–1507

Abstract: Disinfecting port protectors are a supplement to the central line-associated bloodstream infection prevention bundle as an optional recommendation from the Centers for Disease Control and Prevention. Despite evidence of effectiveness, few centers have ... ...

Abstract	Disinfecting port protectors are a supplement to the central line-associated bloodstream infection prevention bundle as an optional recommendation from the Centers for Disease Control and Prevention. Despite evidence of effectiveness, few centers have successfully reported systematic, sustained implementation of these devices. In this article, we discuss a successful implementation in a large tertiary care teaching hospital, using an evidence-based, multidisciplinary approach. Infection prevention; Bacteremia; Ethanol caps; Bundle measures; Quality improvement; Hub infection.
MeSH term(s)	Bacteremia/diagnosis ; Bacteremia/microbiology ; Bacteremia/prevention & control ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/prevention & control ; Catheterization, Central Venous/instrumentation ; Catheters, Indwelling/microbiology ; Cross Infection/diagnosis ; Cross Infection/microbiology ; Cross Infection/prevention & control ; Equipment Contamination/prevention & control ; Equipment Contamination/statistics & numerical data ; Evidence-Based Medicine ; Hospitals, Teaching ; Humans ; Inpatients ; Nurses ; Prospective Studies ; Quality Control ; Tertiary Care Centers
Language	English
Publishing date	2019-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2019.05.016
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Book ; Online: The Petascale DTN Project

Dart, Eli / Allcock, William / Bhimji, Wahid / Boerner, Tim / Cheema, Ravinderjeet / Cherry, Andrew / Draney, Brent / Habib, Salman / Hazen, Damian / Hill, Jason / Kollross, Matt / Parete-Koon, Suzanne / Pelfrey, Daniel / Pope, Adrian / Porter, Jeff / Wheeler, David

High Performance Data Transfer for HPC Facilities

2021

Abstract: The movement of large-scale (tens of Terabytes and larger) data sets between high performance computing (HPC) facilities is an important and increasingly critical capability. A growing number of scientific collaborations rely on HPC facilities for tasks ... ...

Abstract	The movement of large-scale (tens of Terabytes and larger) data sets between high performance computing (HPC) facilities is an important and increasingly critical capability. A growing number of scientific collaborations rely on HPC facilities for tasks which either require large-scale data sets as input or produce large-scale data sets as output. In order to enable the transfer of these data sets as needed by the scientific community, HPC facilities must design and deploy the appropriate data transfer capabilities to allow users to do data placement at scale. This paper describes the Petascale DTN Project, an effort undertaken by four HPC facilities, which succeeded in achieving routine data transfer rates of over 1PB/week between the facilities. We describe the design and configuration of the Data Transfer Node (DTN) clusters used for large-scale data transfers at these facilities, the software tools used, and the performance tuning that enabled this capability.
Keywords	Computer Science - Distributed ; Parallel ; and Cluster Computing ; Computer Science - Performance
Subject code	000
Publishing date	2021-05-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Assessing the accuracy of microwave radiometers and radio acoustic sounding systems for wind energy applications

Bianco, Laura / Friedrich, Katja / Wilczak, James / Hazen, Duane / Wolfe, Daniel / Delgado, Ruben / Oncley, Steve / Lundquist, Julie K.

eISSN: 1867-8548

2016

Abstract: To assess current remote-sensing capabilities for wind energy applications, a remote-sensing system evaluation study, called XPIA (eXperimental Planetary boundary layer Instrument Assessment), was held in the spring of 2015 at NOAA’s Boulder Atmospheric ... ...

Abstract	To assess current remote-sensing capabilities for wind energy applications, a remote-sensing system evaluation study, called XPIA (eXperimental Planetary boundary layer Instrument Assessment), was held in the spring of 2015 at NOAA’s Boulder Atmospheric Observatory (BAO) facility. Several remote-sensing platforms were evaluated to determine their suitability for the verification and validation processes used to test the accuracy of numerical weather prediction models. The evaluation of these platforms was performed with respect to well-defined reference systems: the BAO’s 300-m tower equipped at 6 levels (50, 100, 150, 200, 250, and 300 m) with 12 sonic anemometers and 6 temperature and relative humidity sensors; and approximately 60 radiosonde launches. In this study we first employ these reference measurements to validate temperature profiles retrieved by two co-located microwave radiometers, as well as virtual temperature measured by co-located wind profiling radars equipped with radio acoustic sounding systems. Results indicate a mean absolute error in the temperature retrieved by the microwave radiometers below 1.5 °C in the lowest 5 km of the atmosphere, and a mean absolute error in the virtual temperature measured by the radio acoustic sounding systems below 0.8 °C in the layer of the atmosphere covered by these measurements (up to approximately 1.6–2 km). We also investigated the benefit of the vertical velocity applied to the speed of sound before computing the virtual temperature by the radio acoustic sounding systems. We find that using this correction frequently increases the RASS error, and that it should not be routinely applied to all data. Water vapor density profiles measured by the MWRs were also compared with similar measurements from the soundings, showing the capability of MWRs to follow the vertical profile measured by the sounding, and finding a mean absolute error below 0.5 g m −3 in the lowest 5 km of the atmosphere. However, the relative humidity profiles measured by the microwave radiometer lack the high-resolution details available from radiosonde profiles. An encouraging and significant finding of this study was that the coefficient of determination between the lapse rate measured by the microwave radiometer and the tower measurements over the tower levels between 50 and 300 m ranged from 0.76 to 0.91, proving that these remote-sensing instruments can provide accurate information on atmospheric stability conditions in the lower boundary layer.
Subject code	551
Language	English
Publishing date	2016-10-12
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Alkaloids of Picea

Schneider, M.J / Montali, J.A / Hazen, D / Stanton, C.E

Journal of natural products. May/June 1991. v. 54 (3)

1991

Keywords	Picea engelmannii ; Picea ; alkaloids ; molecular conformation ; antifeedants
Language	English
Dates of publication	1991-05
Size	p. 905-909.
Document type	Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1144: Show issues

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Article: Secretagogue-mediated discharge of nerve growth factor from granular tubules of male mouse submandibular glands: an immunocytochemical study.

Simson, J A / Hazen, D / Spicer, S S / Murphy, R A / Young, M

The Anatomical record

1978 Volume 192, Issue 3, Page(s) 375–387

Abstract: Submandibular glands of male mice were stained for nerve growth factor by light microscopic immunocytochemistry. Nerve growth factor (NGF) was present in the granules of granular tubule cells, with the immunoreactive material often concentrated at the ... ...

Abstract	Submandibular glands of male mice were stained for nerve growth factor by light microscopic immunocytochemistry. Nerve growth factor (NGF) was present in the granules of granular tubule cells, with the immunoreactive material often concentrated at the periphery of granules. Administration of the alpha-adrenergic agent, phenylephrine, to animals resulted in a marked depletion of NGF-containing granules from granular tubules. Some release also occurred following administration of the beta-adrenergic agent, isoproterenol. Cholinergic stimulation (pilocarpine) did not result in appreciable loss of immunoreactive granules from these cells. In vitro results were not as clear cut, immunocytochemically, as those obtained with intact animals. It is concluded that discharge of NGF from male mouse submandibular glands is mediated predominantly by alpha-adrenergic activation, and that this phenomenon is readily demonstrated in the intact animal.
MeSH term(s)	Animals ; Cytoplasmic Granules/analysis ; Immunoenzyme Techniques ; In Vitro Techniques ; Isoproterenol/pharmacology ; Male ; Mice/metabolism ; Nerve Growth Factors/analysis ; Nerve Growth Factors/secretion ; Phenylephrine/pharmacology ; Pilocarpine/pharmacology ; Submandibular Gland/analysis ; Submandibular Gland/drug effects ; Submandibular Gland/secretion
Chemical Substances	Nerve Growth Factors ; Pilocarpine (01MI4Q9DI3) ; Phenylephrine (1WS297W6MV) ; Isoproterenol (L628TT009W)
Language	English
Publishing date	1978-11
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	203685-x
ISSN	0003-276X
ISSN	0003-276X
DOI	10.1002/ar.1091920305
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