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  1. Article ; Online: Clinical Value of PLR, MLR, and NWR in Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer.

    He, Baojun / Wu, Jieli

    publication RETRACTED

    Computational and mathematical methods in medicine

    2022  Volume 2022, Page(s) 8005975

    Abstract: Objective: The clinical value of platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-white blood cell ratio (NWR) in predicting the prognosis of patients with locally advanced gastric cancer after neoadjuvant ... ...

    Abstract Objective: The clinical value of platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-white blood cell ratio (NWR) in predicting the prognosis of patients with locally advanced gastric cancer after neoadjuvant chemotherapy (NACT) was studied.
    Methods: A total of 131 patients with locally advanced gastric cancer treated with neoadjuvant chemotherapy in our hospital from May 2015 to June 2018 were selected as the study subjects, and all were treated with neoadjuvant chemotherapy. The relationship between the values of PLR, MLR, and NWR and the efficacy of neoadjuvant chemotherapy and clinical staging was analyzed; all patients were followed up for 3 years. Patients were divided into death group and survival group according to the survival of patients. The predictive value of PLR, MLR, and NWR values for patients' prognosis was analyzed, and the survival rates of patients with different PLR, MLR, and NWR values were compared.
    Results: The effective rate of neoadjuvant chemotherapy in patients with locally advanced gastric cancer was 62.60% (82/131), and the PLR, MLR, and NWR values in the effective group were lower than those in the ineffective group (
    Conclusions: PLR, MLR, and NWR values are correlated with clinical stage, and the combined detection has value in evaluating the clinical efficacy of neoadjuvant chemotherapy and predicting the prognosis of patients with locally advanced gastric cancer.
    MeSH term(s) Humans ; Lymphocytes ; Monocytes ; Neoadjuvant Therapy ; Neutrophils ; Prognosis ; Retrospective Studies ; Stomach Neoplasms/drug therapy
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2252430-7
    ISSN 1748-6718 ; 1748-670X ; 1027-3662
    ISSN (online) 1748-6718
    ISSN 1748-670X ; 1027-3662
    DOI 10.1155/2022/8005975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6373: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Enhancing Natural Killer Cell-Mediated Cancer Immunotherapy by the Biological Macromolecule

    Wu, Jie / He, Baojun / Miao, Miao / Han, Xibin / Dai, Hongyan / Dou, Heng / Li, Yanqiu / Zhang, Xiaoqing / Wang, Guangchuan

    Pathology oncology research : POR

    2022  Volume 28, Page(s) 1610555

    Abstract: The biological ... ...

    Abstract The biological macromolecule
    MeSH term(s) Animals ; Cytokines ; Granzymes ; Immunotherapy ; Interleukin-2/pharmacology ; Interleukin-6 ; Killer Cells, Natural ; Lung Neoplasms/therapy ; Melanoma ; Mice ; Perforin ; Rhodococcus ; Tumor Necrosis Factor-alpha
    Chemical Substances Cytokines ; Interleukin-2 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Perforin (126465-35-8) ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1375979-6
    ISSN 1532-2807 ; 1219-4956
    ISSN (online) 1532-2807
    ISSN 1219-4956
    DOI 10.3389/pore.2022.1610555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4936: Show issues Location:
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  3. Article ; Online: Methylation of the UNC5C gene and its protein expression in colorectal cancer.

    Wu, Jie / Wang, Guangchuan / He, Baojun / Chen, Xuejun / An, Yuzhi

    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

    2017  Volume 39, Issue 4, Page(s) 1010428317697564

    Abstract: UNC5C is a member of the UNC5H family of transmembrane receptors and functions as a dependence receptor. The expression of UNC5C is lost or markedly reduced in a large proportion of cancers at the messenger RNA level. However, there is little information ...

    Abstract UNC5C is a member of the UNC5H family of transmembrane receptors and functions as a dependence receptor. The expression of UNC5C is lost or markedly reduced in a large proportion of cancers at the messenger RNA level. However, there is little information available regarding the protein expression of UNC5C, the relationship between UNC5C protein expression and UNC5C methylation, and the correlation between patient clinical features and UNC5C protein expression in colorectal cancer. In this study, the methylation and protein expression of UNC5C were examined in 36 adenomatous polyps, 73 colorectal cancers, and 28 corresponding normal mucosa, and the correlation between the methylation, as well as protein expression status, and the clinicopathologic features was evaluated. Furthermore, the relationship between the methylation and protein expression of UNC5C, and correlation between UNC5C protein expression and overall survival were analyzed. The results showed that aberrant methylation of UNC5C was observed in colorectal cancers (78%) and adenomatous polyps (64%). The methylation-specific polymerase chain reaction results were confirmed by bisulfite sequencing of UNC5C promoter region. UNC5C methylation was significantly higher in early tumor, node, metastasis stage (I + II) of colorectal cancers. Compared with the corresponding normal tissues, protein expression of UNC5C was significantly lower in colorectal cancers (42%) and adenomatous polyps (81%). Protein expression of UNC5C was significantly higher in early tumor, node, metastasis stage (I + II) of colorectal cancers compared with advanced tumor, node, metastasis stage. Furthermore, patients with UNC5C-negative expression had a poorer prognosis than those with UNC5C-positive expression through Kaplan-Meier survival analysis ( p = 0.038), univariate ( p = 0.044) and multivariate analysis ( p = 0.045). According to Spearman rank correlation analysis, UNC5C methylation and protein expression were negatively correlated ( r = -0.461, p < 0.001). Together, these results suggest that UNC5C methylation may be an earlier event in the development of colorectal cancer, which was negatively correlated with protein expression. UNC5C may have a critical role in the pathogenesis of colorectal cancers and be a valuable prognostic factor of colorectal cancers patients. UNC5C may be identified as an attractive therapeutic target for the treatment of colorectal cancers in the further studies.
    MeSH term(s) Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; DNA Methylation ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Netrin Receptors ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism
    Chemical Substances Netrin Receptors ; Receptors, Cell Surface ; UNC5C protein, human
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605825-5
    ISSN 1423-0380 ; 0289-5447 ; 1010-4283
    ISSN (online) 1423-0380
    ISSN 0289-5447 ; 1010-4283
    DOI 10.1177/1010428317697564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1598: Show issues Location:
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  4. Article ; Online: Prognostic and Therapeutic Values of Tumor Necrosis Factor-Alpha in Hepatocellular Carcinoma.

    Wang, Hongmei / Liu, Jianmin / Hu, Xuemei / Liu, Shanshan / He, Baojun

    Medical science monitor : international medical journal of experimental and clinical research

    2016  Volume 22, Page(s) 3694–3704

    Abstract: BACKGROUND Hepatocellular carcinoma (HCC) causes many deaths worldwide every year, especially in Asia. It is characterized by high malignancy, recurrence, and short survival time. Inflammation is closely related to the initiation and development of HCC. ... ...

    Abstract BACKGROUND Hepatocellular carcinoma (HCC) causes many deaths worldwide every year, especially in Asia. It is characterized by high malignancy, recurrence, and short survival time. Inflammation is closely related to the initiation and development of HCC. Tumor necrosis factor-α (TNF-α), an essential inflammatory mediator, has been studied as a potential therapy target in many cancers. However, its potential role in HCC diagnosis and therapy is still unclear. MATERIAL AND METHODS In our study, we detected the TNF-α expression in both human HCC tumor tissue and HCC cell lines HepG2 and HuH7. Then, we detected the effect of anti-TNF-α treatment and it synergistic function with 5-FU in an HCC xenograft mouse model and in HCC cell lines. RESULTS Survival analysis and Cox regression analysis based on 97 HCC patients indicated that a high level of TNF-α is an independent predictor of poor survival in HCC patients. Anti-TNF-α treatment by infliximab synergizes with Fluorouracil (5-FU) by promoting apoptosis of HCC tumor cells through complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) effects. CONCLUSIONS Based on these data, we conclude that anti-TNF-α treatment could be a good way to increase the effect of classic chemotherapy of HCC patients, especially for the patients who have modest response to classic chemotherapy, such as 5-FU. TNF-α could also be used as a biomarker to help in early diagnosis of HCC.
    MeSH term(s) Adult ; Aged ; Animals ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Female ; Fluorouracil/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects ; Hep G2 Cells ; Humans ; Infliximab/therapeutic use ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Male ; Mice ; Middle Aged ; Neoplasm Recurrence, Local/genetics ; Prognosis ; Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/therapeutic use ; Xenograft Model Antitumor Assays
    Chemical Substances Tumor Necrosis Factor-alpha ; Infliximab (B72HH48FLU) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2016-10-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/msm.899773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4924: Show issues Location:
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