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  1. Article: Effect of Steam Pressure Toasting Duration on Snowbird Faba Bean Seeds and the Impact on the Intestinal and Metabolic Characteristics in Dairy Cows.

    Rodríguez Espinosa, María E / Guevara-Oquendo, Víctor H / He, Jiangfeng / Zhang, Weixiang / Yu, Peiqiang

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 3

    Abstract: The response of feedstuffs to thermal processing depends on the type of feed and the thermal processing methods being applied. Steam pressure toasting (SPT) has been used to modify the nutrient degradability and enhance the nutritional quality of pulses, ...

    Abstract The response of feedstuffs to thermal processing depends on the type of feed and the thermal processing methods being applied. Steam pressure toasting (SPT) has been used to modify the nutrient degradability and enhance the nutritional quality of pulses, including faba bean seeds (FBS). Strategic feeding approaches are essential for balancing diets and maintaining adequate nutrition, especially in high-performing ruminants. This research aimed to determine the effects of SPT duration in FBS on the intestinal and metabolic characteristics of dairy cows. Faba Bean seeds (three harvesting years) were processed at 121 °C for 0, 30, 60, 90, and 120 min. Rumen degradation and intestinal digestion were determined using the in situ and modified in vitro three-step techniques. The true protein supplied to the small intestine was also determined using the NRC and DVE systems. Our results showed a reduced total digested DM (TDDM) with longer SPT duration (quadratic,
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14030483
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human.

    He, Jiangfeng / Zheng, Zhanglong / Li, Sijin / Liao, Chongshan / Li, Yongming

    BMC oral health

    2023  Volume 23, Issue 1, Page(s) 632

    Abstract: Background: Periodontitis is the most common oral disease and is closely related to immune infiltration in the periodontal microenvironment and its poor prognosis is related to the complex immune response. The progression of periodontitis is closely ... ...

    Abstract Background: Periodontitis is the most common oral disease and is closely related to immune infiltration in the periodontal microenvironment and its poor prognosis is related to the complex immune response. The progression of periodontitis is closely related to necroptosis, but there is still no systematic study of long non-coding RNA (lncRNA) associated with necroptosis for diagnosis and treatment of periodontitis.
    Material and methods: Transcriptome data and clinical data of periodontitis and healthy populations were obtained from the Gene Expression Omnibus (GEO) database, and necroptosis-related genes were obtained from previously published literature. FactoMineR package in R was used to perform principal component analysis (PCA) for obtaining the necroptosis-related lncRNAs. The core necroptosis-related lncRNAs were screened by the Linear Models for Microarray Data (limma) package in R, PCA principal component analysis and lasso algorithm. These lncRNAs were then used to construct a classifier for periodontitis with logistic regression. The receiver operating characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the model. The CIBERSORT method and ssGSEA algorithm were used to estimate the immune infiltration and immune pathway activation of periodontitis. Spearman's correlation analysis was used to further verify the correlation between core genes and periodontitis immune microenvironment. The expression level of core genes in human periodontal ligament cells (hPDLCs) was detected by RT-qPCR.
    Results: A total of 10 core necroptosis-related lncRNAs (10-lncRNAs) were identified, including EPB41L4A-AS1, FAM30A, LINC01004, MALAT1, MIAT, OSER1-DT, PCOLCE-AS1, RNF144A-AS1, CARMN, and LINC00582. The classifier for periodontitis was successfully constructed. The Area Under the Curve (AUC) was 0.952, which suggested that the model had good predictive performance. The correlation analysis of 10-lncRNAs and periodontitis immune microenvironment showed that 10-lncRNAs had an impact on the immune infiltration of periodontitis. Notably, the RT-qPCR results showed that the expression level of the 10-lncRNAs obtained was consistent with the chip analysis results.
    Conclusions: The 10-lncRNAs identified from the GEO dataset had a significant impact on the immune infiltration of periodontitis and the classifier based on 10-lncRNAs had good detection efficiency for periodontitis, which provided a new target for diagnosis and treatment of periodontitis.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; Necroptosis ; Algorithms ; Databases, Factual ; Health Status
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-023-03308-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Research updates and progress on nutritional significance of the amides I and II, alpha-helix and beta-sheet ratios, microbial protein synthesis, and steam pressure toasting condition with globar and synchrotron molecular microspectroscopic techniques with chemometrics.

    Rodriguez-Espinosa, Maria E / Guevara-Oquendo, Victor H / He, Jiangfeng / Zhang, Weixian / Yu, Peiqiang

    Critical reviews in food science and nutrition

    2023  , Page(s) 1–15

    Abstract: This article aims to review research updates and progress on the nutritional significance of the amides I and II, the alpha-helix and beta-sheet ratios, the microbial protein synthesis, and the steam pressure toasting condition in food and feed with ... ...

    Abstract This article aims to review research updates and progress on the nutritional significance of the amides I and II, the alpha-helix and beta-sheet ratios, the microbial protein synthesis, and the steam pressure toasting condition in food and feed with globar and synchrotron molecular microspectroscopic techniques plus chemometrics (both univariate and multivariate techniques). The review focused on (I) impact of the amides I and II, and the alpha-helix and beta-sheet-structure ratios in food and feeds; (II) Current research progress and update in synchrotron technique and application in feed and food molecular structure studies that are associated with nutrition delivery; (III) Impact of thermal processing- steam pressure toasting condition on feed and food; (IV). Impact of the microbial protein synthesis and methodology on feed and food; and (V). Impact on performance and production of ruminants with Faba beans.
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2023.2274442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of processing methods (dry-heating, autoclaving, and (microwave irradiation) on protein-related molecular structure spectral feature and protein nutritive value of cool-seasoned oat varieties in ruminant system in western Canada

    Prates, Luciana L. / Rodríguez Espinosa, Maria E. / Feng, Xin / Tosta, Marcela / He, Jiangfeng / Yu, Peiqiang

    Animal Feed Science and Technology. 2023 Oct., v. 304 p.115736-

    2023  

    Abstract: The objectives of this study were to reveal the effects of heating method and variety on (1) protein molecular structure spectral features revealed by Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and (2) ruminant ... ...

    Abstract The objectives of this study were to reveal the effects of heating method and variety on (1) protein molecular structure spectral features revealed by Attenuated Total Reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and (2) ruminant relevant protein chemical profiles, protein subfractions, rumen degradable protein (RDP), rumen undegradable protein (RUP), and intestinal protein digestibility using the Cornell Net Carbohydrate and Protein System (CNCPS) in oat varieties [CDC Nasser (feed-type oat) and CDC Seabiscuit (milling-type oat)]. Heating method included control (raw), dry heating (DH), moist heating (autoclaving, MH), and microwave irradiation (MIR). The dry matter (DM), crude protein (CP), and neutral detergent fiber (NDF) contents in CDC Nasser were 934, 107, and 252 g/kg DM, respectively; the contents of these nutrients in CDC Seabiscuit were 933, 110, and 268 g/kg DM, respectively. Heat processing significantly affected the total RDP (TRDP, P < 0.001), which was higher for DH than MIR and MH in CDC Nasser (5.46%, 5.01%, and 4.45%DM). Conversely, MIR had a higher value for TRDP than DH and MH in CDC Seabiscuit (5.32%, 5.24%, and 4.51%DM). The total RUP (TRUP) was higher for MH than MIR and DH in both varieties (P < 0.001). The intestinal digestible feed protein was similar between the varieties (P = 0.308); however, DH and MH reduced the value, while MIR increased it compared to the control (P = 0.010) for both varieties. The results from the ATR-FTIR analysis showed an interaction between varieties and heat processing in the protein secondary structures α-helix (P = 0.003), β-sheet (P = 0.031), and their ratio (P = 0.030). Moreover, in the multivariate analyses, no independent groups were observed between the raw and the three heat processing methods in the protein-related molecular structure of oats. In conclusion, heat processing altered the protein subfractions, the TRDP, and TRUP, affecting intestinal protein digestibility. The ATR-FTIR spectroscopy with univariate molecular analysis showed heat processing-induced molecular structure changes in the protein-related spectral profiles in CDC Nasser and CDC Seabiscuit.
    Keywords autoclaving ; carbohydrates ; chemical structure ; crude protein ; digestible protein ; feeds ; heat ; infrared spectroscopy ; intestines ; microwave radiation ; neutral detergent fiber ; oats ; ruminants ; Canada ; Spectroscopy ; Chemometrics ; Uni- and multi-variate spectral analyses ; Heat processing methods ; Ruminant relevant protein nutrition ; Cool-season oat grain
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 196563-3
    ISSN 0377-8401
    ISSN 0377-8401
    DOI 10.1016/j.anifeedsci.2023.115736
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Hydrated Eutectic Electrolytes Stabilizing Quasi-Underpotential Mg Plating/Stripping for High-Voltage Mg Batteries.

    Liu, Guigui / Tang, Yongchao / Li, Hongqing / He, Jiangfeng / Ye, Minghui / Zhang, Yufei / Wen, Zhipeng / Liu, Xiaoqing / Li, Cheng Chao

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 16, Page(s) e202217945

    Abstract: Aqueous rechargeable Mg batteries (ARMBs) usually fail from severe anode passivation, alternatively, executing quasi-underpotential Mg plating/stripping chemistry (UPMC) on a proper heterogeneous metal substrate is a crucial remedy. Herein, a stable UPMC ...

    Abstract Aqueous rechargeable Mg batteries (ARMBs) usually fail from severe anode passivation, alternatively, executing quasi-underpotential Mg plating/stripping chemistry (UPMC) on a proper heterogeneous metal substrate is a crucial remedy. Herein, a stable UPMC on Zn substrate is initially achieved in new hydrated eutectic electrolytes (HEEs), delivering an ultralow UPMC overpotential and high energy/voltage plateau of ARMBs. The unique eutectic property remarkably expands the lower limit of electrochemical stability window (ESW) of HEEs and undermines the competition between hydrogen evolution/corrosion reactions and UPMC, enabling a reversible UPMC. The UPMC is carefully revealed by multiple characterizations, which shows a low overpotential of 50 mV at 0.1 mA cm
    Language English
    Publishing date 2023-03-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202217945
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The abscopal effect of anti-CD95 and radiotherapy in melanoma.

    Xu, Jixiang / He, JiangFeng / He, JiaJun / He, Yuanmin / Zhang, DaoJun / Kong, Rui / Dan, Kena

    Discover. Oncology

    2023  Volume 14, Issue 1, Page(s) 68

    Abstract: Background: Radiotherapy (RT) is frequently adopted to control cancer cell proliferation, which is achieved by altering the tumor microenvironment (TME) and immunogenicity. Apoptosis of cancer cells is the major effect of radiation on tumor tissues. Fas/ ...

    Abstract Background: Radiotherapy (RT) is frequently adopted to control cancer cell proliferation, which is achieved by altering the tumor microenvironment (TME) and immunogenicity. Apoptosis of cancer cells is the major effect of radiation on tumor tissues. Fas/APO-1(CD95) receptors on the cell membrane are death receptors that can be activated by diverse factors, including radiation and integration with CD95L on CD8
    Methods: The effect of activation and radiation of CD95 receptors on melanoma cell lines was examined in vivo and in vitro. In vivo, bilateral lower limbs were given a subcutaneous injection of a dual-tumor. Tumors in the right limb were radiated with a single dose of 10 Gy (primary tumor), while tumors in the left limb (secondary tumor) were spared.
    Results: The anti-CD95 treatment plus radiation (combination treatment) reduced growth rates of both primary and secondary tumors relative to the control or radiation groups. In addition, higher degrees of infiltrating CTLs and DCs were detected in the combination treatment compared to the other groups, but the immune response responsible for secondary tumor rejection was not proven to be tumor specific. In vitro, combination treatment combined with radiation resulted in further apoptosis of melanoma cells relative to controls or cells treated with radiation.
    Conclusions: Targeting CD95 on cancer cells will induce tumor control and the abscopal effect.
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ISSN 2730-6011
    ISSN (online) 2730-6011
    DOI 10.1007/s12672-023-00682-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: In Situ Polymerization of Ionic Liquid with Tunable Phase Separation for Highly Reversible and Ultralong Cycle Life Zn-Ion Battery.

    Zheng, Si / Wei, Licheng / Zhang, Zhaoyu / Pan, Jiageng / He, Jiangfeng / Gao, Liang / Li, Cheng Chao

    Nano letters

    2022  Volume 22, Issue 22, Page(s) 9062–9070

    Abstract: Severe Zn dendrite growth and side reactions greatly limit the application of aqueous zinc-ion batteries. Herein, we design a layer of polyionic liquid (PCAVImBr) film with a tunable pore size and charge density on the Zn anode to endow homogenized ... ...

    Abstract Severe Zn dendrite growth and side reactions greatly limit the application of aqueous zinc-ion batteries. Herein, we design a layer of polyionic liquid (PCAVImBr) film with a tunable pore size and charge density on the Zn anode to endow homogenized distribution of an electronic field, acerated Zn
    MeSH term(s) Ionic Liquids ; Polymerization ; Electronics ; Zinc
    Chemical Substances Ionic Liquids ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-11-04
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.2c03421
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  8. Article ; Online: Hetero-Solvation-Diluted Strongly-Coordinated Zn

    Li, Hongqing / Tang, Yongchao / Liu, Guigui / He, Jiangfeng / Wei, Yue / Ye, Minghui / Zhang, Yufei / Yang, Qi / Li, Hongfei / Wen, Zhipeng / Liu, Xiaoqing / Li, Cheng Chao

    Small methods

    2023  , Page(s) e2301081

    Abstract: Mild aqueous Zn batteries (AZBs) generally suffer a low-voltage/energy dilemma, which compromises their competitiveness for large-scale energy storage. Pushing Zn anode potential downshift is an admissible yet underappreciated approach for high-voltage/ ... ...

    Abstract Mild aqueous Zn batteries (AZBs) generally suffer a low-voltage/energy dilemma, which compromises their competitiveness for large-scale energy storage. Pushing Zn anode potential downshift is an admissible yet underappreciated approach for high-voltage/energy AZBs. Herein, with a mild hybrid electrolyte containing in situ-derived diluted strongly-coordinated Zn
    Language English
    Publishing date 2023-12-10
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202301081
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  9. Article ; Online: Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion.

    Wang, Li-Wei / Cui, Xue-Ying / He, Jiang-Feng / Duan, Shen / Liu, Chun-Rui / Shan, Cheng-Bin / Wang, Yu / Ma, Chao-Mei

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2021  Volume 87, Page(s) 153579

    Abstract: Background: Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effects. However, little is known about the bioactivities of other chemical constituents in Safflower and ... ...

    Abstract Background: Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effects. However, little is known about the bioactivities of other chemical constituents in Safflower and the relationship between enhancement of blood circulation and hepatoprotection by HSYA.
    Purpose: The present research was to evaluate the antithrombotic and hepatoprotective activities of HSYA and C, examine their mechanisms of actions, including influence on the excretion velocity of acetaminophen, and the relationship between the antithrombotic, hepatoprotective, and other bioactivities.
    Methods: The hepatoprotective activities were examined by acetaminophen (APAP)-induced zebrafish toxicity and carbon tetrachloride (CCl
    Results: HSYA and HSYC showed robust protection on APAP-induced toxicity and PHZ-induced thrombosis. The hepatoprotective effects of HSYA and C were more potent than that of the positive control, acetylcysteine (61.7% and 58.0%, respectively, vs. 56.9% at 100 µM) and their antithrombosis effects were more robust than aspirin (95.1% and 86.2% vs. 52.7% at 100 µM). HSYA and C enhanced blood circulation, rescued APAP-treated zebrafish from morphological abnormalities, and mitigated APAP-induced toxicity in liver development in liver-specific RFP-expressing transgenic zebrafish. HSYC attenuated CCl
    Conclusion: HSYA and C are the bioactive constituents of Safflower that are responsible for the herbal drug's traditional use in promoting blood circulation to remove blood stasis. Safflower and its chalcone constituents may protect from damage due to exogenous or disease-induced endogenous toxins by enhancing the excretion velocity of toxins.
    MeSH term(s) Acetaminophen/pharmacokinetics ; Acetaminophen/toxicity ; Animals ; Animals, Genetically Modified ; Blood Circulation/drug effects ; Carbon Tetrachloride/toxicity ; Carthamus tinctorius/chemistry ; Chalcone/analogs & derivatives ; Chalcone/isolation & purification ; Chalcone/pharmacology ; Chalcones/isolation & purification ; Chalcones/pharmacology ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/pathology ; Fibrinolytic Agents/pharmacology ; Glycosides/isolation & purification ; Glycosides/pharmacology ; Hepatocytes/drug effects ; Humans ; Male ; Mice, Inbred ICR ; Phenylhydrazines/toxicity ; Protective Agents/chemistry ; Protective Agents/isolation & purification ; Protective Agents/pharmacology ; Quinones/isolation & purification ; Quinones/pharmacology ; Thrombosis/chemically induced ; Thrombosis/drug therapy ; Zebrafish/genetics ; Mice
    Chemical Substances Chalcones ; Fibrinolytic Agents ; Glycosides ; Phenylhydrazines ; Protective Agents ; Quinones ; hydroxysafflor yellow C ; phenylhydrazine (064F424C9K) ; hydroxysafflor yellow A (146087-19-6) ; Acetaminophen (362O9ITL9D) ; Chalcone (5S5A2Q39HX) ; Carbon Tetrachloride (CL2T97X0V0)
    Language English
    Publishing date 2021-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion

    Wang, Li-Wei / Cui, Xue-Ying / He, Jiang-Feng / Duan, Shen / Liu, Chun-Rui / Shan, Cheng-Bin / Wang, Yu / Ma, Chao-Mei

    Phytomedicine. 2021 July, v. 87

    2021  

    Abstract: Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effects. However, little is known about the bioactivities of other chemical constituents in Safflower and the ... ...

    Abstract Hydroxysafflor yellow A (HSYA) from the flower of Carthamus tinctorius (Safflower) has been reported to have various pharmacological effects. However, little is known about the bioactivities of other chemical constituents in Safflower and the relationship between enhancement of blood circulation and hepatoprotection by HSYA.The present research was to evaluate the antithrombotic and hepatoprotective activities of HSYA and C, examine their mechanisms of actions, including influence on the excretion velocity of acetaminophen, and the relationship between the antithrombotic, hepatoprotective, and other bioactivities.The hepatoprotective activities were examined by acetaminophen (APAP)-induced zebrafish toxicity and carbon tetrachloride (CCl₄)-induced mouse liver injury. The concentrations of APAP in zebrafish and APAP that was excreted to the culture media were quantified by UHPLC-MS. The anti-thrombosis effect of HSYA and C were examined by the phenylhydrazine (PHZ)-induced zebrafish thrombosis.HSYA and HSYC showed robust protection on APAP-induced toxicity and PHZ-induced thrombosis. The hepatoprotective effects of HSYA and C were more potent than that of the positive control, acetylcysteine (61.7% and 58.0%, respectively, vs. 56.9% at 100 µM) and their antithrombosis effects were more robust than aspirin (95.1% and 86.2% vs. 52.7% at 100 µM). HSYA and C enhanced blood circulation, rescued APAP-treated zebrafish from morphological abnormalities, and mitigated APAP-induced toxicity in liver development in liver-specific RFP-expressing transgenic zebrafish. HSYC attenuated CCl₄-induced mouse liver injury and regulated the levels of HIF-1α, iNOS, TNF-α, α-SMA, and NFκB in liver tissues. HSYA was also protective in a dual thrombotic and liver toxicity zebrafish model. By UHPLC-MS, HSYA accelerated the excretion of APAP.HSYA and C are the bioactive constituents of Safflower that are responsible for the herbal drug's traditional use in promoting blood circulation to remove blood stasis. Safflower and its chalcone constituents may protect from damage due to exogenous or disease-induced endogenous toxins by enhancing the excretion velocity of toxins.
    Keywords Carthamus tinctorius ; Danio rerio ; acetaminophen ; acetylcysteine ; aspirin ; blood circulation ; blood stasis ; carbon tetrachloride ; chalcone ; excretion ; flowers ; genetically modified organisms ; hepatoprotective effect ; hepatotoxicity ; herbal medicines ; liver ; mice ; models ; thrombosis
    Language English
    Dates of publication 2021-07
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153579
    Database NAL-Catalogue (AGRICOLA)

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