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  1. Article ; Online: Electrochemotherapy for Pancreatic Cancer: An Emerging Treatment Modality?

    He, Jin

    Annals of surgical oncology

    2020  Volume 27, Issue 11, Page(s) 4086–4087

    MeSH term(s) Electrochemotherapy ; Humans ; Pancreatic Neoplasms/drug therapy ; Treatment Outcome
    Language English
    Publishing date 2020-07-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-020-08791-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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  2. Article ; Online: Seeking the Real Benefits of Laparoscopic Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma.

    Nicolson, Norman G / He, Jin

    JAMA surgery

    2023  Volume 158, Issue 12, Page(s) 1253–1254

    MeSH term(s) Humans ; Pancreaticoduodenectomy ; Pancreatic Neoplasms/surgery ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology ; Laparoscopy ; Retrospective Studies
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.5219
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    Uk I Zs.72: Show issues Location:
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  3. Article ; Online: Is Hepatic Artery Infusion Pump Therapy a New Bridging Strategy to Liver Transplant for Advanced Liver Malignancy?

    He, Jin / Cameron, Andrew M

    Annals of surgical oncology

    2023  Volume 30, Issue 8, Page(s) 4569–4570

    MeSH term(s) Humans ; Hepatic Artery/pathology ; Liver Transplantation ; Liver Neoplasms/drug therapy ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Infusion Pumps, Implantable ; Infusions, Intra-Arterial
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13674-2
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: The residual rate of HPV and the recurrence rate of CIN after LEEP with negative margins: A meta-analysis.

    Lin, Yong / Long, Yan / He, Jin / Yi, Qinqin

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0298520

    Abstract: Background: HPV is detected in up to 47% of CIN and up to 70% of cervical cancers. It can cause intraepithelial neoplasia, which can eventually progress to invasive carcinoma. Almost all cervical cancers are caused by HPV. Therefore, it is especially ... ...

    Abstract Background: HPV is detected in up to 47% of CIN and up to 70% of cervical cancers. It can cause intraepithelial neoplasia, which can eventually progress to invasive carcinoma. Almost all cervical cancers are caused by HPV. Therefore, it is especially important to treat high-risk HPV. For patients who have undergone LEEP surgery, this procedure can effectively treat CIN. However, it has not been studied in a meta-analysis whether HPV remains after the surgery and whether residual HPV increases the recurrence risk of CIN. To address this gap, our study collected all relevant literature to investigate the residual rate of HPV and its potential influence on the recurrence rate of CIN. We aim to provide valuable recommendations for clinicians and patients.
    Methods: The Cochrane Library, EMBASE, and PubMed databases were searched from the establishment of the database until October 2023. Stata 12.0 software was used for the statistical analysis.
    Results: Twelve studies were included, with a total sample size of 1192 cases. The meta-analysis found that the recurrence rate of CIN was quite low [95% CI = 0.5% (0.001, 0.012); P = 0.006] when the margins were negative after LEEP and there was no residual HPV. When HPV was present, the recurrence rate of CIN was significantly higher [95% CI = 18% (0.089, 0.291), P = 0.000], even if the margins were negative. The recurrence rate of CIN with residual HPV was 3.6 times higher than the recurrence rate of CIN without residual HPV. The residual rate of HPV after LEEP with negative margins was 22.7% [95% CI (0.167, 0.294), P = 0.000], which remained relatively high.
    Conclusion: This meta-analysis found that the recurrence rate of CIN without residual HPV and with negative margins after LEEP was quite low, at 0.5%. However, when HPV was residual, the recurrence rate of CIN significantly increased to 18%, even if the margins were negative. The residual rate of HPV was 22.7%, even when the margins were negative after LEEP.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms ; Uterine Cervical Dysplasia ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/surgery ; Neoplasm Recurrence, Local/pathology ; Margins of Excision ; Neoplasm, Residual/pathology ; Retrospective Studies ; Electrosurgery/methods
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298520
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  5. Article ; Online: Untangling the spatial patterns of evolution of specialized villages and influencing factors

    Ning Niu / Chao Wang / He Jin

    Frontiers in Ecology and Evolution, Vol

    2023  Volume 11

    Abstract: IntroductionThe development of specialized villages (SVs) is of great importance for rural revitalization.MethodsThis study integrated SVs, terrain, resource, traffic, market, and economy data to characterize the development of SVs from 2017 to 2021 and ... ...

    Abstract IntroductionThe development of specialized villages (SVs) is of great importance for rural revitalization.MethodsThis study integrated SVs, terrain, resource, traffic, market, and economy data to characterize the development of SVs from 2017 to 2021 and explore its influence factors by the Random Forest Regression model in Henan, China.ResultsThe sustainably developed SVs were mainly distributed in the plain and the transition zone of mountain-hilly, mountain-plain, and hilly-plain, showing a spatially aggregated polycentric characteristic; the market is the key factor for the development of SVs in the transition zone of mountain-hill or mountain-plain, and the traffic factor mainly influences SVs in the plain and the transition zone of hill-plain; compared to the factors influencing the formation of SVs, the influence of terrain and traffic factors on the development of SVs was decreasing, and the influence of market and economic factors was showing an increasing trend.DiscussionThe results of this study can provide practical strategies for the development of SVs in the under-developed areas of interior.
    Keywords specialized villages ; random forest regression ; influencing factors ; spatial patterns of evolution ; China ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
    Subject code 910
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Efficacy and safety of metformin in pregnant women with polycystic ovary syndrome: a systematic review with meta-analysis of randomized and non-randomized controlled trials.

    Zhao, Qian / He, Jin

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2022  Volume 38, Issue 7, Page(s) 558–568

    Abstract: Objective: To evaluate the efficacy and safety of using metformin in pregnant women with polycystic ovarian syndrome (PCOS) and to explore the most effective and safe protocol by using a meta-analysis method.: Methods: Medline, EMBASE, Cochrane ... ...

    Abstract Objective: To evaluate the efficacy and safety of using metformin in pregnant women with polycystic ovarian syndrome (PCOS) and to explore the most effective and safe protocol by using a meta-analysis method.
    Methods: Medline, EMBASE, Cochrane Library, and other databases were searched for randomized controlled trials and prospective cohort studies enrolling pregnant women with PCOS on receiving metformin or placebo or nothing. Subgroup analyses were undertaken.
    Results: A total of 17 studies involving 2899 patients were included. Compared with control group, the use of metformin significantly reduced the incidence of preterm delivery (cumulative rate 3.86% vs 9.19%, relative risk (RR), 0.42 [95% confidence interval (CI), 0.25-0.71,];
    Conclusions: The use of metformin in pregnant women with PCOS can significantly reduce maternal complications. No significant difference was observed in serious maternal adverse events. The efficacy and safety of metformin are worthy of recognition.
    MeSH term(s) Abortion, Spontaneous/epidemiology ; Clinical Trials as Topic ; Female ; Humans ; Hypoglycemic Agents/adverse effects ; Infant, Newborn ; Metformin/adverse effects ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Pregnancy ; Pregnant Women ; Prospective Studies
    Chemical Substances Hypoglycemic Agents ; Metformin (9100L32L2N)
    Language English
    Publishing date 2022-05-27
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2022.2080194
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    Zs.A 2284: Show issues Location:
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    Zs.MO 608: Show issues

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  7. Article: Positive pancreatic neck margins-a telltale sign of complex biology.

    Ghabi, Elie / He, Jin

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 2, Page(s) 302–304

    Language English
    Publishing date 2022-04-18
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-553
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  8. Article ; Online: The function of a conidia specific transcription factor CsgA in Aspergillus nidulans.

    Cho, He-Jin / Park, Hee-Soo

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 15588

    Abstract: Aspergillus spp. mainly reproduce asexually via asexual spores called conidia. In this study, we identified CsgA, a conidia-specific Zn ... 2 ... Cys ... 6 ... transcription factor containing the GAL4-like zinc-finger domain, and characterized the ... ...

    Abstract Aspergillus spp. mainly reproduce asexually via asexual spores called conidia. In this study, we identified CsgA, a conidia-specific Zn<sub>2</sub>Cys<sub>6</sub> transcription factor containing the GAL4-like zinc-finger domain, and characterized the roles of CsgA in the model organism Aspergillus nidulans. In A. nidulans, the ΔcsgA strain produced abnormal conidiophores and exhibited increased conidial production. The deletion of csgA resulted in impaired production of sexual fruiting bodies (cleistothecia) and lower mutA expression levels. Overexpression of csgA led to decreased conidia production but increased cleistothecia production, suggesting that CsgA is essential for proper asexual and sexual development in A. nidulans. In conidia, the deletion of csgA resulted in increased trehalose content, higher spore viability, and increased tolerance to thermal and oxidative stresses. Transcriptomic analysis revealed that the loss of csgA affects the expression of genes related to conidia germination, DNA repair, and secondary metabolite biosynthesis. Further analysis revealed that the ΔcsgA strain exhibited delayed conidial germination and abnormal germ tube length. Additionally, the production of sterigmatocystin increased in the ΔcsgA conidia compared to that in the controls. Overall, these results suggest that CsgA is crucial for proper fungal development, spore viability, conidial germination, and sterigmatocystin production in A. nidulans.
    MeSH term(s) Aspergillus nidulans/metabolism ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Gene Expression Regulation, Fungal ; Spores, Fungal ; Sterigmatocystin ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Trehalose/metabolism ; Zinc/metabolism
    Chemical Substances Fungal Proteins ; Transcription Factors ; Sterigmatocystin (10048-13-2) ; Trehalose (B8WCK70T7I) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-09-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-19749-6
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  9. Article ; Online: Comments regarding "Neoadjuvant Therapy Versus Upfront Resection for Nonpancreatic Periampullary Adenocarcinoma".

    Nicolson, Norman G / He, Jin

    Annals of surgical oncology

    2022  

    Language English
    Publishing date 2022-12-03
    Publishing country United States
    Document type Letter
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12911-4
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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Current status and future application of electrically controlled micro/nanorobots in biomedicine.

    Pu, Ruochen / Yang, Xiyu / Mu, Haoran / Xu, Zhonghua / He, Jin

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1353660

    Abstract: Using micro/nanorobots (MNRs) for targeted therapy within the human body is an emerging research direction in biomedical science. These nanoscale to microscale miniature robots possess specificity and precision that are lacking in most traditional ... ...

    Abstract Using micro/nanorobots (MNRs) for targeted therapy within the human body is an emerging research direction in biomedical science. These nanoscale to microscale miniature robots possess specificity and precision that are lacking in most traditional treatment modalities. Currently, research on electrically controlled micro/nanorobots is still in its early stages, with researchers primarily focusing on the fabrication and manipulation of these robots to meet complex clinical demands. This review aims to compare the fabrication, powering, and locomotion of various electrically controlled micro/nanorobots, and explore their advantages, disadvantages, and potential applications.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1353660
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