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Article ; Online: Integrated transcriptomic and metabolomic analysis of the hepatotoxicity of dichloroacetonitrile.

He, Jinfeng / Liu, Hongyan / Li, Zemeng / Xu, Minhua / Zhang, Yong / Jiang, Tiemin / Mo, Lingyun

2024 Volume 927, Page(s) 172237

Abstract: Dichloroacetonitrile (DCAN), an emerged nitrogenous disinfection by-product (N-DBP) in drinking water, has garnered attention owing to its strong cytotoxicity, genotoxicity, and carcinogenicity. However, there are limited studies on its potential ... ...

Abstract	Dichloroacetonitrile (DCAN), an emerged nitrogenous disinfection by-product (N-DBP) in drinking water, has garnered attention owing to its strong cytotoxicity, genotoxicity, and carcinogenicity. However, there are limited studies on its potential hepatotoxicity mechanisms. Understanding hepatotoxicity is essential in order to identify and assess the potential risks posed by environmental pollutants on liver health and to safeguard public health. Here, we investigated the viability, reactive oxygen species (ROS) levels, and cell cycle profile of DCAN-exposed HepG2 cells and analyzed the mechanism of DCAN-induced hepatotoxicity using both transcriptomic and metabolomic techniques. The study revealed that there was a decrease in cell viability, increase in ROS production, and increase in the number of cells in the G2/M phase with an increase in the concentration of DCAN. Omics analyses showed that DCAN exposure increased cellular ROS levels, leading to oxidative damage in hepatocytes, which further induced DNA damage, cell cycle arrest, and cell growth impairment. Thus, DCAN has significant toxic effects on hepatocytes. Integrated analysis of transcriptomics and metabolomics offers new insights into the mechanisms of DCAN-induced hepatoxicity.
MeSH term(s)	Humans ; Transcriptome/drug effects ; Hep G2 Cells ; Metabolomics ; Acetonitriles/toxicity ; Water Pollutants, Chemical/toxicity ; Reactive Oxygen Species/metabolism ; Hepatocytes/drug effects ; Hepatocytes/metabolism ; Liver/drug effects ; Liver/metabolism
Chemical Substances	Acetonitriles ; dichloroacetonitrile (O0L64V63M9) ; Water Pollutants, Chemical ; Reactive Oxygen Species
Language	English
Publishing date	2024-04-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.172237
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Zs.A 949: Show issues

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Article ; Online: Coupled W-Co

Li, Kaixun / Cen, Xujiang / He, JinFeng / Tong, Yun

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 37, Page(s) 5575–5578

Abstract: Herein, we put forward a novel electrode by electrochemically integrating metal W species and ... ...

Abstract	Herein, we put forward a novel electrode by electrochemically integrating metal W species and Co
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc00931a
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Article ; Online: Hydroxysafflor yellow A attenuates allergic response of ovalbumin induced allergic rhinitis via Nrf2/HO-1 and inflammatory signaling pathways.

Ma, Qikui / Li, Genhong / He, Jinfeng / Wang, Jing / Ye, Ben

Environmental toxicology

2023 Volume 38, Issue 7, Page(s) 1520–1534

Abstract: Allergic reaction is the most common nasal conditions worldwide and it will remain throughout life. The symptoms of an allergic reaction include sneezing, itching, hives, swelling, difficulty breathing, and a runny nose. Hydroxysafflor yellow A (HYA) is ... ...

Abstract	Allergic reaction is the most common nasal conditions worldwide and it will remain throughout life. The symptoms of an allergic reaction include sneezing, itching, hives, swelling, difficulty breathing, and a runny nose. Hydroxysafflor yellow A (HYA) is a flavonoid compound which is the active phyto-constituent of flower of Carthamus tinctorius L., and exhibited the various medicinal activities like antioxidant, anti-inflammatory and cardiovascular protective effects. This study aimed to assess the efficacy and mode of action of HYA against the allergic rhinitis induced by ovalbumin in mice. HYA was given orally to the Swiss BALB/s mice once daily, 1 h before, they were challenged with ovalbumin (OVA) via intranasal administration, after that the mice were sensitized via intraperitoneal injection of OVA. Allergic nasal symptoms, body weight, spleen weight, OVA-specific immunoglobulins, inflammatory cytokines, Th17 cytokines and Th17 transcription factors also estimated. HYA had a significant (p < .001) effect on body weight and reduced spleen weight. It effectively decreased the nasal symptoms of allergy such as sneezing, rubbing, and redness. HYA significantly reduced the level of malonaldehyde (MDA) and improved levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH). It also remarkably decreased the levels of Th2 cytokines and Th17 transcription factors like RAR-related orphan receptor gamma (ROR-γ), signal transducer and activator of transcription 3 (STAT3) and phosphor signal transducer and activator of transcription 3 (p-STAT3), while increasing levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1). The treatment with HYA improved the lung histology in mice with allergic rhinitis. The results suggest that HYA may have therapeutic potential against ovalbumin-induced allergic rhinitis in mice, by altering the Th17/Treg balance and improving the Nrf2/HO-1 signaling pathway.
MeSH term(s)	Animals ; Mice ; Ovalbumin/adverse effects ; STAT3 Transcription Factor/metabolism ; NF-E2-Related Factor 2/metabolism ; Nasal Mucosa/metabolism ; Heme Oxygenase-1/metabolism ; Sneezing ; Rhinitis, Allergic/chemically induced ; Rhinitis, Allergic/drug therapy ; Rhinitis, Allergic/metabolism ; Signal Transduction ; Cytokines/metabolism ; Body Weight ; Mice, Inbred BALB C ; Disease Models, Animal
Chemical Substances	Ovalbumin (9006-59-1) ; hydroxysafflor yellow A (146087-19-6) ; STAT3 Transcription Factor ; NF-E2-Related Factor 2 ; Heme Oxygenase-1 (EC 1.14.14.18) ; Cytokines
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23783
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Zs.A 2676: Show issues

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Article ; Online: Heuristic Reordering Strategy for Quantum Circuit Mapping on LNN Architectures.

He, Jinfeng / Xu, Hai / Feng, Shiguang / Du, Mingzhu

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 1765955

Abstract: Because of the connection constraints of quantum devices, the quantum gate cannot operate directly on nonadjacent qubits. Quantum circuit mapping transforms a logical quantum circuit to a circuit that satisfies the connection constraints by adding SWAP ... ...

Abstract	Because of the connection constraints of quantum devices, the quantum gate cannot operate directly on nonadjacent qubits. Quantum circuit mapping transforms a logical quantum circuit to a circuit that satisfies the connection constraints by adding SWAP gates for nonadjacent qubits. Global and local heuristic reordering strategies are proposed in this paper for quantum circuit mapping over linear nearest neighbor (LNN) architectures, which are one-dimensional topology structures, to reduce the number of SWAP gates added. Experiment results show that the average improvements of the two methods are 13.19% and 15.46%, respectively. In this paper, we consider the quantum circuit mapping problem for linear nearest neighbor (LNN) architectures. We propose a global heuristic qubit reordering optimization algorithm and a local heuristic qubit reordering optimization algorithm. Compared with the other algorithm results, the average improvements of the two methods for quantum cost are 13.19% and 15.46%, respectively. The two methods apply to the realization of quantum circuit neighboring over one-dimensional quantum architectures and can be extended to algorithms that work for other quantum architectures of different topologies.
Language	English
Publishing date	2022-05-05
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/1765955
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Article ; Online: Hydroxysafflor yellow A attenuates allergic response of ovalbumin induced allergic rhinitis via Nrf2/HO‐1 and inflammatory signaling pathways

Ma, Qikui / Li, Genhong / He, Jinfeng / Wang, Jing / Ye, Ben

Environmental Toxicology. 2023 July, v. 38, no. 7 p.1520-1534

2023

Abstract	Allergic reaction is the most common nasal conditions worldwide and it will remain throughout life. The symptoms of an allergic reaction include sneezing, itching, hives, swelling, difficulty breathing, and a runny nose. Hydroxysafflor yellow A (HYA) is a flavonoid compound which is the active phyto‐constituent of flower of Carthamus tinctorius L., and exhibited the various medicinal activities like antioxidant, anti‐inflammatory and cardiovascular protective effects. This study aimed to assess the efficacy and mode of action of HYA against the allergic rhinitis induced by ovalbumin in mice. HYA was given orally to the Swiss BALB/s mice once daily, 1 h before, they were challenged with ovalbumin (OVA) via intranasal administration, after that the mice were sensitized via intraperitoneal injection of OVA. Allergic nasal symptoms, body weight, spleen weight, OVA‐specific immunoglobulins, inflammatory cytokines, Th17 cytokines and Th17 transcription factors also estimated. HYA had a significant (p < .001) effect on body weight and reduced spleen weight. It effectively decreased the nasal symptoms of allergy such as sneezing, rubbing, and redness. HYA significantly reduced the level of malonaldehyde (MDA) and improved levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and glutathione (GSH). It also remarkably decreased the levels of Th2 cytokines and Th17 transcription factors like RAR‐related orphan receptor gamma (ROR‐γ), signal transducer and activator of transcription 3 (STAT3) and phosphor signal transducer and activator of transcription 3 (p‐STAT3), while increasing levels of nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1). The treatment with HYA improved the lung histology in mice with allergic rhinitis. The results suggest that HYA may have therapeutic potential against ovalbumin‐induced allergic rhinitis in mice, by altering the Th17/Treg balance and improving the Nrf2/HO‐1 signaling pathway.
Keywords	Carthamus tinctorius ; allergic rhinitis ; antioxidants ; body weight ; catalase ; cytokines ; ecotoxicology ; flavonoids ; flowers ; glutathione ; glutathione peroxidase ; heme oxygenase (biliverdin-producing) ; histology ; immunoglobulins ; intranasal administration ; intraperitoneal injection ; lungs ; malondialdehyde ; mechanism of action ; nose ; ovalbumin ; signal transduction ; spleen ; superoxide dismutase ; transactivators
Language	English
Dates of publication	2023-07
Size	p. 1520-1534.
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23783
Database	NAL-Catalogue (AGRICOLA)

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Z 4957: Show issues

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Article ; Online: Prognostic significance of the clinical and radiological haemorrhagic transformation subtypes in acute ischaemic stroke: A systematic review and meta-analysis.

He, Jinfeng / Fu, Fangwang / Zhang, Wenyuan / Zhan, Zhenxiang / Cheng, Zicheng

European journal of neurology

2022 Volume 29, Issue 11, Page(s) 3449–3459

Abstract: Background and purpose: The aim was to investigate the associations of haemorrhagic transformation (HT) and its clinical and radiological subtypes with functional outcome, mortality, early neurological deterioration (END) and neurological complications ... ...

Abstract	Background and purpose: The aim was to investigate the associations of haemorrhagic transformation (HT) and its clinical and radiological subtypes with functional outcome, mortality, early neurological deterioration (END) and neurological complications in patients with acute ischaemic stroke (AIS). Methods: A systematic review and meta-analysis of observational studies on the associations of overall HT, clinical HT subtypes (asymptomatic intracerebral haemorrhage [aICH] and symptomatic intracerebral haemorrhage [sICH]) or radiological HT subtypes (haemorrhagic infarction [HI-1 or HI-2] and parenchymal haemorrhage [PH-1 or PH-2]) with prognosis in patients with AIS was performed. PubMed, Web of Science and Embase were systematically searched. Random effects models were used to calculate pooled estimates. Results: Fifty-one studies with 100,510 patients were pooled in the meta-analysis. Overall HT was associated with worse functional outcome (odds ratio [OR] 2.12, 95% confidence interval [CI] 1.55-2.90), increased mortality (OR 1.87, 95% CI 1.52-2.30), END (OR 2.35, 95% CI 1.46-3.77), early-onset seizures (OR 2.58, 95% CI 1.63-4.10) and post-stroke epilepsy (OR 2.23, 95% CI 1.11-4.49). For clinical subtypes, sICH remained significantly associated with the aforementioned poor prognoses except post-stroke epilepsy, and aICH was associated with worse functional outcome but was unrelated to mortality. For radiological subtypes, PH (especially PH-2) was strongly associated with poor prognosis. HI-2 was associated with worse functional outcome, and HI-1 was associated with a lower risk of mortality and END. Conclusions: Regardless of whether AIS patients undergo thrombolysis or thrombectomy, overall HT, sICH and PH (especially PH-2) are associated with a substantially increased risk of worse functional outcome, mortality, END or neurological complications. The presence of aICH is related to worse functional outcome but is independent of increased mortality. HI-2 impairs functional independence, and HI-1 does not cause neurological impairment.
MeSH term(s)	Brain Ischemia/complications ; Brain Ischemia/diagnostic imaging ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging ; Humans ; Ischemic Stroke/complications ; Ischemic Stroke/diagnostic imaging ; Prognosis ; Stroke/complications ; Stroke/diagnostic imaging ; Treatment Outcome
Language	English
Publishing date	2022-07-21
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.15482
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 592: Show issues

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Article ; Online: A multifunctional and self-adaptive double-layer hydrogel dressing based on chitosan for deep wound repair.

Xie, Li / Liu, Rong / Li, Jian / Li, Ying / He, Jinfeng / Zhang, Mengyuan / Yang, Haijin

International journal of biological macromolecules

2023 Volume 253, Issue Pt 6, Page(s) 127033

Abstract: Hydrogel wound dressing for irregular shape and deep wound repair is a research hotspot. Herein, a multifunctional and self-adaptive double-layer hydrogel was constructed, which was comprised of chitosan-based inner layer hydrogel and gellan gum-based ... ...

Abstract	Hydrogel wound dressing for irregular shape and deep wound repair is a research hotspot. Herein, a multifunctional and self-adaptive double-layer hydrogel was constructed, which was comprised of chitosan-based inner layer hydrogel and gellan gum-based outer layer hydrogel. Various properties of inner layer hydrogel were systematically investigated, including injectability, shape-adaptability, solid-liquid phase transition, biocompatibility, hemostasis, antibacterial performance and anti-inflammatory. Thanks to the phase-transition from solid to liquid at body temperature, inner layer hydrogel exhibited stronger adaptability to fill irregular and deep wounds, in which chitosan was liquefied and its therapeutic effect was maximized. Outer layer hydrogel was fabricated by calcium ions and gellan gum, whose certain mechanical strength could provide protection and a moister environment for wounds. Because of these characteristics, double-layer hydrogel markedly promoted skin tissue regeneration and wound closure and thereby possessed potential clinical application prospect as wound dressing for deep wounds.
MeSH term(s)	Hydrogels/pharmacology ; Chitosan ; Anti-Bacterial Agents/pharmacology ; Bandages ; Body Temperature
Chemical Substances	Hydrogels ; Chitosan (9012-76-4) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.127033
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Zs.B 2374: Show issues

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Article: Acute and Subacute Toxicity Evaluation of Erythrocyte Membrane-Coated Boron Nitride Nanoparticles.

He, Jinfeng / Zhang, Xuanping / Liu, Linhong / Wang, Yufei / Liu, Renyu / Li, Min / Gao, Fuping

Journal of functional biomaterials

2023 Volume 14, Issue 4

Abstract: Boron nitride nanoparticles have been reported for boron drug delivery. However, its toxicity has not been systematically elucidated. It is necessary to clarify their potential toxicity profile after administration for clinical application. Here, we ... ...

Abstract	Boron nitride nanoparticles have been reported for boron drug delivery. However, its toxicity has not been systematically elucidated. It is necessary to clarify their potential toxicity profile after administration for clinical application. Here, we prepared erythrocyte membrane-coated boron nitride nanoparticles (BN@RBCM). We expect to use them for boron neutron capture therapy (BNCT) in tumors. In this study, we evaluated the acute toxicity and subacute toxicity of BN@RBCM of about 100 nm and determined the half-lethal dose (LD50) of the particles for mice. The results showed that the LD50 of BN@RBCM was 258.94 mg/kg. No remarkable pathological changes by microscopic observation were observed in the treated animals throughout the study period. These results indicate that BN@RBCM has low toxicity and good biocompatibility, which have great potential for biomedical applications.
Language	English
Publishing date	2023-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb14040181
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Article ; Online: Borneol exerts its antipruritic effects by inhibiting TRPA1 and activating TRPM8.

Luo, Miao / He, Jinfeng / Yin, Liang / Zhan, Ping / Zhao, Zhongqiu / Xiong, Hui / Mei, Zhinan

Journal of ethnopharmacology

2023 Volume 322, Page(s) 117581

Abstract: Ethnopharmacological relevance: Borneol is a long-established traditional Chinese medicine that has been found to be effective in treating pain and itchy skin. However, whether borneol has a therapeutic effect on chronic itch and its related mechanisms ... ...

Abstract	Ethnopharmacological relevance: Borneol is a long-established traditional Chinese medicine that has been found to be effective in treating pain and itchy skin. However, whether borneol has a therapeutic effect on chronic itch and its related mechanisms remain unclear. Aim of the study: To investigate the antipruritic effect of borneol and its molecular mechanism. Materials and methods: DrugBAN framework and molecular docking were applied to predict the targets of borneol, and the calcium imaging or patch-clamp recording analysis were used to detect the effects of borneol on TRPA1, TRPM8 or TRPV3 channels in HEK293T cells. In addition, various mouse models of acute itch and chronic itch were established to evaluate the antipruritic effects of borneol on C57BL/6J mice. Then, the borneol-induced pruritic relief was further investigated in Trpa1 Results: TRPA1, TRPV3 and TRPM8 are the potential targets of borneol according to the results of DrugBAN algorithm and molecular docking. Calcium imaging and patch-clamp recording analysis demonstrated that borneol activates TRPM8 channel-induced cell excitability and inhibits TRPA1 channel-mediated cell excitability in transfected HEK293T cells. Animal behavior analysis showed that borneol can significantly reduce acute and chronic itch behavior in C57BL/6J mice, but this effect was eliminated in Trpa1 Conclusion: Borneol has therapeutic effects on multiple pruritus models in mice and patients with chronic itch, and the mechanism may be through inhibiting TRPA1 and activating TRPM8.
MeSH term(s)	Humans ; Mice ; Animals ; Transient Receptor Potential Channels/genetics ; Antipruritics/pharmacology ; Antipruritics/therapeutic use ; Calcium/metabolism ; HEK293 Cells ; Molecular Docking Simulation ; Mice, Inbred C57BL ; TRPA1 Cation Channel/genetics ; Pruritus/drug therapy ; TRPM Cation Channels/genetics ; TRPV Cation Channels/genetics ; Ganglia, Spinal ; Camphanes ; Membrane Proteins
Chemical Substances	Transient Receptor Potential Channels ; Antipruritics ; isoborneol (L88RA8N5EG) ; Calcium (SY7Q814VUP) ; TRPA1 Cation Channel ; TRPM Cation Channels ; TRPV Cation Channels ; TRPA1 protein, human ; TRPM8 protein, human ; TRPM8 channel-associated factor 1 protein, human ; TRPM8 protein, mouse ; Camphanes ; Membrane Proteins
Language	English
Publishing date	2023-12-14
Publishing country	Ireland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117581
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Zs.A 1494: Show issues

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Article ; Online: Case report: isolated prevotella intermedia causing intracranial infection detected using metagenomic next generation sequencing.

Ye, Zhinan / He, Jinfeng / Ji, Hailong / Xu, Hao / Zhang, Yaping / Zhou, Kaiyu / Liu, Hongwei

BMC neurology

2023 Volume 23, Issue 1, Page(s) 383

Abstract: Background: Isolated Prevotella intermedia, a rare gram-negative, rod-shaped, anaerobic bacterium, is rarely detected in clinical practice. It has been associated with infections of the oral cavity and female genital tract, but has never been detected ... ...

Abstract	Background: Isolated Prevotella intermedia, a rare gram-negative, rod-shaped, anaerobic bacterium, is rarely detected in clinical practice. It has been associated with infections of the oral cavity and female genital tract, but has never been detected in cerebrospinal fluid (CSF) of patients in China. Accurate detection of causative pathogens is still an arduous task owing to the difficult conditions of anaerobic bacterial culture. Isolated Prevotella intermedia can be detected by metagenomic next generation sequencing (mNGS) of the CSF. Correct diagnosis and antibiotic treatment can help patients avoid life-threatening events. Case presentation: Herein, we describe the case of a 64-year-old Chinese woman who presented with typical features of meningoencephalitis. Routine CSF culture failed to identify the causative pathogen. Isolated Prevotella intermedia was detected by mNGS, and the patient was treated with antibacterial agents including ceftriaxone, vancomycin, moxifloxacin, meropenem, metronidazole, and linezolid. The patient underwent surgical treatment for abscess of left frontal parietal lobe, which was observed on magnetic resonance imaging (MRI) and was suspected to be caused by Prevotella intermedia. It was further confirmed that it was a secondary infection from the oral cavity, and the possible etiology might have been dental surgery. Treatment was rendered to the patient based on metagenomic test result, and her condition improved after two months. Conclusions: This case highlights the role of mNGS in accurate diagnosis of patients with central nervous system infection. In particular, mNGS can be used to identify rare pathogens and confirm the diagnosis in patients with unknown etiology.
MeSH term(s)	Humans ; Female ; Middle Aged ; High-Throughput Nucleotide Sequencing ; Base Composition ; Phylogeny ; Prevotella intermedia/genetics ; RNA, Ribosomal, 16S ; Sequence Analysis, DNA ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	RNA, Ribosomal, 16S ; Anti-Bacterial Agents
Language	English
Publishing date	2023-10-23
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-023-03374-5
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