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  1. Article: [Clinical Study of San Wei Sheng Huo Decoction in the Treatment of Refractory Chemotherapy-Induced Thrombocytopenia].

    Li, Ru / Xiong, Shao-Quan / He, Li-Fang / Wu, Guo-Yu / Yuan, Yan-Wen

    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

    2023  Volume 54, Issue 1, Page(s) 161–164

    Abstract: Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.: Methods: A retrospective study was conducted and the data of RCIT ... ...

    Abstract Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.
    Methods: A retrospective study was conducted and the data of RCIT patients treated with SWSHD as the main formula were collected. Changes in peripheral blood platelet (PLT) levels at different time points of treatment were examined and the significant effective rate (SER) and effective rate (ER) were analyzed. We measured the increase in peripheral blood PLT count before and after treatment, analyzed the differences in PLT count increase for different degrees of RCIT treatment, and evaluated the safety of the treatment.
    Results: A total of 35 cases of RCIT were included in the study. With SWSHD as the main treatment formula, the 2-week ER and SER were 74.29% and 14.29%, respectively, the 2-month ER and SER were 84.38% and 60.50, respectively, and the 1-year ER and SER were 92.31% and 80.77%, respectively. PLT count increased at all time points after treatment compared with that before treatment (
    Conclusion: SWSHD takes effect rapidly and its effect is long-lasting and stable. Furthermore, SWSHD has a more significant effect on severe RCIT.
    MeSH term(s) Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Platelet Count ; Blood Platelets ; Antineoplastic Agents/adverse effects
    Chemical Substances Antineoplastic Agents
    Language Chinese
    Publishing date 2023-01-16
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2106840-9
    ISSN 1672-173X
    ISSN 1672-173X
    DOI 10.12182/20230160506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Petroleum contamination significantly changes soil microbial communities in three oilfield locations in Delta State, Nigeria

    Mafiana, Macdonald Ogorm / Kang, Xiao-Hu / Leng, Yan / He, Li-Fang / Li, Shi-Weng

    Environmental science and pollution research. 2021 June, v. 28, no. 24

    2021  

    Abstract: Soil microbial community structure is altered by petroleum contamination in response to compound toxicity and degradation. Understanding the relation between petroleum contamination and soil microbial community structure is crucial to determine the ... ...

    Abstract Soil microbial community structure is altered by petroleum contamination in response to compound toxicity and degradation. Understanding the relation between petroleum contamination and soil microbial community structure is crucial to determine the amenability of contaminated soils to bacterial- and fungal-aided remediation. To understand how petroleum contamination and soil physicochemical properties jointly shaped the microbial structure of soils from different oilfields, high-throughput sequencing of 16S and ITS amplicons were used to evaluate the shifts of microbial communities in the petroleum-contaminated soils in Ughelli East (UE), Utorogu (UT), and Ughelli West (UW) oilfields located in Delta State, Nigeria. The results showed 1515 bacteria and 919 fungal average OTU number, and community richness and diversity, trending as AL > UT > UW > UE and AL > UW > UT > UE for bacteria, and AL > UW > UT > UE and UW > UT > AL > UE for fungi, respectively. The bacterial taxa KCM-B-112, unclassified Saccharibacteria, unclassified Rhizobiales, Desulfurellaceae, and Acidobacteriaceae and fungal Trichocomaceae, unclassified Ascomycota, unclassified Sporidiobolales, and unclassified Fungi were found to be the dominant families in petroleum-contaminated soils. Redundancy analysis (RDA) and Spearman’s correlation analysis revealed that total carbon (TC), electric conductivity (EC), pH, and moisture content (MO) were the major drivers of bacterial and fungal communities, respectively. Gas chromatography-mass spectrophotometer (GC-MS) analysis exhibited that the differences in C₇–C₁₀, C₁₁–C₁₆, and C₁₂–C₂₉ compounds in the crude oil composition and soil MO content jointly constituted the microbial community variance among the contaminated soils. This study revealed the bacterial and fungal communities responsible for the biodegradation of petroleum contamination from these oilfields, which could serve as biomarkers to monitor oil spill site restoration within these areas. Further studies on these contaminated sites could offer useful insights into other contributing factors such as heavy metals.
    Keywords Acidobacteriaceae ; Desulfurellaceae ; Rhizobiales ; Sporidiobolales ; Trichocomaceae ; biodegradation ; biomarkers ; carbon ; community structure ; electrical conductivity ; fungi ; oil fields ; oil spills ; pH ; petroleum ; pollution ; remediation ; research ; soil microorganisms ; spectrophotometers ; toxicity ; variance ; water content ; Nigeria
    Language English
    Dates of publication 2021-06
    Size p. 31447-31461.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-12955-1
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  3. Article ; Online: Petroleum contamination significantly changes soil microbial communities in three oilfield locations in Delta State, Nigeria.

    Mafiana, Macdonald Ogorm / Kang, Xiao-Hu / Leng, Yan / He, Li-Fang / Li, Shi-Weng

    Environmental science and pollution research international

    2021  Volume 28, Issue 24, Page(s) 31447–31461

    Abstract: Soil microbial community structure is altered by petroleum contamination in response to compound toxicity and degradation. Understanding the relation between petroleum contamination and soil microbial community structure is crucial to determine the ... ...

    Abstract Soil microbial community structure is altered by petroleum contamination in response to compound toxicity and degradation. Understanding the relation between petroleum contamination and soil microbial community structure is crucial to determine the amenability of contaminated soils to bacterial- and fungal-aided remediation. To understand how petroleum contamination and soil physicochemical properties jointly shaped the microbial structure of soils from different oilfields, high-throughput sequencing of 16S and ITS amplicons were used to evaluate the shifts of microbial communities in the petroleum-contaminated soils in Ughelli East (UE), Utorogu (UT), and Ughelli West (UW) oilfields located in Delta State, Nigeria. The results showed 1515 bacteria and 919 fungal average OTU number, and community richness and diversity, trending as AL > UT > UW > UE and AL > UW > UT > UE for bacteria, and AL > UW > UT > UE and UW > UT > AL > UE for fungi, respectively. The bacterial taxa KCM-B-112, unclassified Saccharibacteria, unclassified Rhizobiales, Desulfurellaceae, and Acidobacteriaceae and fungal Trichocomaceae, unclassified Ascomycota, unclassified Sporidiobolales, and unclassified Fungi were found to be the dominant families in petroleum-contaminated soils. Redundancy analysis (RDA) and Spearman's correlation analysis revealed that total carbon (TC), electric conductivity (EC), pH, and moisture content (MO) were the major drivers of bacterial and fungal communities, respectively. Gas chromatography-mass spectrophotometer (GC-MS) analysis exhibited that the differences in C
    MeSH term(s) Biodegradation, Environmental ; Humans ; Microbiota ; Nigeria ; Oil and Gas Fields ; Petroleum ; Petroleum Pollution ; RNA, Ribosomal, 16S ; Soil ; Soil Microbiology ; Soil Pollutants/analysis
    Chemical Substances Petroleum ; RNA, Ribosomal, 16S ; Soil ; Soil Pollutants
    Language English
    Publishing date 2021-02-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-12955-1
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  4. Article: [Meta-analysis of efficacy and safety of Hulisan Capsules in treatment of knee osteoarthritis].

    Fu, Min-Rui / He, Li-Fang / Lyu, Jian / Xi, Jun-Yu / Liu, Guang-Yu / Xie, Yan-Ming

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2022  Volume 47, Issue 19, Page(s) 5365–5374

    Abstract: This study aims to assess the efficacy and safety of Hulisan Capsules in the treatment of knee osteoarthritis, which is expected to serve as a reference for clinical practice. To be specific, randomized controlled trial(RCT) on the treatment of knee ... ...

    Abstract This study aims to assess the efficacy and safety of Hulisan Capsules in the treatment of knee osteoarthritis, which is expected to serve as a reference for clinical practice. To be specific, randomized controlled trial(RCT) on the treatment of knee osteoarthritis with Hulisan Capsules was retrieved from EMbase, PubMed, Cochrane Library, Web of Science, CNKI, Wanfang, SinoMed, and VIP(from inception to November 15, 2021). Two researchers independently screened the articles, extracted the data, and evaluated the risk of bias with ROB. RevMan 5.4 was used for Meta-analysis. Finally, 12 RCTs were screened out, involving 1 703 cases(1 075 in the experimental group and 628 in the control group). Meta-analysis showed that conventional treatment + Hulisan Capsules was superior to conventional treatment alone in terms of symptom relief rate(RR=1.19, 95%CI[1.09, 1.30], P<0.000 1), Lysholm score(MD=11.17, 95%CI[7.35, 15.00], P<0.000 01), visual analogue scale(VAS) score(MD=-0.99, 95%CI[-1.30,-0.68], P<0.000 01), and knee function score(RR=8.94, 95%CI[6.51, 11.37], P<0.000 01). Hulisan Capsules alone was superior to the conventional treatment alone in terms of the symptom relief rate(RR=1.38, 95%CI[1.13, 1.69], P=0.002) and knee function score(MD=2.88, 95%CI[0.81, 4.94], P=0.006), but VAS score was insignificantly different between the patients treated with Hulisan Capsules alone and those with conventional treatment alone(MD=-0.57, 95%CI[-1.42, 0.29], P=0.19). Hulisan Capsules + conventional treatment showed insignificant difference in symptom relief rate from the Zhuifeng Tougu Capsules + conventional treatment(RR=1.07, 95%CI[0.91, 1.25], P=0.44). The Lequesne score was insignificantly different between Hulisan Capsules + conventional treatment and conventional treatment/Zhuifeng Tougu Capsules + conventional treatment(MD=-2.17, 95%CI[-6.29, 1.96], P=0.30). The incidence of adverse reactions in the experimental group was significantly lower than control group(RR=0.57, 95%CI[0.34, 0.96], P=0.03). According to the available data and methods, Hulisan Capsules/Hulisan Capsules + conventional treatment could improve the symptom relief rate, Lysholm score, knee function score, and VAS score of patients with knee osteoarthritis, and alleviate the symptoms of pain, stiffness, and swelling of them. No serious adverse reactions were found yet. In the future, more large-sample and standard clinical trials are needed to verify the effect and safety of Hulisan Capsules in the treatment of knee osteoarthritis.
    Language Chinese
    Publishing date 2022-12-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20220627.501
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  5. Article ; Online: Abscisic acid modulates differential physiological and biochemical responses of roots, stems, and leaves in mung bean seedlings to cadmium stress.

    Leng, Yan / Li, Yi / Ma, Yan-Hua / He, Li-Fang / Li, Shi-Weng

    Environmental science and pollution research international

    2020  Volume 28, Issue 5, Page(s) 6030–6043

    Abstract: Experiments were conducted to determine how exogenous abscisic acid (ABA) mediates the tolerance of plants to cadmium (Cd) exposure. Cd stress strongly reduced all the growth parameters of mung bean seedlings. Cd significantly increased ascorbate ... ...

    Abstract Experiments were conducted to determine how exogenous abscisic acid (ABA) mediates the tolerance of plants to cadmium (Cd) exposure. Cd stress strongly reduced all the growth parameters of mung bean seedlings. Cd significantly increased ascorbate peroxidase (APX) and catalase (CAT) activities in roots and stems, and peroxidase (POD) activities in roots, stems, and leaves of mung bean seedlings. Cd caused remarkable increases in the levels of leaf chlorophyll and carotenoid, root polyphenols, and malondialdehyde (MDA) and proline in the three organs. However, Cd greatly decreased leaf CAT activity, root and leaf ascorbic acid (AsA) levels, and stem and leaf polyphenol levels. Foliar application of ABA partially alleviated Cd toxicity on the seedlings. ABA could restore most of the changed biochemical parameters caused by Cd, suggesting that ABA played roles in the protection of membrane lipid peroxidation and the modulation of antioxidative defense systems in response to Cd stress. Our results also implied the differential physiological and biochemical responsive patterns of roots, stems, and leaves to Cd and ABA in mung bean seedlings. The great changes in many biochemical parameters in roots suggested that roots were the first to be affected by Cd and play pivotal roles in response to Cd, especially in chelating Cd and reducing Cd absorption.
    MeSH term(s) Abscisic Acid ; Antioxidants ; Cadmium ; Catalase ; Plant Leaves ; Plant Roots ; Seedlings ; Superoxide Dismutase ; Vigna
    Chemical Substances Antioxidants ; Cadmium (00BH33GNGH) ; Abscisic Acid (72S9A8J5GW) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2020-09-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-020-10843-8
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  6. Article ; Online: Mesothelin-targeted CAR-NK Cells Derived From Induced Pluripotent Stem Cells Have a High Efficacy in Killing Triple-negative Breast Cancer Cells as Shown in Several Preclinical Models.

    Yang, Mei / Guan, Tian / Chen, Chun-Fa / He, Li-Fang / Wu, Hao-Ming / Zhang, Ren-Dong / Li, Yun / Lin, Yan-Chun / Zeng, Haoyu / Wu, Jun-Dong

    Journal of immunotherapy (Hagerstown, Md. : 1997)

    2023  Volume 46, Issue 8, Page(s) 285–294

    Abstract: The emergence of immunotherapy has introduced a promising, novel approach to cancer treatment. While multiple chimeric antigen receptor (CAR) T-cell therapies have demonstrated remarkable clinical efficacy against leukemia, their effect on solid tumors ... ...

    Abstract The emergence of immunotherapy has introduced a promising, novel approach to cancer treatment. While multiple chimeric antigen receptor (CAR) T-cell therapies have demonstrated remarkable clinical efficacy against leukemia, their effect on solid tumors has been limited. One potential option for treating solid tumors is the engineering of natural killer (NK) cells with CARs. Mesothelin (MSLN), a tumor differentiation antigen, is expressed on triple-negative breast cancer (TNBC) cells, making it a potential target for CAR-NK therapy in the treatment of TNBC. We first constructed induced pluripotent stem cells with stable anti-MSLN-CAR expression and subsequently differentiated these cells into mesothelin-targeted CAR-NK (MSLN-NK) cells. We then assessed the effects of MSLN-NK cells on TNBC cells both in vitro (using the MDA-MB-231 cell line), in vivo (in a CDX mouse model), and ex vivo (using patient-specific primary cells and patient-specific organoids), in which MSLN surface expression was confirmed. Our CDX study results indicated that MSLN-NK cells effectively killed MDA-MB-231 (MD231) cells in vitro, reduced tumor growth in the CDX mouse model of TNBC, and lysed patient-specific primary cells and patient-specific organoids derived from the tumor samples of TNBC patients. Our data demonstrated that MSLN-NK cells had high efficacy on killing TNBC cells in in vitro, in vivo, and ex vivo. Therefore, MSLN-NK could be a promising treatment option for TNBC patients.
    MeSH term(s) Humans ; Animals ; Mice ; Mesothelin ; Triple Negative Breast Neoplasms/therapy ; Induced Pluripotent Stem Cells ; Killer Cells, Natural ; Immunotherapy, Adoptive/methods ; Disease Models, Animal ; Cell Line, Tumor ; Antigens, Neoplasm
    Chemical Substances Mesothelin (J27WDC343N) ; Antigens, Neoplasm
    Language English
    Publishing date 2023-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1064067-8
    ISSN 1537-4513 ; 1053-8550 ; 1524-9557
    ISSN (online) 1537-4513
    ISSN 1053-8550 ; 1524-9557
    DOI 10.1097/CJI.0000000000000483
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    Zs.A 1778: Show issues Location:
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  7. Article ; Online: Ischemia-Reperfusion Injury and Immunosuppressants Promote Polyomavirus Replication Through Common Molecular Mechanisms.

    Chen, Xu-Tao / Huang, Yang / Wang, Jing / Li, Ge / Zhang, Yu / He, Li-Fang / Lian, Yue-Xiao / Yang, Shi-Cong / Zhao, Guo-Dong / Zhang, Hui / Qiu, Jiang / Zhang, Lei / Huang, Gang

    Frontiers in immunology

    2022  Volume 13, Page(s) 835584

    Abstract: Background: BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) causes renal allograft dysfunction and graft loss. However, the mechanism of BKPyV replication after kidney transplantation is unclear. Clinical studies have demonstrated that ... ...

    Abstract Background: BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) causes renal allograft dysfunction and graft loss. However, the mechanism of BKPyV replication after kidney transplantation is unclear. Clinical studies have demonstrated that immunosuppressants and renal ischemia-reperfusion injury (IRI) are risk factors for BKPyV infection. Studying the pathogenic mechanism of BKPyV is limited by the inability of BKPyV to infect the animal. Mouse polyomavirus (MPyV) is a close homolog of BKPyV. We used a model of MPyV infection to investigate the core genes and underlying mechanism of IRI and immunosuppressants to promote polyomavirus replication.
    Materials and methods: One-day-old male C57BL/6 mice were intraperitoneally injected with MPyV. At week 9 post-infection, all mice were randomly divided into IRI, immunosuppressant, and control groups and treated accordingly. IRI was established by clamping the left renal pedicle. Subsequently, kidney specimens were collected for detecting MPyV DNA, histopathological observation, and high-throughput RNA sequencing. Weighted gene correlation network analysis (WGCNA), protein-protein interaction network analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to screen for core genes and common signaling pathways involved in promoting MPyV replication by IRI and immunosuppressants.
    Results: After primary infection, MPyV established persistent infection in kidneys and subsequently was significantly increased by IRI or immunosuppressant treatment individually. In the IRI group, viral loads peaked on day 3 in the left kidney, which were significantly higher than those in the right kidney and the control group. In the immunosuppressant group, viral loads in the left kidney were significantly increased on day 3, which were significantly higher than those in the control group. Protein-protein interaction network analysis and WGCNA screened complement C3, epidermal growth factor receptor (EGFR), and FN1 as core genes. Pathway enrichment analysis based on the IRI- or immunosuppressant-related genes selected by WGCNA indicated that the NF-κB signaling pathway was the main pathway involved in promoting MPyV replication. The core genes were further confirmed using published datasets GSE47199 and GSE75693 in human polyomavirus-associated nephropathy.
    Conclusions: Our study demonstrated that IRI and immunosuppressants promote polyomavirus replication through common molecular mechanisms. In future studies, knockdown or specific inhibition of C3, EGFR, FN1, and NF-κB signaling pathway will further validate their critical roles in promoting polyomavirus replication.
    MeSH term(s) Animals ; BK Virus/physiology ; ErbB Receptors ; Female ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B ; Nephritis, Interstitial/complications ; Polyomavirus/genetics ; Polyomavirus Infections ; Reperfusion Injury/drug therapy
    Chemical Substances Immunosuppressive Agents ; NF-kappa B ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.835584
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  8. Article: [Construction and identification of the Bifidobacterium expression system pGEX-TSOL18/B. longum of Taenia solium].

    Zhou, Bi-Ying / Liu, Mei-Chen / He, Li-Fang

    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

    2014  Volume 32, Issue 3, Page(s) 239–241

    Abstract: The TSOL18 gene of Taenia solium was synthesized and cloned into Escherichia coli-Bifidobacteria shuttle vector pGEX-1lambdaT. The recombinant plasmid pGEX-TSOL18 was transformed into Bifidobacterium longum with electroporation. The recombinant plasmid ... ...

    Abstract The TSOL18 gene of Taenia solium was synthesized and cloned into Escherichia coli-Bifidobacteria shuttle vector pGEX-1lambdaT. The recombinant plasmid pGEX-TSOL18 was transformed into Bifidobacterium longum with electroporation. The recombinant plasmid containing TSOL18 gene was identified by restriction endonuclease analysis, PCR and DNA sequencing. The length of synthesized TSOL18 gene was 393 bp. The results indicated that the Bifidobacteria expression system pGEX-TSOL18/B. longum was successfully constructed.
    MeSH term(s) Animals ; Base Sequence ; Bifidobacterium/genetics ; Bifidobacterium/metabolism ; Electroporation ; Escherichia coli ; Genetic Vectors ; Plasmids ; Polymerase Chain Reaction ; Taenia solium/genetics ; Taenia solium/metabolism
    Language Chinese
    Publishing date 2014-06
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639272-6
    ISSN 1000-7423
    ISSN 1000-7423
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  9. Article ; Online: Reduction patterns of Japanese encephalitis incidence following vaccine introduction into long-term expanded program on immunization in Yunnan Province, China.

    Hu, Xiao-Ting / Li, Qiong-Fen / Ma, Chao / Zhao, Zhi-Xian / He, Li-Fang / Tang, Ting-Ting / Yu, Wen / Owiti, Philip

    Infectious diseases of poverty

    2019  Volume 8, Issue 1, Page(s) 102

    Abstract: Background: Japanese encephalitis (JE) is a leading cause of childhood viral encephalitis both at global level and in China. Vaccination is recommended as a key strategy to control JE. In China most JE cases have been reported in southwest provinces, ... ...

    Abstract Background: Japanese encephalitis (JE) is a leading cause of childhood viral encephalitis both at global level and in China. Vaccination is recommended as a key strategy to control JE. In China most JE cases have been reported in southwest provinces, which include Yunnan. In this study, we quantify the epidemiological shift of JE in Yunnan Province from 2005 to 2017, covering before and after the introduction of JE vaccination into routine Expanded Program on Immunization (EPI) in 2007.
    Methods: We used routinely collected data in the case-based JE surveillance system from 2005 through 2017 in Yunnan. Cases were reported from hospital and county-level Centers for Disease Control in line with the National JE Surveillance Guideline. Epidemiological data were extracted, analysed and presented in appropriate ways. Immunization coverage was estimated from actual JE doses administered and new births for each year.
    Results: A total 4780 JE cases (3077 laboratory-confirmed, 1266 clinical and 437 suspected) were reported in the study period. Incidence of JE (per 100 000 population) increased from 0.95 in 2005 to 1.69 in 2007. With increase in vaccination coverage, incidence rates decreased steadily from 1.16 in 2009 to 0.17 in 2017. However, seasonality remained similar across the years, peaking in June-September. Banna (bordering Myanmar and Laos), Dehong (bordering Myanmar), and Zhaotong (an inland prefecture) had the highest incidence rates of 2.3, 1.9, and 1.6, respectively. 97% of all cases were among local residents. As vaccination coverage increased (and incidence decreased), proportion of JE cases among children < 10 years old decreased from 70% in 2005 to 32% in 2017, while that among adults ≥20 years old increased from 12 to 48%. There were a large number of JE cases with unknown treatment outcomes, especially in the earlier years of the surveillance system.
    Conclusions: The 13-year JE surveillance data in Yunnan Province showed dramatic decrease of total incidence and a shift from children to adults. Improving vaccination coverage, including access to adults at risk, and strengthening the JE surveillance system is needed to further control or eliminate JE in the province.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; China/epidemiology ; Encephalitis, Japanese/epidemiology ; Encephalitis, Japanese/prevention & control ; Female ; Humans ; Immunization Programs/statistics & numerical data ; Incidence ; Infant ; Japanese Encephalitis Vaccines/administration & dosage ; Male ; Middle Aged ; Vaccination/statistics & numerical data ; Young Adult
    Chemical Substances Japanese Encephalitis Vaccines
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2689396-4
    ISSN 2049-9957 ; 2049-9957
    ISSN (online) 2049-9957
    ISSN 2049-9957
    DOI 10.1186/s40249-019-0608-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Rapid simultaneous analysis of fluorene, carbazole, benzo[a]pyrene, and perylene by derivative-constant energy synchronous fluorescence spectroscopy].

    Zhang, Ru-ping / He, Li-fang

    Guang pu xue yu guang pu fen xi = Guang pu

    2007  Volume 27, Issue 2, Page(s) 350–354

    Abstract: A new method of derivative constant-energy synchronous fluorescence (CESF) spectroscopy for the simultaneous determination of fluorene, carbazole, benzo[a]pyrene and perylene was developed. The comparison and explanation of its performance are presented. ...

    Abstract A new method of derivative constant-energy synchronous fluorescence (CESF) spectroscopy for the simultaneous determination of fluorene, carbazole, benzo[a]pyrene and perylene was developed. The comparison and explanation of its performance are presented. The derivative CESF spectra are apparently more structured than the direct CESF. The scanning of derivative CESF is more effective than derivative constant-wavelength synchronous fluorescence spectroscopy. By using this method, real samples (tap water, seawater and airborne particulates) were determined directly and good results were obtained. The recoveries in tap water, seawater and airborne particulates were 90.0%-108.0%, 90.0%-104.0% and 90.0%-102.0% respectively.
    Language Chinese
    Publishing date 2007-02
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1000-0593
    ISSN 1000-0593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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