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  1. Book: Mass spectrometry imaging of small molecules

    He, Lin

    (Methods in molecular biology ; 1203 ; Springer protocols)

    2015  

    Author's details ed. by Lin He
    Series title Methods in molecular biology ; 1203
    Springer protocols
    Collection
    Language English
    Size XI, 213 S. : zahlr. Ill.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018491133
    ISBN 978-1-4939-1356-5 ; 9781493913572 ; 1-4939-1356-5 ; 1493913573
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1203- verfügbar in Königswinter Königswinter

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  2. Article: [Genetic counseling for hearing loss today].

    Wang, Qiuju / He, Lin

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

    2024  Volume 38, Issue 1, Page(s) 1–7

    Abstract: Genetic counseling for hearing loss today originated from decoding the genetic code of hereditary hearing loss, which serves as an effective strategy for preventing hearing loss and constitutes a crucial component of the diagnostic and therapeutic ... ...

    Abstract Genetic counseling for hearing loss today originated from decoding the genetic code of hereditary hearing loss, which serves as an effective strategy for preventing hearing loss and constitutes a crucial component of the diagnostic and therapeutic framework. This paper described the main principles and contents of genetic counseling for hearing loss, the key points of counseling across various genetic models and its application in tertiary prevention strategies targeting hearing impairment. The prospects of an AI-assisted genetic counseling decision system and the envisions of genetic counseling in preventing hereditary hearing loss were introduced. Genetic counseling for hearing loss today embodies the hallmark of a new era, which is inseparable from the advancements in science and technology, and will undoubtedly contribute to precise gene intervention!
    MeSH term(s) Humans ; Genetic Counseling ; Deafness/genetics ; Hearing Loss/genetics ; Hearing Loss/therapy ; Hearing Loss/diagnosis ; Hearing Loss, Sensorineural/genetics
    Language Chinese
    Publishing date 2024-02-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2096-7993
    ISSN 2096-7993
    DOI 10.13201/j.issn.2096-7993.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Safety and efficacy of ablation index-guided high-power ablation for the treatment of atrial fibrillation

    Jing Zhu / Xian-he Lin

    Heliyon, Vol 9, Iss 4, Pp e15311- (2023)

    2023  

    Abstract: Objective: To study the safety and efficacy of high-power ablation for atrial fibrillation (AF) guided by lesion size index (LSI) and impedance cutoff. Method: A total of 223 patients who underwent radiofrequency catheter ablation of atrial fibrillation ( ...

    Abstract Objective: To study the safety and efficacy of high-power ablation for atrial fibrillation (AF) guided by lesion size index (LSI) and impedance cutoff. Method: A total of 223 patients who underwent radiofrequency catheter ablation of atrial fibrillation (including paroxyparal atrial fibrillation and persistent atrial fibrillation) in the Department of Cardiology of Anhui Provincial Hospital from February 2019 to July 2020 were enrolled, and were divided into 123 patients in the high-power ablation group (HPAI) and 100 patients in the conventional power ablation group (CPAI). The HPAI group adopted high-power (40–50 W) ablation by impedance cutoff, and the CPAI group adopted conventional-power (30–35 W) ablation. Patients in both groups were ablated guided by the same LSI. For both groups, we analyzed the pulmonary vein single-circle isolation rate, ablation time, X-ray exposure, impedance drop value, incidence of complications, and recurrence rate within one year after operation. Results: There was no significant difference in the success rate of pulmonary vein single-circle isolation, X-ray perspective time, and X-ray exposure quantity between the HPAI group and the CPAI group (88.60% vs 82.00%, P = 0.161; 8.7 ± 3.74 min vs 7.82 ± 3.86 min, P = 0.067; 54.74 ± 28 min vs 52.78 ± 39.58 min, P = 0.139); the annular pulmonary vein ablation time and total ablation time were less in the HPAI group (35.74 ± 7.25 min vs 65.49 ± 7.34 min, P < 0.01; 55.42 ± 11.61 min vs 76.9 ± 6.79 min, P < 0.01); the impedance drop values at 10–15Ω and 15–20Ω were higher in the HPAI group (25.3% vs 19.1%, P < 0.05; 24.1% vs 19.1%, P < 0.05); there was no significant difference in the recurrence rate within one year after operation between the two groups; and no serious complications occurred in the two groups. Conclusion: High-power ablation guided by LSI and impedance cutoff could significantly shorten the AF ablation time and reduce complications.
    Keywords Atrial fibrillation ; High-power ; Lesion size index ; Radiofrequency ablation ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 616
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  4. Article ; Online: Publisher Correction: SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci.

    Shi, Yong Yong / He, Lin

    Cell research

    2023  

    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-023-00805-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: NSD family proteins: Rising stars as therapeutic targets.

    He, Lin / Cao, Yiping / Sun, Luyang

    Cell insight

    2024  Volume 3, Issue 2, Page(s) 100151

    Abstract: Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are ... ...

    Abstract Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are heritable, are independent of primary DNA sequences, undergo dynamic changes during development and differentiation, and are frequently disrupted in human diseases. The reversibility of epigenetic modifications makes them promising targets for therapeutic intervention and drugs targeting epigenetic regulators (e.g., tazemetostat, targeting the H3K27 methyltransferase EZH2) have been applied in clinical therapy for multiple cancers. The NSD family of H3K36 methyltransferase enzymes-including NSD1 (KMT3B), NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1)-are now receiving drug development attention, with the exciting advent of an NSD2 inhibitor (KTX-1001) advancing to Phase I clinical trials for relapsed or refractory multiple myeloma. NSD proteins recognize and catalyze methylation of histone lysine marks, thereby regulating chromatin integrity and gene expression. Multiple studies have implicated NSD proteins in human disease, noting impacts from translocations, aberrant expression, and various dysfunctional somatic mutations. Here, we review the biological functions of NSD proteins, epigenetic cooperation related to NSD proteins, and the accumulating evidence linking these proteins to developmental disorders and tumorigenesis, while additionally considering prospects for the development of innovative epigenetic therapies.
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2772-8927
    ISSN (online) 2772-8927
    DOI 10.1016/j.cellin.2024.100151
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  6. Article ; Online: Performance of the Action Observation-Based Brain-Computer Interface in Stroke Patients and Gaze Metrics Analysis.

    Zhang, Xin / He, Lin / Gao, Qiang / Jiang, Ning

    IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

    2024  Volume 32, Page(s) 1370–1379

    Abstract: Brain-computer interfaces (BCIs) are anticipated to improve the efficacy of rehabilitation for people with motor disabilities. However, applying BCI in clinical practice is still a challenge due to the great diversity of patients. In the current study, a ...

    Abstract Brain-computer interfaces (BCIs) are anticipated to improve the efficacy of rehabilitation for people with motor disabilities. However, applying BCI in clinical practice is still a challenge due to the great diversity of patients. In the current study, a novel action observation (AO) based BCI was proposed and tested on stroke patients. Ten non-hemineglect patients and ten hemineglect patients were recruited. Four AO stimuli were designed, each presenting a decomposed action to complete the reach-and-grasp task. EEG data and eye movement data were collected. Eye movement data was utilized to analyze the reasons for individual differences in BCI performance. Task discriminative component analysis was utilized to perform online target detection. The results showed that the designed AO-based BCI could simultaneously induce steady state motion visual evoked potential (SSMVEP) from the occipital region and sensory motor rhythm from the sensorimotor region in stroke patients. The average online detection accuracy among the four AO stimuli reached 67% within 3 s in the non-hemineglect group, while the accuracy only reached 35% in the hemineglect group. Gaze metrics showed that the average total duration of fixations during the stimulus phase in the hemineglect group was only 1.31 s ± 0.532 s which was significantly lower than that in the non-hemineglect group. The results indicated that hemineglect patients have difficulty gazing at the AO stimulus, resulting in poor detection performance and weak desynchronization in the sensorimotor region. Furthermore, the degree of neglect is inversely proportional to the target detection accuracy in hemineglect stroke patients. In addition, the gaze metrics associated with cognitive load were significantly correlated with the accuracy in non-hemineglect patients. It indicated the cognitive load may affect the AO-based BCI. The current study will expedite the clinical application of AO-based BCI.
    MeSH term(s) Humans ; Brain-Computer Interfaces ; Evoked Potentials, Visual ; Stroke ; Eye Movements ; Electroencephalography/methods
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1166307-8
    ISSN 1558-0210 ; 1063-6528 ; 1534-4320
    ISSN (online) 1558-0210
    ISSN 1063-6528 ; 1534-4320
    DOI 10.1109/TNSRE.2024.3379995
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    Zs.A 4726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: Value of multimodality imaging in a giant thymoma extending to the superior vena cava and the right atrium.

    Wu, Zhenni / He, Lin / Leng, Song / Li, Yuman

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.138
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    Zs.B 2831: Show issues Location:
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  8. Article ; Online: Single-cell analysis reveals microbial spore responses to sodium hypochlorite.

    Yang, Weiming / Yuan, Yufeng / He, Lin / Fan, Haihua

    Journal of biophotonics

    2024  , Page(s) e202400015

    Abstract: Pollution from toxic spores has caused us a lot of problems because spores are extremely resistant and can survive most disinfectants. Therefore, the detection of spore response to disinfectant is of great significance for the development of effective ... ...

    Abstract Pollution from toxic spores has caused us a lot of problems because spores are extremely resistant and can survive most disinfectants. Therefore, the detection of spore response to disinfectant is of great significance for the development of effective decontamination strategies. In this work, we investigated the effect of 0.5% sodium hypochlorite on the molecular and morphological properties of single spores of Bacillus subtilis using single-cell techniques. Laser tweezers Raman spectroscopy showed that sodium hypochlorite resulted in Ca
    Language English
    Publishing date 2024-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202400015
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    Zs.A 6723: Show issues Location:
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  9. Article ; Online: Enhanced phosphorus resistance of sodium-promoted Cu/CHA catalysts towards NH3-SCR

    Jiangfeng Guo / Aiyong Wang / He Lin

    Catalysis Communications, Vol 173, Iss , Pp 106568- (2023)

    1480  

    Abstract: Cu/CHA and sodium-promoted Cu/CHA catalysts were prepared and applied to catalyze NH3-SCR reaction. Also, the effect of phosphorus poisoning on the catalytic performance of these two catalysts were explored. Compared with Cu/CHA catalyst, sodium-promoted ...

    Abstract Cu/CHA and sodium-promoted Cu/CHA catalysts were prepared and applied to catalyze NH3-SCR reaction. Also, the effect of phosphorus poisoning on the catalytic performance of these two catalysts were explored. Compared with Cu/CHA catalyst, sodium-promoted Cu/CHA catalyst presented better catalytic performance, which was attributed to the optimized distribution of copper active sites. Moreover, it was proved that sodium ions as sacrificial sites could effectively protect copper active ions and improve the phosphorus poisoning resistance of the sodium-promoted Cu/CHA catalyst.
    Keywords Phosphorus ; Cu/CHA ; NH3-SCR ; Sodium ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  10. Article ; Online: Study on the Distribution Law of Crustal Stress in Fault Fracture Area

    He-Lin Fu / Wu Xu / Yi-Min Wu

    Applied Sciences, Vol 13, Iss 7678, p

    2023  Volume 7678

    Abstract: Determining crustal stress is crucial in the design and construction of underground engineering projects, particularly in fault fracture zones. This paper aims to identify the characteristic factors that influence the crustal stress of faults, including ... ...

    Abstract Determining crustal stress is crucial in the design and construction of underground engineering projects, particularly in fault fracture zones. This paper aims to identify the characteristic factors that influence the crustal stress of faults, including the difference in deformation characteristics between faults and ordinary formations (expressed by the elastic modulus ratio E r / E f ), the degree of fault fragmentation P , and the angle α between fault tendency and the principal stress direction. Numerical simulations are conducted to investigate the impact of these three factors on the magnitude and direction of the principal stress. Additionally, measured stress values from a specific tunnel are analyzed to validate the findings. The results demonstrate the crucial role of α in determining the increase or decrease of principal stress and the direction of the offset. When α is less than 45°, σ 1 and σ 3 within the fault experience an increase, while σ 1 and σ 3 in the ordinary surrounding rock area near the fault exhibit a slight decrease. Moreover, the σ 1 direction inside the fault deviates towards the parallel fault, whereas σ 1 near the outside slightly deviates towards the vertical fault. Conversely, when α is greater than 45°, the trend of principal stress is reversed. E r / E f affects the magnitude of the principal stress change, with larger values resulting in more pronounced changes. P only affects the stress distribution inside the fault.
    Keywords fault area ; crustal stress ; distribution pattern ; numerical simulation ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 290
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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