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  1. Article ; Online: Development of a prognostic nomogram for sepsis associated-acute respiratory failure patients on 30-day mortality in intensive care units: a retrospective cohort study.

    Luo, Mengdi / He, Qing

    BMC pulmonary medicine

    2023  Volume 23, Issue 1, Page(s) 43

    Abstract: Background: Acute respiratory failure is a type of sepsis complicated by severe organ failure. We have developed a new nomogram for predicting the 30-day risk of death in patients through a retrospective study.: Method: Data was collected and ... ...

    Abstract Background: Acute respiratory failure is a type of sepsis complicated by severe organ failure. We have developed a new nomogram for predicting the 30-day risk of death in patients through a retrospective study.
    Method: Data was collected and extracted from MIMICIV, with 768 eligible cases randomly assigned to the primary cohort (540) and the validation cohort (228). The final six factors were included by Cox regression analysis to create the Nomogram, the accuracy of the Nomogram was assessed using the C-index and calibration curve, and finally, the clinical usefulness of the Nomogram was evaluated using DCA in.
    Results: Multivariate Cox regression analysis showed that age, DBP, lactate, PaO2, platelet, mechanical ventilation were independent factors for 30-day mortality of SA-ARF. The nomogram established based on the six factors. The C-index of nomogram in the primary cohort is 0.731 (95% CI 0.657-0.724) and 0.722 (95%CI 0.622-0.759) in the validation cohort. Besides, the decision curve analysis (DCA) confirmed the clinical usefulness of the nomogram.
    Conclusion: The study developed and validated a risk prediction model for SA-ARF patients that can help clinicians reasonably determine disease risk and further confirm its clinical utility using internal validation.
    MeSH term(s) Humans ; Nomograms ; Prognosis ; Retrospective Studies ; Sepsis/complications ; Intensive Care Units ; Lactic Acid ; Respiratory Distress Syndrome ; Respiratory Insufficiency
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-02302-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of post-dilatation on longitudinal stent deformation and postprocedural stent malapposition in the left main artery by optical coherence tomography (OCT): an in vitro study.

    He, Qing / Fan, Yuqi / Xu, Zuojun / Zhang, Junfeng

    BMC medical imaging

    2024  Volume 24, Issue 1, Page(s) 53

    Abstract: Background: The diameter of the ostial and proximal left main coronary artery can be greater than 5.0 mm. However, the diameters of the mostly available coronary drug-eluting stents (DESs) are ≤ 4.0 mm. Whether high-pressure dilatation can increase the ... ...

    Abstract Background: The diameter of the ostial and proximal left main coronary artery can be greater than 5.0 mm. However, the diameters of the mostly available coronary drug-eluting stents (DESs) are ≤ 4.0 mm. Whether high-pressure dilatation can increase the diameter of stents from 4.0 to 5.0 mm and whether post-dilatation leads to longitudinal stent deformation (LSD) of 4.0-mm-diameter stents have rarely been studied. Therefore, this study aims to evaluate LSD and stent malapposition of six types of commercially available 4.0-mm-diameter stents in China in a 5.0-mm-diameter artificial blood vessel model by optical coherence tomography (OCT) in vitro.
    Methods: The left main coronary artery was simulated by a truncated cone-shaped silicone tube. The internal diameters were 4.0 mm at one end of the silicone tube and 5.0 mm at the other end. Six different types of coronary stents widely used in China were selected for this study. Each stent was respectively implanted into the simulated blood vessel and dilated to a diameter of 4.2 mm according to the stent-balloon pressure compliance table. The stents were subjected to post-dilatation with a 5.0 × 15-mm noncompliant balloon. The LSD ratio of the longitudinal axis of each stent and stent malapposition were measured through OCT, and any fractures of the stents were determined.
    Results: None of the six types of stents fractured following post-dilatation. The longitudinal axes of the BuMA and Excrossal stents were slightly shortened, while the other stents were elongated after high-pressure post-dilatation. All stents expanded to a diameter of 5.0 mm without incomplete stent apposition, except for the Nano Plus stent, which remained malapposed after high-pressure post-dilatation.
    Conclusion: All 4.0-mm-diameter stents can be expanded to a diameter of 5.0 mm by noncompliant balloon post-dilatation without stent strut fracture. Most stents were found to be well apposed after high-pressure post-dilatation. However, LSD was observed after post-balloon dilatation. Stent malapposition might be positively correlated with the percentage change in stent length.
    MeSH term(s) Humans ; Tomography, Optical Coherence/methods ; Dilatation ; Stents/adverse effects ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Silicones
    Chemical Substances Silicones
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-024-01223-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The role of SELENBP1 and its epigenetic regulation in carcinogenic progression.

    Zhang, Yue / He, Qing

    Frontiers in genetics

    2022  Volume 13, Page(s) 1027726

    Abstract: The initiation and progression of cancer is modulated through diverse genetic and epigenetic modifications. The epigenetic machinery regulates gene expression through intertwined DNA methylation, histone modifications, and miRNAs without affecting their ... ...

    Abstract The initiation and progression of cancer is modulated through diverse genetic and epigenetic modifications. The epigenetic machinery regulates gene expression through intertwined DNA methylation, histone modifications, and miRNAs without affecting their genome sequences. SELENBP1 belongs to selenium-binding proteins and functions as a tumor suppressor. Its expression is significantly downregulated and correlates with carcinogenic progression and poor survival in various cancers. The role of SELENBP1 in carcinogenesis has not been fully elucidated, and its epigenetic regulation remains poorly understood. In this review, we summarize recent findings on the function and regulatory mechanisms of SELENBP1 during carcinogenic progression, with an emphasis on epigenetic mechanisms. We also discuss the potential cancer treatment targeting epigenetic modification of SELENBP1, either alone or in combination with selenium-containing compounds or dietary selenium.
    Language English
    Publishing date 2022-11-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1027726
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  4. Article ; Online: Neural Mechanisms of Visual Field Recovery after Perceptual Training in Cortical Blindness.

    He, Qing / Gan, Shuoqiu

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 10, Page(s) 1886–1887

    MeSH term(s) Blindness, Cortical ; Humans ; Vision Disorders ; Visual Cortex ; Visual Fields
    Language English
    Publishing date 2022-03-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1953-21.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
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  5. Article ; Online: The Missing Chalcogen Bonding Donor: Strongly Polarized Oxygen of Water.

    Zhang, Qinpeng / Luo, Ke / Zhou, Wei / Li, Aimin / He, Qing

    Journal of the American Chemical Society

    2024  Volume 146, Issue 6, Page(s) 3635–3639

    Abstract: A biscyclen molecular cabin, synthesized by connecting two cyclen macrocycles with four linkages, entraps a ... ...

    Abstract A biscyclen molecular cabin, synthesized by connecting two cyclen macrocycles with four linkages, entraps a Li
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c13604
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  6. Article ; Online: Feasibility and potential efficacy of a family-based intervention on promoting physical activity levels and fundamental movement skills in preschoolers: A cluster randomised controlled trial.

    He, Qing / Ha, Amy S C / Zheng, Binbin / Okely, Anthony D

    Applied psychology. Health and well-being

    2024  

    Abstract: Physical activity (PA) is crucial for preschool-aged children's health and development. However, limited evidence exists regarding the feasibility of implementing home-based interventions and how program components influence parent cognitions and ... ...

    Abstract Physical activity (PA) is crucial for preschool-aged children's health and development. However, limited evidence exists regarding the feasibility of implementing home-based interventions and how program components influence parent cognitions and practices and child PA. This study evaluated the feasibility and potential efficacy of a family-based PA intervention on objectively measured PA, fundamental movement skills (FMS), parental efficacy, support, goal setting and parent-child co-activity. Guided by social cognitive theory, an 8-week cluster randomised controlled trial was conducted in Hong Kong. The trial included parental workshops, FMS training, PA homework, social media activity sharing and exercise equipment provision. Data were collected at baseline (Time 1; April 2019) and at the end of the intervention period (Time 2; approximately 2 months later) from 108 parent-child pairs in five preschools. The intervention led to increased moderate-to-vigorous PA and FMS in children, along with improved parental self-efficacy, goal setting, supportiveness and co-participation. However, parental PA did not show significant changes. Parents expressed high satisfaction, supporting the need for tailoring interventions to address the unique needs and preferences of young children and their parents. Reinforcing the parental role and providing informative materials and training can promote healthy lifestyles in early childhood.
    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2483053-7
    ISSN 1758-0854 ; 1758-0846
    ISSN (online) 1758-0854
    ISSN 1758-0846
    DOI 10.1111/aphw.12527
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  7. Article: Seroprevalence of Diphtheria and Tetanus Immunoglobulin G among the General Health Population in Guangzhou, China.

    He, Qing / Wu, Yejian / Hou, Shuiping / Luo, Lei / Zhang, Zhoubin

    Vaccines

    2024  Volume 12, Issue 4

    Abstract: A seroepidemiological study was conducted in 2018 to assess diphtheria and tetanus antibodies in Guangzhou, China. Diphtheria and tetanus antibody concentrations were measured with an enzyme-linked immunosorbent assay. A total of 715 subjects were ... ...

    Abstract A seroepidemiological study was conducted in 2018 to assess diphtheria and tetanus antibodies in Guangzhou, China. Diphtheria and tetanus antibody concentrations were measured with an enzyme-linked immunosorbent assay. A total of 715 subjects were enrolled in the study. The overall diphtheria and tetanus toxoid IgG-specific antibody levels were 0.126 IU/mL (95% CI: 0.115, 0.137) and 0.210 IU/mL (95% CI: 0.185, 0.240), respectively; the overall positivity rate was 61.82% (95% CI: 58.14, 65.39) and 71.61% (95% CI: 68.3, 74.92), respectively. The diphtheria and tetanus antibody concentration was decreased by age and increased by doses. The geometric mean concentrations and positivity rate of diphtheria and tetanus antibodies were lowest and below the essential protection level in people over 14 years of age. Compared to children and adolescents, middle-aged people and the aged are at much higher risk of infection with Corynebacterium diphtheriae and Clostridium tetani. The current diphtheria and tetanus immunization schedule does not provide persistent protection after childhood. There is an urgent need to adjust the current immunization schedule.
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12040381
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  8. Article ; Online: Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFC.

    He, Qing / Wang, Feng / O'Donnell, Michael E / Li, Huilin

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 18, Page(s) e2319727121

    Abstract: The DNA sliding clamp PCNA is a multipurpose platform for DNA polymerases and many other proteins involved in DNA metabolism. The topologically closed PCNA ring needs to be cracked open and loaded onto DNA by a clamp loader, e.g., the well-studied ... ...

    Abstract The DNA sliding clamp PCNA is a multipurpose platform for DNA polymerases and many other proteins involved in DNA metabolism. The topologically closed PCNA ring needs to be cracked open and loaded onto DNA by a clamp loader, e.g., the well-studied pentameric ATPase complex RFC (RFC1-5). The CTF18-RFC complex is an alternative clamp loader found recently to bind the leading strand DNA polymerase ε and load PCNA onto leading strand DNA, but its structure and the loading mechanism have been unknown. By cryo-EM analysis of in vitro assembled human CTF18-RFC-DNA-PCNA complex, we have captured seven loading intermediates, revealing a detailed PCNA loading mechanism onto a 3'-ss/dsDNA junction by CTF18-RFC. Interestingly, the alternative loader has evolved a highly mobile CTF18 AAA+ module likely to lower the loading activity, perhaps to avoid competition with the RFC and to limit its role to leading strand clamp loading. To compensate for the lost stability due to the mobile AAA+ module, CTF18 has evolved a unique β-hairpin motif that reaches across RFC2 to interact with RFC5, thereby stabilizing the pentameric complex. Further, we found that CTF18 also contains a separation pin to locally melt DNA from the 3'-end of the primer; this ensures its ability to load PCNA to any 3'-ss/dsDNA junction, facilitated by the binding energy of the E-plug to the major groove. Our study reveals unique structural features of the human CTF18-RFC and contributes to a broader understanding of PCNA loading by the alternative clamp loaders.
    MeSH term(s) Humans ; ATPases Associated with Diverse Cellular Activities ; Cryoelectron Microscopy/methods ; DNA/metabolism ; DNA/chemistry ; DNA Replication ; Models, Molecular ; Nuclear Proteins ; Proliferating Cell Nuclear Antigen/metabolism ; Proliferating Cell Nuclear Antigen/chemistry ; Protein Binding ; Replication Protein C/metabolism ; Replication Protein C/chemistry
    Chemical Substances ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; CHTF18 protein, human ; DNA (9007-49-2) ; Nuclear Proteins ; PCNA protein, human ; Proliferating Cell Nuclear Antigen ; Replication Protein C (EC 3.6.4.-) ; SLC19A1 protein, human
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2319727121
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  9. Article ; Online: Head and Neck Hemangiopericytoma: A Rare Case Report and Literature Review.

    Liu, Hanlin / Lu, Yuting / He, Qing / Cao, Xiaolin

    Ear, nose, & throat journal

    2023  , Page(s) 1455613231191379

    Abstract: Hemangiopericytomas (HPCs) are rare vascular tumors, and head and neck hemangiopericytoma (HNHPC) accounts for 11% to 16% of all HPCs, possibly occurring at any age. However, according to a recent study, HNHPC was most frequently observed in middle-aged ... ...

    Abstract Hemangiopericytomas (HPCs) are rare vascular tumors, and head and neck hemangiopericytoma (HNHPC) accounts for 11% to 16% of all HPCs, possibly occurring at any age. However, according to a recent study, HNHPC was most frequently observed in middle-aged adults and had a slight predominance of female patients. In the present case, we report the successful treatment of HNHPC.
    Language English
    Publishing date 2023-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613231191379
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 107: Show issues Location:
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  10. Article ; Online: Knowledge Construction in Problem-Based Learning: A Lag-Sequential Analysis of Teachers' and Students' Discourse Moves.

    Zheng, Binbin / He, Qing / Lei, Junru

    Teaching and learning in medicine

    2023  , Page(s) 1–14

    Abstract: ... ...

    Abstract Phenomenon
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1038640-3
    ISSN 1532-8015 ; 1040-1334
    ISSN (online) 1532-8015
    ISSN 1040-1334
    DOI 10.1080/10401334.2023.2230559
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2754: Show issues Location:
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