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  1. Article ; Online: Bordetella pertussis isolates in Finland after acellular vaccination: serotype change and biofilm formation.

    Niinikoski, Vili / Barkoff, Alex-Mikael / Mertsola, Jussi / He, Qiushui

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  Volume 30, Issue 5, Page(s) 683.e1–683.e3

    Abstract: Objectives: In Finland, whole cell pertussis vaccine (wP) was introduced in 1952 and was replaced by acellular pertussis vaccine (aP) without fimbrial (FIM) antigen in 2005. We aimed to analyse the changes in serotypes of circulating Bordetella ... ...

    Abstract Objectives: In Finland, whole cell pertussis vaccine (wP) was introduced in 1952 and was replaced by acellular pertussis vaccine (aP) without fimbrial (FIM) antigen in 2005. We aimed to analyse the changes in serotypes of circulating Bordetella pertussis before and after acellular vaccination and to explore the relationship between biofilm formation and serotype diversity after the introduction of aP vaccine.
    Methods: Serotyping of 1399 B. pertussis isolates collected at the Finnish National Reference Laboratory for Pertussis and Diphtheria in Turku, Finland, from 1974 to 2023 was performed by slide agglutination or indirect ELISA. Of 278 isolates collected after 2005, 53 were selected, genotyped for fim3 and fim2 alleles, and tested for biofilm formation. The selection criteria included maintaining a relatively equal distribution of isolates per time interval, ensuring approximately a 50:50 ratio of FIM2 (N = 26) and FIM3 (N = 27) serotypes. The reference strain Tohama I was used as a control.
    Results: During the wP era, the majority of circulating B. pertussis exhibited the FIM2 serotype. However, FIM3 strains have appeared since 1999 and become prevalent. After the implementation of aP vaccines, the distribution of serotypes has exhibited substantial variability. FIM3 isolates displayed an enhanced biofilm formation compared to FIM2 isolates (Geometric mean value (95% CI): 0.90 (0.79-1.03) vs. 0.75 (0.65-0.85); p < 0.05). Of the 27 FIM3 isolates, 8 harboured fim3-1 and 19 fim3-2 alleles. FIM3 isolates with fim3-2 allele were significantly associated with increased biofilm formation when compared to those with fim3-1 (1.07 (0.96-1.19) vs. 0.61 (0.52-0.72); p < 0.0001).
    Conclusion: Following the implementation of aP vaccines, the distribution of serotypes in Finland has exhibited substantial variability. FIM3 isolates with the fim3-2 allele displayed an enhanced biofilm formation capability compared to FIM2 isolates.
    MeSH term(s) Biofilms/growth & development ; Finland/epidemiology ; Bordetella pertussis/genetics ; Bordetella pertussis/classification ; Bordetella pertussis/immunology ; Bordetella pertussis/isolation & purification ; Humans ; Whooping Cough/microbiology ; Whooping Cough/epidemiology ; Whooping Cough/prevention & control ; Serogroup ; Pertussis Vaccine/immunology ; Pertussis Vaccine/administration & dosage ; Vaccines, Acellular/immunology ; Fimbriae Proteins/genetics ; Fimbriae Proteins/immunology ; Serotyping ; Genotype ; Child, Preschool ; Child ; Infant ; Vaccination ; Antigens, Bacterial ; Virulence Factors, Bordetella
    Chemical Substances Pertussis Vaccine ; Vaccines, Acellular ; Fimbriae Proteins (147680-16-8) ; fim2 protein, Bordetella ; fim3 protein, Bordetella ; Antigens, Bacterial ; Virulence Factors, Bordetella
    Language English
    Publishing date 2024-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evolution of Bordetella pertussis.

    He, Qiushui

    The Pediatric infectious disease journal

    2016  Volume 35, Issue 8, Page(s) 915–917

    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000001218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: ST2 and IL-33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children.

    Teräsjärvi, Johanna T / Toivonen, Laura / Mertsola, Jussi / Peltola, Ville / He, Qiushui

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2024  

    Abstract: The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in ... ...

    Abstract The ST2/IL-33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL-33 polymorphisms with serum soluble (s) ST2 and IL-33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single-nucleotide polymorphisms (SNPs) in ST2 and IL-33 were determined, and associations of the SNP variants with serum levels of sST2 and IL-33 at age of 13 months and with recurrent wheezing and childhood asthma at 7 years of age were analyzed. Children with ST2 rs1041973 AC/AA genotypes had significantly lower level of serum sST2 (2453 pg/mL; IQR 2265) than those with CC genotype (5437 pg/mL; IQR 2575; p = < 0.0001). Similar difference was also observed with ST2 rs13408661. No differences were observed between subjects with studied IL-33 SNPs. Children who carried genetic variants of ST2 rs1041973 or rs13408661 seemed to have a higher risk of asthma. In contrast, children who carried genetic variants of IL-33 rs12551268 were less often diagnosed with asthma. Even though these SNPs seemed to associate with asthma, the differences were not statistically significant.
    Language English
    Publishing date 2024-04-02
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.13411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Integrated analysis of gut and oral microbiome in men who have sex with men with HIV Infection.

    Li, Shuang / Su, Bin / Wu, Hao / He, Qiushui / Zhang, Tong

    Microbiology spectrum

    2023  Volume 11, Issue 6, Page(s) e0106423

    Abstract: Importance: Our longitudinal integrated study has shown the marked alterations in the gut and oral microbiome resulting from acute and chronic HIV infection and from antiretroviral therapy. Importantly, the relationship between oral and gut microbiomes ... ...

    Abstract Importance: Our longitudinal integrated study has shown the marked alterations in the gut and oral microbiome resulting from acute and chronic HIV infection and from antiretroviral therapy. Importantly, the relationship between oral and gut microbiomes in people living with acute and chronic HIV infection and "healthy" controls has also been explored. These findings might contribute to a better understanding of the interactions between the oral and gut microbiomes and its potential role in HIV disease progression.
    MeSH term(s) Male ; Humans ; HIV Infections ; Homosexuality, Male ; Sexual and Gender Minorities ; Microbiota ; Gastrointestinal Microbiome ; RNA, Ribosomal, 16S
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01064-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply: Genetic findings depend on the context of the study.

    Korppi, Matti / He, Qiushui

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 109, Issue 10, Page(s) 2118

    MeSH term(s) Bronchiolitis ; Humans ; Infant ; Interleukin-33 ; Rhinitis, Allergic ; Schools
    Chemical Substances IL33 protein, human ; Interleukin-33
    Language English
    Publishing date 2020-02-27
    Publishing country Norway
    Document type Letter ; Comment
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15226
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  6. Book ; Thesis: Diagnosis of Bordetella pertussis infection and investigation of pertussis immunity by PCR and EIA serology

    He, Qiushui

    (Turun Yliopiston julkaisuja : Sarja D ; 145)

    1994  

    Author's details by Qiushui He
    Series title Turun Yliopiston julkaisuja : Sarja D ; 145
    Turun Yliopiston julkaisuja
    Turun Yliopiston julkaisuja ; Sarja D
    Collection Turun Yliopiston julkaisuja
    Turun Yliopiston julkaisuja ; Sarja D
    Language English
    Size Getr. Zählung : Ill.
    Publisher Turun Yliopisto
    Publishing place Turku
    Publishing country Finland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Turku, Univ., Diss., 1994
    HBZ-ID HT006839160
    ISBN 951-29-0242-7 ; 978-951-29-0242-2
    Database Catalogue ZB MED Medicine, Health

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  7. Article: Macrolide Resistance in

    Ivaska, Lauri / Barkoff, Alex-Mikael / Mertsola, Jussi / He, Qiushui

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: Pertussis is a highly contagious respiratory infection caused ... ...

    Abstract Pertussis is a highly contagious respiratory infection caused by
    Language English
    Publishing date 2022-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11111570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease.

    Zhang, Nan / Mou, Danlei / Li, Tongzeng / Chen, Zhiyun / Ma, Chunhua / Liang, Lianchun / He, Qiushui

    Emerging microbes & infections

    2023  Volume 12, Issue 1, Page(s) 2192819

    Abstract: Little is known about alternation and difference in gut microbiota between patients with mild and severe hand, foot, and mouth disease (HFMD). We investigated the differences in gut and oropharynx microbiota between mild and severe HFMD in young children ...

    Abstract Little is known about alternation and difference in gut microbiota between patients with mild and severe hand, foot, and mouth disease (HFMD). We investigated the differences in gut and oropharynx microbiota between mild and severe HFMD in young children and changes in bacterial profiles as the disease progresses from acute to convalescent phase. Forty-two patients with confirmed HFMD were studied, among which 32 had severe HFMD and 10 had mild HFMD. First rectal swabs were collected from all patients at an average of 2 days (acute phase) after the onset of symptoms, and second rectal swabs were collected from 8 severe patients at day 9 (convalescent phase) after the onset. Oropharyngeal swabs were obtained from 10 patients in the acute phase and 6 in the convalescent phase. 16S rRNA sequencing was performed for all 70 samples. Compared with mild HFMD, severe HFMD exhibited significantly decreased diversity and richness of gut microbiota. Gut microbiota bacterial profiles observed in the acute and convalescent phases resembled each other but differed from those in mild cases. Additionally, 50% of patients with severe HFMD in the acute phase harboured a dominant pathobiontic bacterial genus. However, none of the patients with mild HFMD had such bacteria. Similar bacterial compositions in oropharynx microbiota were detected between mild and severe cases. Our findings indicate that severe HFMD exhibits significantly impaired diversity of gut microbiota and frequent gut and oropharyngeal inflammation-inducing bacteria. However, the results should be interpreted with caution as the number of subjects was limited.
    MeSH term(s) Humans ; Child ; Infant ; Child, Preschool ; Hand, Foot and Mouth Disease ; RNA, Ribosomal, 16S/genetics ; Inflammation ; Gastrointestinal Microbiome ; Bacteria/genetics ; Oropharynx ; China
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2192819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Molecular Epidemiology of Bordetella pertussis.

    Barkoff, Alex-Mikael / He, Qiushui

    Advances in experimental medicine and biology

    2019  Volume 1183, Page(s) 19–33

    Abstract: Although vaccination has been effective, Bordetella pertussis is increasingly causing epidemics, especially in industrialized countries using acellular vaccines (aPs). One factor behind the increased circulation is the molecular changes on the pathogen ... ...

    Abstract Although vaccination has been effective, Bordetella pertussis is increasingly causing epidemics, especially in industrialized countries using acellular vaccines (aPs). One factor behind the increased circulation is the molecular changes on the pathogen level. After pertussis vaccinations were introduced, changes in the fimbrial (Fim) serotype of the circulating strains was observed. When bacterial typing methods improved, further changes between the vaccine and circulating strains, especially among the common virulence genes including pertussis toxin (PT) and pertactin (PRN) were noticed. Moreover, development of genome based techniques including pulsed-field gel electrophoresis (PFGE), multiple-locus variable number tandem repeat analysis (MLVA) and whole-genome sequencing (WGS) have offered a better resolution to monitor B. pertussis strains. After the introduction of aP vaccines, B. pertussis strains that are deficient to vaccine antigens, especially PRN, have appeared widely. On the other hand, antimicrobial resistance to first line drugs (macrolides) against B. pertussis is still low in many countries and therefore no globally evaluated antimicrobial susceptibility test values have been recommended. In this review, we focus on the molecular changes in the bacteria, which have or may have affected the past and current epidemiology of pertussis.
    MeSH term(s) Bacterial Outer Membrane Proteins ; Bordetella pertussis/genetics ; Bordetella pertussis/isolation & purification ; Humans ; Molecular Epidemiology ; Pertussis Toxin ; Pertussis Vaccine/administration & dosage ; Whooping Cough/immunology ; Whooping Cough/microbiology ; Whooping Cough/prevention & control
    Chemical Substances Bacterial Outer Membrane Proteins ; Pertussis Vaccine ; Pertussis Toxin (EC 2.4.2.31)
    Language English
    Publishing date 2019-07-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/5584_2019_402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Oral fluid-based lateral flow point-of-care assays for pertussis serology.

    Knuutila, Aapo / Duncan, John / Li, Fu / Eletu, Seyi / Litt, David / Fry, Norman / He, Qiushui

    Journal of medical microbiology

    2023  Volume 72, Issue 2

    Abstract: Introduction. ...

    Abstract Introduction.
    MeSH term(s) Humans ; Bordetella pertussis ; Point-of-Care Systems ; Antibodies, Bacterial ; Immunoglobulin G ; Whooping Cough/diagnosis ; Pertussis Toxin ; Enzyme-Linked Immunosorbent Assay/methods
    Chemical Substances Antibodies, Bacterial ; Immunoglobulin G ; Pertussis Toxin (EC 2.4.2.31)
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 218356-0
    ISSN 1473-5644 ; 0022-2615
    ISSN (online) 1473-5644
    ISSN 0022-2615
    DOI 10.1099/jmm.0.001668
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