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Article ; Online: Diesel exhaust inhalation exposure induced toxicity on olfactory bulb in mice through inflammatory response mediated by activating glial cells

Yingying JIANG / Yanting LI / Xinglin ZHANG / He SUN / Xiaoya JI

环境与职业医学, Vol 40, Iss 5, Pp 508-

2023 Volume 514

Abstract: BackgroundAir pollution is related to the occurrence and development of mental diseases. Olfactory bulb damage might be the potential prodromal symptom and sign of these diseases. The toxicity of diesel exhaust (DE), one of the main sources of air ... ...

Abstract	BackgroundAir pollution is related to the occurrence and development of mental diseases. Olfactory bulb damage might be the potential prodromal symptom and sign of these diseases. The toxicity of diesel exhaust (DE), one of the main sources of air pollution, on olfactory bulb and the underlying mechanisms remain to be elucidated. ObjectiveTo explore the toxicity of DE on mouse olfactory bulb and underlying mechanisms. MethodsA total of 40 C57BL/6 mice were randomly divided into four groups for exposure to DE by systemic inhalation: control group (filtered air), low exposure group (750 μg·m−3 DE), medium exposure group (1500 μg·m−3 DE), and high exposure group (3000 μg·m−3 DE). The mouse inhalation exposure to DE was performed 1 h per day for 28 d. HE staining was performed to observe pathological changes in mouse olfactory bulb tissue. TUNEL assay was used to observe apop-tosis in olfactory bulb. Kyoto Encyclopedia of Genes and Genomes (KEGG) was exhibited to explore potential mechanisms of olfactory bulb damage associated with DE. Quantitative real-time PCR (qPCR) was used to determine mRNA expression levels of inflammatory factors including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Immunofluorescence staining was conducted to observed the microglia and astrocyte activation in olfactory bulb. ResultsThe HE staining results showed that the number of periglomerular cells in the glomerular layer of olfactory bulb decreased in a dose-dependent manner, and the cells in the granule cell layer of olfactory bulb became disordered after DE exposure. The TUNEL staining showed that TUNEL positive cells in olfactory bulb tissue and neuronal apoptosis increased in the exposed groups compared with the control group (P＜0.05). The KEGG pathway analysis showed that DE associated with significant enrichment of TNF signaling pathway in olfactory bulb tissue. The qPCR results showed that the TNF-α relative expression level significantly increased by 67% and the IL-6 relative expression level by 340% in the DE high ...
Keywords	diesel exhaust ; olfactory bulb ; microglia ; astrocyte ; inflammatory response ; Medicine (General) ; R5-920 ; Toxicology. Poisons ; RA1190-1270
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Editorial Committee of Journal of Environmental and Occupational Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nature Scenes Counter Mental Fatigue-Induced Performance Decrements in Soccer Decision-Making

He Sun / Kim Geok Soh / Xiaowei Xu

Frontiers in Psychology, Vol

2022 Volume 13

Abstract: BackgroundIt has been well investigated that nature exposure intervention can restore directed attention and improve subsequent cognitive performance. The impairment of decision-making skills in mentally fatigued soccer players was attributed to the ... ...

Abstract	BackgroundIt has been well investigated that nature exposure intervention can restore directed attention and improve subsequent cognitive performance. The impairment of decision-making skills in mentally fatigued soccer players was attributed to the inability of attention allocation. However, nature exposure as the potential intervention to counter mental fatigue and improve the subsequent decision-making skill in soccer players has never been investigated.ObjectsThis study aimed to evaluate the effects of nature exposure intervention on decision-making skills among mentally fatigued university soccer players. Moreover, different durations of nature exposure were also evaluated.MethodsA random control between-subject design was adopted. Players were randomly assigned into six groups with three different durations of the experimental group compared with the corresponding control group (4.17 min: Exp 1 vs. Con 1; 8.33 min: Exp 2 vs. Con 2; and 12.50 min: Exp 3 vs. Con 3). All players were first mentally fatigued by performing a 45-min Stroop task; then, they viewed virtual photos of natural or urban scenes; and finally, they performed a soccer decision-making task.ResultsThe subjective ratings of mental fatigue were significantly higher following the Stroop task. Only Exp 3 (12.50 min viewing natural scenes) significantly improved decision-making reaction time compared with Con 3 (p = 0.09). Moreover, the accuracy slightly increased in Exp 3 after the intervention.ConclusionIn line with attention restoration theory, nature exposure significantly improved decision-making skills in mentally fatigue university players. However, the duration must be 12.50 min for each stimulus to stay longer to attract involuntary attention.
Keywords	nature exposure ; mental fatigue ; decision-making ; soccer ; performance ; Psychology ; BF1-990
Subject code	796 ; 150
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Caution of retinal toxicity using chloroquine and hydroxychloroquine in the treatment of COVID-19

Li-Yuan Wang / He Sun

Guoji Yanke Zazhi, Vol 20, Iss 7, Pp 1290-

2020 Volume 1294

Abstract: Chloroquine phosphate” was listed as a trial drug in diagnosis and treatment program of COVID-19(trial sixth edition), and the application of chloroquine and hydroxychloroquine treatment for COVID-19 in medical institutions also increased. Chloroquine ... ...

Abstract	“Chloroquine phosphate” was listed as a trial drug in diagnosis and treatment program of COVID-19(trial sixth edition), and the application of chloroquine and hydroxychloroquine treatment for COVID-19 in medical institutions also increased. Chloroquine and hydroxychloroquine have certain retinal toxicity, its mechanism is still unclear, due to different drug tolerance, the risk degree of retinal toxicity in COVID-19 treatment is unclear. Therefore, when using chloroquine and hydroxychloroquine in the treatment of COVID-19, it is recommended to choose the appropriate dosage according to patients' situation, and adopt necessary ophthalmic screening for patients with high risk to prevent the occurrence of retinopathy. In this paper, we described the risk factors, clinical manifestations and screening methods of retinal toxicity caused by chloroquine and hydroxychloroquine, in order to provide references for the safer use of chloroquine and hydroxychloroquine in the treatment of COVID-19.
Keywords	chloroquine ; hydroxychloroquine ; covid-19 ; retinal toxicity ; Ophthalmology ; RE1-994 ; covid19
Subject code	610
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Press of International Journal of Ophthalmology (IJO PRESS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efficacy and safety of curcumin in diabetic retinopathy

Liyuan Wang / Jiayu Xu / Tianyang Yu / Hanli Wang / Xiaojun Cai / He Sun

PLoS ONE, Vol 18, Iss

A protocol for systematic review and meta-analysis

2023 Volume 4

Abstract: Background Diabetic retinopathy (DR) is one of the most common complications of diabetes and has become a major global cause of blindness. Curcumin, an extract of Curcuma longa (turmeric), is effective in preventing and treating diabetes. Recent studies ... ...

Abstract	Background Diabetic retinopathy (DR) is one of the most common complications of diabetes and has become a major global cause of blindness. Curcumin, an extract of Curcuma longa (turmeric), is effective in preventing and treating diabetes. Recent studies have shown that curcumin can delay DR development. However, there has been no systematic review of its treatment of DR. This study will conduct a systematic review and meta-analysis of currently published randomized controlled trials (RCT) of curcumin for treating DR patients to evaluate its efficacy and safety. Methods We will search the relevant studies of curcumin in the treatment of DR in PubMed, Medline, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases from their respective inception dates to May 2022. A meta-analysis of the data extracted from qualified RCTs will be conducted, including the progression of DR, visual acuity, visual field, macular edema, quality of life, and adverse events. The meta-analysis will be performed using Review Manager 5.4.1 software, and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence. Results The results of this study will provide sound and high-quality evidence for the efficacy and safety of curcumin in the treatment of DR. Conclusion This study will be the first meta-analysis to comprehensively assess the efficacy and safety of curcumin in the treatment of DR and will provide helpful evidence for the clinical management of this disease. Systematic review registration INPLASY202250002.
Keywords	Medicine ; R ; Science ; Q
Subject code	028
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Urban fringes green space fragmentation on ecosystem service value.

Yingying Guan / Xueming Li / Songbo Li / He Sun / He Liu

PLoS ONE, Vol 17, Iss 2, p e

2022 Volume 0263452

Abstract: In this study, an urban fringe green space classification system was established to explore the spatiotemporal variation of green space landscape and ecosystem service value (ESV) based on multi-source land-use data of Ganjingzi district from 2000 to ... ...

Abstract	In this study, an urban fringe green space classification system was established to explore the spatiotemporal variation of green space landscape and ecosystem service value (ESV) based on multi-source land-use data of Ganjingzi district from 2000 to 2018. (1) Results show that the total green space area declined from 359.57 to 213.46 km2 over the study period. Green space large plaque index (LPI) and class area both gradually declined, whereas the number of plaques (NP) and plaque density (PD) gradually increased, indicating green space landscape fragmentation. (2) Additionally, the value of green space ecosystem services reduced from 397.42 to 124.93 million yuan. The dynamic degree of ESV change in green space increased or decreased moderately, always being < 0 and showing a decreasing trend of ESV. From a spatial variation perspective, dynamic degrees of ESV variation in the western and northern regions with relatively intensive green space were higher than those in the east. Regarding ESV of various green space types, forest land had the highest functional values of ecological regulation and support, whereas arable land provided the highest functional values of production supply. (3) The ecological service function value of green space system is negatively correlated with PD, NP, edge density, landscape shape index, and Shannon's diversity index, and positively correlated with aggregation index, contagion metrics, and LPI. The correlation coefficient between the climate regulation function of forest and the change of number of plaques is -0.874. The correlation coefficient of the recreation and culture of the wetland to the plaque density change is no less than -0.214.
Keywords	Medicine ; R ; Science ; Q
Subject code	710
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A new method of observation data processing to improve the precision of naval gun

XIE Wei-he, SUN Dong-yan, ZHAO Cong

Zhihui kongzhi yu fangzhen, Vol 42, Iss 2, Pp 65-

2023 Volume 68

Abstract: The observation data procession of target about traditional naval gun is based on installation site,dues to factors such as swing and deformation datum change will cause observation data error and affect firing accuracy,this paper analyzes the naval gun ... ...

Abstract	The observation data procession of target about traditional naval gun is based on installation site,dues to factors such as swing and deformation datum change will cause observation data error and affect firing accuracy,this paper analyzes the naval gun firing accutacy caused by the state of platform and naval gun enchmark assumptions, new methods of data processing is put forward, the mathematical model for calculating the arameters of observation target is established, which provides a new way to process the observation data.
Keywords	shipborn-gun\|shooting precision\|relative coordinates\|smoothing\|coordinate system ; Military Science ; U
Language	Chinese
Publishing date	2023-04-01T00:00:00Z
Publisher	Editorial Office of Command Control and Simulation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Taichi Chuan on health-related physical fitness in adults: A systematic review with meta-analysis.

Qi, Fengmeng / Soh, Kim Geok / Nasiruddin, Nasnoor Juzaily Mohd / Leong, Ong Swee / He, Sun / Liu, Huange

Complementary therapies in medicine

2023 Volume 77, Page(s) 102971

Abstract: Purpose: Taichi Chuan was previously shown to benefit physical health, but the results were inconsistent. The main reason is that the mechanism is not clear and may be interpreted differently. In this systematic review, we analyzed the data obtained ... ...

Abstract	Purpose: Taichi Chuan was previously shown to benefit physical health, but the results were inconsistent. The main reason is that the mechanism is not clear and may be interpreted differently. In this systematic review, we analyzed the data obtained from various randomized controlled trials to identify the effectiveness of Taichi Chuan and the mechanism by which it improves the physical health of adults. Methods: We systematically searched various databases, including PubMed, Web of Science, Scopus, Embase, EBSCO Host, Science Direct, CNKI, Wan-Fang, and VPCS, and obtained 1448 articles for review. The articles were selected following the PICO eligibility criteria. We performed a systematic review and meta-analysis to interpret the results of the different studies. Results: We included 16 studies in the systematic review. Six of them were of very high quality, ten were of acceptable quality. Overall, the results showed that Taichi Chuan is beneficial to physical fitness, but not all indices supported this statement. Specifically, the effects were significant on Balance (ES = - 0.33; P = 0.02), BMI (ES = - 0.83; P < 0.00001), body fat (ES = - 0.45; P < 0.00001), and vital capacity (ES = 23.39; P = 0.01). However, there were no significant effects on systolic blood pressure (ES = 0.07; P = 0.94) and diastolic blood pressure (ES = 0.03; P = 0.97). Conclusion: We found sufficient high-quality evidence to suggest that Taichi Chuan affects balance, BMI, body fat, vital capacity, and flexibility (sit-reach) in adults. The mechanism can be explained by low posture (balance) and moderate intensity of Taichi Chuan. However, no study has explained how to maintain concentration while keeping a dynamic low posture, which made it difficult to validate the finding that Taichi Chuan can reduce sympathetic tension under stress. In this study, we assumed that relaxation methods, which work on the central nervous system that links the body and the mind, might be the key explanation. However, further studies based on scientific, replicable methods need to be performed to confirm our findings.
MeSH term(s)	Humans ; Adult ; Physical Fitness ; Blood Pressure ; Relaxation Therapy
Language	English
Publishing date	2023-08-14
Publishing country	Scotland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2023.102971
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Key person ethical decision-making and substandard drugs rejection intentions.

Xiaohong Ren / Xiaoyan Wang / He Sun

PLoS ONE, Vol 15, Iss 3, p e

2020 Volume 0229412

Abstract: Substandard drugs are a major public health issue worldwide. Key person such as the Qualified Person in China and Europe is responsible for rejecting substandard drugs during the manufacturing stage. This study applies the Hunt-Vitell ethical decision- ... ...

Abstract	Substandard drugs are a major public health issue worldwide. Key person such as the Qualified Person in China and Europe is responsible for rejecting substandard drugs during the manufacturing stage. This study applies the Hunt-Vitell ethical decision-making model to study their rejection intentions on substandard drugs. Using the experimental vignette methodology, two scenarios were developed to represent different levels of deviation from regulations in pharmaceutical manufacturing. Responses from 204 Chinese key persons show a decline in deontology, ethical judgment, and rejection intention, and an increase in teleology in the minor deviation scenario, in comparison with the major deviation scenario. The results from the two scenarios show that the Hunt-Vitell ethical decision-making model is well fitted to explain substandard drug rejection intentions. Organizational and occupational commitments have a significant positive impact on deontological evaluation. Whereas, occupational commitments have a significant negative impact on teleological evaluation. This study suggests that strengthening occupational commitment can significantly affect key person's rejection intentions of substandard drugs.
Keywords	Medicine ; R ; Science ; Q
Subject code	170
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Network Integration Analysis and Immune Infiltration Analysis Reveal Potential Biomarkers for Primary Open-Angle Glaucoma

Liyuan Wang / Tianyang Yu / Xiaohui Zhang / Xiaojun Cai / He Sun

Frontiers in Cell and Developmental Biology, Vol

2021 Volume 9

Abstract: Primary open-angle glaucoma (POAG) is a progressive optic neuropathy and its damage to vision is irreversible. Therefore, early diagnosis assisted by biomarkers is essential. Although there were multiple researches on the identification of POAG ... ...

Abstract	Primary open-angle glaucoma (POAG) is a progressive optic neuropathy and its damage to vision is irreversible. Therefore, early diagnosis assisted by biomarkers is essential. Although there were multiple researches on the identification of POAG biomarkers, few studies systematically revealed the transcriptome dysregulation mechanism of POAG from the perspective of pre- and post-transcription of genes. Here, we have collected multiple sets of POAG’s aqueous humor (AH) tissue transcription profiles covering long non-coding RNA (lncRNA), mRNA and mircoRNA (miRNA). Through differential expression analysis, we identified thousands of significant differentially expressed genes (DEGs) between the AH tissue of POAG and non-glaucoma. Further, the DEGs were used to construct a competing endogenous RNA (ceRNA) regulatory network and 1,653 qualified lncRNA-miRNA-mRNA regulatory units were identified. Two ceRNA regulatory subnets were identified based on the random walk algorithm and revealed to be involved in the regulation of multiple complex diseases. At the pre-transcriptional regulation level, a transcriptional regulatory network was constructed and three transcription factors (FOS, ATF4, and RELB) were identified to regulate the expression of multiple genes and participate in the regulation of T cells. Moreover, we revealed the immune desert status of AH tissue for POAG patients based on immune infiltration analysis and identified a specific AL590666.2-hsa−miR−339−5p-UROD axis can be used as a biomarker of POAG. Taken together, the identification of regulatory mechanisms and biomarkers will contribute to the individualized diagnosis and treatment for POAG.
Keywords	primary open-angle glaucoma ; ceRNA ; transcription factors ; immune infiltration ; biomarkers ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Evolution of the Urban Residential Space Structure and Driving Forces in the Megacity—A Case Study of Shenyang City

He Sun / Xueming Li / Yingying Guan / Shenzhen Tian / He Liu

Land, Vol 10, Iss 1081, p

2021 Volume 1081

Abstract: For megacities, they are in a period of transformation from extensive development to smart growth. Recognizing new characteristics and new changes of the residential space in megacities under the backdrop of new development has great practical ... ...

Abstract	For megacities, they are in a period of transformation from extensive development to smart growth. Recognizing new characteristics and new changes of the residential space in megacities under the backdrop of new development has great practical significance for realizing the sustainable development of the city. As the only megacity in Northeast China, Shenyang was selected to be the research object, with 1989–2018 as the research period. The research comprehensively used multiple spatial representation methods and statistical methods to study the residential space pattern and driving factors in Shenyang City. The results showed that: (1) Residential space expansion can be divided into four stages: slow development, rapid expansion, speedy expansion, and stable extension. (2) The residential space structure presented a spatial evolution characteristic of overall expansion, forming multiple secondary core density centers. The east-west direction had a larger extension range than the northeast-southwest direction. There was an axisymmetric zonal distribution on both sides of the Hun River. (3) The agglomeration of different residential forms was obvious, and the spatial heterogeneity was increasingly stronger. (4) Urban planning measures and economic strength were the main driving forces of residential space expansion.
Keywords	residential space ; structural evolution ; multiple linear regression analysis ; Shenyang City ; Agriculture ; S
Subject code	710
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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