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Article: Identification of key genes as potential diagnostic and therapeutic targets for comorbidity of myasthenia gravis and COVID-19.

Huang, Liyan / Zuo, Yao / Yang, Hui / He, Xiaofang / Zhang, Lin

2024 Volume 14, Page(s) 1334131

Abstract: Introduction: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder. Coronavirus disease 2019 (COVID-19) has a significant impact on the health and quality of life of MG patients and may even trigger the onset of MG in some cases. With ... ...

Abstract	Introduction: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder. Coronavirus disease 2019 (COVID-19) has a significant impact on the health and quality of life of MG patients and may even trigger the onset of MG in some cases. With the worldwide development of the COVID-19 vaccination, several new-onset MG cases and exacerbations following the COVID-19 vaccines have been acknowledged. The potential link between myasthenia gravis (MG) and COVID-19 has prompted the need for further investigation into the underlying molecular mechanism. Methods and results: The differential expression analysis identified six differentially expressed genes (DEGs) shared by myasthenia gravis (MG) and COVID-19, namely SAMD9, PLEK, GZMB, JUNB, NR4A1, and NR1D1. The relationship between the six common genes and immune cells was investigated in the COVID-19 dataset. The predictive value of the shared genes was assessed and a nomogram was constructed using machine learning algorithms. The regulatory miRNAs, transcription factors and small molecular drugs were predicted, and the molecular docking was carried out by AutoDock. Discussion: We have identified six common DEGs of MG and COVID-19 and explored their immunological effects and regulatory mechanisms. The result may provide new insights for further mechanism research.
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1334131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dual Effects of Cold Storage and Stored Host Eggs of

Qiu, Ranran / Li, Jun / Desneux, Nicolas / Zang, Liansheng / He, Xiaofang / Lü, Xin

Insects

2024 Volume 15, Issue 4

Abstract: Spodoptera ... ...

Abstract	Spodoptera frugiperda
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects15040233
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Decoding emotional resilience in aging: unveiling the interplay between daily functioning and emotional health.

Guo, Minhua / Xu, Songyang / He, Xiaofang / He, Jiawei / Yang, Hui / Zhang, Lin

Frontiers in public health

2024 Volume 12, Page(s) 1391033

Abstract: Background: EPs pose significant challenges to individual health and quality of life, attracting attention in public health as a risk factor for diminished quality of life and healthy life expectancy in middle-aged and older adult populations. Therefore, ...

Abstract	Background: EPs pose significant challenges to individual health and quality of life, attracting attention in public health as a risk factor for diminished quality of life and healthy life expectancy in middle-aged and older adult populations. Therefore, in the context of global aging, meticulous exploration of the factors behind emotional issues becomes paramount. Whether ADL can serve as a potential marker for EPs remains unclear. This study aims to provide new evidence for ADL as an early predictor of EPs through statistical analysis and validation using machine learning algorithms. Methods: Data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) national baseline survey, comprising 9,766 samples aged 45 and above, were utilized. ADL was assessed using the BI, while the presence of EPs was evaluated based on the record of "Diagnosed with Emotional Problems by a Doctor" in CHARLS data. Statistical analyses including independent samples Results: Population demographic analysis revealed a significantly lower average BI score of 65.044 in the "Diagnosed with Emotional Problems by a Doctor" group compared to 85.128 in the "Not diagnosed with Emotional Problems by a Doctor" group. Pearson correlation analysis indicated a significant negative correlation between ADL and EPs ( Conclusion: This study, employing various statistical methods, identified a negative correlation between ADL and EPs, with machine learning algorithms confirming this finding. Impaired ADL increases susceptibility to EPs.
MeSH term(s)	Humans ; Female ; Male ; Aged ; Middle Aged ; Longitudinal Studies ; Activities of Daily Living ; China ; Aging/psychology ; Aging/physiology ; Machine Learning ; Resilience, Psychological ; Quality of Life ; Aged, 80 and over ; Mental Health ; Emotions
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2024.1391033
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insights into the Activation Mode of α-Carbonyl Sulfoxonium Ylides in Rhodium-Catalyzed C-H Activation: A Theoretical Study.

Zhang, Dianmin / He, Xiaofang / Yang, Tao / Liu, Song

ChemistryOpen

2022 Volume 11, Issue 7, Page(s) e202100254

Abstract: A computational study has been performed to investigate the mechanism of ... ...

Abstract	A computational study has been performed to investigate the mechanism of Rh
MeSH term(s)	Catalysis ; Models, Theoretical ; Rhodium/chemistry
Chemical Substances	Rhodium (DMK383DSAC)
Language	English
Publishing date	2022-02-24
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2655605-4
ISSN	2191-1363 ; 2191-1363
ISSN (online)	2191-1363
ISSN	2191-1363
DOI	10.1002/open.202100254
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bacterial Community Survey of

Guo, Wei / Zhang, Meijiao / Lin, Liangguan / Zeng, Chenxu / Zhang, Yuping / He, Xiaofang

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: ... ...

Abstract	Wolbachia
MeSH term(s)	Animals ; Male ; Hymenoptera ; Anti-Bacterial Agents/pharmacology ; Temperature ; Wolbachia/genetics ; Parthenogenesis ; Wasps/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098448
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Article: Hypoglycemic effects of dendrobium officinale leaves.

Lv, Ming / Liang, Qingqing / He, Xiaofang / Du, Xiaocui / Liu, Yuhan / Liu, Yan / Fang, Chongye

Frontiers in pharmacology

2023 Volume 14, Page(s) 1163028

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1163028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The association of asthma duration with body mass index and Weight-Adjusted-Waist index in a nationwide study of the U.S. adults.

Han, Xiaoxiao / He, Xiaofang / Hao, Gui / Cao, Lifang / Qi, Yinliang / Han, Kexing

European journal of medical research

2023 Volume 28, Issue 1, Page(s) 122

Abstract: Backgrounds: The association between obesity and asthma has been of interest, but whether the duration of asthma has an effect on obesity is still limitedly studied.: Aim: The purpose of this study was to investigate the association between asthma ... ...

Abstract	Backgrounds: The association between obesity and asthma has been of interest, but whether the duration of asthma has an effect on obesity is still limitedly studied. Aim: The purpose of this study was to investigate the association between asthma duration and obesity-related indexes, where obesity-related indexes include Body mass index (BMI) and Weight-adjusted-waist index (WWI). Methods: Data from National Health and Nutrition Examination Survey (NHANES) 2009-2018 were obtained to conduct this cross-sectional study. Duration of asthma was used as the independent variable and obesity-related indexes as the response variables. Multiple linear regression was used to assess the association between the independent variable and the response variables, and subsequently smoothed curve fitting and threshold effect analysis were performed to clarify whether there was a nonlinear correlation between the independent variable and the response variables. Finally, subgroup analysis was conducted to find sensitive populations. Results: A total of 9170 participants were included in the analysis. Asthma duration was statistically different between the two groups when all participants were grouped by median WWI (Q1 < 11.65, Q2 ≥ 11.65) (P < 0.001), but not by median BMI (Q1 < 31.8, Q2 ≥ 31.8) (P = 0.130). There was a positive association between asthma duration and WWI [β = 0.016, 95% CI (0.016, 0.017)], but a negative one with BMI [β = - 0.098, 95% CI (- 0.112, - 0.085)], and the correlations between the independent and response variables became more pronounced with increasing asthma duration (P for trend < 0.01). In addition, there were nonlinear relationships between asthma duration with BMI and WWI (log likelihood ratio < 0.001), with the best valid inflection points for asthma duration being 2 years (with WWI as the response variable) and 3 years (with BMI as the response variable), respectively. In the subgroup analysis, the positive association between asthma duration and WWI was more pronounced in the participants who were male, aged less than 40 years, and had asthma onset before 12 years of age. In contrast, when BMI was used as the response variable, the negative association between it and asthma duration was more pronounced among participants of female, aged 60 years or older, and with asthma onset less than 12 years of age. Conclusions: In US adults, asthma duration might cause changes in obesity-related indexes. Longer asthma duration might cause weight loss, but might increase the risk of abdominal obesity.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Middle Aged ; Body Mass Index ; Nutrition Surveys ; Cross-Sectional Studies ; Obesity/epidemiology ; Obesity/complications ; Asthma/epidemiology ; Asthma/complications
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-023-01089-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dietary rutin improves breast meat quality in heat‐stressed broilers and protects mitochondria from oxidative attack via the AMPK/PINK1–Parkin pathway

Chen, Shun / Liu, Huijuan / Zhang, Jiaqi / Zhou, BinBin / He, Xiaofang / Wang, Tian / Wang, Chao

Journal of the Science of Food and Agriculture. 2023 Mar. 30, v. 103, no. 5 p.2367-2377

2023

Abstract: BACKGROUND: This study was conducted to investigate the effect of dietary rutin on the meat quality, antioxidant status and mitochondrial structure and function in the breast muscle of heat‐stressed broilers. A total of 192 male broilers were randomly ... ...

Abstract	BACKGROUND: This study was conducted to investigate the effect of dietary rutin on the meat quality, antioxidant status and mitochondrial structure and function in the breast muscle of heat‐stressed broilers. A total of 192 male broilers were randomly assigned into three groups and treated with normal control (CON), heat stress (34 °C, HS), and HS with 500 mg kg⁻¹ rutin supplementation (HS + Rutin), respectively. RESULTS: Dietary rutin significantly reversed HS‐induced decrease in body weight, average daily feed intake, average daily gain, and feed efficiency. Rutin supplementation attenuated HS‐induced impaired meat quality by decreasing the lightness, drip loss at 24 and 48 h, the peak time of free water (T₂₂) and the peak area ratio of free water (P₂₂), and increasing the pH₂₄ₕ and peak area ratio of immobilized water (P₂₁). Rutin supplementation promoted superoxide dismutase, glutathione peroxidase activities and total antioxidant capacity, and decreased malondialdehyde levels compared with the HS group. Moreover, rutin attenuated HS‐induced mitochondrial damage by increasing the mitochondrial DNA copy number and improving mitochondrial morphology. Dietary rutin significantly increased mitochondrial biogenesis‐related mRNA (proliferator‐activated γ receptor coactivator‐1α [PGC‐1α], nuclear respiratory factor 1 [NRF1], and mitochondrial transcription factor A [TFAM]) expression via the AMP‐activated protein kinase (AMPK) signaling pathway. HS significantly increased mitophagy‐related genes and proteins (Parkin, PTEN‐induced putative kinase 1 [PINK1], microtubule associated protein light chain 3‐II [LC3‐II]) expression, and dietary rutin significantly reversed these alterations. CONCLUSION: Dietary rutin attenuated the HS‐induced decline in meat quality and antioxidant capacity of broilers, which may be related to inhibition of the AMPK/PINK1–Parkin signaling pathway to attenuate mitochondrial damage. © 2023 Society of Chemical Industry.
Keywords	AMP-activated protein kinase ; agriculture ; antioxidant activity ; antioxidants ; average daily gain ; body weight ; breast meat ; breast muscle ; decline ; drip loss ; feed conversion ; feed intake ; glutathione peroxidase ; heat stress ; males ; malondialdehyde ; meat quality ; microtubules ; mitochondria ; mitochondrial DNA ; rutin ; superoxide dismutase ; transcription factors
Language	English
Dates of publication	2023-0330
Size	p. 2367-2377.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.12431
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Dietary Association with Midgut Microbiota Components of Eocanthecona furcellata (Wolff)

Kuang, Zhaolang / Wen, Jian / Zhu, Yongji / He, Xiaofang / Chen, Kewei

Diversity. 2022 Dec. 16, v. 14, no. 12

2022

Abstract: Eocanthecona furcellata is an important predatory stinkbug that attacks many lepidopteran pests. For mass-rearing, artificial diets are used to rear this predator in the laboratory; however, the fitness of the predators is reduced, and little is known ... ...

Abstract	Eocanthecona furcellata is an important predatory stinkbug that attacks many lepidopteran pests. For mass-rearing, artificial diets are used to rear this predator in the laboratory; however, the fitness of the predators is reduced, and little is known about the cause. Since gut microbiota plays vital roles in the digestion and development of many hosts and can consequently affect host fitness, an understanding of the microbial community composition of E. furcellata may help to solve this unresolved problem. We compared the development and reproduction of E. furcellata reared on an artificial diet, and a natural (Spodoptera litura) or semi-natural (Tenebrio molitor) diet, and then the midgut microbiota were assessed using high-throughput 16S rRNA. The results of the high-throughput 16S rRNA show that the bacterial richness and diversity in the artificial diet gut samples increased considerably compared with the other samples. Proteobacteria and Firmicutes were the dominant phyla in E. furcellata. At the genus level, Serratia (however, the relative abundance was lower in the artificial diet gut samples), Enterococcus, and an uncultured bacterium genus of family Enterobacteriaceae, were dominant. The midgut microbiota components significantly differed among the diets, indicating that the gut bacteria had a dietary association with E. furcellata. This study provides a better understanding of midgut microbiota and the artificial diets that might affect them in E. furcellata.
Keywords	Enterococcus ; Eocanthecona furcellata ; Serratia ; Spodoptera litura ; Tenebrio molitor ; artificial diets ; bacteria ; community structure ; digestion ; intestinal microorganisms ; mass rearing ; microbial communities ; midgut ; reproduction
Language	English
Dates of publication	2022-1216
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d14121130
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Rubbing Salt in the Wound: Molecular Evolutionary Analysis of Pain-Related Genes Reveals the Pain Adaptation of Cetaceans in Seawater

Ding, Xiaoyue / Yu, Fangfang / He, Xiaofang / Xu, Shixia / Yang, Guang / Ren, Wenhua

Animals. 2022 Dec. 16, v. 12, no. 24

2022

Abstract: Pain, usually caused by a strong or disruptive stimulus, is an unpleasant sensation that serves as a warning to organisms. To adapt to extreme environments, some terrestrial animals have evolved to be inherently insensitive to pain. Cetaceans are known ... ...

Abstract	Pain, usually caused by a strong or disruptive stimulus, is an unpleasant sensation that serves as a warning to organisms. To adapt to extreme environments, some terrestrial animals have evolved to be inherently insensitive to pain. Cetaceans are known as supposedly indifferent to pain from soft tissue injury representatives of marine mammals. However, the molecular mechanisms that explain how cetaceans are adapted to pain in response to seawater environment remain unclear. Here, we performed a molecular evolutionary analysis of pain-related genes in selected representatives of cetaceans. ASIC4 gene was identified to be pseudogenized in all odontocetes (toothed whales) except from Physeter macrocephalus (sperm whales), and relaxed selection of this gene was detected in toothed whales with pseudogenized ASIC4. In addition, positive selection was detected in pain perception (i.e., ASIC3, ANO1, CCK, and SCN9A) and analgesia (i.e., ASIC3, ANO1, CCK, and SCN9A) genes among the examined cetaceans. In this study, potential convergent amino acid substitutions within predicted proteins were found among the examined cetaceans and other terrestrial mammals, inhabiting extreme environments (e.g., V441I of TRPV1 in cetaceans and naked mole rats). Moreover, specific amino acid substitutions within predicted sequences of several proteins were found in the studied representatives of cetaceans (e.g., F56L and D163A of ASIC3, E88G of GRK2, and F159L of OPRD1). Most of the substitutions were located within important functional domains of proteins, affecting their protein functions. The above evidence suggests that cetaceans might have undergone adaptive molecular evolution in pain-related genes through different evolutionary patterns to adapt to pain, resulting in greater sensitivity to pain and more effective analgesia. This study could have implications for diagnosis and treatment of human pain.
Keywords	Physeter macrocephalus ; amino acids ; analgesia ; evolution ; genes ; humans ; moles ; pain ; seawater ; spermatozoa ; tissues ; transient receptor potential vanilloid channels
Language	English
Dates of publication	2022-1216
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12243571
Database	NAL-Catalogue (AGRICOLA)

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