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  1. Article ; Online: Hollow Cu

    Gao, Qianqian / He, Xuelu / He, Lulu / Lin, Jie / Wang, Le / Xie, Yujiao / Wu, Aiguo / Li, Juan

    Nanoscale

    2023  Volume 15, Issue 44, Page(s) 17987–17995

    Abstract: Chemodynamic therapy (CDT) and photothermal therapy (PTT) have gained popularity due to their non-invasive characteristics and satisfying therapeutic expectations. A Cu-based nanomaterial serving as a Fenton-like nanocatalyst for CDT together with a ... ...

    Abstract Chemodynamic therapy (CDT) and photothermal therapy (PTT) have gained popularity due to their non-invasive characteristics and satisfying therapeutic expectations. A Cu-based nanomaterial serving as a Fenton-like nanocatalyst for CDT together with a photothermal agent for simultaneous PTT seems to be a powerful strategy. In this work, the morphological effect of Cu
    MeSH term(s) Humans ; Combined Modality Therapy ; Autophagy ; Chloroquine ; Nanoparticles ; Nanostructures ; Cell Line, Tumor ; Neoplasms
    Chemical Substances Chloroquine (886U3H6UFF)
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr03260d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A D-Y Shaped Neuropeptide Y Mimetic Peptide-Dye Self-Assembly with Maximal Emission Beyond 1300 nm and Glioma Mitochondrial Activity Modulation.

    Li, Yanying / He, Xuelu / Wang, Pin / Yuan, Bo / Pan, Yuanbo / Hu, Xueyin / Lu, Liheng / Wu, Aiguo / Li, Juan

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 20, Issue 13, Page(s) e2308621

    Abstract: Neuropeptide Y (NPY), as one of the most abundant neuropeptides known, is widely distributed in the central and peripheral nervous system. However, most of the reported NPY-mimetic peptides are hard to cross the blood-brain barrier, target glioma ... ...

    Abstract Neuropeptide Y (NPY), as one of the most abundant neuropeptides known, is widely distributed in the central and peripheral nervous system. However, most of the reported NPY-mimetic peptides are hard to cross the blood-brain barrier, target glioma mitochondria, and achieve self-assembly nanostructure in situ. Here, based on the α-helix structure of the novel chiral NPY-mimetic peptides
    MeSH term(s) Neuropeptide Y ; Receptors, Neuropeptide Y/metabolism ; Blood-Brain Barrier/metabolism
    Chemical Substances Neuropeptide Y ; Receptors, Neuropeptide Y
    Language English
    Publishing date 2023-12-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202308621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy

    He, Xuelu / Jiang, Zhenqi / Akakuru, Ozioma Udochukwu / Li, Juan / Wu, Aiguo

    Chemical communications. 2021 Nov. 23, v. 57, no. 93

    2021  

    Abstract: Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of ... ...

    Abstract Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability in vivo, thus impeding their further biomedical applications. This Review focuses on the controlled design strategies of nanoscale COFs (NCOFs), unique properties of NCOFs for biomedical applications, and recent progress in NCOFs for cancer therapy. In addition, current challenges for the biomedical use of NCOFs and perspectives for further improvements are presented.
    Keywords bioavailability ; biocompatibility ; cancer therapy ; catalytic activity ; energy ; medicine ; porosity ; surface area
    Language English
    Dates of publication 2021-1123
    Size p. 12417-12435.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04846e
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy.

    He, Xuelu / Jiang, Zhenqi / Akakuru, Ozioma Udochukwu / Li, Juan / Wu, Aiguo

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 93, Page(s) 12417–12435

    Abstract: Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of ... ...

    Abstract Covalent organic frameworks (COFs), as a new type of crystalline porous materials, mainly consist of light-weight elements (H, B, C, N and O) linked by dynamic covalent bonds to form periodical structures of two or three dimensions. As an attribute of their low density, large surface area, and excellent adjustable pore size, COFs show great potential in many fields including energy storage and separation, catalysis, sensing, and biomedicine. However, compared with metal organic frameworks (MOFs), the relatively large size and irregular morphology of COFs affect their biocompatibility and bioavailability
    MeSH term(s) Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Biocompatible Materials/chemical synthesis ; Biocompatible Materials/pharmacology ; Biocompatible Materials/therapeutic use ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Humans ; Metal-Organic Frameworks/chemistry ; Nanostructures/chemistry ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplasms/therapy ; Phototherapy
    Chemical Substances Antineoplastic Agents ; Biocompatible Materials ; Drug Carriers ; Metal-Organic Frameworks
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04846e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Recent progress on near-infrared fluorescence heptamethine cyanine dye-based molecules and nanoparticles for tumor imaging and treatment.

    Qiu, Yue / Yuan, Bo / Cao, Yi / He, Xuelu / Akakuru, Ozioma Udochukwu / Lu, Liheng / Chen, Nengwen / Xu, Mengting / Wu, Aiguo / Li, Juan

    Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

    2023  Volume 15, Issue 5, Page(s) e1910

    Abstract: Recenly, near-infrared fluorescence heptamethine cyanine dyes have shown satisfactory values in bioengineering, biology, and pharmacy especially in cancer diagnosis and treatment, owing to their excellent fluorescence property and biocompatibility. In ... ...

    Abstract Recenly, near-infrared fluorescence heptamethine cyanine dyes have shown satisfactory values in bioengineering, biology, and pharmacy especially in cancer diagnosis and treatment, owing to their excellent fluorescence property and biocompatibility. In order to achieve broad application prospects, diverse structures, and chemical properties of heptamethine cyanine dyes have been designed to develop novel functional molecules and nanoparticles over the past decade. For fluorescence and photoacoustic tumor imaging properties, heptamethine cyanine dyes are equipped with good photothermal performance and reactive oxygen species production properties under near-infrared light irradiation, thus holding great promise in photodynamic and/or photothermal cancer therapies. This review offers a comprehensive scope of the structures, comparisons, and applications of heptamethine cyanine dyes-based molecules as well as nanoparticles in tumor treatment and imaging in current years. Therefore, this review may drive the development and innovation of heptamethine cyanine dyes, significantly offering opportunities for improving tumor imaging and treatment in a precise noninvasive manner. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
    MeSH term(s) Humans ; Fluorescence ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Nanoparticles/therapeutic use ; Nanoparticles/chemistry ; Coloring Agents ; Fluorescent Dyes/therapeutic use ; Fluorescent Dyes/chemistry ; Optical Imaging
    Chemical Substances heptamethine cyanine dye ; Coloring Agents ; Fluorescent Dyes
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2502698-7
    ISSN 1939-0041 ; 1939-5116
    ISSN (online) 1939-0041
    ISSN 1939-5116
    DOI 10.1002/wnan.1910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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