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  1. Article ; Online: Correspondence to "intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6-mediated protection associated with cecal microbiota changes".

    Chen, Xin / He, Yan-Qiu

    Allergy

    2024  

    Language English
    Publishing date 2024-02-25
    Publishing country Denmark
    Document type Letter
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.16075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 125: Show issues

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  2. Article: IER5L

    Chen, Xin / He, Yan-Qiu / Miao, Ti-Wei / Yin, Jie / Liu, Jie / Zeng, Hong-Ping / Zhu, Qi

    International journal of general medicine

    2023  Volume 16, Page(s) 5889–5908

    Abstract: Purpose: Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. Immediate early response 5 like (: Patients and methods: Gene expression and mutation profiles, DNA methylation data, and clinical information for cancers ... ...

    Abstract Purpose: Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. Immediate early response 5 like (
    Patients and methods: Gene expression and mutation profiles, DNA methylation data, and clinical information for cancers were downloaded from multiple databases. Relative expression, prognostic value, and correlation with disease progression of
    Results: Pan-cancer analysis displayed that
    Conclusion: Our findings show that increased
    Language English
    Publishing date 2023-12-13
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2452220-X
    ISSN 1178-7074
    ISSN 1178-7074
    DOI 10.2147/IJGM.S439190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: NGEF is a potential prognostic biomarker and could serve as an indicator for immunotherapy and chemotherapy in lung adenocarcinoma.

    Chen, Xin / Zhang, Tao / He, Yan-Qiu / Miao, Ti-Wei / Yin, Jie / Ding, Qian / Yang, Mei / Chen, Fang-Ying / Zeng, Hong-Ping / Liu, Jie / Zhu, Qi

    BMC pulmonary medicine

    2024  Volume 24, Issue 1, Page(s) 248

    Abstract: Background: Neuronal guanine nucleotide exchange factor (NGEF) plays a key role in several cancers; however, its role in lung adenocarcinoma (LUAD) remains unclear. The aim of this study was to evaluate the efficacy of NGEF as a prognostic biomarker and ...

    Abstract Background: Neuronal guanine nucleotide exchange factor (NGEF) plays a key role in several cancers; however, its role in lung adenocarcinoma (LUAD) remains unclear. The aim of this study was to evaluate the efficacy of NGEF as a prognostic biomarker and potential therapeutic target for LUAD.
    Methods: NGEF expression data for multiple cancers and LUAD were downloaded from multiple databases. The high- and low-NGEF expression groups were constructed based on median NGEF expression in LUAD samples, and then performed Kaplan-Meier survival analysis. Differentially expressed genes (DEGs) from the two NGEF expression groups were screened and applied to construct a protein-protein interaction network. The primary pathways were obtained using gene set enrichment analysis. The associations between NGEF expression and clinical characteristics, immune infiltration, immune checkpoint inhibitors (ICIs), sensitivity to chemotherapy, and tumor mutation burden (TMB) were investigated using R. Levels of NGEF expression in the lung tissue was validated using single-cell RNA sequencing, quantitative polymerase chain reaction (qPCR), immunohistochemical staining, and western blot analysis.
    Results: The expression of NGEF mRNA was upregulated in multiple cancers. mRNA and protein expression levels of NGEF were higher in patients with LUAD than in controls, as validated using qPCR and western blot. High NGEF expression was an independent prognostic factor for LUAD and was associated with advanced tumor stage, large tumor size, more lymph node metastasis, and worse overall survival (OS). A total of 182 overlapping DEGs were screened between The Cancer Genome Atlas and GSE31210, among which the top 20 hub genes were identified. NGEF expression was mainly enriched in the pathways of apoptosis, cell cycle, and DNA replication. Moreover, elevated NGEF expression were associated with a high fraction of activated memory CD4
    Conclusion: NGEF expression is upregulated in LUAD and is significantly associated with tumor stages, OS probability, immune infiltration, immunotherapy response, and chemotherapy response. NGEF may be a potential diagnostic and prognostic biomarker and therapeutic target in LUAD.
    MeSH term(s) Humans ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/pathology ; Adenocarcinoma of Lung/immunology ; Adenocarcinoma of Lung/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Lung Neoplasms/metabolism ; Prognosis ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Immunotherapy/methods ; Male ; Female ; Middle Aged ; Kaplan-Meier Estimate ; Gene Expression Regulation, Neoplastic ; Immune Checkpoint Inhibitors/therapeutic use ; Aged ; Protein Interaction Maps
    Language English
    Publishing date 2024-05-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-024-03046-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Construction of a redox-related gene signature for overall survival prediction and immune infiltration in non-small-cell lung cancer.

    Miao, Ti-Wei / Yang, De-Qing / Gao, Li-Juan / Yin, Jie / Zhu, Qi / Liu, Jie / He, Yan-Qiu / Chen, Xin

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 942402

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.942402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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