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Article ; Online: The Clinical Significance and the Potential Regulatory Mechanism of the LncRNA OIP5-AS1 in Paediatric Severe Community-Acquired Pneumonia Blood Through the MiR-150-5p/PDCD4 Axis.

Lu, Juan / Ren, Qingguo / Qi, Weiwei / Yang, Ning / He, Yuanyuan

2024 , Page(s) 1–18

Abstract: Background: This study aimed to elucidate the clinical significance and regulatory mechanism of the long non-coding RNA OIP5-AS1 in severe community-acquired pneumonia (SCAP) among paediatric patients.: Methods: qRT-PCR was used to assess the mRNA ... ...

Abstract	Background: This study aimed to elucidate the clinical significance and regulatory mechanism of the long non-coding RNA OIP5-AS1 in severe community-acquired pneumonia (SCAP) among paediatric patients. Methods: qRT-PCR was used to assess the mRNA levels of OIP5-AS1. ROC curve analysis was used to assess the diagnostic significance of OIP5-AS1. Short-term prognostic significance was evaluated through Kaplan-Meier survival. An in vitro cell model was developed using LPS-induced MRC-5 cells. CCK-8, flow cytometry, and ELISA were conducted to measure cell viability, apoptosis, and inflammatory factor levels. The association between miR-150-5p and PDCD4 was confirmed through DLR assays. Results: Elevated OIP5-AS1 were observed in paediatric patients with SCAP, which enabled effective differentiation from healthy individuals. High expression of OIP5-AS1 correlated with reduced survival rates. OIP5-AS1 knockdown attenuated cell viability suppression and the promotion of apoptosis and inflammatory factors induced by LPS. However, this attenuation was reversed by reduced levels of miR-150-5p. miR-150-5p was identified as a target of PDCD4 and OIP5-AS1. Conclusion: Increased OIP5-AS1 levels show potential as a valuable diagnostic and prognostic biomarker for paediatric patients with SCAP. This study illustrates its role in regulating cell viability, apoptosis, and the inflammatory response via the miR-150-5p/PDCD4 axis, acting as a ceRNA.
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2024.2309557
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Article ; Online: Carbon dot and silver nanoparticle-based fluorescent probe for the determination of sulfite and bisulfite via inner-filter effect and competitive redox reactions.

He, Yuanyuan / Wang, Yongbo / Wang, Shaojie

Mikrochimica acta

2023 Volume 190, Issue 5, Page(s) 190

Abstract: A new sensitive fluorescent probe (CDs-AgNP/ ... ...

Abstract	A new sensitive fluorescent probe (CDs-AgNP/H
Language	English
Publishing date	2023-04-24
Publishing country	Austria
Document type	Journal Article
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-023-05782-3
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Article ; Online: Cold atmospheric plasma stabilizes mismatch repair for effective, uniform treatment of diverse colorectal cancer cell types.

He, Yuanyuan / Lu, Fu / Jiang, Chenmin / Gong, Fanwu / Wu, Zhengwei / Ostrikov, Kostya

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3599

Abstract: Mismatch Repair (MMR) mechanisms play a pivotal role in rectifying DNA replication errors and maintaining the stability of DNA microsatellite structure. Colorectal cancer (CRC) can be characterized into microsatellite stability (MSS) and microsatellite ... ...

Abstract	Mismatch Repair (MMR) mechanisms play a pivotal role in rectifying DNA replication errors and maintaining the stability of DNA microsatellite structure. Colorectal cancer (CRC) can be characterized into microsatellite stability (MSS) and microsatellite instability (MSI) subtypes based on the functionality of MMR. MSI CRC notably exhibits enhanced chemotherapy resistance, attributable to diminished MMR-related protein expression. Cold atmospheric plasma (CAP) has emerged as a promising treatment modality, demonstrating efficacy in inducing apoptosis in various cancer cells. However, the therapeutic impact of CAP on MSI colorectal cancer, and the underlying mechanisms remain elusive. In this study, we investigated the effects of CAP on MSI (MC38, HCT116, and LOVO) and MSS (CT26 and HT29) CRC cell lines. We are probing into the products of CAP treatment. Our findings indicate that CAP treatment induces comparable effects on apoptosis, reactive oxygen species (ROS), and reactive nitrogen species (RNS), as well as the expression of apoptosis-related proteins in both MSI and MSS cells. Mechanistically, CAP treatment led to an elevation in the expression of mismatch repair proteins (MLH1 and MSH2), particularly in MSI cells, which notably have been proven to facilitate the activation of apoptosis-related proteins. Collectively, our study reveals that CAP enhances apoptotic signaling and induces apoptosis in MSI colorectal cancer cells by upregulating the expression of MMR-related proteins, thereby reinforcing MMR stabilization.
MeSH term(s)	Humans ; DNA Mismatch Repair ; Adaptor Proteins, Signal Transducing/genetics ; MutS Homolog 2 Protein/genetics ; Microsatellite Instability ; Microsatellite Repeats ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/drug therapy
Chemical Substances	Adaptor Proteins, Signal Transducing ; MutS Homolog 2 Protein (EC 3.6.1.3)
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54020-0
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Article ; Online: Antibody inhibition of influenza A virus assembly and release.

He, Yuanyuan / Guo, Zijian / Subiaur, Sofie / Benegal, Ananya / Vahey, Michael D

Journal of virology

2024 Volume 98, Issue 2, Page(s) e0139823

Abstract: Antibodies are frontline defenders against influenza virus infection, providing protection through multiple complementary mechanisms. Although a subset of monoclonal antibodies (mAbs) has been shown to restrict replication at the level of virus assembly ... ...

Abstract	Antibodies are frontline defenders against influenza virus infection, providing protection through multiple complementary mechanisms. Although a subset of monoclonal antibodies (mAbs) has been shown to restrict replication at the level of virus assembly and release, it remains unclear how potent and pervasive this mechanism of protection is, due in part to the challenge of separating this effect from other aspects of antibody function. To address this question, we developed imaging-based assays to determine how effectively a broad range of mAbs against the IAV surface proteins can specifically restrict viral egress. We find that classically neutralizing antibodies against hemagglutinin are broadly multifunctional, inhibiting virus assembly and release at concentrations 1-20-fold higher than the concentrations at which they inhibit viral entry. These antibodies are also capable of altering the morphological features of shed virions, reducing the proportion of filamentous particles. We find that antibodies against neuraminidase and M2 also restrict viral egress and that inhibition by anti-neuraminidase mAbs is only partly attributable to a loss in enzymatic activity. In all cases, antigen crosslinking-either on the surface of the infected cell, between the viral and cell membrane, or both-plays a critical role in inhibition, and we are able to distinguish between these modes experimentally and through a structure-based computational model. Together, these results provide a framework for dissecting antibody multifunctionality that could help guide the development of improved therapeutic antibodies or vaccines and that can be extended to other viral families and antibody isotypes.IMPORTANCEAntibodies against influenza A virus provide multifaceted protection against infection. Although sensitive and quantitative assays are widely used to measure inhibition of viral attachment and entry, the ability of diverse antibodies to inhibit viral egress is less clear. We address this challenge by developing an imaging-based approach to measure antibody inhibition of virus release across a panel of monoclonal antibodies targeting the influenza A virus surface proteins. Using this approach, we find that inhibition of viral egress is common and can have similar potency to the ability of an antibody to inhibit viral entry. Insights into this understudied aspect of antibody function may help guide the development of improved countermeasures.
MeSH term(s)	Humans ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza A virus/drug effects ; Influenza Vaccines ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Membrane Proteins ; Neuraminidase/metabolism ; Virus Assembly/drug effects
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Hemagglutinin Glycoproteins, Influenza Virus ; Influenza Vaccines ; Membrane Proteins ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01398-23
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Article ; Online: Generating bioactive and antiseptic interfaces with nano-silver hydroxyapatite-based coatings by pulsed electrochemical deposition for long-term efficient cervical soft tissue sealing.

Chen, Jie / Gai, Kuo / He, Yuanyuan / Xu, Yuchan / Guo, Weihua

Journal of materials chemistry. B

2023 Volume 11, Issue 2, Page(s) 345–358

Abstract: Infections related to osseointegrated implants have sparked the interest in studying titanium modification for long-term effective soft tissue sealing. Constructing a silver (Ag)-hydroxyapatite (HA) coating is regarded as an effective strategy for ... ...

Abstract	Infections related to osseointegrated implants have sparked the interest in studying titanium modification for long-term effective soft tissue sealing. Constructing a silver (Ag)-hydroxyapatite (HA) coating is regarded as an effective strategy for integrating antibiosis with osteanagenesis; however, the outcome for long-term cervical soft tissue sealing
MeSH term(s)	Dogs ; Animals ; Durapatite/pharmacology ; Durapatite/chemistry ; Osteogenesis ; Coated Materials, Biocompatible/pharmacology ; Coated Materials, Biocompatible/chemistry ; Anti-Infective Agents, Local/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
Chemical Substances	Durapatite (91D9GV0Z28) ; Coated Materials, Biocompatible ; Anti-Infective Agents, Local ; Anti-Bacterial Agents ; colloidal silver
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb02098j
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Article ; Online: Risk factors for readmission for hyperbilirubinemia in neonates with ABO hemolytic disease: a single-center retrospective cohort study.

Xu, Chuncai / Bao, Yingying / He, Yuanyuan / Wu, Mingyuan / Zhu, Jiajun

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2023 Volume 36, Issue 2, Page(s) 2238106

Abstract: Objective: ABO hemolytic disease of the newborn (ABO-HDN) is a major risk factor for severe hyperbilirubinemia, a common readmission reason for newborns. In this study, we aimed to assess the risk factors for readmission associated with ... ...

Abstract	Objective: ABO hemolytic disease of the newborn (ABO-HDN) is a major risk factor for severe hyperbilirubinemia, a common readmission reason for newborns. In this study, we aimed to assess the risk factors for readmission associated with hyperbilirubinemia in neonates with ABO-HDN. Methods: A retrospective cohort study was conducted including newborns with gestational age ≥35 weeks and ABO-HDN in 2018. Among 291 newborns, 36 were readmitted for hyperbilirubinemia and defined as the readmission group. The remaining 255 cases were used as a control group. We then performed between-group comparisons of clinical conditions associated with hyperbilirubinemia. Logistic regression was used to select risk predictors of readmission associated with hyperbilirubinemia due to ABO-HDN. Results: Baseline characteristics were similar between both groups ( Conclusions: Earlier age of phototherapy initiation, higher TSB levels at the time of initiating phototherapy and rebound hyperbilirubinemia after the first phototherapy treatment may increase the risk of readmission for hyperbilirubinemia in neonates with ABO-HDN. These factors should be considered in discharge planning and follow-up for newborns with ABO-HDN associated hyperbilirubinemia.
MeSH term(s)	Female ; Infant, Newborn ; Humans ; Infant ; Retrospective Studies ; Patient Readmission ; Bilirubin ; Hyperbilirubinemia/therapy ; Erythroblastosis, Fetal/therapy ; Risk Factors ; Phototherapy ; Hyperbilirubinemia, Neonatal/therapy ; ABO Blood-Group System
Chemical Substances	Bilirubin (RFM9X3LJ49) ; ABO Blood-Group System
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2023.2238106
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Zs.A 3510: Show issues

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Article ; Online: Plasma-microbubble treatment and sustainable agriculture application of diclofenac-contaminated wastewater

Liu, Qi / Ouyang, Wenchong / Yang, Xusheng / He, Yuanyuan / Wu, Zhengwei / Ostrikov, Kostya (Ken)

Elsevier Ltd Chemosphere. 2023 Sept., v. 334 p.138998-

2023

Abstract: The demand for efficient wastewater treatment is becoming increasingly urgent due to the rising threat of pharmaceutical residues in water. As a sustainable advanced oxidation process, cold plasma technology is a promising approach for water treatment. ... ...

Abstract	The demand for efficient wastewater treatment is becoming increasingly urgent due to the rising threat of pharmaceutical residues in water. As a sustainable advanced oxidation process, cold plasma technology is a promising approach for water treatment. However, the adoption of the technology encounters several challenges, including the low treatment efficiency and the potentially unknown environmental impact. Here, microbubble generation was integrated with cold plasma system to enhance treatment of wastewater contaminated with diclofenac (DCF). The degradation efficiency depended on the discharge voltage, gas flow, initial concentration, and pH value. The best degradation efficiency was 90.9% after 45 min plasma-bubble treatment under the optimum process parameters. The hybrid plasma-bubble system exhibited strongly synergistic performance heralded by up to seven-times higher DCF removal rates than the two systems operated separately. The plasma-bubble treatment remains effective even after addition of SO₄²⁻, Cl⁻, CO₃²⁻, HCO₃⁻, and humic acid (HA) as interfering background substances. The contributions of •O₂⁻, O₃, •OH, and H₂O₂ reactive species to the DCF degradation process were specified. The synergistic mechanisms for DCF degradation were deduced through the analysis of the degradation intermediates. Further, the plasma-bubble treated water was proven safe and effective to stimulate seed germination and plant growth for sustainable agriculture applications. Overall, these findings provide new insights and a feasible approach with a highly synergistic removal effect for the plasma-enhanced microbubble wastewater treatment, without generating secondary contaminants.
Keywords	cold ; diclofenac ; electric potential difference ; environmental impact ; humic acids ; microbubbles ; oxidation ; pH ; plant growth ; seed germination ; sustainable agriculture ; wastewater ; wastewater treatment ; Cold plasma ; Diclofenac degradation ; Synergistic effect
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.138998
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2540: Show issues

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Article ; Online: Recent advances on the relationship between the delta-like noncanonical Notch ligand 1 system and central precocious puberty†.

Lin, Yating / He, Yuanyuan / Sun, Wen / Wang, Yonghong / Yu, Jian

Biology of reproduction

2022 Volume 107, Issue 3, Page(s) 679–683

Abstract: Precocious puberty, as a common pediatric endocrine disease, can be divided into central precocious puberty and peripheral precocious puberty, even though most cases of precocious puberty are diagnosed as central precocious puberty. According to its ... ...

Abstract	Precocious puberty, as a common pediatric endocrine disease, can be divided into central precocious puberty and peripheral precocious puberty, even though most cases of precocious puberty are diagnosed as central precocious puberty. According to its etiology, central precocious puberty can be further divided into organic and idiopathic central precocious puberty. However, the mechanisms of idiopathic central precocious puberty have not yet been fully elucidated. Currently, four genes, including the kisspeptin gene, the kisspeptin receptor gene, the makorin ring finger protein 3, and the delta-like noncanonical Notch ligand 1, have been implicated in central precocious puberty cases, of which delta-like noncanonical Notch ligand 1 has been determined to represent a key, recently found central precocious puberty-related gene. In this review, we will not only highlight the latest discoveries on the relationship between the delta-like noncanonical Notch ligand 1 system and central precocious puberty but also explore the involvement of the system as well as the Notch signaling pathway in central precocious puberty occurrence.
MeSH term(s)	Child ; Humans ; Kisspeptins/genetics ; Ligands ; Puberty, Precocious/genetics ; Signal Transduction ; Ubiquitin-Protein Ligases
Chemical Substances	Kisspeptins ; Ligands ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioac106
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Zs.A 551: Show issues

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Article ; Online: Organic Small-Molecule Electrodes: Emerging Organic Composite Materials in Supercapacitors for Efficient Energy Storage.

He, Yuanyuan / Wei, Qiaoqiao / An, Ning / Meng, Congcong / Hu, Zhongai

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 22

Abstract: Organic small molecules with electrochemically active and reversible redox groups are excellent candidates for energy storage systems due to their abundant natural origin and design flexibility. However, their practical application is generally limited ... ...

Abstract	Organic small molecules with electrochemically active and reversible redox groups are excellent candidates for energy storage systems due to their abundant natural origin and design flexibility. However, their practical application is generally limited by inherent electrical insulating properties and high solubility. To achieve both high energy density and power density, organic small molecules are usually immobilized on the surface of a carbon substrate with a high specific surface area and excellent electrical conductivity through non-covalent interactions or chemical bonds. The resulting composite materials are called organic small-molecule electrodes (OMEs). The redox reaction of OMEs occurs near the surface with fast kinetic and higher utilization compared to storing charge through diffusion-limited Faraday reactions. In the past decade, our research group has developed a large number of novel OMEs with different connections or molecular skeletons. This paper introduces the latest development of OMEs for efficient energy storage. Furthermore, we focus on the design motivation, structural advantages, charge storage mechanism, and various electrode parameters of OMEs. With small organic molecules as the active center, OMEs can significantly improve the energy density at low molecular weight through proton-coupled electron transfer, which is not limited by lattice size. Finally, we outline possible trends in the rational design of OMEs toward high-performance supercapacitors.
Language	English
Publishing date	2022-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27227692
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Article ; Online: IOFS-SA: An interactive online feature selection tool for survival analysis.

Zhao, Xudong / He, Yuanyuan / Wu, Youlin / Liu, Tong / Wang, Guohua

Computers in biology and medicine

2022 Volume 150, Page(s) 106121

Abstract: Background: Survival analysis is a primary problem before clinical treatments to cancer patients after their operations. In order to make this kind of analysis simple, many corresponding tools have been proposed. Though these tools are easy to use, ... ...

Abstract	Background: Survival analysis is a primary problem before clinical treatments to cancer patients after their operations. In order to make this kind of analysis simple, many corresponding tools have been proposed. Though these tools are easy to use, there exist still two fatal flaws. One is that sample grouping is commonly empirical and wrongly based on original gene expressions or survival time. The other is that their feature selection methods mostly depend univariate semi-supervised regression or the multivariate one without considering the small sample size compared with the high dimension. Objective: In order to solve the two problems, we design an automatic feature selection web tool which can also satisfy interactive sample grouping. Methods: An automatic feature selection is performed on user-defined data or TCGA data. users can also perform manual feature selection. Then, hierarchical clustering is used and an automatic re-clustering strategy is proposed after interactive risk score split. Kaplan-Meier survival curve and log-rank test are utilized as the measurement. Results: Experimental results on 53 datasets from TCGA demonstrate the effectiveness of our method. The tree view, heat map and scatter map can intuitively display the result of the selected genes to the doctors for further research. Conclusions: This method is suitable for survival analysis of high-dimensional small sample data sets. At the same time, it also provides a platform for researchers to analyze custom data. It solves the problems of the existing web tools and provides an effective feature selection method for survival analysis. Availability: The full code package is freely available and can be downloaded at https://github.com/Yuan-23/IOFS-SA-ecp-data-main, and the online version at https://bioinfor.nefu.edu.cn/IOFS-SA/ is ready for use freely.
MeSH term(s)	Humans ; Software ; Survival Analysis ; Kaplan-Meier Estimate ; Neoplasms/genetics ; Cluster Analysis
Language	English
Publishing date	2022-09-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2022.106121
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