LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="He, Yudou"
  2. AU="Dadas, Osman"
  3. AU="Chen, Fiona"
  4. AU=Itoh Nobuyuki
  5. AU="Adorjan, Kristina"
  6. AU="Humaid Al-Shamsi, Mohammed"
  7. AU="TATIANA B. FANTAZZINI"
  8. AU="Yonan, Charles"
  9. AU="Denic, Milica"
  10. AU="Pértega-Díaz, Sonia"
  11. AU=Passos Maria do Carmo Friche
  12. AU=Lumb Bridget M
  13. AU="Drabo, Emmanuel F"
  14. AU="Raux, M"
  15. AU="Kubba, Haytham"
  16. AU="Hence, Deanna"
  17. AU="Swiger, James"
  18. AU="Loftus Jr, E. V."
  19. AU="Pozzi Mucelli, Roberto"
  20. AU="Subedi, Prajan"
  21. AU=Xiao Xizhu
  22. AU="Franzén, Anna"
  23. AU=Klonoff David C
  24. AU="DeCobelli, Francesco"
  25. AU="Zhang, KaiDong"

Search results

Result 1 - 10 of total 12

Search options

  1. Article ; Online: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.

    Zhivagui, Maria / Hoda, Areebah / Valenzuela, Noelia / Yeh, Yi-Yu / Dai, Jason / He, Yudou / Nandi, Shuvro P / Otlu, Burcak / Van Houten, Bennett / Alexandrov, Ludmil B

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 276

    Abstract: Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation ... ...

    Abstract Ultraviolet A light is commonly emitted by UV-nail polish dryers with recent reports suggesting that long-term use may increase the risk for developing skin cancer. However, no experimental evaluation has been conducted to reveal the effect of radiation emitted by UV-nail polish dryers on mammalian cells. Here, we show that irradiation by a UV-nail polish dryer causes high levels of reactive oxygen species, consistent with 8-oxo-7,8-dihydroguanine damage and mitochondrial dysfunction. Analysis of somatic mutations reveals a dose-dependent increase of C:G>A:T substitutions in irradiated samples with mutagenic patterns similar to mutational signatures previously attributed to reactive oxygen species. In summary, this study demonstrates that radiation emitted by UV-nail polish dryers can both damage DNA and permanently engrave mutations on the genomes of primary mouse embryonic fibroblasts, human foreskin fibroblasts, and human epidermal keratinocytes.
    MeSH term(s) Animals ; Humans ; Mice ; DNA Damage ; Fibroblasts ; Keratinocytes/radiation effects ; Mammals ; Mutation/radiation effects ; Reactive Oxygen Species/metabolism ; Ultraviolet Rays/adverse effects ; Nails
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-35876-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Author Correction: DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.

    Zhivagui, Maria / Hoda, Areebah / Valenzuela, Noelia / Yeh, Yi-Yu / Dai, Jason / He, Yudou / Nandi, Shuvro P / Otlu, Burcak / Van Houten, Bennett / Alexandrov, Ludmil B

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 1424

    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37245-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas.

    Ghosh, Pradipta / Campos, Vinicius J / Vo, Daniella T / Guccione, Caitlin / Goheen-Holland, Vanae / Tindle, Courtney / Mazzini, Guilherme S / He, Yudou / Alexandrov, Ludmil B / Lippman, Scott M / Gurski, Richard R / Das, Soumita / Yadlapati, Rena / Curtius, Kit / Sahoo, Debashis

    JCI insight

    2022  Volume 7, Issue 18

    Abstract: Although Barrett's metaplasia of the esophagus (BE) is the only known precursor lesion to esophageal adenocarcinomas (EACs), drivers of cellular transformation in BE remain incompletely understood. We use an artificial intelligence-guided network ... ...

    Abstract Although Barrett's metaplasia of the esophagus (BE) is the only known precursor lesion to esophageal adenocarcinomas (EACs), drivers of cellular transformation in BE remain incompletely understood. We use an artificial intelligence-guided network approach to study EAC initiation and progression. Key predictions are subsequently validated in a human organoid model, in patient-derived biopsy specimens of BE, a case-control study of genomics of BE progression, and in a cross-sectional study of 113 patients with BE and EACs. Our model classified healthy esophagus from BE and BE from EACs in several publicly available gene expression data sets (n = 932 samples). The model confirmed that all EACs must originate from BE and pinpointed a CXCL8/IL8↔neutrophil immune microenvironment as a driver of cellular transformation in EACs and gastroesophageal junction adenocarcinomas. This driver is prominent in White individuals but is notably absent in African Americans (AAs). Network-derived gene signatures, independent signatures of neutrophil processes, CXCL8/IL8 expression, and an absolute neutrophil count (ANC) are associated with risk of progression. SNPs associated with changes in ANC by ethnicity (e.g., benign ethnic neutropenia [BEN]) modify that risk. Findings define a racially influenced immunological basis for cell transformation and suggest that BEN in AAs may be a deterrent to BE→EAC progression.
    MeSH term(s) Adenocarcinoma/pathology ; Artificial Intelligence ; Barrett Esophagus/genetics ; Barrett Esophagus/pathology ; Case-Control Studies ; Cell Transformation, Neoplastic/genetics ; Cross-Sectional Studies ; Esophageal Neoplasms/pathology ; Esophagogastric Junction/metabolism ; Esophagogastric Junction/pathology ; Ethnicity ; Humans ; Interleukin-8/genetics ; Tumor Microenvironment
    Chemical Substances Interleukin-8
    Language English
    Publishing date 2022-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.161334
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

    Brin, Elena / Wu, Katherine / Lu, Hsin-Tze / He, Yudou / Dai, Zhaoming / He, Wei

    Oncotarget

    2017  Volume 8, Issue 35, Page(s) 58948–58963

    Abstract: PEGylated arginine deiminase (ADI-PEG 20) is being investigated in clinical studies in arginine auxotrophic cancers and is well-tolerated. The anti-tumor properties of ADI-PEG 20 have been extensively investigated - ADI-PEG 20 inhibits the growth of ... ...

    Abstract PEGylated arginine deiminase (ADI-PEG 20) is being investigated in clinical studies in arginine auxotrophic cancers and is well-tolerated. The anti-tumor properties of ADI-PEG 20 have been extensively investigated - ADI-PEG 20 inhibits the growth of auxotrophic cancers
    Language English
    Publishing date 2017-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.19564
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus.

    Luebeck, Jens / Ng, Alvin Wei Tian / Galipeau, Patricia C / Li, Xiaohong / Sanchez, Carissa A / Katz-Summercorn, Annalise C / Kim, Hoon / Jammula, Sriganesh / He, Yudou / Lippman, Scott M / Verhaak, Roel G W / Maley, Carlo C / Alexandrov, Ludmil B / Reid, Brian J / Fitzgerald, Rebecca C / Paulson, Thomas G / Chang, Howard Y / Wu, Sihan / Bafna, Vineet /
    Mischel, Paul S

    Nature

    2023  Volume 616, Issue 7958, Page(s) 798–805

    Abstract: Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with ... ...

    Abstract Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours and their resistance to treatment, and is associated with poor outcomes for patients with cancer
    MeSH term(s) Humans ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Barrett Esophagus/genetics ; Barrett Esophagus/pathology ; Case-Control Studies ; DNA/genetics ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/pathology ; Carcinogenesis/genetics ; Whole Genome Sequencing ; Cohort Studies ; Biopsy ; Disease Progression ; Oncogenes ; Immunomodulation ; DNA Copy Number Variations ; Gene Amplification ; Early Detection of Cancer/methods
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-04-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-05937-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Stability and function of a putative microtubule-organizing center in the human parasite

    Leung, Jacqueline M / He, Yudou / Zhang, Fangliang / Hwang, Yu-Chen / Nagayasu, Eiji / Liu, Jun / Murray, John M / Hu, Ke

    Molecular biology of the cell

    2017  Volume 28, Issue 10, Page(s) 1361–1378

    Abstract: The organization of the microtubule cytoskeleton is dictated by microtubule nucleators or organizing centers. ...

    Abstract The organization of the microtubule cytoskeleton is dictated by microtubule nucleators or organizing centers.
    MeSH term(s) Animals ; Cytoskeleton/physiology ; Humans ; Microtubule-Organizing Center/physiology ; Microtubules/metabolism ; Microtubules/physiology ; Parasites/metabolism ; Parasites/physiology ; Protozoan Proteins/metabolism ; Toxoplasma/metabolism ; Toxoplasma/physiology ; Toxoplasmosis/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2017-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E17-01-0045
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 410: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: TRAIL stabilization and cancer cell sensitization to its pro-apoptotic activity achieved through genetic fusion with arginine deiminase.

    Brin, Elena / Wu, Katherine / Dagostino, Eleanor / Meng-Chiang Kuo, Mario / He, Yudou / Shia, Wei-Jong / Chen, Li-Chang / Stempniak, Mariusz / Hickey, Richard / Almassy, Robert / Showalter, Richard / Thomson, James

    Oncotarget

    2018  Volume 9, Issue 97, Page(s) 36914–36928

    Abstract: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical ... ...

    Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. Recombinant TRAIL has shown good safety and efficacy profiles in preclinical cancer models. However, clinical success has been limited due to poor PK and development of resistance to death receptor-induced apoptosis. We have addressed these issues by creating a fusion protein of TRAIL and arginine deiminase (ADI). The fusion protein benefits from structural and functional synergies between its two components and has an extended half-life
    Language English
    Publishing date 2018-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.26398
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Uncovering novel mutational signatures by

    Islam, S M Ashiqul / Díaz-Gay, Marcos / Wu, Yang / Barnes, Mark / Vangara, Raviteja / Bergstrom, Erik N / He, Yudou / Vella, Mike / Wang, Jingwei / Teague, Jon W / Clapham, Peter / Moody, Sarah / Senkin, Sergey / Li, Yun Rose / Riva, Laura / Zhang, Tongwu / Gruber, Andreas J / Steele, Christopher D / Otlu, Burçak /
    Khandekar, Azhar / Abbasi, Ammal / Humphreys, Laura / Syulyukina, Natalia / Brady, Samuel W / Alexandrov, Boian S / Pillay, Nischalan / Zhang, Jinghui / Adams, David J / Martincorena, Iñigo / Wedge, David C / Landi, Maria Teresa / Brennan, Paul / Stratton, Michael R / Rozen, Steven G / Alexandrov, Ludmil B

    Cell genomics

    2022  Volume 2, Issue 11, Page(s) None

    Abstract: Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool ... ...

    Abstract Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for
    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Journal Article
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2022.100179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii.

    Liu, Jun / He, Yudou / Benmerzouga, Imaan / Sullivan, William J / Morrissette, Naomi S / Murray, John M / Hu, Ke

    Molecular biology of the cell

    2015  Volume 27, Issue 3, Page(s) 549–571

    Abstract: Although all microtubules within a single cell are polymerized from virtually identical subunits, different microtubule populations carry out specialized and diverse functions, including directional transport, force generation, and cellular morphogenesis. ...

    Abstract Although all microtubules within a single cell are polymerized from virtually identical subunits, different microtubule populations carry out specialized and diverse functions, including directional transport, force generation, and cellular morphogenesis. Functional differentiation requires specific targeting of associated proteins to subsets or even subregions of these polymers. The cytoskeleton of Toxoplasma gondii, an important human parasite, contains at least five distinct tubulin-based structures. In this work, we define the differential localization of proteins along the cortical microtubules of T. gondii, established during daughter biogenesis and regulated by protein expression and exchange. These proteins distinguish cortical from mitotic spindle microtubules, even though the assembly of these subsets is contemporaneous during cell division. Finally, proteins associated with cortical microtubules collectively protect the stability of the polymers with a remarkable degree of functional redundancy.
    MeSH term(s) Amino Acid Sequence ; Animals ; Cercopithecus aethiops ; Female ; HeLa Cells ; Humans ; Mice, Inbred BALB C ; Microtubules/metabolism ; Microtubules/ultrastructure ; Molecular Sequence Data ; Protein Binding ; Protein Stability ; Protein Transport ; Protozoan Proteins/metabolism ; Protozoan Proteins/ultrastructure ; Toxoplasma/metabolism ; Toxoplasma/ultrastructure ; Vero Cells
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2015-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E15-11-0754
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 410: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.

    Wang, Zhiyong / Wu, Victoria H / Allevato, Michael M / Gilardi, Mara / He, Yudou / Luis Callejas-Valera, Juan / Vitale-Cross, Lynn / Martin, Daniel / Amornphimoltham, Panomwat / Mcdermott, James / Yung, Bryan S / Goto, Yusuke / Molinolo, Alfredo A / Sharabi, Andrew B / Cohen, Ezra E W / Chen, Qianming / Lyons, J Guy / Alexandrov, Ludmil B / Gutkind, J Silvio

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 5546

    Abstract: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 ... ...

    Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Tobacco use is the main risk factor for HNSCC, and tobacco-associated HNSCCs have poor prognosis and response to available treatments. Recently approved anti-PD-1 immune checkpoint inhibitors showed limited activity (≤20%) in HNSCC, highlighting the need to identify new therapeutic options. For this, mouse models that accurately mimic the complexity of the HNSCC mutational landscape and tumor immune environment are urgently needed. Here, we report a mouse HNSCC model system that recapitulates the human tobacco-related HNSCC mutanome, in which tumors grow when implanted in the tongue of immunocompetent mice. These HNSCC lesions have similar immune infiltration and response rates to anti-PD-1 (≤20%) immunotherapy as human HNSCCs. Remarkably, we find that >70% of HNSCC lesions respond to intratumoral anti-CTLA-4. This syngeneic HNSCC mouse model provides a platform to accelerate the development of immunotherapeutic options for HNSCC.
    MeSH term(s) Animals ; Antineoplastic Agents, Immunological/therapeutic use ; Carcinoma, Squamous Cell/chemically induced ; Carcinoma, Squamous Cell/therapy ; Cell Line, Tumor ; Disease Models, Animal ; Head and Neck Neoplasms/chemically induced ; Head and Neck Neoplasms/therapy ; Humans ; Immunotherapy/methods ; Ipilimumab/therapeutic use ; Mice ; Mouth Neoplasms/chemically induced ; Mouth Neoplasms/therapy ; Nicotiana/adverse effects
    Chemical Substances Antineoplastic Agents, Immunological ; Ipilimumab
    Language English
    Publishing date 2019-12-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-13471-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top