Article ; Online: IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
2024 Volume 15, Page(s) 1293883
Abstract: Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell ... ...
Abstract | Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell activation has been identified as a central mechanism for promoting fibrosis downstream of TGFβ. IL11 signaling has recently been reported to promote fibroblast-to-myofibroblast transition, thus leading to various pro-fibrotic phenotypic changes. We confirmed increased mRNA expression of IL11 and IL11Rα in fibrotic diseases by OMICs approaches and |
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MeSH term(s) | Humans ; Transforming Growth Factor beta/metabolism ; Interleukin-11 ; Signal Transduction ; Fibrosis ; Myofibroblasts/metabolism |
Chemical Substances | Transforming Growth Factor beta ; Interleukin-11 |
Language | English |
Publishing date | 2024-02-22 |
Publishing country | Switzerland |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2606827-8 |
ISSN | 1664-3224 ; 1664-3224 |
ISSN (online) | 1664-3224 |
ISSN | 1664-3224 |
DOI | 10.3389/fimmu.2024.1293883 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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