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  1. Article ; Online: Simulating multiple scenarios of land use/cover change using a coupled model to capture ecological and economic effects

    Li, Yuechen / Liu, Xian / Wang, Yue / He, Zhiming

    Land Degradation & Development. 2023 June, v. 34, no. 10 p.2862-2879

    2023  

    Abstract: The conflict between the demands of ecological protection and economic development is increasingly prominent. Land use change is sensitive to whether economic or ecological profits dominate, and prediction of future land use changes has become an ... ...

    Abstract The conflict between the demands of ecological protection and economic development is increasingly prominent. Land use change is sensitive to whether economic or ecological profits dominate, and prediction of future land use changes has become an important scientific issue. This article constructs a coupled model that comprises the grey model (GM), the fuzzy multiple objective linear programming model (FMOLP) and the future land use simulation model (FLUS). We used this model to calculate a macro‐scale quantitative forecast using the top‐down GM‐FMOLP model, and calculated micro‐scale spatial simulations of land use/cover change (LUCC) using the bottom‐up FLUS model under three dissimilar future scenarios, with different emphases on ecological and economic benefits. The scenarios were designed to meet different planning requirements in Chongqing: ecological benefits maximization, economic benefits maximization, and combined ecological and economic benefits maximization. The proposed model, FLUS, was applied to a LUCC simulation for Chongqing in 2015, beginning from verified historical land use data from 2010. The results show that the simulation agrees well with the actual land use in 2015. The overall accuracy and kappa coefficient are 85.92% and 0.76, respectively, which indicates the model performs well. The three land use types with the highest producer and user accuracies are forest, cropland and water areas. The GM‐FMOLP model was used to forecast future LUCC quantity demand, and the FLUS model was then used to calculate spatial predictions for the three scenarios for 2040. The prediction results for the six land use types were significantly different under the three different scenarios. The total areas of forest, urban land and water increased by different degrees under the three scenarios, and the unused land area dwindled. Cropland areas were largely converted into forest, urban land and water areas. The increases in forest and urban land areas generally represents internal gap‐filling between disparate areas and peripheral expansion of areas of the same land use type. The increase in water area results from increased surface runoff in mountainous valleys with severe terrain. Areas of unused land are fully transformed into other land use types. The outcomes from the designed scenarios demonstrate that the proposed models are reliable and effective for future LUCC simulation, and highlight key areas where land use changes differently according to the scenario. In summary, in the predictions for the scenario that combined ecological and economic benefits maximization, each land use type tried to maximize ecological and economic benefits under the constraints, taking into account ecological safety and economic growth, which is in line with the coordination, comprehensiveness and binding requirements in Chongqing's development plan. Therefore, this scenario becomes the optimal scenario for land use optimization in Chongqing in the future. This study provides an example of the application of simulation and forecast models in land use management, remediation and urban planning, and addresses the growing requirement for low‐cost and effective tools for prediction of dynamic land use succession patterns.
    Keywords cropland ; economic development ; forests ; land degradation ; land use change ; land use planning ; landscapes ; mountains ; prediction ; remediation ; runoff ; simulation models
    Language English
    Dates of publication 2023-06
    Size p. 2862-2879.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 1319202-4
    ISSN 1085-3278
    ISSN 1085-3278
    DOI 10.1002/ldr.4653
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Evaluation of rural vitality and development types in mountainous areas of southwestern China: A case study of Wuxi County, Chongqing.

    Luo, Yun / Liu, Chunxia / Li, Yuechen / Jin, Xianfeng / He, Zhiming / Chen, Qi

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e27660

    Abstract: Protecting and stimulating rural vitality is a critical step towards driving rural revitalization and development; This study outlined the application of a measurement system that indexes rural vitality levels at the township scale and evaluates rural ... ...

    Abstract Protecting and stimulating rural vitality is a critical step towards driving rural revitalization and development; This study outlined the application of a measurement system that indexes rural vitality levels at the township scale and evaluates rural vitality in terms of potential regeneration, survivability, and development. This study combined the CRITIC weighting method, the TOPSIS pros and cons solution-distance method, and a vertical-horizontal comparison method to evaluate the rural vitality of 30 townships in Wuxi County, Chongqing. Using these results, this study divided the townships according to their type of rural development. A natural breakpoint method was used to visualize the spatial pattern of rural development levels.The research showed that: (1) The average value of the composite score of rural vitality in Wuxi County is 0.342, and more than half of the townships' composite vitality values are lower than the average value of the overall vitality, which leads to the conclusion that the overall level of rural vitality is low; (2) the comprehensive level of rural vitality in Wuxi County decreased from southwest to northeast, and showed local variations; (3) the degree of development within the study area was categorized as either dominant, comprehensive, or polarized, developmental deficiency type. This research argued that promoting the development of rural vitality in different villages requires careful scientific planning, detailed knowledge of individual geographic characteristics, and a clear rural development path that spans a range of spatial scales. Specific and specialized rural development strategies are thus required for each type of development.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Understanding Stimulation of Conjugal Gene Transfer by Nonantibiotic Compounds: How Far Are We?

    He, Zhiming / Dechesne, Arnaud / Schreiber, Frank / Zhu, Yong-Guan / Larsson, D G Joakim / Smets, Barth F

    Environmental science & technology

    2024  

    Abstract: A myriad of nonantibiotic compounds is released into the environment, some of which may contribute to the dissemination of antimicrobial resistance by stimulating conjugation. Here, we analyzed a collection of studies to (i) identify patterns of transfer ...

    Abstract A myriad of nonantibiotic compounds is released into the environment, some of which may contribute to the dissemination of antimicrobial resistance by stimulating conjugation. Here, we analyzed a collection of studies to (i) identify patterns of transfer stimulation across groups and concentrations of chemicals, (ii) evaluate the strength of evidence for the proposed mechanisms behind conjugal stimulation, and (iii) examine the plausibility of alternative mechanisms. We show that stimulatory nonantibiotic compounds act at concentrations from 1/1000 to 1/10 of the minimal inhibitory concentration for the donor strain but that stimulation is always modest (less than 8-fold). The main proposed mechanisms for stimulation via the reactive oxygen species/SOS cascade and/or an increase in cell membrane permeability are not unequivocally supported by the literature. However, we identify the reactive oxygen species/SOS cascade as the most likely mechanism. This remains to be confirmed by firm molecular evidence. Such evidence and more standardized and high-throughput conjugation assays are needed to create technologies and solutions to limit the stimulation of conjugal gene transfer and contribute to mitigating global antibiotic resistance.
    Language English
    Publishing date 2024-05-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c06060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: In Vivo Investigation of Gene Function in Muscle Stem Cells by CRISPR/Cas9-Mediated Genome Editing.

    He, Liangqiang / He, Zhiming / Li, Yuying / Sun, Hao / Wang, Huating

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2640, Page(s) 287–311

    Abstract: Skeletal muscle satellite cells (SCs) are adult stem cells responsible for muscle development and injury-induced muscle regeneration. Functional elucidation of intrinsic regulatory factors governing SC activity is constrained partially by the ... ...

    Abstract Skeletal muscle satellite cells (SCs) are adult stem cells responsible for muscle development and injury-induced muscle regeneration. Functional elucidation of intrinsic regulatory factors governing SC activity is constrained partially by the technological limitations in editing SCs in vivo. Although the power of CRISPR/Cas9 in genome manipulation has been widely documented, its application in endogenous SCs remains largely untested. Our recent study generates a muscle-specific genome editing system leveraging the Cre-dependent Cas9 knockin mice and AAV9-mediated sgRNAs delivery, which allows gene disruption in SCs in vivo. Here, we illustrate the step-by-step procedure for achieving efficient editing using the above system.
    MeSH term(s) Mice ; Animals ; Gene Editing/methods ; CRISPR-Cas Systems/genetics ; Satellite Cells, Skeletal Muscle ; Muscles
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3036-5_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: FoxO3 Regulates the Progress and Development of Aging and Aging-Related Diseases.

    Chang, Zao-Shang / He, Zhi-Ming / Xia, Jing-Bo

    Current molecular medicine

    2022  Volume 23, Issue 10, Page(s) 991–1006

    Abstract: Aging is an inevitable risk factor for many diseases, including cardiovascular diseases, neurodegenerative diseases, cancer, and diabetes. Investigation into the molecular mechanisms involved in aging and longevity will benefit the treatment of age- ... ...

    Abstract Aging is an inevitable risk factor for many diseases, including cardiovascular diseases, neurodegenerative diseases, cancer, and diabetes. Investigation into the molecular mechanisms involved in aging and longevity will benefit the treatment of age-dependent diseases and the development of preventative medicine for agingrelated diseases. Current evidence has revealed that FoxO3, encoding the transcription factor (FoxO)3, a key transcription factor that integrates different stimuli in the intrinsic and extrinsic pathways and is involved in cell differentiation, protein homeostasis, stress resistance and stem cell status, plays a regulatory role in longevity and in age-related diseases. However, the precise mechanisms by which the FoxO3 transcription factor modulates aging and promotes longevity have been unclear until now. Here, we provide a brief overview of the mechanisms by which FoxO3 mediates signaling in pathways involved in aging and aging-related diseases, as well as the current knowledge on the role of the FoxO3 transcription factor in the human lifespan and its clinical prospects. Ultimately, we conclude that FoxO3 signaling pathways, including upstream and downstream molecules, may be underlying therapeutic targets in aging and age-related diseases.
    MeSH term(s) Humans ; Aging/genetics ; Forkhead Box Protein O3/genetics ; Longevity ; Neoplasms/genetics
    Chemical Substances Forkhead Box Protein O3 ; FOXO3 protein, human
    Language English
    Publishing date 2022-10-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2064873-X
    ISSN 1875-5666 ; 1566-5240
    ISSN (online) 1875-5666
    ISSN 1566-5240
    DOI 10.2174/1566524023666221014140817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Therapeutic potential of translocator protein ligands for age-related macular degeneration.

    Li, Xing / He, Zhiming / Shu, Xinhua

    Neural regeneration research

    2021  Volume 17, Issue 4, Page(s) 793–794

    Language English
    Publishing date 2021-09-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.322460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intertwin nuchal translucency difference predicts the chance of co-twin death after fetal reduction in dichorionic triplet pregnancies: a retrospective analysis study.

    Xia, Shuting / You, Kaniok / Lin, Minhuan / Huang, Linhuan / He, Zhiming / Huang, Xuan / Luo, Yanmin

    BMC pregnancy and childbirth

    2023  Volume 23, Issue 1, Page(s) 747

    Abstract: Objectives: To compare the clinical outcomes of different multifetal pregnancy reduction (MFPR) programs in dichorionic (DC) triplets, and explore the association between early ultrasound characteristics and co-twin death after potassium chloride (KCl) ... ...

    Abstract Objectives: To compare the clinical outcomes of different multifetal pregnancy reduction (MFPR) programs in dichorionic (DC) triplets, and explore the association between early ultrasound characteristics and co-twin death after potassium chloride (KCl) injection into one monochorionic (MC) twin.
    Methods: We retrospectively reviewed the data of DC triplets who underwent MFPR at our center during 2012-2021. Patients were grouped as follows: intracardiac KCl injection into one MC twin (group A), intracardiac KCl injection into both MC twins simultaneously (group B), and reduction of the singleton fetus (group C) and pregnancy outcomes were compared. Logistic regression was used to determine whether ultrasound measurements at 11-13
    Results: Finally, we enrolled 184 patients. 153 cases were in group A, and 18, 13 cases were in group B and C respectively. Gestational age at the time of MFPR did not differ among the 3 groups (median: [Formula: see text] weeks). The survival rate was 89.6%, 88.9%, and 92.3% in group A, B, and C respectively, which was comparable among groups. Preterm birth was more common in group C (10/12, 83.3%). After KCl injection into one MC twin, co-twin death occurred in 86.3% cases (132/153) within 1 day; however, 3 patients had 2 live births each, with normal postnatal development. Intertwin nuchal translucency (NT) difference/discordance significantly predicted co-twin death within 1 day after MFPR, and the areas under the ROC curve were 0.694 and 0.689, respectively.
    Conclusions: For MFPR in DC triplet pregnancies, reduction of the MC twins results in less preterm birth, and women with KCl injection into either one or both MC twins had similar outcomes. Large intertwin NT difference/discordance was associated with co-twin death within 1 day after KCl injection into one of the MC twins.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; Pregnancy ; Gestational Age ; Nuchal Translucency Measurement ; Pregnancy Outcome ; Pregnancy Reduction, Multifetal/methods ; Pregnancy, Triplet ; Pregnancy, Twin ; Premature Birth ; Retrospective Studies ; Ultrasonography, Prenatal
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article ; Twin Study
    ZDB-ID 2059869-5
    ISSN 1471-2393 ; 1471-2393
    ISSN (online) 1471-2393
    ISSN 1471-2393
    DOI 10.1186/s12884-023-06064-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Contribution of genetic variants to congenital heart defects in both singleton and twin fetuses: a Chinese cohort study.

    Lin, Shaobin / Shi, Shanshan / Lu, Jian / He, Zhiming / Li, Danlun / Huang, Linhuan / Huang, Xuan / Zhou, Yi / Luo, Yanmin

    Molecular cytogenetics

    2024  Volume 17, Issue 1, Page(s) 2

    Abstract: Background: The contribution of genetic variants to congenital heart defects (CHDs) has been investigated in many postnatal cohorts but described in few prenatal fetus cohorts. Overall, specific genetic variants especially copy number variants (CNVs) ... ...

    Abstract Background: The contribution of genetic variants to congenital heart defects (CHDs) has been investigated in many postnatal cohorts but described in few prenatal fetus cohorts. Overall, specific genetic variants especially copy number variants (CNVs) leading to CHDs are somewhat diverse among different prenatal cohort studies. In this study, a total of 1118 fetuses with confirmed CHDs were recruited from three units over a 5-year period, composing 961 of singleton pregnancies and 157 of twin pregnancies. We performed chromosomal microarray analysis on all cases to detect numerical chromosomal abnormalities (NCAs) and pathogenic/likely pathogenic CNVs (P/LP CNVs) and employed whole-exome sequencing for some cases without NCAs and P/LP CNVs to detect P/LP sequence variants (P/LP SVs).
    Results: Overall, NCAs and P/LP CNVs were identified in 17.6% (197/1118) of cases, with NCA accounting for 9.1% (102/1118) and P/LP CNV for 8.5% (95/1118). Nonisolated CHDs showed a significantly higher frequency of NCA than isolated CHD (27.3% vs. 4.4%, p < 0.001), but there was no significant difference in the frequency of P/LP CNVs between isolated and nonisolated CHD (11.7% vs. 7.7%). A total of 109 P/LP CNVs were identified in 95 fetuses, consisting of 97 (89.0%) de novo, 6 (5.5%) parental inherited and 6 (5.5%) with unavailable parental information. The 16p11.2 proximal BP4-BP5 deletion was detected in 0.9% (10/1118) of all cases, second only to the most common 22q11.21 proximal A-D deletion (2.1%, 23/1118). Most of the 16p11.2 deletions (8/10) detected were de novo, and were enriched in CHD cases compared with a control cohort from a previous study. Additionally, SV was identified in 12.9% (8/62) of cases without NCA and P/LP CNV, most of which were de novo with autosomal dominant inheritance.
    Conclusions: Our cohort study provides a deep profile of the contribution of genetic variants to CHDs in both singleton and twin fetuses; NCA and P/LP CNV contribute to 9.1% and 8.5% of CHD in fetuses, respectively. We confirmed the 16p11.2 deletion as a CHD-associated hotspot CNV, second only to the 22q11.21 deletion in frequency. Most 16p11.2 deletions detected were de novo. Additionally, P/LP SV was identified in 12.9% (8/62) of fetuses without NCA or P/LP CNV.
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2420849-8
    ISSN 1755-8166
    ISSN 1755-8166
    DOI 10.1186/s13039-023-00664-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Differential effects of PTH (1-34), PTHrP (1-36) and abaloparatide on the murine osteoblast transcriptome.

    Mosca, Michael J / He, Zhiming / Ricarte, Florante R / Le Henaff, Carole / Partridge, Nicola C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Teriparatide (PTH(1-34)) and its analogs, PTHrP(1-36) and abaloparatide (ABL) have been used for the treatment of osteoporosis, but their efficacy over long-term use is significantly limited. The 3 peptides exert time- and dose-dependent differential ... ...

    Abstract Teriparatide (PTH(1-34)) and its analogs, PTHrP(1-36) and abaloparatide (ABL) have been used for the treatment of osteoporosis, but their efficacy over long-term use is significantly limited. The 3 peptides exert time- and dose-dependent differential responses in osteoblasts, leading us to hypothesize that they may also differentially modulate the osteoblast transcriptome. We show that treatment of mouse calvarial osteoblasts with 1 nM of the 3 peptides for 4 h results in RNA-Seq data with PTH(1-34) regulating 367 genes, including 194 unique genes; PTHrP(1-36) regulating 117 genes, including 15 unique genes; and ABL regulating 179 genes, including 20 unique genes. There were 83 genes shared among all 3 peptides. Gene ontology analyses showed differences in Wnt signaling, cAMP-mediated signaling, bone mineralization, morphogenesis of a branching structure in biological processes; receptor ligand activity, transcription factor activity, cytokine receptor/binding activity and many other actions in molecular functions. The 3 peptides increased
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.11.523646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Abaloparatide Has the Same Catabolic Effects on Bones of Mice When Infused as PTH (1-34).

    Le Henaff, Carole / Finnie, Brandon / Pacheco, Maria / He, Zhiming / Johnson, Joshua / Partridge, Nicola C

    JBMR plus

    2023  Volume 7, Issue 2, Page(s) e10710

    Abstract: Abaloparatide is a peptide analog of parathyroid hormone-related protein (PTHrP 1-34) and was approved in 2017 as the second osteoanabolic peptide for treating osteoporosis. We previously showed that intermittent abaloparatide is equally as effective as ... ...

    Abstract Abaloparatide is a peptide analog of parathyroid hormone-related protein (PTHrP 1-34) and was approved in 2017 as the second osteoanabolic peptide for treating osteoporosis. We previously showed that intermittent abaloparatide is equally as effective as PTH (1-34). This study was designed to compare the catabolic effects of PTH (1-34) and abaloparatide on bone in young female wild-type mice. Two-month-old C57Bl/6J female mice were continuously infused with human PTH (1-34) or abaloparatide at 80 μg/kg BW/day or vehicle for 2 weeks. At euthanasia, DEXA-PIXImus was performed to assess bone mineral density (BMD) in the whole body, femurs, tibiae, and vertebrae. Bone turnover marker levels were measured in sera, femurs were harvested for micro-computer tomography (μCT) analyses and histomorphometry, and tibiae were separated into cortical and trabecular fractions for gene expression analyses. Our results demonstrated that the infusion of abaloparatide resulted in a similar decrease in BMD as infused PTH (1-34) at all sites. μCT and histomorphometry analyses showed similar decreases in cortical bone thickness and BMD associated with an increase in bone turnover from the increased bone formation rate found by in vivo double labeling and serum P1NP and increased bone resorption as shown by osteoclast numbers and serum cross-linked C-telopeptide. Trabecular bone did not show major changes with either treatment. Osteoblastic gene expression analyses of trabecular and cortical bone revealed that infusion of PTH (1-34) or abaloparatide led to similar and different actions in genes of osteoblast differentiation and activity. As with intermittent and in vitro treatment, both infused PTH (1-34) and abaloparatide similarly regulated downstream genes of the PTHR1/SIK/HDAC4 pathway such as
    Language English
    Publishing date 2023-01-05
    Publishing country England
    Document type Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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