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Article ; Online: Monitoring and modulation of the tumor microenvironment for enhanced cancer modeling.

Head, Tristen / Cady, Nathaniel C

Experimental biology and medicine (Maywood, N.J.)

2022 Volume 247, Issue 7, Page(s) 598–613

Abstract: Cancer treatments utilizing biologic or cytotoxic drugs compose the frontline of therapy, and though gains in treatment efficacy have been persistent in recent decades, much work remains in understanding cancer progression and treatment. Compounding this ...

Abstract	Cancer treatments utilizing biologic or cytotoxic drugs compose the frontline of therapy, and though gains in treatment efficacy have been persistent in recent decades, much work remains in understanding cancer progression and treatment. Compounding this situation is the low rate of success when translating preclinical drug candidates to the clinic, which raises costs and development timelines. This underperformance is due in part to the poor recapitulation of the tumor microenvironment, a critical component of cancer biology, in cancer model systems. New technologies capable of both accurately observing and manipulating the tumor microenvironment are needed to effectively model cancer response to treatment. In this review, conventional cancer models are summarized, and a primer on emerging techniques for monitoring and modulating the tumor microenvironment is presented and discussed.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-01-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702221074293
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Article: Lithographically patterned micro-nozzles for controlling fluid flow profiles for drug delivery and in vitro imaging applications.

Head, Tristen / Tokranova, Natalya / Cady, Nathaniel C

MRS communications

2021 Volume 11, Issue 5, Page(s) 584–589

Abstract: Precisely controlling delivery of drugs and other reagents is important for intravital microscopy studies. In this work, photolithographic integration of micro-nozzles onto a microfluidic platform was performed to tune the fluid flow profile and depth of ...

Abstract	Precisely controlling delivery of drugs and other reagents is important for intravital microscopy studies. In this work, photolithographic integration of micro-nozzles onto a microfluidic platform was performed to tune the fluid flow profile and depth of penetration into biological tissue mimics. Performance characteristics were measured by correlating the flow rate through the device to the applied pressure and/or delivery of dyes into solution and agarose gel-based phantom tissue. From these results, the implementation of micro-nozzles was demonstrated to significantly improve the lateral dispersion of delivered fluid and increase the depth of penetration into phantom tissue.
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2645443-9
ISSN	2159-6867 ; 2159-6859
ISSN (online)	2159-6867
ISSN	2159-6859
DOI	10.1557/s43579-021-00078-0
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Article ; Online: Discriminating extra virgin olive oils from common edible oils: Comparable performance of PLS-DA models trained on low-field and high-field

Head, Thomas / Giebelhaus, Ryland T / Nam, Seo Lin / de la Mata, A Paulina / Harynuk, James J / Shipley, Paul R

Phytochemical analysis : PCA

2024

Abstract: Introduction: Olive oil, derived from the olive tree (Olea europaea L.), is used in cooking, cosmetics, and soap production. Due to its high value, some producers adulterate olive oil with cheaper edible oils or fraudulently mislabel oils as olive to ... ...

Abstract	Introduction: Olive oil, derived from the olive tree (Olea europaea L.), is used in cooking, cosmetics, and soap production. Due to its high value, some producers adulterate olive oil with cheaper edible oils or fraudulently mislabel oils as olive to increase profitability. Adulterated products can cause allergic reactions in sensitive individuals and can lack compounds which contribute to the perceived health benefits of olive oil, and its corresponding premium price. Objective: There is a need for robust methods to rapidly authenticate olive oils. By utilising machine learning models trained on the nuclear magnetic resonance (NMR) spectra of known olive oil and edible oils, samples can be classified as olive and authenticated. While high-field NMRs are commonly used for their superior resolution and sensitivity, they are generally prohibitively expensive to purchase and operate for routine screening purposes. Low-field benchtop NMR presents an affordable alternative. Methods: We compared the predictive performance of partial least squares discrimination analysis (PLS-DA) models trained on low-field 60 MHz benchtop proton ( Results: We demonstrate that PLS-DA models trained on low-field NMR spectra are highly predictive when classifying EVOOs from other oils and perform comparably to those trained on high-field spectra. We demonstrated that variance was primarily driven by regions of the spectra arising from olefinic protons and ester protons from unsaturated fatty acids in models derived from data at both field strengths.
Language	English
Publishing date	2024-03-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3348
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Book ; Online: Civil Liberties

Head, Tom

A Beginner''s Guide

(Beginner''s Guides)

2012

Abstract: ... Torture, freedom of speech, freedom of religion, privacy - contrary to what public apathy would have you believe, civil liberties are worth fighting for and are almost always under threat. Tom Head tours the world to show civil liberties in action, ... ...

Series title	Beginner''s Guides
Abstract	Torture, freedom of speech, freedom of religion, privacy - contrary to what public apathy would have you believe, civil liberties are worth fighting for and are almost always under threat. Tom Head tours the world to show civil liberties in action, and shows how you can make a difference. Tom Head serves as civil liberties guide for About.com.
Language	English
Size	Online-Ressource (306 p)
Publisher	Oneworld Publications
Publishing place	New York
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781851686445 ; 1851686444
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Perspective: use and reuse of NMR-based metabolomics data: what works and what remains challenging.

Gouveia, Goncalo Jorge / Head, Thomas / Cheng, Leo L / Clendinen, Chaevien S / Cort, John R / Du, Xiuxia / Edison, Arthur S / Fleischer, Candace C / Hoch, Jeffrey / Mercaldo, Nathaniel / Pathmasiri, Wimal / Raftery, Daniel / Schock, Tracey B / Sumner, Lloyd W / Takis, Panteleimon G / Copié, Valérie / Eghbalnia, Hamid R / Powers, Robert

Metabolomics : Official journal of the Metabolomic Society

2024 Volume 20, Issue 2, Page(s) 41

Abstract: Background: The National Cancer Institute issued a Request for Information (RFI; NOT-CA-23-007) in October 2022, soliciting input on using and reusing metabolomics data. This RFI aimed to gather input on best practices for metabolomics data storage, ... ...

Abstract	Background: The National Cancer Institute issued a Request for Information (RFI; NOT-CA-23-007) in October 2022, soliciting input on using and reusing metabolomics data. This RFI aimed to gather input on best practices for metabolomics data storage, management, and use/reuse. Aim of review: The nuclear magnetic resonance (NMR) Interest Group within the Metabolomics Association of North America (MANA) prepared a set of recommendations regarding the deposition, archiving, use, and reuse of NMR-based and, to a lesser extent, mass spectrometry (MS)-based metabolomics datasets. These recommendations were built on the collective experiences of metabolomics researchers within MANA who are generating, handling, and analyzing diverse metabolomics datasets spanning experimental (sample handling and preparation, NMR/MS metabolomics data acquisition, processing, and spectral analyses) to computational (automation of spectral processing, univariate and multivariate statistical analysis, metabolite prediction and identification, multi-omics data integration, etc.) studies. Key scientific concepts of review: We provide a synopsis of our collective view regarding the use and reuse of metabolomics data and articulate several recommendations regarding best practices, which are aimed at encouraging researchers to strengthen efforts toward maximizing the utility of metabolomics data, multi-omics data integration, and enhancing the overall scientific impact of metabolomics studies.
MeSH term(s)	Metabolomics/methods ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Imaging ; Mass Spectrometry/methods ; Automation
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2250617-2
ISSN	1573-3890 ; 1573-3882
ISSN (online)	1573-3890
ISSN	1573-3882
DOI	10.1007/s11306-024-02090-6
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Article: The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis.

Head, Trajen / Daunert, Sylvia / Goldschmidt-Clermont, Pascal J

Frontiers in genetics

2017 Volume 8, Page(s) 216

Abstract: A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is ... ...

Abstract	A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is the dominant risk factor for clinically significant atherosclerotic lesion formation, yet the heightened impact of aging on the disease is not accounted for by changes in traditional risk factors, such as lack of physical activity, smoking, hypertension, hyperlipidemia, or diabetes mellitus. This review will examine the pathological and biochemical processes of atherosclerotic plaque formation and growth, with particular focus on the aging risk vis-a-vis arterial homeostasis. Particular focus will be placed on the impact of a number of important contributors to arterial homeostasis including bone marrow (BM)-derived vascular progenitor cells, differential monocyte subpopulations, and the role of cellular senescence. Finally, this review will explore many critical observations in the way the disease process has been reassessed both by clinicians and researchers, and will highlight recent advances in this field that have provided a greater understanding of this aging-driven disease.
Language	English
Publishing date	2017-12-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2017.00216
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Article ; Online: Do relationship education programs reduce relationship aggression? A meta-analytic study.

Karantzas, Gery C / Curtis, Ashlee / Knox, Laura / Staiger, Petra K / Head, Travis / Toumbourou, John W / Gruenert, Stefan / Romano, Daniel A / Miller, Peter G

Clinical psychology review

2023 Volume 104, Page(s) 102285

Abstract: There is an increasing focus on evaluating the effectiveness of Relationship Education (RE) programs on reducing relationship aggression. Nevertheless, there has been little by way of a systematic quantitative synthesis of research to date. The primary ... ...

Abstract	There is an increasing focus on evaluating the effectiveness of Relationship Education (RE) programs on reducing relationship aggression. Nevertheless, there has been little by way of a systematic quantitative synthesis of research to date. The primary aim of this research was to conduct a meta-analysis into the effects of RE programs on relationship aggression and provide a comprehensive assessment as to the moderating effects of various methodological characteristics of studies. A secondary aim was to determine whether RE programs reduce negative aspects of relationship functioning that are known to exacerbate relationship aggression. Thirty-one studies (n = 25,527) were included comprising of pre-post comparison studies and control trials. Overall, RE programs were significantly associated with reductions in relationship aggression (d = 0.11, p = .001). Pre-post studies yielded a significantly larger effect size (d = 0.28, p < .001) than RCT studies (d = 0.05, p = .10). Subgroup analysis revealed that participants who reported moderate to severe relationship aggression upon RE program entry demonstrated large reductions in physical (d = 0.66, p = .01) and psychological (d = 0.85, p < .001) aggression compared to those who reported minimal to low relationship aggression on entry (physical aggression d = 0.07, p = .009; psychological aggression d = -0.04; p = .17). Amongst participants who reported moderate to severe relationship aggression, RE programs were also found to reduce controlling behavior (d = 0.20, p < .01) and conflict behavior (d = 0.40, p < .001). Findings demonstrate the emerging efficacy of RE programs for reducing relationship aggression and conflict behavior, particularly in those with a history of moderate to severe levels of relationship aggression.
MeSH term(s)	Humans ; Aggression/psychology ; Interpersonal Relations
Language	English
Publishing date	2023-05-13
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	604577-7
ISSN	1873-7811 ; 0272-7358
ISSN (online)	1873-7811
ISSN	0272-7358
DOI	10.1016/j.cpr.2023.102285
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Article ; Online: Reagentless electrochemical biosensors through incorporation of unnatural amino acids on the protein structure.

Zeynaloo, Elnaz / Zahran, Elsayed M / Yang, Yu-Ping / Dikici, Emre / Head, Trajen / Bachas, Leonidas G / Daunert, Sylvia

Biosensors & bioelectronics

2021 Volume 200, Page(s) 113861

Abstract: Typical protein biosensors employ chemical or genetic labeling of the protein, thus introducing an extraneous molecule to the wild-type parent protein, often changing the overall structure and properties of the protein. While these labeling methods have ... ...

Abstract	Typical protein biosensors employ chemical or genetic labeling of the protein, thus introducing an extraneous molecule to the wild-type parent protein, often changing the overall structure and properties of the protein. While these labeling methods have proven successful in many cases, they also have a series of disadvantages associated with their preparation and function. An alternative route for labeling proteins is the incorporation of unnatural amino acid (UAA) analogues, capable of acting as a label, into the structure of a protein. Such an approach, while changing the local microenvironment, poses less of a burden on the overall structure of the protein. L-DOPA is an analog of phenylalanine and contains a catechol moiety that participates in a quasi-reversible, two-electron redox process, thus making it suitable as an electrochemical label/reporter. The periplasmic glucose/galactose binding protein (GBP) was chosen to demonstrate this detection principle. Upon glucose binding, GBP undergoes a significant conformational change that is manifested as a change in the electrochemistry of L-DOPA. The electroactive GBP was immobilized onto gold nanoparticle-modified, polymerized caffeic acid, screen-printed carbon electrodes (GBP-LDOPA/AuNP/PCA/SPCE) for the purpose of direct measurement of glucose levels and serves as a proof-of-concept of the use of electrochemically-active unnatural amino acids as the label. The resulting reagentless GBP biosensors exhibited a highly selective and sensitive binding affinity for glucose in the micromolar range, laying the foundation for a new biosensing methodology based on global incorporation of an electroactive amino acid into the protein's primary sequence for highly selective electrochemical detection of compounds of interest.
MeSH term(s)	Amino Acids ; Biosensing Techniques ; Electrochemical Techniques ; Electrochemistry ; Electrodes ; Gold ; Metal Nanoparticles
Chemical Substances	Amino Acids ; Gold (7440-57-5)
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113861
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Article ; Online: Bioluminescent detection of zearalenone using recombinant peptidomimetic Gaussia luciferase fusion protein.

Peltomaa, Riikka / Fikacek, Sabrina / Benito-Peña, Elena / Barderas, Rodrigo / Head, Trajen / Deo, Sapna / Daunert, Sylvia / Moreno-Bondi, María C

Mikrochimica acta

2020 Volume 187, Issue 10, Page(s) 547

Abstract: The development of a bioluminescent immunosensor is reported for the determination of zearalenone (ZEA) based on a peptide mimetic identified by phage display. The peptide mimetic GW, with a peptide sequence GWWGPYGEIELL, was used to create recombinant ... ...

Abstract	The development of a bioluminescent immunosensor is reported for the determination of zearalenone (ZEA) based on a peptide mimetic identified by phage display. The peptide mimetic GW, with a peptide sequence GWWGPYGEIELL, was used to create recombinant fusion proteins with the bioluminescent Gaussia luciferase (GLuc) that were directly used as tracers for toxin detection in a competitive immunoassay without the need for secondary antibodies or further labeling. The bioluminescent sensor, based on protein G-coupled magnetic beads for antibody immobilization, enabled determination of ZEA with a detection limit of 4.2 ng mL
MeSH term(s)	Peptidomimetics/chemistry ; Recombinant Fusion Proteins/chemistry ; Zearalenone/chemistry
Chemical Substances	Peptidomimetics ; Recombinant Fusion Proteins ; Zearalenone (5W827M159J)
Language	English
Publishing date	2020-09-04
Publishing country	Austria
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-020-04538-7
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Article ; Online: Ten simple rules for writing Dockerfiles for reproducible data science.

Nüst, Daniel / Sochat, Vanessa / Marwick, Ben / Eglen, Stephen J / Head, Tim / Hirst, Tony / Evans, Benjamin D

PLoS computational biology

2020 Volume 16, Issue 11, Page(s) e1008316

Abstract: Computational science has been greatly improved by the use of containers for packaging software and data dependencies. In a scholarly context, the main drivers for using these containers are transparency and support of reproducibility; in turn, a ... ...

Abstract	Computational science has been greatly improved by the use of containers for packaging software and data dependencies. In a scholarly context, the main drivers for using these containers are transparency and support of reproducibility; in turn, a workflow's reproducibility can be greatly affected by the choices that are made with respect to building containers. In many cases, the build process for the container's image is created from instructions provided in a Dockerfile format. In support of this approach, we present a set of rules to help researchers write understandable Dockerfiles for typical data science workflows. By following the rules in this article, researchers can create containers suitable for sharing with fellow scientists, for including in scholarly communication such as education or scientific papers, and for effective and sustainable personal workflows.
MeSH term(s)	Algorithms ; Data Science ; Guidelines as Topic ; Programming Languages ; Reproducibility of Results ; Software
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1008316
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