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  1. Article ; Online: Achieving the protection of high peak bone mass.

    Heaney, R P

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2016  Volume 27, Issue 4, Page(s) 1279–1280

    MeSH term(s) Bone Density/physiology ; Bone Development/physiology ; Exercise/physiology ; Humans ; Nutritional Physiological Phenomena/physiology ; Osteoporotic Fractures/prevention & control
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Editorial
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-015-3467-5
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    Zs.A 3163: Show issues Location:
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  2. Article ; Online: Toward a physiological referent for the vitamin D requirement.

    Heaney, R P

    Journal of endocrinological investigation

    2014  Volume 37, Issue 11, Page(s) 1127–1130

    MeSH term(s) Animals ; Female ; Homeostasis/drug effects ; Homeostasis/physiology ; Humans ; Lactation/drug effects ; Lactation/metabolism ; Reference Values ; Vitamin D/metabolism ; Vitamin D/pharmacology ; Vitamin D/therapeutic use ; Vitamin D Deficiency/drug therapy ; Vitamin D Deficiency/metabolism
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2014-10-12
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/s40618-014-0190-6
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  3. Article ; Online: The effect of vitamin D dose on bone mineral density.

    Heaney, R P

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2011  Volume 23, Issue 2, Page(s) 789–90; author reply 791

    MeSH term(s) Bone Density/drug effects ; Cholecalciferol/administration & dosage ; Dietary Supplements ; Female ; Humans ; Osteoporosis, Postmenopausal/drug therapy
    Chemical Substances Cholecalciferol (1C6V77QF41)
    Language English
    Publishing date 2011-11-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-011-1844-2
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  4. Article: Determinants of vitamin D status in older men living in a subtropical climate.

    Heaney, R P

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2007  Volume 18, Issue 6, Page(s) 833–4; author reply 835–6

    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Reference Values ; Seasons ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/therapeutic use ; Vitamin D Deficiency/diagnosis
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2007-02-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-007-0342-z
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  5. Article: Calcium, dairy, and prostate cancer.

    Heaney, R P

    British journal of cancer

    2007  Volume 96, Issue 6, Page(s) 1008; author reply 1009

    MeSH term(s) Calcium, Dietary/administration & dosage ; Calcium, Dietary/adverse effects ; Dairy Products/adverse effects ; Humans ; Male ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/etiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Calcium, Dietary ; Vitamin D (1406-16-2) ; 1,25-dihydroxyvitamin D (66772-14-3)
    Language English
    Publishing date 2007-03-26
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/sj.bjc.6603680
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  6. Article: Vitamin D and BMC.

    Heaney, R P

    Calcified tissue international

    2007  Volume 80, Issue 5, Page(s) 348

    MeSH term(s) Bone Density/drug effects ; Bone and Bones/metabolism ; Calcium/metabolism ; Humans ; Male ; Vitamin D/pharmacology
    Chemical Substances Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2007-05
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0171-967X ; 0944-0747 ; 0008-0594
    ISSN (online) 1432-0827
    ISSN 0171-967X ; 0944-0747 ; 0008-0594
    DOI 10.1007/s00223-007-9009-1
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    Zs.A 317: Show issues Location:
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  7. Article: Vitamin D--the iceberg nutrient.

    Heaney, R P

    Journal of musculoskeletal & neuronal interactions

    2006  Volume 6, Issue 4, Page(s) 334–335

    MeSH term(s) Calcium, Dietary/metabolism ; Calcium, Dietary/therapeutic use ; Cholecalciferol/metabolism ; Ergocalciferols/metabolism ; Humans ; Osteoporosis/metabolism ; Osteoporosis/prevention & control ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/metabolism ; Vitamin D/therapeutic use
    Chemical Substances Calcium, Dietary ; Ergocalciferols ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2006-10
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2041366-X
    ISSN 1108-7161
    ISSN 1108-7161
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    Zs.A 5401: Show issues Location:
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  8. Article: Serum 25-hydroxyvitamin D and parathyroid hormone exhibit threshold behavior.

    Heaney, R P

    Journal of endocrinological investigation

    2005  Volume 28, Issue 2, Page(s) 180–182

    MeSH term(s) Differential Threshold ; Humans ; Parathyroid Hormone/blood ; Vitamin D/analogs & derivatives ; Vitamin D/blood
    Chemical Substances Parathyroid Hormone ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2005-05-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 432272-1
    ISSN 1720-8386 ; 0391-4097 ; 1121-1369
    ISSN (online) 1720-8386
    ISSN 0391-4097 ; 1121-1369
    DOI 10.1007/bf03345364
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    Zs.A 1480: Show issues Location:
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  9. Article ; Online: Variability in the measured response of bone to teriparatide.

    Heaney, R P / Watson, P

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

    2010  Volume 22, Issue 6, Page(s) 1703–1708

    Abstract: Unlabelled: Apparent failures of bone mineral density (BMD) response to teriparatide at spine or hip occur even in a high compliance context (15% spine and 55% hip). Apparent non-responders nevertheless show good biomarker response, suggesting that ... ...

    Abstract Unlabelled: Apparent failures of bone mineral density (BMD) response to teriparatide at spine or hip occur even in a high compliance context (15% spine and 55% hip). Apparent non-responders nevertheless show good biomarker response, suggesting that apparent BMD non-response is due to measurement imprecision. Calcium intake may be an important determinant of hip response.
    Introduction: Individuals vary in response to bone active agents, but that variability is poorly quantified and its basis is not well understood. The study included 203 postmenopausal women with moderately severe osteoporosis, all treated with teriparatide, calcium, and vitamin D. The study was performed at the Creighton University Medical Center, a single site.
    Methods: This is a prospective study of change in bone mineral density and resorption biomarkers over a 12-month treatment period. BMD response at spine and total hip was quantified by computing slopes for each participant's values, and biomarker change by the difference in values across the 12-month study period.
    Results: Of the total number of participants, 85.2% exhibited a significant spine BMD response, while only 44.8% had a significant change at the hip. However, mean biomarker response was marginally larger for the BMD non-responders at either site than for the responders, indicating biological, if not measurable densitometric, activity of teriparatide in essentially all participants.
    Conclusions: Occasional apparent failures of BMD response in patients receiving teriparatide are probably not due to failure of response at the level of the bone remodeling apparatus, but instead reflect a combination of measurement imprecision and variable bone remodeling balance. The reason for the latter remains unclear.
    MeSH term(s) Aged ; Biomarkers/urine ; Bone Density/drug effects ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use ; Bone Remodeling/drug effects ; Collagen Type I/urine ; Female ; Hip Joint/drug effects ; Hip Joint/physiopathology ; Humans ; Hydroxyproline/urine ; Lumbar Vertebrae/drug effects ; Lumbar Vertebrae/physiopathology ; Middle Aged ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/physiopathology ; Osteoporosis, Postmenopausal/urine ; Peptides/urine ; Prospective Studies ; Teriparatide/pharmacology ; Teriparatide/therapeutic use ; Treatment Outcome
    Chemical Substances Biomarkers ; Bone Density Conservation Agents ; Collagen Type I ; Peptides ; collagen type I trimeric cross-linked peptide ; Teriparatide (10T9CSU89I) ; Hydroxyproline (RMB44WO89X)
    Language English
    Publishing date 2010-09-09
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 1064892-6
    ISSN 1433-2965 ; 0937-941X
    ISSN (online) 1433-2965
    ISSN 0937-941X
    DOI 10.1007/s00198-010-1376-1
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  10. Article: Effects of caffeine on bone and the calcium economy.

    Heaney, R P

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

    2002  Volume 40, Issue 9, Page(s) 1263–1270

    Abstract: Caffeine-containing beverage consumption has been reported to be associated with reduced bone mass and increased fracture risk in some, but not most, observational studies. Human physiological studies and controlled balance studies show a clear but only ... ...

    Abstract Caffeine-containing beverage consumption has been reported to be associated with reduced bone mass and increased fracture risk in some, but not most, observational studies. Human physiological studies and controlled balance studies show a clear but only a very small depressant effect of caffeine itself on intestinal calcium absorption, and no effect on total 24-h urinary calcium excretion. The epidemiologic studies showing a negative effect may be explained in part by an inverse relationship between consumption of milk and caffeine-containing beverages. Low calcium intake is clearly linked to skeletal fragility, and it is likely that a high caffeine intake is often a marker for a low calcium intake. The negative effect of caffeine on calcium absorption is small enough to be fully offset by as little as 1-2 tablespoons of milk. All of the observations implicating caffeine-containing beverages as a risk factor for osteoporosis have been made in populations consuming substantially less than optimal calcium intakes. There is no evidence that caffeine has any harmful effect on bone status or on the calcium economy in individuals who ingest the currently recommended daily allowances of calcium.
    MeSH term(s) Animals ; Bone Density/drug effects ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Caffeine/administration & dosage ; Caffeine/pharmacology ; Calcium/metabolism ; Humans ; Phosphodiesterase Inhibitors/administration & dosage ; Phosphodiesterase Inhibitors/pharmacology
    Chemical Substances Phosphodiesterase Inhibitors ; Caffeine (3G6A5W338E) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2002-10-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 782617-5
    ISSN 1873-6351 ; 0278-6915
    ISSN (online) 1873-6351
    ISSN 0278-6915
    DOI 10.1016/s0278-6915(02)00094-7
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