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  1. AU="Heather Limburg"
  2. AU="Gross, Boris"
  3. AU="Perkins, George H"
  4. AU="Jormanainen, J"
  5. AU="Pichardo-González, Priamo A"
  6. AU="Cannegieter, Suzanne"
  7. AU="Trocino, Giuseppe"
  8. AU="Emiliano, Thais Moura"
  9. AU=Sinelli Mariateresa
  10. AU="De-guo LÜ"
  11. AU="Benoit-Pilven, Clara"
  12. AU="Lanza, Stefania"
  13. AU="Chilingarian, A"
  14. AU="Baldovini, Nicolas"
  15. AU="López Rodríguez, David"
  16. AU="Alexander König"
  17. AU="Jakobsen, Henrik L"
  18. AU="Yong-Zhao Dai"
  19. AU="Tara L. Pukala"
  20. AU="Addo‐Danso, Shalom D."
  21. AU=Ficheux Q.
  22. AU="Tomoyo Sawada"
  23. AU="Mohammad Kawsar Sharif Siam"
  24. AU=Kushnareva Yulia
  25. AU="Canova, Christopher T"
  26. AU="Hasnaoui, Naoual"
  27. AU="Maradana, Jhansi"
  28. AU="Raggini, Elisa"
  29. AU="Baxter, A."
  30. AU="Jackson, Shirnae"
  31. AU="Schenzle, Lisa"
  32. AU="Veronica Phillips"
  33. AU="Braun, Jörg"
  34. AU="Cassandra E. Holbert"
  35. AU="Trevisan Alexandra"

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  1. Artikel ; Online: PROTOCOL

    Olivia Magwood / Alison Riddle / Jennifer Petkovic / Lyubov Lytvyn / Joanne Khabsa / Pearl Atwere / Elie A. Akl / Pauline Campbell / Vivian Welch / Maureen Smith / Reem A. Mustafa / Heather Limburg / Leonila F. Dans / Nicole Skoetz / Sean Grant / Thomas W. Concannon / Peter Tugwell

    Campbell Systematic Reviews, Vol 18, Iss 2, Pp n/a-n/a (2022)

    Barriers and facilitators to stakeholder engagement in health guideline development: A qualitative evidence synthesis

    2022  

    Abstract: Abstract Background There is a need for the development of comprehensive, global, evidence‐based guidance for stakeholder engagement in guideline development. Stakeholders are any individual or group who is responsible for or affected by health‐ and ... ...

    Abstract Abstract Background There is a need for the development of comprehensive, global, evidence‐based guidance for stakeholder engagement in guideline development. Stakeholders are any individual or group who is responsible for or affected by health‐ and healthcare‐related decisions. This includes patients, the public, providers of health care and policymakers for example. As part of the guidance development process, Multi‐Stakeholder Engagement (MuSE) Consortium set out to conduct four concurrent systematic reviews to summarise the evidence on: (1) existing guidance for stakeholder engagement in guideline development, (2) barriers and facilitators to stakeholder engagement in guideline development, (3) managing conflicts of interest in stakeholder engagement in guideline development and (4) measuring the impact of stakeholder engagement in guideline development. This protocol addresses the second systematic review in the series. Objectives The objective of this review is to identify and synthesise the existing evidence on barriers and facilitators to stakeholder engagement in health guideline development. We will address this objective through two research questions: (1) What are the barriers to multi‐stakeholder engagement in health guideline development across any of the 18 steps of the GIN‐McMaster checklist? (2) What are the facilitators to multi‐stakeholder engagement in health guideline development across any of the 18 steps of the GIN‐McMaster checklist? Search Methods A comprehensive search strategy will be developed and peer‐reviewed in consultation with a medical librarian. We will search the following databases: MEDLINE, Cumulative Index to Nursing & Allied Health Literature (CINAHL), EMBASE, PsycInfo, Scopus, and Sociological Abstracts. To identify grey literature, we will search the websites of agencies who actively engage stakeholder groups such as the AHRQ, Canadian Institutes of Health Research (CIHR) Strategy for Patient‐Oriented Research (SPOR), INVOLVE, the National Institute for Health and ...
    Schlagwörter Social Sciences ; H
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: PROTOCOL

    Joanne Khabsa / Jennifer Petkovic / Alison Riddle / Lyubov Lytvyn / Olivia Magwood / Pearl Atwere / Pauline Campbell / Srinivasa V. Katikireddi / Bronwen Merner / Mona Nasser / Stephanie Chang / Alejandra Jaramillo Garcia / Heather Limburg / Jeanne‐Marie Guise / Peter Tugwell / Elie A. Akl

    Campbell Systematic Reviews, Vol 18, Iss 2, Pp n/a-n/a (2022)

    Conflict of interest issues when engaging stakeholders in health and healthcare guideline development: a systematic review

    2022  

    Abstract: Abstract This is the protocol for a Campbell systematic review. The overall objective of this study is to gather and summarize the existing literature on conflict of interest issues when engaging stakeholders in guideline development. ...

    Abstract Abstract This is the protocol for a Campbell systematic review. The overall objective of this study is to gather and summarize the existing literature on conflict of interest issues when engaging stakeholders in guideline development.
    Schlagwörter Social Sciences ; H
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism

    KristanJAronson / HeatherLimburg / ChristyWoolcott / LeanneLBedard

    Frontiers in Oncology, Vol

    influence on prostate cancer risk and interactions

    2012  Band 2

    Abstract: Purpose: Folate is essential to DNA methylation and synthesis and may have a complex dualistic role in prostate cancer. Alcohol use may increase risk and epigenetic factors may interact with lifestyle exposures. We aimed to characterize the independent ... ...

    Abstract Purpose: Folate is essential to DNA methylation and synthesis and may have a complex dualistic role in prostate cancer. Alcohol use may increase risk and epigenetic factors may interact with lifestyle exposures. We aimed to characterize the independent and joint effects of folate intake, alcohol consumption, and the MTHFR C677T gene polymorphism on prostate cancer risk, while accounting for intakes of vitamins B2, B6, B12, methionine, total energy, and confounders. Methods: A case-control study was conducted at Kingston General Hospital of 80 incident primary prostate cancer cases and 334 urology clinic controls, all with normal age-specific PSA levels (to exclude latent prostate cancers). Participants completed a questionnaire on folate and alcohol intakes and potential confounders prior to knowledge of diagnosis, eliminating recall bias, and blood was drawn for MTHFR genotyping. Joint effects of exposures were assessed using unconditional logistic regression and significance of multiplicative and additive interactions using general linear models. Results: Folate, vitamins B2, B6, B12, methionine, and the CT and TT genotypes were not associated with prostate cancer risk. The highest tertile of lifetime alcohol consumption was associated with increased risk (OR=2.08; 95% CI: 1.12-3.86). Consumption of >5 alcoholic drinks/week was associated with increased prostate cancer risk among men with low folate intake (OR=2.38; 95% CI: 1.01-5.57) and higher risk among those with the CC MTHFR genotype (OR=4.43; 95% CI: 1.15-17.05). Increased risk was also apparent for weekly alcohol consumption when accounting for the multiplicative interaction between folate intake and MTHFR C677T genotype (OR=3.22; 95% CI: 1.36-7.59). Conclusion: Alcohol consumption is associated with increased prostate cancer risk, and this association is stronger among men with low folate intake, with the CC MTHFR genotype, and when accounting for the joint effect of folate intake and MTHFR C677T genotype.
    Schlagwörter Men ; genetic variants ; alcohol ; prostate cancer ; gene-environment interactions ; Carbon Metabolism ; Folate ; C677T MTHFR gene polymorphism ; case-control study ; male health ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2012-08-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Screening for prostate cancer

    Alexandria Bennett / Andrew Beck / Nicole Shaver / Roland Grad / Allana LeBlanc / Heather Limburg / Casey Gray / Ahmed Abou-Setta / Scott Klarenbach / Navindra Persaud / Guylène Thériault / Brett D. Thombs / Keith J. Todd / Neil Bell / Philipp Dahm / Andrew Loblaw / Lisa Del Giudice / Xiaomei Yao / Becky Skidmore /
    Elizabeth Rolland-Harris / Melissa Brouwers / Julian Little / David Moher

    Systematic Reviews, Vol 11, Iss 1, Pp 1-

    protocol for updating multiple systematic reviews to inform a Canadian Task Force on Preventive Health Care guideline update

    2022  Band 19

    Abstract: Abstract Purpose To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series ... ...

    Abstract Abstract Purpose To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening for prostate cancer in adults aged 18 years and older in primary care. This protocol outlines the planned scope and methods for a series of systematic reviews. Methods Updates of two systematic reviews and a de novo review will be conducted to synthesize the evidence on the benefits and harms of screening for prostate cancer with a prostate-specific antigen (PSA) and/or digital rectal examination (DRE) (with or without additional information) and patient values and preferences. Outcomes for the benefits of screening include reduced prostate cancer mortality, all-cause mortality, and incidence of metastatic prostate cancer. Outcomes for the harms of screening include false-positive screening tests, overdiagnosis, complications due to biopsy, and complications of treatment including incontinence (urinary or bowel), and erectile dysfunction. The quality of life or functioning (overall and disease-specific) and psychological effects outcomes are considered as a possible benefit or harm. Outcomes for the values and preferences review include quantitative or qualitative information regarding the choice to screen or intention to undergo screening. For the reviews on benefits or harms, we will search for randomized controlled trials, quasi-randomized, and controlled studies in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. For the review on values and preferences, we will search for experimental or observational studies in MEDLINE, Embase, and PsycInfo. For all reviews, we will also search websites of relevant organizations, gray literature, and reference lists of included studies. Title and abstract screening, full-text review, data extraction, and risk of bias assessments will be completed independently by pairs of reviewers with any disagreements resolved by consensus or by consulting with a third reviewer. The GRADE (Grading of Recommendations Assessment, Development and ...
    Schlagwörter Systematic review ; Adults ; Guideline ; Primary care ; Prostate cancer ; Screening ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-10-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Screening to prevent fragility fractures among adults 40 years and older in primary care

    Michelle Gates / Jennifer Pillay / Guylène Thériault / Heather Limburg / Roland Grad / Scott Klarenbach / Christina Korownyk / Donna Reynolds / John J. Riva / Brett D. Thombs / Gregory A. Kline / William D. Leslie / Susan Courage / Ben Vandermeer / Robin Featherstone / Lisa Hartling

    Systematic Reviews, Vol 8, Iss 1, Pp 1-

    protocol for a systematic review

    2019  Band 21

    Abstract: Abstract Purpose To inform recommendations by the Canadian Task Force on Preventive Health Care by systematically reviewing direct evidence on the effectiveness and acceptability of screening adults 40 years and older in primary care to reduce fragility ... ...

    Abstract Abstract Purpose To inform recommendations by the Canadian Task Force on Preventive Health Care by systematically reviewing direct evidence on the effectiveness and acceptability of screening adults 40 years and older in primary care to reduce fragility fractures and related mortality and morbidity, and indirect evidence on the accuracy of fracture risk prediction tools. Evidence on the benefits and harms of pharmacological treatment will be reviewed, if needed to meaningfully influence the Task Force’s decision-making. Methods A modified update of an existing systematic review will evaluate screening effectiveness, the accuracy of screening tools, and treatment benefits. For treatment harms, we will integrate studies from existing systematic reviews. A de novo review on acceptability will be conducted. Peer-reviewed searches (Medline, Embase, Cochrane Library, PsycINFO [acceptability only]), grey literature, and hand searches of reviews and included studies will update the literature. Based on pre-specified criteria, we will screen studies for inclusion following a liberal-accelerated approach. Final inclusion will be based on consensus. Data extraction for study results will be performed independently by two reviewers while other data will be verified by a second reviewer; there may be some reliance on extracted data from the existing reviews. The risk of bias assessments reported in the existing reviews will be verified and for new studies will be performed independently. When appropriate, results will be pooled using either pairwise random effects meta-analysis (screening and treatment) or restricted maximum likelihood estimation with Hartun-Knapp-Sidnick-Jonkman correction (risk prediction model calibration). Subgroups of interest to explain heterogeneity are age, sex, and menopausal status. Two independent reviewers will rate the certainty of evidence using the GRADE approach, with consensus reached for each outcome rated as critical or important by the Task Force. Discussion Since the publication of other ...
    Schlagwörter Systematic review ; Guideline ; Fragility fractures ; Screening ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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