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  1. Article ; Online: MetaTreeMap: An Alternative Visualization Method for Displaying Metagenomic Phylogenic Trees.

    Hebrard, Maxime / Taylor, Todd D

    PloS one

    2016  Volume 11, Issue 6, Page(s) e0158261

    Abstract: Metagenomic samples can contain hundreds or thousands of different species. The most common method to identify these species is to sequence the samples and then classify the reads to nodes along a phylogenic tree. Linear representations of trees with so ... ...

    Abstract Metagenomic samples can contain hundreds or thousands of different species. The most common method to identify these species is to sequence the samples and then classify the reads to nodes along a phylogenic tree. Linear representations of trees with so many nodes face legibility issues. In addition, such views are not optimal for appreciating the read quantity assigned to each node. The problem is exaggerated when comparison between multiple samples is needed. MetaTreeMap adapts a visualization method that addresses these weaknesses. The tree is represented by nested rectangles that illustrate the number or percentage of assigned reads. MetaTreeMap implements various options specific to phylogenic trees that allow for quick overview and investigation of the information. More generally, the goal of this software is to provide the user with the ability to easily display phylogenic trees based on various quantities assigned to the nodes, such as read number, percentage or other values. The tool can be used online at http://metasystems.riken.jp/visualization/treemap/.
    MeSH term(s) Computer Graphics ; Metagenomics/methods ; Phylogeny ; Software ; User-Computer Interface ; Web Browser
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0158261
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  2. Article ; Online: SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.

    Leuzzi, Giuseppe / Vasciaveo, Alessandro / Taglialatela, Angelo / Chen, Xiao / Firestone, Tessa M / Hickman, Allison R / Mao, Wendy / Thakar, Tanay / Vaitsiankova, Alina / Huang, Jen-Wei / Cuella-Martin, Raquel / Hayward, Samuel B / Kesner, Jordan S / Ghasemzadeh, Ali / Nambiar, Tarun S / Ho, Patricia / Rialdi, Alexander / Hebrard, Maxime / Li, Yinglu /
    Gao, Jinmei / Gopinath, Saarang / Adeleke, Oluwatobi A / Venters, Bryan J / Drake, Charles G / Baer, Richard / Izar, Benjamin / Guccione, Ernesto / Keogh, Michael-Christopher / Guerois, Raphael / Sun, Lu / Lu, Chao / Califano, Andrea / Ciccia, Alberto

    Cell

    2024  Volume 187, Issue 4, Page(s) 861–881.e32

    Abstract: Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify the SNF2-family DNA ... ...

    Abstract Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify the SNF2-family DNA translocase SMARCAL1 as a factor that favors tumor immune evasion by a dual mechanism involving both the suppression of innate immune signaling and the induction of PD-L1-mediated immune checkpoint responses. Mechanistically, SMARCAL1 limits endogenous DNA damage, thereby suppressing cGAS-STING-dependent signaling during cancer cell growth. Simultaneously, it cooperates with the AP-1 family member JUN to maintain chromatin accessibility at a PD-L1 transcriptional regulatory element, thereby promoting PD-L1 expression in cancer cells. SMARCAL1 loss hinders the ability of tumor cells to induce PD-L1 in response to genomic instability, enhances anti-tumor immune responses and sensitizes tumors to immune checkpoint blockade in a mouse melanoma model. Collectively, these studies uncover SMARCAL1 as a promising target for cancer immunotherapy.
    MeSH term(s) Animals ; Mice ; B7-H1 Antigen/metabolism ; Genomic Instability ; Immunity, Innate ; Melanoma/immunology ; Melanoma/metabolism ; Tumor Escape ; DNA Helicases/metabolism
    Chemical Substances B7-H1 Antigen ; Smarcal1 protein, mouse (EC 2.7.7.-) ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.008
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  3. Article ; Online: EHMT2 epigenetically suppresses Wnt signaling and is a potential target in embryonal rhabdomyosarcoma.

    Pal, Ananya / Leung, Jia Yu / Ang, Gareth Chin Khye / Rao, Vinay Kumar / Pignata, Luca / Lim, Huey Jin / Hebrard, Maxime / Chang, Kenneth Te / Lee, Victor Km / Guccione, Ernesto / Taneja, Reshma

    eLife

    2020  Volume 9

    Abstract: Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstrate ... ...

    Abstract Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstrate that EHMT2 suppresses canonical Wnt signaling by activating expression of the Wnt antagonist
    MeSH term(s) Animals ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Dimethyl Sulfoxide/pharmacology ; Epigenesis, Genetic ; Gene Expression Regulation, Developmental/drug effects ; Gene Expression Regulation, Developmental/physiology ; Gene Expression Regulation, Neoplastic/drug effects ; Gene Expression Regulation, Neoplastic/physiology ; Genetic Predisposition to Disease ; Histocompatibility Antigens/genetics ; Histocompatibility Antigens/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Mice ; Mice, Nude ; Puromycin/pharmacology ; Pyrazines/pharmacology ; Pyridines/pharmacology ; Quinazolines/pharmacology ; RNA Interference ; Rhabdomyosarcoma, Embryonal/genetics ; Rhabdomyosarcoma, Embryonal/metabolism ; Wnt Signaling Pathway/physiology
    Chemical Substances Histocompatibility Antigens ; Pyrazines ; Pyridines ; Quinazolines ; UNC0642 ; Puromycin (4A6ZS6Q2CL) ; EHMT2 protein, human (EC 2.1.1.43) ; G9a protein, mouse (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; LGK974 (U27F40013Q) ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2020-11-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.57683
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  4. Article ; Online: Transcriptomic study of Salmonella enterica subspecies enterica serovar Typhi biofilm.

    Chin, Khee Chian Jason / Taylor, Todd Duane / Hebrard, Maxime / Anbalagan, Kogaan / Dashti, Marjan Ganjali / Phua, Kia Kien

    BMC genomics

    2017  Volume 18, Issue 1, Page(s) 836

    Abstract: Background: Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). In chronic carriers, the bacteria survive the harsh environment of the gallbladder by producing biofilm. The ... ...

    Abstract Background: Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). In chronic carriers, the bacteria survive the harsh environment of the gallbladder by producing biofilm. The phenotype of S. Typhi biofilm cells is significantly different from the free-swimming planktonic cells, and studies have shown that they are associated with antibiotic resistance, immune system evasion, and bacterial persistence. However, the mechanism of this transition and the events leading to biofilm formation are unknown. High throughput sequencing was performed to identify the genes involved in biofilm formation and to postulate the mechanism of action.
    Results: Planktonic S. Typhi cells were cultured using standard nutrient broth whereas biofilm cells were cultured in a stressful environment using high shearing-force and bile to mimic the gallbladder. Sequencing libraries were prepared from S. Typhi planktonic cells and mature biofilm cells using the Illumina HiSeq 2500 platform, and the transcriptome data obtained were processed using Cufflinks bioinformatics suite of programs to investigate differential gene expression between the two phenotypes. A total of 35 up-regulated and 29 down-regulated genes were identified. The identities of the differentially expressed genes were confirmed using NCBI BLAST and their functions were analyzed. The results showed that the genes associated with metabolic processes and biofilm regulations were down-regulated while those associated with the membrane matrix and antibiotic resistance were highly up-regulated.
    Conclusions: It is proposed that the biofilm phenotype of S. Typhi allows the bacteria to increase production of the membrane matrix in order to serve as a physical shield and to adhere to surfaces, and enter an energy conservation state in response to the stressful environment. Conversely, the planktonic phenotype allows the bacteria to produce flagella and increase metabolic activity to enable the bacteria to migrate and form new colonies of infection. This data provide a basis for further studies to uncover the mechanism of biofilm formation in S. Typhi and to discover novel genes or pathways associated with the development of the typhoid carrier state.
    MeSH term(s) Biofilms/growth & development ; Gene Expression Profiling/methods ; Gene Expression Regulation, Bacterial ; High-Throughput Nucleotide Sequencing ; Humans ; Salmonella typhi/genetics ; Salmonella typhi/growth & development ; Transcriptome
    Language English
    Publishing date 2017-10-31
    Publishing country England
    Document type Journal Article
    ISSN 1471-2164
    ISSN (online) 1471-2164
    DOI 10.1186/s12864-017-4212-6
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  5. Article ; Online: ScripTree: scripting phylogenetic graphics.

    Chevenet, François / Croce, Olivier / Hebrard, Maxime / Christen, Richard / Berry, Vincent

    Bioinformatics (Oxford, England)

    2010  Volume 26, Issue 8, Page(s) 1125–1126

    Abstract: Unlabelled: There is a large amount of tools for interactive display of phylogenetic trees. However, there is a shortage of tools for the automation of tree rendering. Scripting phylogenetic graphics would enable the saving of graphical analyses ... ...

    Abstract Unlabelled: There is a large amount of tools for interactive display of phylogenetic trees. However, there is a shortage of tools for the automation of tree rendering. Scripting phylogenetic graphics would enable the saving of graphical analyses involving numerous and complex tree handling operations and would allow the automation of repetitive tasks. ScripTree is a tool intended to fill this gap. It is an interpreter to be used in batch mode. Phylogenetic graphics instructions, related to tree rendering as well as tree annotation, are stored in a text file and processed in a sequential way.
    Availability: ScripTree can be used online or downloaded at www.scriptree.org, under the GPL license.
    Implementation: ScripTree, written in Tcl/Tk, is a cross-platform application available for Windows and Unix-like systems including OS X. It can be used either as a stand-alone package or included in a bioinformatic pipeline and linked to a HTTP server.
    MeSH term(s) Databases, Genetic ; Genomics/methods ; Phylogeny ; Software ; User-Computer Interface
    Language English
    Publishing date 2010-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btq086
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  6. Article ; Online: Analysis of clinically relevant variants from ancestrally diverse Asian genomes.

    Chan, Sock Hoai / Bylstra, Yasmin / Teo, Jing Xian / Kuan, Jyn Ling / Bertin, Nicolas / Gonzalez-Porta, Mar / Hebrard, Maxime / Tirado-Magallanes, Roberto / Tan, Joanna Hui Juan / Jeyakani, Justin / Li, Zhihui / Chai, Jin Fang / Chong, Yap Seng / Davila, Sonia / Goh, Liuh Ling / Lee, Eng Sing / Wong, Eleanor / Wong, Tien Yin / Prabhakar, Shyam /
    Liu, Jianjun / Cheng, Ching-Yu / Eisenhaber, Birgit / Karnani, Neerja / Leong, Khai Pang / Sim, Xueling / Yeo, Khung Keong / Chambers, John C / Tai, E-Shyong / Tan, Patrick / Jamuar, Saumya S / Ngeow, Joanne / Lim, Weng Khong

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 6694

    Abstract: Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation in 9051 genomes representing East Asian, South Asian, and severely under-represented Austronesian-speaking Southeast Asian ... ...

    Abstract Asian populations are under-represented in human genomics research. Here, we characterize clinically significant genetic variation in 9051 genomes representing East Asian, South Asian, and severely under-represented Austronesian-speaking Southeast Asian ancestries. We observe disparate genetic risk burden attributable to ancestry-specific recurrent variants and identify individuals with variants specific to ancestries discordant to their self-reported ethnicity, mostly due to cryptic admixture. About 27% of severe recessive disorder genes with appreciable carrier frequencies in Asians are missed by carrier screening panels, and we estimate 0.5% Asian couples at-risk of having an affected child. Prevalence of medically-actionable variant carriers is 3.4% and a further 1.6% harbour variants with potential for pathogenic classification upon additional clinical/experimental evidence. We profile 23 pharmacogenes with high-confidence gene-drug associations and find 22.4% of Asians at-risk of Centers for Disease Control and Prevention Tier 1 genetic conditions concurrently harbour pharmacogenetic variants with actionable phenotypes, highlighting the benefits of pre-emptive pharmacogenomics. Our findings illuminate the diversity in genetic disease epidemiology and opportunities for precision medicine for a large, diverse Asian population.
    MeSH term(s) Child ; Humans ; Asians/genetics ; Genome, Human/genetics ; Ethnicity ; Pharmacogenetics ; Phenotype
    Language English
    Publishing date 2022-11-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-34116-9
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  7. Article ; Online: A five-safes approach to a secure and scalable genomics data repository.

    Shih, Chih Chuan / Chen, Jieqi / Lee, Ai Shan / Bertin, Nicolas / Hebrard, Maxime / Khor, Chiea Chuen / Li, Zheng / Juan Tan, Joanna Hui / Meah, Wee Yang / Peh, Su Qin / Mok, Shi Qi / Sim, Kar Seng / Liu, Jianjun / Wang, Ling / Wong, Eleanor / Li, Jingmei / Tin, Aung / Cheng, Ching-Yu / Heng, Chew-Kiat /
    Yuan, Jian-Min / Koh, Woon-Puay / Saw, Seang Mei / Friedlander, Yechiel / Sim, Xueling / Chai, Jin Fang / Chong, Yap Seng / Davila, Sonia / Goh, Liuh Ling / Lee, Eng Sing / Wong, Tien Yin / Karnani, Neerja / Leong, Khai Pang / Yeo, Khung Keong / Chambers, John C / Lim, Su Chi / Goh, Rick Siow Mong / Tan, Patrick / Dorajoo, Rajkumar

    iScience

    2023  Volume 26, Issue 4, Page(s) 106546

    Abstract: Genomic researchers increasingly utilize commercial cloud service providers (CSPs) to manage data and analytics needs. CSPs allow researchers to grow Information Technology (IT) infrastructure on demand to overcome bottlenecks when combining large ... ...

    Abstract Genomic researchers increasingly utilize commercial cloud service providers (CSPs) to manage data and analytics needs. CSPs allow researchers to grow Information Technology (IT) infrastructure on demand to overcome bottlenecks when combining large datasets. However, without adequate security controls, the risk of unauthorized access may be higher for data stored on the cloud. Additionally, regulators are mandating data access patterns and specific security protocols for the storage and use of genomic data. While CSP provides tools for security and regulatory compliance, building the necessary controls required for cloud solutions is not trivial. Research Assets Provisioning and Tracking Online Repository (RAPTOR) by the Genome Institute of Singapore is a cloud-native genomics data repository and analytics platform that implements a "five-safes" framework to provide security and governance controls to data contributors and users, leveraging CSP for sharing and analysis of genomic datasets without the risk of security breaches or running afoul of regulations.
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106546
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  8. Article ; Online: The Singapore National Precision Medicine Strategy.

    Wong, Eleanor / Bertin, Nicolas / Hebrard, Maxime / Tirado-Magallanes, Roberto / Bellis, Claire / Lim, Weng Khong / Chua, Chee Yong / Tong, Philomena Mei Lin / Chua, Raymond / Mak, Kenneth / Lim, Tit Meng / Cheong, Wei Yang / Thien, Kwee Eng / Goh, Khean Teik / Chai, Jin-Fang / Lee, Jimmy / Sung, Joseph Jao-Yiu / Wong, Tien Yin / Chin, Calvin Woon Loong /
    Gluckman, Peter D / Goh, Liuh Ling / Ban, Kenneth Hon Kim / Tan, Tin Wee / Sim, Xueling / Cheng, Ching-Yu / Davila, Sonia / Karnani, Neerja / Leong, Khai Pang / Liu, Jianjun / Prabhakar, Shyam / Maurer-Stroh, Sebastian / Verma, Chandra Shekhar / Krishnaswamy, Pavitra / Goh, Rick Siow Mong / Chia, Irenaeus / Ho, Clarissa / Low, Doreen / Virabhak, Suchin / Yong, Jacklyn / Zheng, Weiling / Seow, Shih Wee / Seck, Yee Kwang / Koh, Mingshi / Chambers, John C / Tai, E Shyong / Tan, Patrick

    Nature genetics

    2023  Volume 55, Issue 2, Page(s) 178–186

    Abstract: Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine. ...

    Abstract Precision medicine promises to transform healthcare for groups and individuals through early disease detection, refining diagnoses and tailoring treatments. Analysis of large-scale genomic-phenotypic databases is a critical enabler of precision medicine. Although Asia is home to 60% of the world's population, many Asian ancestries are under-represented in existing databases, leading to missed opportunities for new discoveries, particularly for diseases most relevant for these populations. The Singapore National Precision Medicine initiative is a whole-of-government 10-year initiative aiming to generate precision medicine data of up to one million individuals, integrating genomic, lifestyle, health, social and environmental data. Beyond technologies, routine adoption of precision medicine in clinical practice requires social, ethical, legal and regulatory barriers to be addressed. Identifying driver use cases in which precision medicine results in standardized changes to clinical workflows or improvements in population health, coupled with health economic analysis to demonstrate value-based healthcare, is a vital prerequisite for responsible health system adoption.
    MeSH term(s) Humans ; Singapore ; Precision Medicine/methods ; Delivery of Health Care ; Asia
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-022-01274-x
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  9. Article ; Online: Homozygosity mapping in autosomal recessive retinitis pigmentosa families detects novel mutations.

    Bocquet, Béatrice / Marzouka, Nour Al Dain / Hebrard, Maxime / Manes, Gaël / Sénéchal, Audrey / Meunier, Isabelle / Hamel, Christian P

    Molecular vision

    2013  Volume 19, Page(s) 2487–2500

    Abstract: Purpose: Autosomal recessive retinitis pigmentosa (arRP) is a genetically heterogeneous disease resulting in progressive loss of photoreceptors that leads to blindness. To date, 36 genes are known to cause arRP, rendering the molecular diagnosis a ... ...

    Abstract Purpose: Autosomal recessive retinitis pigmentosa (arRP) is a genetically heterogeneous disease resulting in progressive loss of photoreceptors that leads to blindness. To date, 36 genes are known to cause arRP, rendering the molecular diagnosis a challenge. The aim of this study was to use homozygosity mapping to identify the causative mutation in a series of inbred families with arRP.
    Methods: arRP patients underwent standard ophthalmic examination, Goldman perimetry, fundus examination, retinal OCT, autofluorescence measurement, and full-field electroretinogram. Fifteen consanguineous families with arRP excluded for USH2A and EYS were genotyped on 250 K SNP arrays. Homozygous regions were listed, and known genes within these regions were PCR sequenced. Familial segregation and mutation analyzes were performed.
    Results: We found ten mutations, seven of which were novel mutations in eight known genes, including RP1, IMPG2, NR2E3, PDE6A, PDE6B, RLBP1, CNGB1, and C2ORF71, in ten out of 15 families. The patients carrying RP1, C2ORF71, and IMPG2 mutations presented with severe RP, while those with PDE6A, PDE6B, and CNGB1 mutations were less severely affected. The five families without mutations in known genes could be a source of identification of novel genes.
    Conclusions: Homozygosity mapping combined with systematic screening of known genes results in a positive molecular diagnosis in 66.7% of families.
    MeSH term(s) Adolescent ; Adult ; Consanguinity ; Exons ; Eye Proteins/genetics ; Female ; Genes, Recessive ; Genotyping Techniques ; Homozygote ; Humans ; Introns ; Male ; Middle Aged ; Mutation ; Pedigree ; Polymorphism, Genetic ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/pathology ; Sequence Analysis, DNA ; Severity of Illness Index
    Chemical Substances Eye Proteins
    Language English
    Publishing date 2013-12-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2017540-1
    ISSN 1090-0535 ; 1090-0535
    ISSN (online) 1090-0535
    ISSN 1090-0535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Population genomics of picophytoplankton unveils novel chromosome hypervariability.

    Blanc-Mathieu, Romain / Krasovec, Marc / Hebrard, Maxime / Yau, Sheree / Desgranges, Elodie / Martin, Joel / Schackwitz, Wendy / Kuo, Alan / Salin, Gerald / Donnadieu, Cecile / Desdevises, Yves / Sanchez-Ferandin, Sophie / Moreau, Hervé / Rivals, Eric / Grigoriev, Igor V / Grimsley, Nigel / Eyre-Walker, Adam / Piganeau, Gwenael

    Science advances

    2017  Volume 3, Issue 7, Page(s) e1700239

    Abstract: Tiny photosynthetic microorganisms that form the picoplankton (between 0.3 and 3 μm in diameter) are at the base of the food web in many marine ecosystems, and their adaptability to environmental change hinges on standing genetic variation. Although the ... ...

    Abstract Tiny photosynthetic microorganisms that form the picoplankton (between 0.3 and 3 μm in diameter) are at the base of the food web in many marine ecosystems, and their adaptability to environmental change hinges on standing genetic variation. Although the genomic and phenotypic diversity of the bacterial component of the oceans has been intensively studied, little is known about the genomic and phenotypic diversity within each of the diverse eukaryotic species present. We report the level of genomic diversity in a natural population of
    MeSH term(s) Chromosomes ; Disease Susceptibility ; Evolution, Molecular ; Genetic Variation ; Genetics, Population ; Genomics/methods ; Mutation ; Phenotype ; Phylogeny ; Phytoplankton/classification ; Phytoplankton/genetics ; Phytoplankton/virology ; Polymorphism, Single Nucleotide ; Selection, Genetic
    Language English
    Publishing date 2017-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.1700239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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