Article ; Online: Postsurgical Latent Pain Sensitization Is Driven by Descending Serotonergic Facilitation and Masked by µ-Opioid Receptor Constitutive Activity in the Rostral Ventromedial Medulla.
The Journal of neuroscience : the official journal of the Society for Neuroscience
2022 Volume 42, Issue 30, Page(s) 5870–5881
Abstract: Following tissue injury, latent sensitization (LS) of nociceptive signaling can persist indefinitely, kept in remission by compensatory µ-opioid receptor constitutive activity ( ... ...
Abstract | Following tissue injury, latent sensitization (LS) of nociceptive signaling can persist indefinitely, kept in remission by compensatory µ-opioid receptor constitutive activity (MOR |
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MeSH term(s) | Analgesics, Opioid ; Animals ; Female ; Hyperalgesia/metabolism ; Male ; Medulla Oblongata/physiology ; Mice ; Narcotic Antagonists/pharmacology ; Pain, Postoperative/metabolism ; Receptors, Opioid, mu/metabolism ; Serotonin/metabolism |
Chemical Substances | Analgesics, Opioid ; Narcotic Antagonists ; Receptors, Opioid, mu ; Serotonin (333DO1RDJY) |
Language | English |
Publishing date | 2022-06-14 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural |
ZDB-ID | 604637-x |
ISSN | 1529-2401 ; 0270-6474 |
ISSN (online) | 1529-2401 |
ISSN | 0270-6474 |
DOI | 10.1523/JNEUROSCI.2038-21.2022 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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