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  1. Article ; Online: Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson’s disease

    Ji-Hye Oh / Sungyang Jo / Kye Won Park / Eun-Jae Lee / Seung Hyun Lee / Yun Su Hwang / Ha Ra Jeon / Yeonjin Ryu / Hee Jeong Yoon / Sung-Min Chun / Chong Jai Kim / Tae Won Kim / Chang Ohk Sung / Sehyun Chae / Sun Ju Chung

    Experimental and Molecular Medicine, Vol 55, Iss 3, Pp 555-

    2023  Volume 564

    Abstract: Parkinson’s disease: genetic risk factors in a Korean population A whole-genome sequencing study of Korean individuals with Parkinson’s disease (PD) has identified several new genetic risk factors, ranging from single nucleotide variations (SNVs) to ... ...

    Abstract Parkinson’s disease: genetic risk factors in a Korean population A whole-genome sequencing study of Korean individuals with Parkinson’s disease (PD) has identified several new genetic risk factors, ranging from single nucleotide variations (SNVs) to larger DNA deletions. PD is the second most prevalent neurodegenerative disease globally, but most studies have focused on SNVs in European populations. Using whole-genome sequencing, Ji-Hye Oh at the University of Ulsan, Seoul, South Korea, and co-workers were able to identify genetic differences between PD patients and healthy controls, including deletions, gains, and several new SNVs. In particular, deletions of small non-coding regions that regulate gene expression may be key contributors to PD. These results provide a whole-genome perspective on genetic risk factors for PD in a Korean population, and illuminate how a whole-genome sequencing approach may be helpful in identifying genetic factors underlying other diseases.
    Keywords Medicine ; R ; Biochemistry ; QD415-436
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Spin-phonon interaction increased by compressive strain in antiferromagnetic MnO thin films.

    Kashir, Alireza / Goian, Veronica / Pacherová, Oliva / Savinov, Maxim / Hee Jeong, Yoon / Lee, Gil-Ho / Kamba, Stanislav

    Journal of physics. Condensed matter : an Institute of Physics journal

    2020  Volume 32, Issue 17, Page(s) 175402

    Abstract: MnO thin films with various thicknesses and strains were grown on MgO substrates by pulsed laser deposition technique, then characterized using x-ray diffraction and infrared reflectance spectroscopy. Films grown on (0 0 1)-oriented MgO substrates ... ...

    Abstract MnO thin films with various thicknesses and strains were grown on MgO substrates by pulsed laser deposition technique, then characterized using x-ray diffraction and infrared reflectance spectroscopy. Films grown on (0 0 1)-oriented MgO substrates exhibit homogenous biaxial compressive strain which increases as the film thickness is reduced. For that reason, in paramagnetic phase, the frequency of doubly-degenerate phonon increases with the strain, and splits below Néel temperature T
    Language English
    Publishing date 2020-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472968-4
    ISSN 1361-648X ; 0953-8984
    ISSN (online) 1361-648X
    ISSN 0953-8984
    DOI 10.1088/1361-648X/ab6be9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cytotoxicity Evaluation of Turmeric Extract Incorporated Oil-in-Water Nanoemulsion

    Hee Jeong Yoon / Xiaowei Zhang / Min Gyeong Kang / Gyeong Jin Kim / Sun Young Shin / Sang Hong Baek / Bom Nae Lee / Su Jung Hong / Jun Tae Kim / Kwonho Hong / Hojae Bae

    International Journal of Molecular Sciences, Vol 19, Iss 1, p

    2018  Volume 280

    Abstract: To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the ... ...

    Abstract To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8.6 made by increasing the content of natural emulsifier (lecithin) to reduce the potential toxicity of nanoemulsion were cultured with various cells (NIH3T3, H9C2, HepG2, hCPC, and hEPC) and the changes of each cell were observed followed by nanoemulsion treatment. As a result, the two nanoemulsions (TE-NEP-10.6 and TE-NEP-8.6) did not show significant difference in cell viability. In the case of cell line (NIH3T3, H9C2, and HepG2), toxicity was not observed at an experimental concentration of less than 1 mg/mL, however, the cell survival rate decreased in a concentration dependent manner in the case of primary cultured cells. These results from our study can be used as a basic data to confirm the cell type dependent toxicity of nanoemulsion.
    Keywords turmeric ; curcumin ; nanoemulsion ; cytotoxicity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 500
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cold Water Fish Gelatin Methacryloyl Hydrogel for Tissue Engineering Application.

    Hee Jeong Yoon / Su Ryon Shin / Jae Min Cha / Soo-Hong Lee / Jin-Hoi Kim / Jeong Tae Do / Hyuk Song / Hojae Bae

    PLoS ONE, Vol 11, Iss 10, p e

    2016  Volume 0163902

    Abstract: Gelatin methacryloyl (GelMA) is a versatile biomaterial that has been used in various biomedical fields. Thus far, however, GelMA is mostly obtained from mammalian sources, which are associated with a risk of transmission of diseases, such as mad cow ... ...

    Abstract Gelatin methacryloyl (GelMA) is a versatile biomaterial that has been used in various biomedical fields. Thus far, however, GelMA is mostly obtained from mammalian sources, which are associated with a risk of transmission of diseases, such as mad cow disease, as well as certain religious restrictions. In this study, we synthesized GelMA using fish-derived gelatin by a conventional GelMA synthesis method, and evaluated its physical properties and cell responses. The lower melting point of fish gelatin compared to porcine gelatin allowed larger-scale synthesis of GelMA and enabled hydrogel fabrication at room temperature. The properties (mechanical strength, water swelling degree and degradation rate) of fish GelMA differed from those of porcine GelMA, and could be tuned to suit diverse applications. Cells adhered, proliferated, and formed networks with surrounding cells on fish GelMA, and maintained high initial cell viability. These data suggest that fish GelMA could be utilized in a variety of biomedical fields as a substitute for mammalian-derived materials.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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