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  1. Article ; Online: Pankreaserkrankungen.

    Heeg, Steffen / Thimme, Robert

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 4, Page(s) 213

    Title translation Pancreatic diseases.
    Language German
    Publishing date 2021-02-16
    Publishing country Germany
    Document type Editorial
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1219-5592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer.

    Heeg, Steffen

    Pharmacogenomics and personalized medicine

    2015  Volume 8, Page(s) 171–180

    Abstract: Immortalization is an important step toward the malignant transformation of human cells and is critically dependent upon telomere maintenance. There are two known mechanisms to maintain human telomeres. The process of telomere maintenance is either ... ...

    Abstract Immortalization is an important step toward the malignant transformation of human cells and is critically dependent upon telomere maintenance. There are two known mechanisms to maintain human telomeres. The process of telomere maintenance is either mediated through activation of the enzyme telomerase or through an alternative mechanism of telomere lengthening called ALT. While 85% of all human tumors show reactivation of telomerase, the remaining 15% are able to maintain telomeres via ALT. The therapeutic potential of telomerase inhibitors is currently investigated in a variety of human cancers. Gastrointestinal tumors are highly dependent on telomerase as a mechanism of telomere maintenance, rendering telomeres as well as telomerase potential targets for cancer therapy. This article focuses on the molecular mechanisms of telomere biology and telomerase activation in gastrointestinal cancers and reviews strategies of telomerase inhibition and their potential therapeutic use in these tumor entities.
    Language English
    Publishing date 2015-12-04
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508173-1
    ISSN 1178-7066
    ISSN 1178-7066
    DOI 10.2147/PGPM.S52808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pankreaserkrankungen

    Heeg, Steffen / Thimme, Robert

    DMW - Deutsche Medizinische Wochenschrift

    2021  Volume 145, Issue 04, Page(s) 213–213

    Language German
    Publishing date 2021-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1219-5592
    Database Thieme publisher's database

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  4. Article ; Online: Akute Pankreatitis.

    Schiemer, Moritz / Treiber, Maryam / Heeg, Steffen

    Deutsche medizinische Wochenschrift (1946)

    2021  Volume 146, Issue 4, Page(s) 229–236

    Abstract: Acute pancreatitis is one of the most common gastrointestinal diseases requiring acute hospitalization and its incidence is increasing. A particular challenge is the prediction and treatment of severe cases, which only affect a minority of patients, but ... ...

    Title translation Acute Pancreatitis.
    Abstract Acute pancreatitis is one of the most common gastrointestinal diseases requiring acute hospitalization and its incidence is increasing. A particular challenge is the prediction and treatment of severe cases, which only affect a minority of patients, but are associated with mortality rates of up to 30 percent. In this review, we consider the diagnostic evaluation of the disease and provide an overview of current conservative and interventional treatment strategies.
    Language German
    Publishing date 2021-02-16
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1221-7186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Successful PRRT-rechallenge in a metastasized neuroendocrine tumor of the middle ear.

    Ruf, Juri / Becker, Christoph / Dovi-Akué, Philippe / Brass, Volker / Heeg, Steffen

    Nuklearmedizin. Nuclear medicine

    2022  Volume 61, Issue 5, Page(s) 416–417

    Title translation Erfolgreiche Rechallenge-PRRT eines metastasierten neuroendokrinen Tumors des Mittelohrs.
    MeSH term(s) Ear, Middle/pathology ; Humans ; Neuroendocrine Tumors/diagnostic imaging ; Neuroendocrine Tumors/pathology ; Octreotide ; Pancreatic Neoplasms
    Chemical Substances Octreotide (RWM8CCW8GP)
    Language English
    Publishing date 2022-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2030804-8
    ISSN 2567-6407 ; 0029-5566
    ISSN (online) 2567-6407
    ISSN 0029-5566
    DOI 10.1055/a-1856-4290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Akute Pankreatitis

    Schiemer, Moritz / Treiber, Maryam / Heeg, Steffen

    DMW - Deutsche Medizinische Wochenschrift

    2021  Volume 145, Issue 04, Page(s) 229–236

    Keywords akute Pankreatitis ; Klassifikation ; Diagnose ; Therapie ; acute pancreatitis ; classification ; diagnosis ; treatment
    Language German
    Publishing date 2021-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-1221-7186
    Database Thieme publisher's database

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  7. Article: Successful PRRT-rechallenge in a metastasized neuroendocrine tumor of the middle ear

    Ruf, Juri / Becker, Christoph / Dovi-Akué, Philippe / Brass, Volker / Heeg, Steffen

    Nuklearmedizin - NuclearMedicine

    2022  Volume 61, Issue 05, Page(s) 416–417

    Language English
    Publishing date 2022-08-18
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2030804-8
    ISSN 2567-6407 ; 0029-5566
    ISSN (online) 2567-6407
    ISSN 0029-5566
    DOI 10.1055/a-1856-4290
    Database Thieme publisher's database

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  8. Book ; Online ; Thesis: Der EGFR-Signalweg als ein Schlüsselmechanismus in der In-vitro-Transformation und Telomerasereaktivierung

    Heeg, Steffen [Verfasser]

    2007  

    Author's details vorgelegt von Steffen Heeg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  9. Article ; Online: Radiofrequency ablation is a treatment option for early stages of verrucous esophageal carcinoma.

    Knoop, Richard F / Richter-Schrag, Hans-Juergen / Heeg, Steffen / Hoeppner, Jens / Fischer, Andreas

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2016  Volume 1, Issue 4, Page(s) 78–81

    Keywords covid19
    Language English
    Publishing date 2016-10-08
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2016.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effect of Hyperthermic Intraperitoneal Chemotherapy on Cytoreductive Surgery in Gastric Cancer With Synchronous Peritoneal Metastases: The Phase III GASTRIPEC-I Trial.

    Rau, Beate / Lang, Hauke / Koenigsrainer, Alfred / Gockel, Ines / Rau, Horst-Guenter / Seeliger, Hendrik / Lerchenmueller, Christian / Reim, Daniel / Wahba, Roger / Angele, Martin / Heeg, Steffen / Keck, Tobias / Weimann, Arved / Topp, Stefan / Piso, Pompiliu / Brandl, Andreas / Schuele, Silke / Jo, Peter / Pratschke, Johann /
    Wegel, Sandra / Rehders, Alexander / Moosmann, Nicolas / Gaedcke, Jochen / Heinemann, Volker / Trips, Evelyn / Loeffler, Markus / Schlag, Peter Michael / Thuss-Patience, Peter

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 42, Issue 2, Page(s) 146–156

    Abstract: Purpose: In patients with peritoneal metastasis (PM) from gastric cancer (GC), chemotherapy is the treatment of choice. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are still being debated. This randomized, ... ...

    Abstract Purpose: In patients with peritoneal metastasis (PM) from gastric cancer (GC), chemotherapy is the treatment of choice. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are still being debated. This randomized, controlled, open-label, multicenter phase III trial (EudraCT 2006-006088-22; ClinicalTrials.gov identifier: NCT02158988) explored the impact on overall survival (OS) of HIPEC after CRS.
    Patients and methods: Adult patients with GC and histologically proven PM were randomly assigned (1:1) to perioperative chemotherapy and CRS alone (CRS-A) or CRS plus HIPEC (CRS + H). HIPEC comprised mitomycin C 15 mg/m
    Results: Between March 2014 and June 2018, 105 patients were randomly assigned (53 patients to CRS-A and 52 patients to CRS + H). The trial stopped prematurely because of slow recruitment. In 55 patients, treatment stopped before CRS mainly due to disease progression/death. Median OS was the same for both groups (CRS + H, 14.9 [97.2% CI, 8.7 to 17.7] months
    Conclusion: This study showed no OS difference between CRS + H and CRS-A. PFS and MFS were significantly better in the CRS + H group, which needs further exploration. HIPEC did not increase AEs.
    MeSH term(s) Adult ; Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery ; Peritoneal Neoplasms/drug therapy ; Peritoneal Neoplasms/secondary ; Hyperthermic Intraperitoneal Chemotherapy ; Combined Modality Therapy ; Cytoreduction Surgical Procedures/adverse effects ; Hyperthermia, Induced ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Survival Rate ; Retrospective Studies
    Chemical Substances crisamicin A (KJ7654W82V)
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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