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Book: Eye pathology

Heegaard, Steffen / Grossniklaus, Hans E.

an illustrated guide

2015

Author's details	Steffen Heegaard ; Hans Grossniklaus ed
Keywords	Augenkrankheit
Subject	Ophthalmopathia ; Ophthalmopathie ; Augenerkrankung
Language	English
Size	VIII, 739 S. : zahlr. Ill.
Publisher	Springer
Publishing place	Heidelberg u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT018511425
ISBN	978-3-662-43381-2 ; 978-3-662-51182-4 ; 3-662-43381-8 ; 9783662433829 ; 3-662-51182-7 ; 3662433826
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2015 A 143	available for loan (reading room)	Lesesaal EG

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Book: Morphology of the vitreoretinal border region

Heegaard, Steffen

(Acta ophthalmologica Scandinavica : Supplement ; 222)

1997

Title variant	København, Univ., Diss., 1997
Author's details	Steffen Heegaard
Series title	Acta ophthalmologica Scandinavica : Supplement ; 222 Acta ophthalmologica Scandinavica Acta ophthalmologica Scandinavica ; Supplement
Collection	Acta ophthalmologica Scandinavica Acta ophthalmologica Scandinavica ; Supplement
Keywords	Retina / anatomy & histology ; Vitreous Body / anatomy & histology ; Netzhaut ; Morphologie ; Glaskörper
Subject	Tiermorphologie ; Morphologie ; Corpus vitreum ; Retina
Language	English
Size	31 S. : Ill., graph. Darst.
Publisher	Scriptor
Publishing place	Copenhagen
Publishing country	Denmark
Document type	Book
HBZ-ID	HT007676089
ISBN	87-7264-055-3 ; 978-87-7264-055-6
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Ul I Zs 90 -Suppl.222-	verfügbar in Königswinter	Königswinter

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Article: Aquaporins in Eye.

Tran, Thuy Linh / Hamann, Steffen / Heegaard, Steffen

Advances in experimental medicine and biology

2023 Volume 1398, Page(s) 203–209

Abstract: The major part of the eye consists of water. Continuous movement of water and ions between the ocular compartments and to the systemic circulation is pivotal for many physiological functions in the eye. The movement of water facilitates removal of the ... ...

Abstract	The major part of the eye consists of water. Continuous movement of water and ions between the ocular compartments and to the systemic circulation is pivotal for many physiological functions in the eye. The movement of water facilitates removal of the many metabolic products of corneal-, ciliary body-, lens-, and retinal metabolism, while maintaining transparency in the optical compartments. Transport across the corneal epithelium and endothelium maintains the corneal transparency. Also, aqueous humor is continuously secreted by the epithelia of the ciliary body and maintains the intraocular pressure. In the retina, water is transported into the vitreous body and across the retinal pigment epithelium to regulate the extracellular environment and the hydration of the retina. Aquaporins are a major contributor in the water transport throughout the eye.
MeSH term(s)	Eye/metabolism ; Aquaporins/metabolism ; Retina/metabolism ; Cornea ; Lens, Crystalline/metabolism ; Water/metabolism
Chemical Substances	Aquaporins ; Water (059QF0KO0R)
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-981-19-7415-1_14
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Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Surgical Procedures in the Treatment of Dry Eye Disease.

Møller-Hansen, Michael / Utheim, Tor Paaske / Heegaard, Steffen

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

2023 Volume 39, Issue 10, Page(s) 692–698

Abstract: Dry eye disease (DED) is a multifactorial disease affecting 5% to 50% in different populations. The most severe cases of DED are often caused by aqueous deficient dry eye disease (ADDE) due to lacrimal gland (LG) hypofunction. Many patients with severe ... ...

Abstract	Dry eye disease (DED) is a multifactorial disease affecting 5% to 50% in different populations. The most severe cases of DED are often caused by aqueous deficient dry eye disease (ADDE) due to lacrimal gland (LG) hypofunction. Many patients with severe ADDE do not experience adequate symptom relief from topical treatment, severely reducing their quality of life. The focus of this review is to describe the surgical interventions presently being used or investigated when topical treatment with eye drops is insufficient. The conventional surgical approach is to proceed to punctal occlusion or partial or total tarsorrhaphy. However, novel surgical procedures have been reported to have higher efficacy and patient satisfaction than conventional treatments. These procedures include amniotic membrane transplantation, transposition or transplantation of the salivary glands, and cell-based injections into the LG, each with strengths and weaknesses. Further development of these treatment modalities might prove pivotal in treating dry eye patients in the future.
MeSH term(s)	Humans ; Quality of Life ; Dry Eye Syndromes/drug therapy ; Dry Eye Syndromes/surgery ; Dry Eye Syndromes/diagnosis ; Lacrimal Apparatus/surgery ; Tears
Language	English
Publishing date	2023-08-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1237021-6
ISSN	1557-7732 ; 1080-7683
ISSN (online)	1557-7732
ISSN	1080-7683
DOI	10.1089/jop.2023.0063
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Zs.A 2099: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Human Papillomavirus Related Neoplasia of the Ocular Adnexa.

Ramberg, Ingvild / Heegaard, Steffen

Viruses

2021 Volume 13, Issue 8

Abstract: Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well ... ...

Abstract	Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.
MeSH term(s)	Carcinoma in Situ/virology ; Carcinoma, Squamous Cell/virology ; Conjunctiva/cytology ; Conjunctiva/virology ; Humans ; Lacrimal Apparatus/virology ; Papillomaviridae/pathogenicity ; Papillomavirus Infections/complications
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13081522
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Article: Human Papillomavirus Related Neoplasia of the Ocular Adnexa

Ramberg, Ingvild / Heegaard, Steffen

Viruses. 2021 Aug. 02, v. 13, no. 8

2021

Abstract	Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.
Keywords	DNA ; Papillomaviridae ; biomarkers ; conjunctiva ; drainage systems ; eyelids ; humans ; mucosa
Language	English
Dates of publication	2021-0802
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13081522
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Challenges in diagnosing canine spindle cell tumours using immunohistochemistry, illustrated by three nonpigmented malignant cases from the nictitating membrane.

Bundgaard Kjellingbro, Kristine / Naranjo Freixa, Carolina / Hjorth Mikkelsen, Lauge / Heegaard, Steffen

Acta veterinaria Scandinavica

2024 Volume 66, Issue 1, Page(s) 7

Abstract: Background: Nonpigmented malignant spindle cell tumours of the membrana nictitans are rare in dogs. In twenty-three years only three cases have been diagnosed in Scandinavia. This study describes the three cases of malignant tumours of the membrana ... ...

Abstract	Background: Nonpigmented malignant spindle cell tumours of the membrana nictitans are rare in dogs. In twenty-three years only three cases have been diagnosed in Scandinavia. This study describes the three cases of malignant tumours of the membrana nictitans recorded by the Eye Pathology Section, University of Copenhagen, Denmark, with reference to the clinical appearance and work-up, the treatment and prognosis, and the histopathological description including immunohistochemistry. The three cases are compared to previous publications on canine tumours of the nictitating membrane. We emphasize the importance of using protocols that are adapted to the specific species such as dogs. Opposite the human tissue responses, we even need more than one marker when diagnosing melanomas in dogs. Results: The dogs presented were an 8-year-old Dachshund, a 12-year-old Akita and a 14-year-old Shetland Sheepdog. All three dogs were entire females. All three nictitating membrane tumours developed on the right nictitating membrane as firm or multilobulated hyperaemic masses. Two of the tumours were macroscopically nonpigmented, the third being partly pigmented on the surface and ulcerated. According to the histopathology and for two of the cases immunohistochemistry with dog-adapted protocols the diagnoses included one hemangiosarcoma and two amelanotic melanomas. Tumour regrowth developed in all three cases and repeated resections were completed 1, 2 and 3 times, respectively, with recurrence experienced within 1.5 months - 3 years. Conclusions: Nonpigmented malignant spindle cell tumours of the canine membrana nictitans are rare. Treatment of choice should be complete excision with a minimal histologic tumour-free distance and in case of a recurrence a full resection of the nictitating membrane. We strongly recommend a dog-adapted protocol for immunohistochemistry.
MeSH term(s)	Female ; Humans ; Dogs ; Animals ; Nictitating Membrane/pathology ; Nictitating Membrane/surgery ; Immunohistochemistry ; Prognosis ; Dog Diseases/pathology ; Neoplasms/veterinary
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	40137-7
ISSN	1751-0147 ; 0044-605X
ISSN (online)	1751-0147
ISSN	0044-605X
DOI	10.1186/s13028-024-00727-z
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Zs.B 484: Show issues

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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: A rare case of lacrimal sac angioleiomyoma managed with dacryocystectomy and turbinectomy.

Næser, Kristian / Pagh, Priyanka / Friis, Per / Heegaard, Steffen

Orbit (Amsterdam, Netherlands)

2022 Volume 43, Issue 1, Page(s) 147–150

Abstract: We report a rare case of a lacrimal sac angioleiomyoma. A 56-year-old woman complained of pain in the right medial canthal region over a period of 2 years. There were no complaints of epiphora or ocular infection, and no visible or palpable masses in the ...

Abstract	We report a rare case of a lacrimal sac angioleiomyoma. A 56-year-old woman complained of pain in the right medial canthal region over a period of 2 years. There were no complaints of epiphora or ocular infection, and no visible or palpable masses in the medial canthal region. Computed tomography scan revealed a solid tumor of the lacrimal sac expanding to the nasolacrimal duct and protruding under the inferior turbinate. The tumor was removed by external dacryocystectomy combined with endonasal, endoscopic anterior turbinectomy, and nasal mucosal resection. Histological and immunohistological findings were consistent with an angioleiomyoma of the venous type. There was no recurrence of the tumor at the three-year follow-up. Angioleiomyomas should be included in the differential diagnosis of lacrimal sac tumors. The definitive diagnoses rely on histology and immunohistological reactions. The treatment is complete surgical resection.
MeSH term(s)	Female ; Humans ; Middle Aged ; Nasolacrimal Duct/surgery ; Angiomyoma/diagnostic imaging ; Angiomyoma/surgery ; Turbinates ; Lacrimal Apparatus/pathology ; Lacrimal Apparatus Diseases/diagnostic imaging ; Lacrimal Apparatus Diseases/surgery ; Dacryocystorhinostomy/methods
Language	English
Publishing date	2022-06-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	603157-2
ISSN	1744-5108 ; 0167-6830
ISSN (online)	1744-5108
ISSN	0167-6830
DOI	10.1080/01676830.2022.2085306
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Zs.A 1735: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Primary mucosal melanomas of the urogenital tract: a clinical, pathological, and genetic nationwide survey of Danish patients 1990-2019.

Znaider, Victoria K / Mikkelsen, Lauge H / Jensen, Christian Fuglesang S / Sønksen, Jens / Heegaard, Steffen

Scandinavian journal of urology

2023 Volume 58, Page(s) 52–59

Abstract: Purpose: To describe the epidemiologic, clinical, histopathological, and genetic features of primary mucosal melanoma of the urinary tract in a national Danish cohort with cases included from the year 1990 to 2019.: Material and methods: Patients of ... ...

Abstract	Purpose: To describe the epidemiologic, clinical, histopathological, and genetic features of primary mucosal melanoma of the urinary tract in a national Danish cohort with cases included from the year 1990 to 2019. Material and methods: Patients of the Danish cohort were found using national databases. Only primary tumours were included in the cohort. Appropriate formalin-fixed paraffin-embedded blocks underwent next-generation sequencing. Results: Eight cases of primary urinary bladder melanomas and 18 cases of primary urethral melanomas were included. Bladder melanomas had an incidence of 0.05 cases/million/year. Mean age at diagnosis was 67 years. The most frequent primary treatment was cystectomy. Adjuvant treatment was given in three cases and consisted of chemotherapy or radiotherapy. Mutations were found in the NF1, KRAS, ATRX, TP53, RAC1, and BRAF genes. Urethral melanomas were found to have an incidence of 0.12 cases/million/year. Average age at diagnosis was 77 years. The most frequent treatment was excision of the tumour. Adjuvant treatment was given in nine cases and most frequently consisted of radiotherapy. Mutations were found in the NF1, TERT PROMOTOR, NRAS, ATRX, TP53, ATM, TSC2, and CREBBP genes. The 5-year survival of patients with bladder melanoma was 12.5% and 22.2% for patients with urethral melanoma. Conclusion: Our study highlights the rarity of urinary tract melanomas and their poor prognosis. The most widely used treatment for urogenital mucosal melanoma remains surgical while adjuvant therapy strategies are evolving. Next-generation sequencing showed mutational patterns with no location-specific patterns. The most frequent mutations were in the NF1, ATRX, NRAS, and TP53 genes.
MeSH term(s)	Humans ; Aged ; Melanoma/epidemiology ; Melanoma/genetics ; Melanoma/therapy ; Urethral Neoplasms ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/therapy ; Cystectomy ; Adjuvants, Immunologic ; Denmark/epidemiology
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2023-08-27
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	2701936-6
ISSN	2168-1813 ; 2168-1805
ISSN (online)	2168-1813
ISSN	2168-1805
DOI	10.2340/sju.v58.8489
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Zs.A 601: Show issues

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Article: The Role of Obstructive Sleep Apnea in Vision-Threatening Diabetic Retinopathy-A National Register-Based Study.

Ba-Ali, Shakoor / Jennum, Poul Jørgen / Brøndsted, Adam Elias / Heegaard, Steffen / Lund-Andersen, Henrik

Journal of personalized medicine

2023 Volume 13, Issue 11

Abstract: Introduction: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR).: Methods: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes ... ...

Abstract	Introduction: we investigated the association between OSA and vision-threatening diabetic retinopathy (VTDR). Methods: we used three nationwide registers to identify subjects with and without OSA and patients with type 1 (T1DM) or type 2 diabetes mellitus (T2DM). The Danish Civil Registration System was used to link OSA with diabetes diagnosis. The primary outcome was the occurrence of VTDR in diabetic patients with and without OSA. The secondary outcome was the prevalence of diabetes mellitus in patients with and without OSA. Results: we included 532,828 diabetic subjects comprising 13,279 patients with OSA (2.5%) and 519,549 without OSA (97.5%). Diabetic patients with OSA had a 57% lower risk of VTDR compared to diabetic patients without OSA (OR 0.43, 95% CI 0.38-0.50, Conclusions: our findings indicate that OSA is associated with a lower risk of VTDR. Since we did not adjust our outcomes for diabetes duration, hypertension control and hemoglobin A1c, future studies are needed to confirm our findings.
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13111529
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