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Article ; Online: Intralesional injection of Candida albicans antigen versus measles, mumps, and rubella vaccine for treatment of plantar warts.

Rageh, Rania Mahmoud / Hewedy, El-Sayed Shaaban / Hegab, Doaa Salah

Acta dermatovenerologica Alpina, Pannonica, et Adriatica

2021 Volume 30, Issue 1, Page(s) 1–5

Abstract: Introduction: Many therapeutic modalities have been used for management of plantar warts; however, no optimal treatment with high efficacy and no or low recurrence has been explored to date. Intralesional immunotherapy has shown promising results in the ...

Abstract	Introduction: Many therapeutic modalities have been used for management of plantar warts; however, no optimal treatment with high efficacy and no or low recurrence has been explored to date. Intralesional immunotherapy has shown promising results in the treatment of different types of warts.Here we compare the efficacy of Candida albicans-specific antigen versus measles, mumps, and rubella (MMR) vaccine for treatment of plantar warts by intralesional injection. Methods: Sixty patients with refractory or recurrent plantar warts were randomly divided into two equal groups. Group A was treated with C. albicans antigen and Group B with MMR vaccine. Both groups were injected intralesionally in a single wart every 3 weeks until complete clearance of the wart or for a maximum of five sessions. The patients were followed up for an additional 2 months. Results: C. albicans antigen yielded a statistically significant higher cure rate (80,0%) than MMR vaccine (26.7%) in the treatment of plantar warts through a mean of 3.98 sessions versus 4.24 sessions, respectively (p = 0.002), and both modalities were well tolerated, with no remarkable side effects and no recurrence in cured patients during follow-up. Conclusions: Intralesional C. albicans antigen injection is an easy and effective treatment tool for plantar warts, even resistant and recalcitrant ones, with no post-procedural downtime and only transient occasional side effects. MMR vaccine is thought to be less effective.
MeSH term(s)	Candida albicans ; Humans ; Injections, Intralesional ; Measles ; Measles-Mumps-Rubella Vaccine/therapeutic use ; Mumps ; Treatment Outcome ; Warts/drug therapy
Chemical Substances	Measles-Mumps-Rubella Vaccine
Language	English
Publishing date	2021-02-20
Publishing country	Slovenia
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1235900-2
ISSN	1581-2979 ; 1318-4458 ; 0302-4466
ISSN (online)	1581-2979
ISSN	1318-4458 ; 0302-4466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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ab Jg. 2022: Lesesaal (EG)

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Article: Topical Oxybutynin 3% Gel Versus Aluminum Chloride 15% Lotion in Treatment of Primary Focal Hyperhidrosis.

El-Agamy El-Samadony, Amany / Hegab, Doaa Salah / El Maghraby, Gamal Mohamed / El-Maadawy, Iman Hamed

Dermatology practical & conceptual

2023 Volume 13, Issue 3

Abstract: Introduction: Hyperhidrosis is excessive sweating beyond thermoregulatory needs. It is a potentially disabling condition with challenging management. Aluminum chloride is the established topical treatment; however, response remains unsatisfactory. ... ...

Abstract	Introduction: Hyperhidrosis is excessive sweating beyond thermoregulatory needs. It is a potentially disabling condition with challenging management. Aluminum chloride is the established topical treatment; however, response remains unsatisfactory. Oxybutynin is an anticholinergic drug that stands as a therapeutic chance for hyperhidrosis. Objectives: comparing the efficacy of topical oxybutynin 3% gel versus aluminum chloride 15% lotion in treatment of primary focal hyperhidrosis. Methods: Forty patients with hyperhidrosis were randomly distributed into 2 equal groups treated by either topical oxybutynin 3% gel or topical aluminum chloride 15% lotion once daily night application for 4 weeks (both groups). Evaluation was done at 2 and 4 weeks of treatment and after 1 month of the end of treatment for follow up by Minor iodine starch test, hyperhidrosis disease severity scale (HDSS) and dermatology life quality index (DLQI). Results: Both treatment modalities were effective with insignificant differences between patients of both groups regarding improvement in Minor iodine starch test and HDSS after 2 weeks of treatment (P = 0.561, 0.33 respectively). Oxybutynin 3% gel yielded significantly better improvement of Minor's test, HDSS and patient's quality of life at the end of 4 weeks of treatment with lower recurrence rate than aluminum chloride 15% lotion at 1 month follow up. Minimal adverse effects were noted in both studied groups. Conclusions: Oxybutynin 3% gel could be considered as a promising treatment modality for hyperhidrosis with higher efficacy than aluminum chloride 15% lotion and lower recurrence rate.
Language	English
Publishing date	2023-07-01
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2685397-8
ISSN	2160-9381
ISSN	2160-9381
DOI	10.5826/dpc.1303a192
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Article: Efficacy and Safety of Topical Tranexamic Acid Alone or in Combination with Either Fractional Carbon Dioxide Laser or Microneedling for the Treatment of Melasma.

Mamdouh Kamal Dawaud, Safaa / Hegab, Doaa Salah / Mohamed El Maghraby, Gamal / Ahmad El-Ashmawy, Amal

Dermatology practical & conceptual

2023 Volume 13, Issue 3

Abstract: Introduction: Tranexamic acid (TXA) is a promising treatment modality for melasma. Microneedling (MN) and fractional carbon dioxide (CO: Objectives: To compare efficacy and safety of topical TXA alone or in combination with either fractional CO: ... ...

Abstract	Introduction: Tranexamic acid (TXA) is a promising treatment modality for melasma. Microneedling (MN) and fractional carbon dioxide (CO Objectives: To compare efficacy and safety of topical TXA alone or in combination with either fractional CO Methods: Thirty females with facial melasma were divided randomly into 3 equal groups after excluding pregnant and lactating women and those using oral contraceptives or other hormonal therapy. Patients of group A were treated with fractional CO Results: Statistically significant improvement of mMASI was reported in all studied groups with a significantly better improvement in patients of groups A and B than those of group C, meanwhile the difference between groups A and B was statistically insignificant. Conclusions: Topical TXA is a safe and fairly effective treatment modality for facial melasma. Combining TXA with either fractional CO
Language	English
Publishing date	2023-07-01
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2685397-8
ISSN	2160-9381
ISSN	2160-9381
DOI	10.5826/dpc.1303a195
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Article ; Online: Comparative study between topical tranexamic acid alone versus its combination with autologous platelet rich plasma for treatment of melasma.

Gamea, Mohamed Mahmoud / Kamal, Doha Ali / Donia, Ahmed Atef / Hegab, Doaa Salah

The Journal of dermatological treatment

2020 Volume 33, Issue 2, Page(s) 798–804

Abstract: Background: Tranexamic acid is a promising drug for melasma treatment, but its topical formulation has limited efficacy. Its use as liposome based cream or in combination with other modalities might help to achieve better results.: Objective: ... ...

Abstract	Background: Tranexamic acid is a promising drug for melasma treatment, but its topical formulation has limited efficacy. Its use as liposome based cream or in combination with other modalities might help to achieve better results. Objective: Comparing efficacy of topical tranexamic acid 5% in liposome base alone versus its combination with intradermal platelet rich plasma (PRP) for melisma treatment. Methods: Forty female patients with melasma were divided randomly into 2 equal groups who were treated with topical tranexamic acid 5% cream twice daily for 12 weeks and group B received additional intradermal injections of PRP every 3 weeks throughout the treatment period. Evaluation was done through modified MASI score and patient satisfaction after one month from the end of treatment. Results: Both groups showed significant improvement of modified MASI score after treatment. Significantly better treatment response and patient satisfaction were detected in patients of group B ( Conclusion: 5% topical tranexamic acid in liposome base is thought to be safe and effective modality for treatment of melasma. PRP is advisable as an autologous safe elixir which boosts the therapeutic effect of tranexamic acid.
MeSH term(s)	Administration, Cutaneous ; Female ; Humans ; Melanosis/drug therapy ; Platelet-Rich Plasma ; Tranexamic Acid/therapeutic use ; Treatment Outcome
Chemical Substances	Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2020.1781755
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Zs.A 2627: Show issues

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Article ; Online: Platelet-rich plasma in alopecia areata: intradermal injection versus topical application with transepidermal delivery via either fractional carbon dioxide laser or microneedling.

Ragab, Sally Esam Marouf / Nassar, Samia Othman / Morad, Heba Ahmed / Hegab, Doaa Salah

Acta dermatovenerologica Alpina, Pannonica, et Adriatica

2021 Volume 29, Issue 4, Page(s) 169–173

Abstract: Introduction: Alopecia areata (AA) is a common cause of non-scarring alopecia with variable response to treatment. Platelet-rich plasma (PRP) stimulates proliferation and differentiation of stem cells in the hair-follicle bulge via multiple mechanisms. ... ...

Abstract	Introduction: Alopecia areata (AA) is a common cause of non-scarring alopecia with variable response to treatment. Platelet-rich plasma (PRP) stimulates proliferation and differentiation of stem cells in the hair-follicle bulge via multiple mechanisms. Although beneficial, pain during injection in addition to unequal delivery and coverage is a major drawback of intralesional PRP in alopecia, particularly for extensive lesions and in patients with a low pain threshold. This study evaluates intradermal injection of PRP versus its topical use with enhanced transepidermal delivery through either fractional CO2 laser (FCL) or microneedling in treatment of AA. Methods: Sixty AA patients were randomized into three equal groups to receive monthly sessions of either PRP intradermal injection, FCL followed by topical PRP, or microneedling followed by topical PRP for 3 consecutive months. Assessment was done through the Severity of Alopecia Tool (SALT) score and patient satisfaction at the end of sessions (2 weeks after the last session) and after 3 additional months of follow-up. Results: Patients in all groups showed satisfactory results of PRP treatment, with statistically insignificant differences in the degree of improvement among patients of the three groups studied according to the two assessment parameters. Intralesional PRP injection was associated with significantly higher pain scores. Conclusions: PRP is potentially effective and safe for treatment of AA. FCL and microneedling could facilitate topical PRP delivery and considerably decrease pain associated with intradermal injection while preserving PRP efficacy. These methods could be helpful for extensive lesions and in children.
MeSH term(s)	Alopecia Areata/therapy ; Combined Modality Therapy/methods ; Dermatologic Agents/therapeutic use ; Female ; Humans ; Lasers, Gas/therapeutic use ; Low-Level Light Therapy/methods ; Male ; Patient Satisfaction ; Platelet-Rich Plasma ; Treatment Outcome
Chemical Substances	Dermatologic Agents
Language	English
Publishing date	2021-01-29
Publishing country	Slovenia
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1235900-2
ISSN	1581-2979 ; 1318-4458 ; 0302-4466
ISSN (online)	1581-2979
ISSN	1318-4458 ; 0302-4466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4287: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Intralesional pentoxifylline, triamcinolone acetonide, and their combination for treatment of keloid scars.

Serag-Eldin, Yasmin Magdy Abdulrahman / Mahmoud, Wael Hussein / Gamea, Mohamed Mahmoud / Hegab, Doaa Salah

Journal of cosmetic dermatology

2021 Volume 20, Issue 10, Page(s) 3330–3340

Abstract: Background: Keloids are common fibroproliferative tumors, and their treatment still represents a dilemma. Intralesional triamcinolone acetonide (TAC) injection is effective, but frequently associated with side effects. Pentoxifyllin (PTX) is a ... ...

Abstract	Background: Keloids are common fibroproliferative tumors, and their treatment still represents a dilemma. Intralesional triamcinolone acetonide (TAC) injection is effective, but frequently associated with side effects. Pentoxifyllin (PTX) is a vasodilator, anti-inflammatory, and antifibrotic agent. Its intralesional injection in keloids has not been evaluated yet. Aims: Evaluating the efficacy and safety of intralesional PTX versus intralesional TAC and their combination for treatment of keloids. Patients/methods: Thirty patients with keloids were divided into three equal groups and treated by intralesional injection of TAC, PTX, or their combination (admixed in 1:1 ratio). Injections were repeated every 3 weeks until lesional flattening or for maximum of 5 sessions. The evaluation was done using the Vancouver Scar Scale and the Verbal Rating Scale for pain and itching. Results: A significant improvement in VSS was detected in all groups. Significantly better improvements in keloid height, pliability, pain, and itching were detected in the TAC and combination groups than in the PTX group. There was a significantly higher incidence of side effects (atrophy, hypopigmentation, telangiectasia, and precipitation of TAC) in the TAC group than in the combination group, while no side effects were reported in the PTX group. A statistically significant reduction in the number of treatment sessions (required to achieve best results) was detected in patients in the combination group. Conclusions: Intralesional injection of PTX is a potentially helpful, safe, and well-tolerated therapeutic tool for keloids, but with lower efficacy than intralesional TAC when used solely. Combining PTX and TAC produces significantly better results for keloid treatment and lowers the risk of TAC-induced side effects.
MeSH term(s)	Cicatrix, Hypertrophic/drug therapy ; Humans ; Injections, Intralesional ; Keloid/drug therapy ; Keloid/pathology ; Pentoxifylline ; Treatment Outcome ; Triamcinolone Acetonide/adverse effects
Chemical Substances	Triamcinolone Acetonide (F446C597KA) ; Pentoxifylline (SD6QCT3TSU)
Language	English
Publishing date	2021-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6539: Show issues

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Article ; Online: Pulsed-dye laser versus intralesional Candida albicans antigen injection in treatment of genital warts.

Elmaadawy, Eman Hamed / Shams, Shaimaa Saeed / Hegab, Doaa Salah / Zaki, Raghda Ahmed

Acta dermatovenerologica Alpina, Pannonica, et Adriatica

2019 Volume 28, Issue 1, Page(s) 21–26

Abstract: Introduction: Genital warts are a troublesome therapeutic issue. Pulsed-dye laser (PDL) is a non-ablative therapeutic tool for viral warts. Intralesional Candida albicans (C. albicans) immunotherapy has yielded promising results in treatment of various ... ...

Abstract	Introduction: Genital warts are a troublesome therapeutic issue. Pulsed-dye laser (PDL) is a non-ablative therapeutic tool for viral warts. Intralesional Candida albicans (C. albicans) immunotherapy has yielded promising results in treatment of various types of warts. We aimed to evaluate the effectiveness of PDL versus C. albicans immunotherapy for treatment of genital warts. Methods: Forty adult patients with genital warts were divided into two equal groups; the first was treated using PDL and the second using intralesional C. albicans antigen injection. Treatments were performed at 3-week intervals until complete lesion resolution or for a maximum of three sessions. Results: PDL yielded higher complete clearance rates (95%) than C. albicans antigen (50%; p = 0.001), which in turn had the advantage of treating distant and internal genital warts. Apart from pain during the session in PDL, both modalities were well tolerated with no recurrence in cured patients during the 16-week follow-up period. Conclusions: PDL and C. albicans antigen injection are safe and effective treatment alternatives for genital warts. PDL yielded better frequencies of clearance, but C. albicans antigen has additional advantages, including a single injection site and treating distant and internal mucosal uninjected warts, which are usually difficult to treat.
MeSH term(s)	Adult ; Antigens, Fungal/therapeutic use ; Candida albicans/immunology ; Cohort Studies ; Condylomata Acuminata/diagnosis ; Condylomata Acuminata/therapy ; Egypt ; Female ; Humans ; Immunotherapy/methods ; Injections, Intralesional ; Laser Therapy/methods ; Lasers, Dye/therapeutic use ; Male ; Middle Aged ; Patient Safety ; Risk Assessment ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Chemical Substances	Antigens, Fungal
Language	English
Publishing date	2019-04-15
Publishing country	Slovenia
Document type	Comparative Study ; Journal Article
ZDB-ID	1235900-2
ISSN	1581-2979 ; 1318-4458 ; 0302-4466
ISSN (online)	1581-2979
ISSN	1318-4458 ; 0302-4466
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4287: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Are Peripheral Natural Killer Cells and Interleukin-21 Interrelated in Psoriasis Pathogenesis?

Hegab, Doaa Salah / Elgarhy, Lamia Hamouda / Attia, Mohamed

Annals of dermatology

2017 Volume 29, Issue 1, Page(s) 108–110

Language	English
Publishing date	2017-02-03
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	1012662-4
ISSN	2005-3894 ; 1013-9087
ISSN (online)	2005-3894
ISSN	1013-9087
DOI	10.5021/ad.2017.29.1.108
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Zs.A 2800: Show issues

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Article ; Online: Combined intralesional triamcinolone acetonide and platelet rich plasma versus intralesional triamcinolone acetonide alone in treatment of keloids.

Hewedy, El-Sayed Shaaban / Sabaa, Basma El-Saeed Ibrahim / Mohamed, Wesam Salah / Hegab, Doaa Salah

The Journal of dermatological treatment

2020 Volume 33, Issue 1, Page(s) 150–156

Abstract: Background: Keloids are benign fibro-proliferative growths occurring after skin injury or spontaneously. Intralesional triamcinolone acetonide (TA) is their first-line therapy, but commonly associated with side effects or recurrence. Platelet rich ... ...

Abstract	Background: Keloids are benign fibro-proliferative growths occurring after skin injury or spontaneously. Intralesional triamcinolone acetonide (TA) is their first-line therapy, but commonly associated with side effects or recurrence. Platelet rich plasma (PRP) is an autologous blood-derived product with promising results in improving wound healing with lower keloid occurrence. Objective: To compare the efficacy of combined intralesional TA and PRP versus TA alone in keloids treatment. Methods: Forty patients with keloids were divided randomly into two equal groups (A and B). Both groups received intralesional TA (20 mg/ml) for four sessions, 3 weeks apart. Group A patients received additional intralesional PRP 1 week after TA injections. Evaluation was done after 3 months of follow up by Vancouver scar scale (VSS) and verbal rating scale (VRS) for pain and itching. Results: Both groups showed significant improvement in all parameters of VSS and VRS in comparison with baseline. Significantly better improvement in height, pigmentation, and pliability and overall VSS was detected in patients of group A. A significantly higher incidence of post-TA atrophy and hypopigmentation was observed in group B. Conclusion: Combining intralesional PRP with TA could yield cosmetically better outcomes in keloid treatment with lower incidence of TA-induced side effects especially atrophy and hypopigmentation.
MeSH term(s)	Humans ; Injections, Intralesional ; Keloid/drug therapy ; Keloid/pathology ; Platelet-Rich Plasma ; Treatment Outcome ; Triamcinolone Acetonide/therapeutic use
Chemical Substances	Triamcinolone Acetonide (F446C597KA)
Language	English
Publishing date	2020-03-04
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2020.1730742
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Zs.A 2627: Show issues

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Article ; Online: A comparative study of intralesional injection of

Hodeib, Abeer Abd Elhakam / Al-Sharkawy, Basma Gamal / Hegab, Doaa Salah / Talaat, Raghda Ahmed Zaki

The Journal of dermatological treatment

2019 Volume 32, Issue 6, Page(s) 663–668

Abstract: Background: Several therapeutic modalities for the treatment of verruca plana (VP) are available, but none has achieved complete cure in all cases with associated risk of side effects.: Objective: To evaluate efficacy and safety of intralesional ... ...

Abstract	Background: Several therapeutic modalities for the treatment of verruca plana (VP) are available, but none has achieved complete cure in all cases with associated risk of side effects. Objective: To evaluate efficacy and safety of intralesional injection of Methods: Sixty patients with VP were randomly divided into three equal groups who were treated using Results: A statistically significant higher incidence of complete response was achieved with bleomycin (85%) than Conclusions: Candida albicans
MeSH term(s)	Bleomycin/therapeutic use ; Candida albicans ; Fluorouracil/therapeutic use ; Humans ; Injections, Intralesional ; Treatment Outcome ; Warts/drug therapy
Chemical Substances	Bleomycin (11056-06-7) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2019-11-12
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1036299-x
ISSN	1471-1753 ; 0954-6634
ISSN (online)	1471-1753
ISSN	0954-6634
DOI	10.1080/09546634.2019.1688236
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