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  1. Article ; Online: Relationship between ambient air pollution and preterm birth: a retrospective birth cohort study in Yan'an, China.

    He, Jinwei / Cao, Na / Hei, Jiangrong / Wang, Huiling / He, Jinrong / Liu, Yizhao / Ren, Yuanyuan

    Environmental science and pollution research international

    2022  Volume 29, Issue 48, Page(s) 73271–73281

    Abstract: Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a ... ...

    Abstract Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a retrospective birth cohort study in Yan'an city, a typical valley city in the west of China, and analyze the effects of air pollutants on premature delivery, identify critical windows for maternal air pollutants exposure and PTB. The pregnant women who gave birth in the Affiliated Hospital of Yan'an University and Yan'an people's Hospital from January 1, 2018 to December 31, 2019 were selected as the research objects. A questionnaire survey and medical records were conducted. The daily average concentrations of particulate matter with aerodynamic diameters of ≤ 2.5 μm (PM
    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; Birth Cohort ; China/epidemiology ; Cohort Studies ; Female ; Humans ; Infant, Newborn ; Maternal Exposure ; Nitrogen Dioxide/toxicity ; Ozone/toxicity ; Particulate Matter/analysis ; Pregnancy ; Premature Birth/chemically induced ; Premature Birth/epidemiology ; Retrospective Studies ; Sulfur Dioxide/toxicity
    Chemical Substances Air Pollutants ; Particulate Matter ; Sulfur Dioxide (0UZA3422Q4) ; Ozone (66H7ZZK23N) ; Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2022-05-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-20852-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Relationship between ambient air pollution and preterm birth: a retrospective birth cohort study in Yan’an, China

    He, Jinwei / Cao, Na / Hei, Jiangrong / Wong, Wai-ling / He, Jinrong / Liu, Yizhao / Ren, Yuanyuan

    Environ Sci Pollut Res. 2022 Oct., v. 29, no. 48 p.73271-73281

    2022  

    Abstract: Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a ... ...

    Abstract Preterm birth (PTB) has been associated with exposure to air pollution, but it is unclear whether effects might vary among air pollution sources in a valley city, and yet few studies have investigated refined susceptible windows for PTB. We performed a retrospective birth cohort study in Yan’an city, a typical valley city in the west of China, and analyze the effects of air pollutants on premature delivery, identify critical windows for maternal air pollutants exposure and PTB. The pregnant women who gave birth in the Affiliated Hospital of Yan’an University and Yan’an people’s Hospital from January 1, 2018 to December 31, 2019 were selected as the research objects. A questionnaire survey and medical records were conducted. The daily average concentrations of particulate matter with aerodynamic diameters of ≤ 2.5 μm (PM₂.₅) and ≤ 10 μm (PM₁₀), nitrogen dioxide (NO₂), sulfur dioxide (SO₂) and ozone (O₃) in Yan’an City from January 1, 2017 to December 31, 2019 were collected. After controlling the confounding factors of PTB by logistic regression model, the effect of air pollutants on preterm birth was analyzed. After controlling the confounding factors such as maternal age, gestational times and gestational hypertension syndrome, PTB was associated with exposure to third trimester PM₁₀ (adjusted odds ratio [aOR] = 1.019, 95% confidence interval [95%CI] = 1.004–1.035). PTB risk increased with second trimester exposure to SO₂ (aOR = 1.039, CI = 1.011–1.068), also with third trimester (aOR = 1.031, CI = 1.010–1.053). PTB was also associated with third trimester O₃ (aOR = 1.023, CI = 1.005–1.041). This study indicates that maternal exposure to PM₁₀, SO₂ and O₃ might lead to increased risk of PTB, and critical exposure windows were inconsistent.
    Keywords aerodynamics ; air ; air pollution ; cohort studies ; confidence interval ; hospitals ; hypertension ; maternal exposure ; nitrogen dioxide ; odds ratio ; ozone ; particulates ; people ; premature birth ; questionnaires ; regression analysis ; risk ; sulfur dioxide ; China
    Language English
    Dates of publication 2022-10
    Size p. 73271-73281.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-20852-4
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  3. Article: Long non-coding RNA H19 regulates proliferation of ovarian granulosa cells via STAT3 in polycystic ovarian syndrome.

    Li, Li / Wei, Jianxun / Hei, Jiangrong / Ren, Yongbian / Li, Hongmei

    Archives of medical science : AMS

    2019  Volume 17, Issue 3, Page(s) 785–791

    Abstract: Introduction: Studies have shown that long non-coding RNAs (lncRNA) are aberrantly expressed in polycystic ovarian syndrome (PCOS) ovaries and may have a role in PCOS development. In this study, the role and therapeutic implications of lncRNA H19 were ... ...

    Abstract Introduction: Studies have shown that long non-coding RNAs (lncRNA) are aberrantly expressed in polycystic ovarian syndrome (PCOS) ovaries and may have a role in PCOS development. In this study, the role and therapeutic implications of lncRNA H19 were investigated in PCOS ovaries and granulosa cells.
    Material and methods: qRT-PCR was used for expression analysis. Cell Counting Kit 8 (CCK-8) assay was used for cell viability and acridine orange/ethidium bromide (AO/EB) and Annexin V/propidium iodide staining was used to detect apoptosis. All transfections were carried out with Lipofectamine 2000 reagent. Western blot analysis was used for protein expression analysis.
    Results: The expression of lncRNA H19 was remarkably upregulated in the PCOS ovarian tissues as well as the granulosa cells. Suppression of lncRNA H19 expression caused the inhibition of KGN granulosa cell proliferation due to the triggering of apoptosis. Bioinformatic analysis revealed the presence of the GAS binding site for STAT3 in the promoter of lncRNA H19. Silencing of STAT3 suppressed the expression of lncRNA H19 in KGN cells and also halted their growth by triggering apoptosis. Co-transfect experiments revealed that STAT3 and lncRNA H19 silencing cause inhibition of KGN growth synergistically.
    Conclusions: lncRNA H19 regulates the growth of ovarian granulosa cells and might prove to be a therapeutic target for management of PCOS.
    Language English
    Publishing date 2019-10-25
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2203781-0
    ISSN 1734-1922
    ISSN 1734-1922
    DOI 10.5114/aoms.2019.89254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Premature rupture of the fetal membrane combined with subclinical chorioamnionitis negatively affects pregnancy outcomes by a mechanism associated with reduced levels of matrix metalloproteinase-2.

    Zhang, Hongli / Wang, L U / Wang, Jing / Hei, Jiangrong / Ruan, Cailian

    Experimental and therapeutic medicine

    2015  Volume 10, Issue 2, Page(s) 561–566

    Abstract: The present study aimed to investigate whether premature rupture of the fetal membrane, combined with subclinical chorioamnionitis, affects pregnancy outcomes. In addition, the association between premature rupture of the fetal membrane (PROM) and the ... ...

    Abstract The present study aimed to investigate whether premature rupture of the fetal membrane, combined with subclinical chorioamnionitis, affects pregnancy outcomes. In addition, the association between premature rupture of the fetal membrane (PROM) and the levels of matrix metalloproteinase-2 (MMP-2), an inactive proenzyme that can be activated by other factors or signals in humans, was examined. In total, 80 pregnant patients with PROM were classified into the experimental and control groups, according to their final placental pathological diagnosis results. The 40 patients in the experimental group suffered from subclinical chorioamnionitis, while the 40 patients in the control group exhibited no lesions of the placenta or fetal membrane. Tissue samples were collected and the total protein and mRNA were extracted for western blot and quantitative polymerase chain reaction analyses. ELISA was performed in order to detect the levels of MMP-2 in the serum of the two groups of patients. The rates of cesarean section, puerperal infection, postpartum hemorrhage, preterm incidence, placenta accreta, residual placental blood and stillbirth were all significantly higher in the experimental group compared with the control group. In addition, the mRNA and protein expression levels of MMP-2 were reduced in the experimental group compared with the control group. ELISA results indicated that the serum MMP-2 concentrations were also reduced in the patients with PROM. Therefore, the present study demonstrated that the PROM, combined with subclinical chorioamnionitis, significantly affected pregnancy outcomes and was associated with reduced levels of MMP-2.
    Language English
    Publishing date 2015-06-10
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2015.2559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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