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  1. AU="Hei Sook Sul"
  2. AU="Jubil Thomas"
  3. AU="Liu, Mingjun"
  4. AU="Ramírez, Cecilia de la Luna"
  5. AU="Cloquell, Ana"
  6. AU="William P. Cawthorn"
  7. AU="Graham-Brown, M P M"
  8. AU="Smedholen, Madelen Foss"
  9. AU="Waldner, Andreas"
  10. AU="Awni Alshurafa"
  11. AU="Qiqi Xin"
  12. AU="Jamal, Bilal"
  13. AU="Andeol, Guillaume"
  14. AU=Binz Thomas
  15. AU=Yorlets Rachel R.
  16. AU="Klawitter, Sandra"
  17. AU="Wheeler, Jeanna M"
  18. AU="Kavishe, Bazil Baltazar"
  19. AU=Muench Ricardo AU=Muench Ricardo
  20. AU="Guler, Emrah"
  21. AU="Kim, Kyeong Bae"
  22. AU="Birindelli, S"
  23. AU="Monguió-Tortajada, Marta"
  24. AU="Kumta, Nikhil A"
  25. AU="Wu, Wenli"
  26. AU="Curland, Nele"
  27. AU="Redish, A David"
  28. AU="Patterson, Bradley"
  29. AU="Lombardi, Gianmarco"
  30. AU="Rassl, Doris"
  31. AU="Román, Pablo"

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Treffer 1 - 10 von insgesamt 11

Suchoptionen

  1. Artikel ; Online: Pref-1, a Gatekeeper of Adipogenesis

    Hei SookSul

    Frontiers in Endocrinology, Vol

    2013  Band 4

    Abstract: Preadipocyte factor 1 (Pref-1, also called Dlk1/ FA1) is a molecular gatekeeper of adipogenesis by maintaining preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane ... ...

    Abstract Preadipocyte factor 1 (Pref-1, also called Dlk1/ FA1) is a molecular gatekeeper of adipogenesis by maintaining preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enzyme (TACE) to generate a soluble form, which acts as an autocrine/paracrine factor. Pref-1 upregulates Sox9 expression by activating the ERK/MAPK pathway and the Pref-1 interaction with fibronectin is required for inhibition of adipogenesis. Pref-1 also prevents brown adipocyte differentiation and its thermogenic function. Here, we highlight the recent evidence for the role of Pref-1 in adipogenesis.
    Schlagwörter Adipogenesis ; SOX9 Transcription Factor ; Brown Fat ; fibronectin ; Progenitors ; Pref-1 ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2013-07-01T00:00:00Z
    Verlag Frontiers
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

    Jose A. Viscarra / Yuhui Wang / Hai P. Nguyen / Yoon Gi Choi / Hei Sook Sul

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Band 16

    Abstract: In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone ... ...

    Abstract In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenetic mechanism.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-02-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells

    Olga Gulyaeva / Hai Nguyen / Audrey Sambeat / Kartoosh Heydari / Hei Sook Sul

    Cell Reports, Vol 25, Iss 4, Pp 1002-1017.e

    2018  Band 4

    Abstract: Summary: Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular ... ...

    Abstract Summary: Adipocytes arise from the commitment and differentiation of adipose precursors in white adipose tissue (WAT). In studying adipogenesis, precursor markers, including Pref-1 and PDGFRα, are used to isolate precursors from stromal vascular fractions of WAT, but the relation among the markers is not known. Here, we used the Pref-1 promoter-rtTA system in mice for labeling Pref-1+ cells and for inducible inactivation of the Pref-1 target Sox9. We show the requirement of Sox9 for the maintenance of Pref-1+ proliferative, early precursors. Upon Sox9 inactivation, these Pref-1+ cells become PDGFRα+ cells that express early adipogenic markers. Thus, we show that Pref-1+ cells precede PDGFRα+ cells in the adipogenic pathway and that Sox9 inactivation is required for WAT growth and expansion. Furthermore, we show that in maintaining early adipose precursors, Sox9 activates Meis1, which prevents adipogenic differentiation. Our study also demonstrates the Pref-1 promoter-rtTA system for inducible gene inactivation in early adipose precursor populations. : The relationship among Sox9+, Pref-1+, and PDGFRα+ WAT precursors has not been studied. Gulyaeva et al. show that Pref-1+ cells are early adipose precursors and, upon Sox9 inactivation, they become PDGFRα+ cells at a later stage of the adipogenic pathway. In maintaining Pref-1+ adipose precursors, Sox9 activates Meis1, which prevents adipogenic differentiation. Keywords: adipose precursors, adipocyte differentiation, Pref-1, Sox9, PDGFRα, Meis1
    Schlagwörter Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2018-10-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

    Purna A. Joshi / Paul D. Waterhouse / Katayoon Kasaian / Hui Fang / Olga Gulyaeva / Hei Sook Sul / Paul C. Boutros / Rama Khokha

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 14

    Abstract: The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the ... ...

    Abstract The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the expanding epithelium during development, hormone exposure and pregnancy.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

    Purna A. Joshi / Paul D. Waterhouse / Katayoon Kasaian / Hui Fang / Olga Gulyaeva / Hei Sook Sul / Paul C. Boutros / Rama Khokha

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Band 14

    Abstract: The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the ... ...

    Abstract The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the expanding epithelium during development, hormone exposure and pregnancy.
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Zc3h10 Acts as a Transcription Factor and Is Phosphorylated to Activate the Thermogenic Program

    Danielle Yi / Jon M. Dempersmier / Hai P. Nguyen / Jose A. Viscarra / Jennie Dinh / Chihiro Tabuchi / Yuhui Wang / Hei Sook Sul

    Cell Reports, Vol 29, Iss 9, Pp 2621-2633.e

    2019  Band 4

    Abstract: Summary: Brown adipose tissue harbors UCP1 to dissipate chemical energy as heat. However, the transcriptional network that governs the thermogenic gene program is incompletely understood. Zc3h10, a CCCH-type zinc finger protein, has recently been ... ...

    Abstract Summary: Brown adipose tissue harbors UCP1 to dissipate chemical energy as heat. However, the transcriptional network that governs the thermogenic gene program is incompletely understood. Zc3h10, a CCCH-type zinc finger protein, has recently been reported to bind RNA. However, we report here that Zc3h10 functions as a transcription factor to activate UCP1 not through the enhancer region, but by binding to a far upstream region of the UCP1 promoter. Upon sympathetic stimulation, Zc3h10 is phosphorylated at S126 by p38 mitogen-activated protein kinase (MAPK) to increase binding to the distal region of the UCP1 promoter. Zc3h10, as well as mutant Zc3h10, which cannot bind RNA, enhances thermogenic capacity and energy expenditure, protecting mice from diet-induced obesity. Conversely, Zc3h10 ablation in UCP1+ cells in mice impairs thermogenic capacity and lowers oxygen consumption, leading to weight gain. Hence, Zc3h10 plays a critical role in the thermogenic gene program and may present future targets for obesity therapeutics. : Zc3h10 is a RNA-binding protein. Here, Yi et al. report Zc3h10 is a transcription factor that activates UCP1 and other BAT genes. Cold/β3 stimulation causes phosphorylation of Zc3h10 at S126 by p38 MAPK to increase its binding to targets genes and, thus, promotes thermogenic capacity and energy expenditure. Keywords: Zc3h10, RNA binding, phosphorylation, thermogenesis, UCP1, brown fat, brown adipose tissue, transcription factor
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2019-11-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

    Danielle Yi / Hai P Nguyen / Jennie Dinh / Jose A Viscarra / Ying Xie / Frances Lin / Madeleine Zhu / Jon M Dempersmier / Yuhui Wang / Hei Sook Sul

    eLife, Vol

    2020  Band 9

    Abstract: Brown adipose tissue is a metabolically beneficial organ capable of dissipating chemical energy into heat, thereby increasing energy expenditure. Here, we identify Dot1l, the only known H3K79 methyltransferase, as an interacting partner of Zc3h10 that ... ...

    Abstract Brown adipose tissue is a metabolically beneficial organ capable of dissipating chemical energy into heat, thereby increasing energy expenditure. Here, we identify Dot1l, the only known H3K79 methyltransferase, as an interacting partner of Zc3h10 that transcriptionally activates the Ucp1 promoter and other BAT genes. Through a direct interaction, Dot1l is recruited by Zc3h10 to the promoter regions of thermogenic genes to function as a coactivator by methylating H3K79. We also show that Dot1l is induced during brown fat cell differentiation and by cold exposure and that Dot1l and its H3K79 methyltransferase activity is required for thermogenic gene program. Furthermore, we demonstrate that Dot1l ablation in mice using Ucp1-Cre prevents activation of Ucp1 and other target genes to reduce thermogenic capacity and energy expenditure, promoting adiposity. Hence, Dot1l plays a critical role in the thermogenic program and may present as a future target for obesity therapeutics.
    Schlagwörter brown adipose tissue ; transcription ; thermogenesis ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Lifespan prolonging mechanisms and insulin upregulation without fat accumulation in long-lived reproductives of a higher termite

    Sarah Séité / Mark C. Harrison / David Sillam-Dussès / Roland Lupoli / Tom J. M. Van Dooren / Alain Robert / Laure-Anne Poissonnier / Arnaud Lemainque / David Renault / Sébastien Acket / Muriel Andrieu / José Viscarra / Hei Sook Sul / Z. Wilhelm de Beer / Erich Bornberg-Bauer / Mireille Vasseur-Cognet

    Communications Biology, Vol 5, Iss 1, Pp 1-

    2022  Band 16

    Abstract: Séité, Harrison, et al. investigate the mechanisms underlying long lifespan in queens and kings of the highly social termite Macrotermes natalensis. Using transcriptomics, lipidomics and metabolomics, this study shows that several aging-related processes ...

    Abstract Séité, Harrison, et al. investigate the mechanisms underlying long lifespan in queens and kings of the highly social termite Macrotermes natalensis. Using transcriptomics, lipidomics and metabolomics, this study shows that several aging-related processes are reduced in the fat bodies of these reproductives and that an upregulated insulin-like peptide, Ilp9, does not lead to deleterious fat storage in old queens, while simple sugars dominate in their hemolymph.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Nature Portfolio
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  9. Artikel ; Online: LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program

    Audrey Sambeat / Olga Gulyaeva / Jon Dempersmier / Kevin M. Tharp / Andreas Stahl / Sarah M. Paul / Hei Sook Sul

    Cell Reports, Vol 15, Iss 11, Pp 2536-

    2016  Band 2549

    Abstract: Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of ...

    Abstract Zfp516, a brown fat (BAT)-enriched and cold-inducible transcription factor, promotes transcription of UCP1 and other BAT-enriched genes for non-shivering thermogenesis. Here, we identify lysine-specific demethylase 1 (LSD1) as a direct binding partner of Zfp516. We show that, through interaction with Zfp516, LSD1 is recruited to UCP1 and other BAT-enriched genes, such as PGC1α, to function as a coactivator by demethylating H3K9. We also show that LSD1 is induced during brown adipogenesis and that LSD1 and its demethylase activity is required for the BAT program. Furthermore, we show that LSD1 ablation in mice using Myf5-Cre alters embryonic BAT development. Moreover, BAT-specific deletion of LSD1 via the use of UCP1-Cre impairs the BAT program and BAT development, making BAT resemble WAT, reducing thermogenic activity and promoting obesity. Finally, we demonstrate an in vivo requirement of the Zfp516-LSD1 interaction for LSD1 function in BAT gene activation.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2016-06-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Pref-1 Marks Very Early Mesenchymal Precursors Required for Adipose Tissue Development and Expansion

    Carolyn S. Hudak / Olga Gulyaeva / Yuhui Wang / Seung-min Park / Luke Lee / Chulho Kang / Hei Sook Sul

    Cell Reports, Vol 8, Iss 3, Pp 678-

    2014  Band 687

    Abstract: Pref-1 is an EGF-repeat-containing protein that inhibits adipocyte differentiation. To better understand the origin and development of white adipose tissue (WAT), we generated transgenic mouse models for transient or permanent fluorescent labeling of ... ...

    Abstract Pref-1 is an EGF-repeat-containing protein that inhibits adipocyte differentiation. To better understand the origin and development of white adipose tissue (WAT), we generated transgenic mouse models for transient or permanent fluorescent labeling of cells using the Pref-1 promoter, facilitating inducible ablation. We show that Pref-1-marked cells retain proliferative capacity and are very early adipose precursors, prior to expression of Zfp423 or PPARγ. In addition, the Pref-1-marked cells establish that adipose precursors are mesenchymal, but not endothelial or pericytal, in origin. During embryogenesis, Pref-1-marked cells first appear in the dorsal mesenteric region as early as embryonic day 10.5 (E10.5). These cells become lipid-laden adipocytes at E17.5 in the subcutaneous region, whereas visceral WAT develops after birth. Finally, ablation of Pref-1-marked cells prevents not only embryonic WAT development but also later adult adipose expansion upon high-fat feeding, demonstrating the requirement of Pref-1 cells for adipogenesis.
    Schlagwörter Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2014-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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