LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Heidi G Standke"
  2. AU="Banville, Isabelle"
  3. AU=Morrow Lee E
  4. AU="Cuss, Chad W."
  5. AU="Carter, Paul (Interviewpartner)"
  6. AU=Lubozynski M F
  7. AU="Yves, Ville"
  8. AU="Bayer, Emily A"
  9. AU=Roesch Saskia
  10. AU="Tam, Benjamin"
  11. AU="Mori, Kousuke"
  12. AU="Steuer, Melanie"
  13. AU="Sood Hemant"
  14. AU="Jennifer Schaff"
  15. AU="Maji, Manideepa"
  16. AU=Evans Heather L
  17. AU="Cheng, Shuai"
  18. AU="Zalis, Joshua"

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Pathogenic prion structures at high resolution.

    Byron Caughey / Heidi G Standke / Efrosini Artikis / Forrest Hoyt / Allison Kraus

    PLoS Pathogens, Vol 18, Iss 6, p e

    2022  Volume 1010594

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.

    Patricia Aguilar-Calvo / Adela Malik / Daniel R Sandoval / Christopher Barback / Christina D Orrù / Heidi G Standke / Olivia R Thomas / Chrissa A Dwyer / Donald P Pizzo / Jaidev Bapat / Katrin Soldau / Ryotaro Ogawa / Mckenzie B Riley / K Peter R Nilsson / Allison Kraus / Byron Caughey / Jeffrey J Iliff / David R Vera / Jeffrey D Esko /
    Christina J Sigurdson

    PLoS Pathogens, Vol 19, Iss 9, p e

    2023  Volume 1011487

    Abstract: Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar ... ...

    Abstract Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar plaque growth within the brain is unclear. Here we found that prion-bound HS chains are highly sulfated, and that the sulfation is essential for accelerating prion conversion in vitro. Using conditional knockout mice to deplete the HS sulfation enzyme, Ndst1 (N-deacetylase / N-sulfotransferase) from neurons or astrocytes, we investigated how reducing HS sulfation impacts survival and prion aggregate distribution during a prion infection. Neuronal Ndst1-depleted mice survived longer and showed fewer and smaller parenchymal plaques, shorter fibrils, and increased vascular amyloid, consistent with enhanced aggregate transit toward perivascular drainage channels. The prolonged survival was strain-dependent, affecting mice infected with extracellular, plaque-forming, but not membrane bound, prions. Live PET imaging revealed rapid clearance of recombinant prion protein monomers into the CSF of neuronal Ndst1- deficient mice, neuronal, further suggesting that HS sulfate groups hinder transit of extracellular prion protein monomers. Our results directly show how a host cofactor slows the spread of prion protein through the extracellular space and identify an enzyme to target to facilitate aggregate clearance.
    Keywords Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top