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  1. Article ; Online: Speicheldrüsentumoren: Limitationen der internationalen Guidelines und Bearbeitungsstand der AWMF-S3-Leitlinie.

    Beck-Broichsitter, Benedicta / Heiland, Max / Guntinas-Lichius, Orlando

    Laryngo- rhino- otologie

    2024  Volume 103, Issue 2, Page(s) 135–149

    Abstract: Primary salivary gland carcinomas are not among the common head and neck tumors. They are characterized by manifold different histological types. Clinically, malignant tumors often cannot be distinguished from benign tumors, so that in these cases ... ...

    Title translation Salivary Gland Tumors: Limitations of International Guidelines and Status of the planned AWMF-S3-Guideline.
    Abstract Primary salivary gland carcinomas are not among the common head and neck tumors. They are characterized by manifold different histological types. Clinically, malignant tumors often cannot be distinguished from benign tumors, so that in these cases malignancy is only established by histopathological diagnosis. These are all reasons why there are relatively few clinical trials on the diagnosis, therapy and follow-up of these tumors. This in turn has the consequence that often only recommendations with limited evidence can be made in clinical guidelines. The most important international guidelines are the National Comprehensive Cancer Network (NCCN) guideline of 2023, the American Society of Clinical Oncology (ASCO) guideline of 2021, the European Society for Medical Oncology (ESMO) guideline of 2022 and still the British National Multidisciplinary guideline of 2016. These 4 international guidelines with their strengths and limitations are presented and commented here. Against this background, the development of a first German S3 clinical guideline on salivary gland tumors is important and expected to be completed in 2023. For the first time in the German guideline program on oncology, benign and malignant tumors are presented together in order to comprehensively do justice to the special features of salivary gland tumors.
    MeSH term(s) Humans ; Head and Neck Neoplasms ; Salivary Gland Neoplasms
    Language German
    Publishing date 2024-02-06
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-2150-2670
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.95: Show issues Location:
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  2. Article: Einführung zum Thema: Minimal-invasive Chirurgie. Introduction to the topic: Minimally invasive surgery

    Heiland, M.

    Der MKG-Chirurg

    2017  Volume 10, Issue 1, Page(s) 1

    Language German
    Document type Article
    ZDB-ID 2408833-X
    ISSN 1865-9659
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6739: Show issues Location:
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  3. Book ; Thesis: Methoden zur Bewegungsverfolgung des schlagenden Herzens an hochauflösenden CSPAMM-Bildfolgen und Optimierung von MR-Perfusionssequenzen

    Heiland, Marc

    2000  

    Author's details vorgelegt von Marc Heiland
    Language German
    Size 102 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2001
    HBZ-ID HT013184548
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  4. Article: Beneficial Effect of Metformin on the Five-Year Survival in about 40,000 Patients with Head and Neck Cancer.

    Gaertner, Florian / Preissner, Saskia / Heiland, Max / Preissner, Robert / Wüster, Jonas

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Introduction: Even in times of new therapy regimes, the overall survival of patients with head and neck cancer remains low. Since the previous studies showed the beneficial effect of metformin medication on the survival of patients with cancer, our ... ...

    Abstract Introduction: Even in times of new therapy regimes, the overall survival of patients with head and neck cancer remains low. Since the previous studies showed the beneficial effect of metformin medication on the survival of patients with cancer, our objective was to investigate if-and in which way-metformin medication affects the overall survival of patients with head and neck cancer.
    Methods: Clinical data pertaining to patients diagnosed with head and neck cancer (International Classification of Diseases 10 codes C00-C14, C31, and C32) were retrospectively retrieved from the TriNetX network (TriNetX, Cambridge, MA, USA). The initial cohort extracted from the network was stratified into two groups: patients on metformin medication (cohort I), and individuals not on metformin medication (cohort II). The matching criteria included age, gender, BMI, type 2 diabetes, and risk factors, such as nicotine and alcohol abuse/dependence. Kaplan-Meier analysis, risk analysis, and the calculation of odds and hazard ratios were conducted. Additionally, the Hemoglobin A1c values were subject to analysis.
    Results: Following matching, each cohort comprised 20,416 patients. Cohort I exhibited a higher five-year survival rate at 75.3%, in contrast to cohort II, which registered a rate of 69.8%. The odds ratio was 0.79 (95% CI = 0.75-0.83), and the hazard ratio was 0.78 (95% CI = 0.75-0.82).
    Conclusion: Metformin medication may correlate with improved five-year survival rates in patients with head and neck cancer. Since potentially influencing factors such as comorbidities and the initial tumor stage were not available, the results of our retrospectively conducted study must be interpreted with caution.
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Publication performance of university maxillofacial surgeons in Germany.

    Reyer, Lea Sophie / Heiland, Max / Debus, Eike Sebastian / Grundmann, Reinhart T

    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

    2024  Volume 52, Issue 5, Page(s) 565–569

    Abstract: The aim of this bibliometric analysis was to benchmark the publication activities of German university departments of oral and maxillofacial surgery. The publication performance of staff surgeons (chief and consultants), documented by first or last ... ...

    Abstract The aim of this bibliometric analysis was to benchmark the publication activities of German university departments of oral and maxillofacial surgery. The publication performance of staff surgeons (chief and consultants), documented by first or last authorship, from 37 German university departments was captured over a 10-year period (January 1, 2010, to December 31, 2019). All publications listed in PubMed were included. Additionally, the Impact Factor (IF) was determined. A total of 213 surgeons were identified, of whom 158 (74.2%) were publishing. The number of publications was 1,777, published in 311 journals. Publication activity ranged from an average of 23.3 publications per staff surgeon in the top-ranked department to 0 publications in the last-ranked. The same trend was observed for the total cumulative IFs (CIFs) per member (range from 56.2 to 0). The most common used journal was the Journal of Cranio-Maxillofacial Surgery (19.7%), with focus on "dentoalveolar surgery" (24%) and "operative techniques and procedures" (28.3%). Women constituted 19.2% of the staff, contributing to 8.5% of the publications. The publication performance of German university departments of oral and maxillofacial surgery exhibits a high variance, which did not correlate with the number of personnel and could only be explained by different research motivations.
    MeSH term(s) Germany ; Humans ; Bibliometrics ; Publishing/statistics & numerical data ; Oral and Maxillofacial Surgeons/statistics & numerical data ; Female ; Male ; Surgery, Oral/statistics & numerical data ; Universities ; Journal Impact Factor
    Language English
    Publishing date 2024-02-03
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 91267-0
    ISSN 1878-4119 ; 1010-5182 ; 0301-0503
    ISSN (online) 1878-4119
    ISSN 1010-5182 ; 0301-0503
    DOI 10.1016/j.jcms.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Speicheldrüsentumoren: Limitationen der internationalen Guidelines und Bearbeitungsstand der AWMF-S3-Leitlinie

    Beck-Broichsitter, Benedicta / Heiland, Max / Guntinas-Lichius, Orlando

    Laryngo-Rhino-Otologie

    2024  Volume 103, Issue 02, Page(s) 135–149

    Keywords Speicheldrüsen ; Leitlinie ; Tumor ; Glandula parotis ; Glandula submandibularis ; Glandula sublingualis ; kleine Speicheldrüsen ; Diagnostik ; Therapie ; Chirurgie ; Radiotherapie ; Nachsorge ; Salivary glands ; guideline ; tumor ; parotid gland ; submandibular gland ; sublingual gland ; minor salivary glands ; diagnosis ; therapy ; surgery ; radiotherapy ; aftercare
    Language German
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/a-2150-2670
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.95: Show issues Location:
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  7. Article ; Online: Association of Herpes simplex infection with significantly increased risk of head and neck cancer: real-world evidence of about 500,000 patients.

    von Stebut, Jennifer / Heiland, Max / Preissner, Robert / Rendenbach, Carsten / Preissner, Saskia

    International journal of dermatology

    2024  

    Abstract: Background: The role of viral agents in the development of head and neck cancers has remained controversial. While markers of viral origin have been isolated from oral cancer tissues, a causative relationship has yet to be shown. The aim of this study ... ...

    Abstract Background: The role of viral agents in the development of head and neck cancers has remained controversial. While markers of viral origin have been isolated from oral cancer tissues, a causative relationship has yet to be shown. The aim of this study was to evaluate the relationship between head and neck cancers and Herpes simplex virus, one of the most common viral infections of the oral orifice.
    Methods: Here, we conducted a retrospective analysis of two age- and gender-matched cohorts extracted from the real-world database TriNetX on March 10th, 2023, each consisting of 249,272 patients with and without Herpes simplex infections (ICD-10: B00). The diagnoses C00-C14 were analyzed, and risk analysis and Kaplan-Meier survival statics were computed.
    Results: The strongest association was found for lip cancer (ICD-10: C00) with a hazard ratio [HR (CI 95% low-high)] of 3.08 (1.77-5.35). A significant association with HR of 1.17 (1.02-1.34) was found for the entire group of head and neck cancers. Confounders like smoking and alcohol dependence were considered using propensity score matching.
    Conclusion: The surprisingly strong correlation with lip, oral cavity, and pharynx neoplasms sheds new light on supposedly harmless herpes simplex infections, suggesting them as a possible new factor for risk stratification.
    Language English
    Publishing date 2024-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.189: Show issues Location:
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  8. Book ; Thesis: Vergleichende Beurteilung der Reinnervation von gestielten und freien Musculus latissimus dorsi-Transplantaten sowie Radialislappen mit Hilfe von Semmes-Weinstein Monofilamenten

    Heiland, Max

    2001  

    Author's details vorgelegt von Max Heiland
    Language German
    Size 63 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hamburg, Univ., Diss., 2001
    HBZ-ID HT013435647
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 D 2891 order for loan Magazin

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  9. Article: Antibiotics Significantly Decrease the Survival of Head and Neck Carcinoma Patients with Immunotherapy: A Real-World Analysis of More Than 3000 Cases.

    Preissner, Saskia / Heiland, Max / Preissner, Robert / Wirth, Markus / Wollenberg, Barbara

    Cancers

    2023  Volume 15, Issue 8

    Abstract: Objective: The human gut microbiome is strongly influenced by the administration of drugs, namely antibiotics. We hypothesized that the effectiveness of immunotherapy with pembrolizumab in oral squamous cell carcinoma patients is decreased by the ... ...

    Abstract Objective: The human gut microbiome is strongly influenced by the administration of drugs, namely antibiotics. We hypothesized that the effectiveness of immunotherapy with pembrolizumab in oral squamous cell carcinoma patients is decreased by the administration of antibiotics three months before and after immunotherapy.
    Methods: We retrieved data from patients diagnosed with head and neck squamous cell carcinoma (HNSCC) (International Classification of Diseases [ICD]-10 codes C00-C14) and receiving immunotherapy with pembrolizumab from the TriNetX network. Two cohorts were built: patients in cohort I did not receive any antibiotics within three months before or up to three months after immunotherapy, while patients in cohort II were administered antibiotics at least once within three months before or after immunotherapy. To exclude confounders, we matched cohorts 1:1 for age, sex, secondary lymph node metastases, nicotine dependence, the insertion of feeding devices, body mass index (BMI) and severe sepsis. After defining the primary outcome as "death", a Kaplan-Meier analysis was performed, and the risk ratio (RR), odds ratio (OR) and hazard ratio (HR) were calculated.
    Results: A total of 3651 patients were enrolled, and after matching, each cohort consisted of 1362 patients. Among cohorts I and II, 346 and 511 patients were deceased within one year (risk of death = 25.5 and 38.3%, respectively), whereby the risk difference was significant (
    Conclusions: Our hypothesis was confirmed: administering antibiotics significantly decreases the drug effectiveness of immunotherapy. We hypothesize that this finding is associated with antibiotic-related changes in the gut microbiome. Prospective clinical studies on the gut microbiome in cancer patients are necessary to understand the complex ecosystem of microbiota during immunotherapy.
    Trial registration: Due to the retrospective nature of the study, no registration was necessary.
    Language English
    Publishing date 2023-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15082342
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The risk of osteomyelitis after mandibular fracture is doubled in men versus women: analysis of 300,000 patients.

    Voss, Jan Oliver / Heiland, Max / Preissner, Robert / Preissner, Saskia

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 20871

    Abstract: Postoperative complications following mandibular fracture treatment vary from local wound infections to severe conditions including osteomyelitis and impaired fracture healing. Several risk factors have been associated with the development healing ... ...

    Abstract Postoperative complications following mandibular fracture treatment vary from local wound infections to severe conditions including osteomyelitis and impaired fracture healing. Several risk factors have been associated with the development healing disorders, including fracture localisation, treatment modality and substance abuse. However, limited research on the sex-specific influence of these complications exists. A total of about 300,000 female and male patients with mandibular fractures were examined in two cohorts. After matching for confounders (age, nicotine and alcohol dependence, malnutrition, overweight, anaemia, diabetes, osteoporosis and vitamin D deficiency), two cohorts were compared with propensity-score-matched patients according to outcomes (osteomyelitis, pseudoarthrosis and disruption of the wound) within 1 year after fracture. There were significant differences between female and male patients regarding the occurrence of osteomyelitis (odds ratio [OR] [95% confidence interval]: 0.621 [0.563; 0.686]) and disruption of the wound (OR [95% confidence interval]: 0.703 [0.632; 0.782]). Surprisingly, matching for the expected confounders did not change the results substantially. Sex plays a dominant role in determining the risk stratification for postoperative osteomyelitis and disruption of the wound, after accounting for other potential confounding factors. Additional research is needed to understand the underlying mechanisms and to develop sex-specific strategies to prevent these complications.
    MeSH term(s) Humans ; Male ; Female ; Mandibular Fractures/complications ; Postoperative Complications ; Osteomyelitis/complications ; Osteoporosis/complications ; Wound Infection ; Retrospective Studies
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48235-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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