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  1. Article: Akute Bewegungsstörungen in der Notaufnahme in 10 Minuten

    Heim, B.

    Neurologisch : Sonderausgabe

    2021  Volume -, Issue 2, Page(s) 32

    Language German
    Document type Article
    ZDB-ID 2970821-7
    Database Current Contents Medicine

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    Zs.A 7184 -Sonderausg.-: Show issues Location:
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  2. Article ; Online: Valbenazine as treatment for Huntington's disease chorea.

    Heim, Beatrice / Seppi, Klaus

    The Lancet. Neurology

    2023  Volume 22, Issue 6, Page(s) 459–460

    MeSH term(s) Humans ; Huntington Disease/complications ; Huntington Disease/drug therapy ; Chorea/drug therapy ; Tetrabenazine/pharmacology ; Tetrabenazine/therapeutic use ; Valine
    Chemical Substances valbenazine (54K37P50KH) ; Tetrabenazine (Z9O08YRN8O) ; Valine (HG18B9YRS7)
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00163-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5955: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article: Neu formiert in die Zukunft: Arbeitsgruppe Junge Neurologie

    Heim, B. / Parvizi, T. / Fandler-Höfler, S.

    Neurologisch

    2023  Volume 2, Issue 2, Page(s) 12

    Language German
    Document type Article
    ZDB-ID 2475252-6
    ISSN 2223-0629
    Database Current Contents Medicine

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    Zs.A 7184: Show issues Location:
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  4. Article: Neu formiert in die Zukunft: Arbeitsgruppe Junge Neurologie

    Heim, B. / Parvizi, T. / Fandler-Höfler, S.

    Neurologisch

    2023  Volume -, Issue 2, Page(s) 12

    Language German
    Document type Article
    ZDB-ID 2475252-6
    ISSN 2223-0629
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7184: Show issues Location:
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  5. Article: Pimavanserin: A Truly Effective Treatment for Parkinson's Disease Psychosis? A Review of Interventions.

    Heim, Beatrice / Peball, Marina / Krismer, Florian / Djamshidian, Atbin / Seppi, Klaus

    Neuropsychiatric disease and treatment

    2023  Volume 19, Page(s) 1303–1312

    Abstract: Parkinson's disease (PD) is the second-most common neurodegenerative disorder with a long-term 60% cumulative prevalence of PD psychosis. Medical treatment is limited to few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, ...

    Abstract Parkinson's disease (PD) is the second-most common neurodegenerative disorder with a long-term 60% cumulative prevalence of PD psychosis. Medical treatment is limited to few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved by the US Food and Drug Administration (FDA) as the only treatment for PD psychosis (PDP). This article provides an overview of the epidemiology, pathophysiology, and treatment options for PDP and illuminates the mode of action and therapy options with pimavanserin and the current study data.
    Language English
    Publishing date 2023-05-30
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S371641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6068: Show issues Location:
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  6. Conference proceedings ; Online: FAIR WISH project – developing metadata templates for IGSN Registration for various sample types

    Wieczorek, M. / Brauser, A. / Heim, B. / Frenzel, S. / Baldewein, L. / Kleeberg, U. / Elger, K.

    Abstracts

    2023  

    Abstract: The International Generic Sample Number (IGSN) is a unique and persistent identifier for physical objects that was originally developed in the Geosciences. In 2022, after 10 years of service operation and more than 10 million registered samples worldwide, ...

    Abstract The International Generic Sample Number (IGSN) is a unique and persistent identifier for physical objects that was originally developed in the Geosciences. In 2022, after 10 years of service operation and more than 10 million registered samples worldwide, IGSN e.V. and DataCite have agreed on a strategic partnership. As a result, all IGSNs are now registered as DataCite DOIs and the IGSN metadata schema will be mapped to the DataCite Metadata Schema according to agreed guidelines. This will, on the one hand, enrich the very limited mandatory information shared by IGSN allocating agents so far. On the other hand, the DataCite metadata schema is not designed for the comprehensive description of physical objects and their provenance. The IGSN Metadata Schema is modular: the mandatory Registration Schema only included information on the IGSN identifier, the minting agent and a date - complemented by the IGSN Description Schema (for data discovery) and additional extensions by the allocating agents to customise the sample description according to their sample’s subdomain. Within the project “FAIR Workflows to establish IGSN for Samples in the Helmholtz Association (FAIR WISH)”, funded by the Helmholtz Metadata Collaboration Platform (HMC), we (1) customised the GFZ-specific schema to describe water, soil and vegetation samples and (2) support the metadata collection by the individual researcher with a user-friendly, easy-to-use batch registration template in MS Excel. The information collected with the template can directly be converted to XML files (or JSON in the future) following the IGSN Metadata schema that is required to generate IGSN landing pages. The template is also the source for the generation of DataCite metadata. The integration of linked data vocabularies (RDF, SKOS) in the metadata is an essential step in harmonising information across different research groups and institutions and important for the implementation of the FAIR Principles (Findable, Accessible, Interoperable, Reusable) for sample ...
    Subject code 020
    Publishing country de
    Document type Conference proceedings ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Symptomatic Care in Multiple System Atrophy: State of the Art.

    Grossauer, Anna / Sidoroff, Victoria / Heim, Beatrice / Seppi, Klaus

    Cerebellum (London, England)

    2022  Volume 22, Issue 3, Page(s) 433–446

    Abstract: Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a multidisciplinary strategy of symptom control. In the present review, we will focus on state of the art treatment ... ...

    Abstract Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a multidisciplinary strategy of symptom control. In the present review, we will focus on state of the art treatment in MSA and additionally give a short overview about ongoing randomized controlled trials in this field.
    MeSH term(s) Humans ; Multiple System Atrophy/diagnosis ; Longitudinal Studies
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2112586-7
    ISSN 1473-4230 ; 1473-4222
    ISSN (online) 1473-4230
    ISSN 1473-4222
    DOI 10.1007/s12311-022-01411-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5795: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Differentiating PSP from MSA using MR planimetric measurements: a systematic review and meta-analysis.

    Heim, Beatrice / Krismer, Florian / Seppi, Klaus

    Journal of neural transmission (Vienna, Austria : 1996)

    2021  Volume 128, Issue 10, Page(s) 1497–1505

    Abstract: Differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology. Quantitative MR planimetric measurements were reported to discriminate between progressive supranuclear palsy (PSP) and non-PSP-parkinsonism. Several ...

    Abstract Differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology. Quantitative MR planimetric measurements were reported to discriminate between progressive supranuclear palsy (PSP) and non-PSP-parkinsonism. Several studies have used midbrain to pons ratio (M/P) and the Magnetic Resonance Parkinsonism Index (MRPI) in distinguishing PSP patients from those with Parkinson's disease. The current meta-analysis aimed to compare the performance of these measures in discriminating PSP from multiple system atrophy (MSA). A systematic MEDLINE review identified 59 out of 2984 studies allowing a calculation of sensitivity and specificity using the MRPI or M/P. Meta-analyses of results were carried out using random effects modelling. To assess study quality and risk of bias, the QUADAS-2 tool was used. Eight studies were suitable for analysis. The meta-analysis showed a pooled sensitivity and specificity for the MRPI of PSP versus MSA of 79.2% (95% CI 72.7-84.4%) and 91.2% (95% CI 79.5-96.5%), and 84.1% (95% CI 77.2-89.2%) and 89.2% (95% CI 81.8-93.8%), respectively, for the M/P. The QUADAS-2 toolbox revealed a high risk of bias regarding the methodological quality of patient selection and index test, as all patients were seen in a specialized outpatient department without avoiding case control design and no predefined threshold was given regarding MRPI or M/P cut-offs. Planimetric brainstem measurements, in special the MRPI and M/P, yield high diagnostic accuracy for the discrimination of PSP from MSA. However, there is an urgent need for well-designed, prospective validation studies to ameliorate the concerns regarding the risk of bias.
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Multiple System Atrophy/diagnosis ; Parkinson Disease/diagnosis ; Parkinsonian Disorders ; Supranuclear Palsy, Progressive/diagnosis
    Language English
    Publishing date 2021-06-08
    Publishing country Austria
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 184163-4
    ISSN 1435-1463 ; 0300-9564
    ISSN (online) 1435-1463
    ISSN 0300-9564
    DOI 10.1007/s00702-021-02362-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.150: Show issues Location:
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  9. Article ; Online: A Blinded Evaluation of Brain Morphometry for Differential Diagnosis of Atypical Parkinsonism.

    Kawabata, Kazuya / Krismer, Florian / Heim, Beatrice / Hussl, Anna / Mueller, Christoph / Scherfler, Christoph / Gizewski, Elke R / Seppi, Klaus / Poewe, Werner

    Movement disorders clinical practice

    2024  Volume 11, Issue 4, Page(s) 381–390

    Abstract: Background: Advanced imaging techniques have been studied for differential diagnosis between PD, MSA, and PSP.: Objectives: This study aims to validate the utility of individual voxel-based morphometry techniques for atypical parkinsonism in a ... ...

    Abstract Background: Advanced imaging techniques have been studied for differential diagnosis between PD, MSA, and PSP.
    Objectives: This study aims to validate the utility of individual voxel-based morphometry techniques for atypical parkinsonism in a blinded fashion.
    Methods: Forty-eight healthy controls (HC) T1-WI were used to develop a referential dataset and fit a general linear model after segmentation into gray matter (GM) and white matter (WM) compartments. Segmented GM and WM with PD (n = 96), MSA (n = 18), and PSP (n = 20) were transformed into z-scores using the statistics of referential HC and individual voxel-based z-score maps were generated. An imaging diagnosis was assigned by two independent raters (trained and untrained) blinded to clinical information and final diagnosis. Furthermore, we developed an observer-independent index for ROI-based automated differentiation.
    Results: The diagnostic performance using voxel-based z-score maps by rater 1 and rater 2 for MSA yielded sensitivities: 0.89, 0.94 (95% CI: 0.74-1.00, 0.84-1.00), specificities: 0.94, 0.80 (0.90-0.98, 0.73-0.87); for PSP, sensitivities: 0.85, 0.90 (0.69-1.00, 0.77-1.00), specificities: 0.98, 0.94 (0.96-1.00, 0.90-0.98). Interrater agreement was good for MSA (Cohen's kappa: 0.61), and excellent for PSP (0.84). Receiver operating characteristic analysis using the ROI-based new index showed an area under the curve (AUC): 0.89 (0.77-1.00) for MSA, and 0.99 (0.98-1.00) for PSP.
    Conclusions: These evaluations provide support for the utility of this imaging technique in the differential diagnosis of atypical parkinsonism demonstrating a remarkably high differentiation accuracy for PSP, suggesting potential use in clinical settings in the future.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Diagnosis, Differential ; Supranuclear Palsy, Progressive/diagnosis ; Parkinsonian Disorders/diagnosis ; Brain/diagnostic imaging
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Article ; Online: Standardized organic geochemistry data of sediment core EN18208 from Lake Ilirney (Chukotka, Russia)

    Biskaborn, B. / Pfalz, G. / Vyse, S. / Diekmann, B. / Andreev, A. / Nowaczyk, N. / Heim, B. / Wieczorek, M. / Pestryakova, L. / Herzschuh, U.

    2023  

    Abstract: This data set is part of a larger data harmonization effort to make lake sediment core data machine readable and comparable. Here we standardized radiocarbon and OSL age data of sediment core EN18208, retrieved in 2018 from Lake Ilirney (Chukotka, Russia) ...

    Abstract This data set is part of a larger data harmonization effort to make lake sediment core data machine readable and comparable. Here we standardized radiocarbon and OSL age data of sediment core EN18208, retrieved in 2018 from Lake Ilirney (Chukotka, Russia) at 10.76 m water depth. The glacial lake Ilirney is situated in the forest tundra mountain area and has one outflow, one main inflow and several smaller inflows. It lies at an elevation of ca. 428 m a.s.l. with a surface area of ca. 30 km2 and a maximum lake water depth of estimated 44 m. The 10.76 m sediment core was retrieved by a UWITEC piston corer during the RU-Land_2018_Chukotka expedition of the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (AWI, Germany, Potsdam) in cooperation with the North Eastern Federal State University (NEFU, Russia, Yakutsk). Water content and organic matter was analysed at AWI Potsdam. Dried and milled samples were analysed using a Vario EL III carbon-nitrogen-sulphur analyser. Organic carbon content was determined using a Vario MAX C analyser.
    Subject code 550 ; 333
    Language English
    Publisher PANGAEA
    Publishing country de
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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