LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 63

Search options

  1. Article ; Online: Suicide Mortality Among Retired National Football League Players Who Played 5 or More Seasons.

    Lehman, Everett J / Hein, Misty J / Gersic, Christine M

    The American journal of sports medicine

    2016  Volume 44, Issue 10, Page(s) 2486–2491

    Abstract: Background: There is current disagreement in the scientific literature about the relationship between playing football and suicide risk, particularly among professional players in the National Football League (NFL). While some research indicates players ...

    Abstract Background: There is current disagreement in the scientific literature about the relationship between playing football and suicide risk, particularly among professional players in the National Football League (NFL). While some research indicates players are at high risk of football-related concussions, which may lead to chronic traumatic encephalopathy and suicide, other research finds such a connection to be speculative and unsupported by methodologically sound research.
    Purpose: To compare the suicide mortality of a cohort of NFL players to what would be expected in the general population of the United States.
    Study design: Cohort study; Level of evidence, 3.
    Methods: A cohort of 3439 NFL players with at least 5 credited playing seasons between 1959 and 1988 was assembled for statistical analysis. The vital status for this cohort was updated through 2013. Standardized mortality ratios (SMRs), the ratio of observed deaths to expected deaths, and 95% CIs were computed for the cohort; 95% CIs that excluded unity were considered statistically significant. For internal comparison purposes, standardized rate ratios were calculated to compare mortality results between players stratified into speed and nonspeed position types.
    Results: Suicide among this cohort of professional football players was significantly less than would be expected in comparison with the United States population (SMR = 0.47; 95% CI, 0.24-0.82). There were no significant differences in suicide mortality between speed and nonspeed position players.
    Conclusion: There is no indication of elevated suicide risk in this cohort of professional football players with 5 or more credited seasons of play. Because of the unique nature of this cohort, these study results may not be applicable to professional football players who played fewer than 5 years or to college or high school players.
    MeSH term(s) Adolescent ; Adult ; Cohort Studies ; Football/statistics & numerical data ; Humans ; Male ; Middle Aged ; Retirement ; Seasons ; Suicide/statistics & numerical data ; United States/epidemiology
    Language English
    Publishing date 2016-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/0363546516645093
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls.

    Ruder, Avima M / Hein, Misty J / Hopf, Nancy B / Waters, Martha A

    American journal of industrial medicine

    2017  Volume 60, Issue 2, Page(s) 198–207

    Abstract: Background: We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers.: Methods: Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ... ...

    Abstract Background: We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers.
    Methods: Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ratios. Trends in prostate cancer incidence with cumulative PCB exposure were evaluated using standardized rate ratios and Cox regression models. For selected sites, cumulative PCB exposure was compared between aggressive (fatal/distant stage) and localized/regional cancers.
    Results: We identified 3,371 invasive first primary cancer diagnoses among 21,317 eligible workers through 2007. Overall relative incidence was reduced. Elevations were only observed for respiratory cancers and among women, urinary organ cancers. Among men, prostate cancer incidence was reduced and not associated with cumulative PCB exposure although median exposures were significantly higher for aggressive compared to localized/regional prostate cancers.
    Conclusion: Previously observed associations between cumulative PCB exposure and prostate cancer mortality were not confirmed in this analysis; prostate cancer stage at diagnosis may explain the discrepancy. Am. J. Ind. Med. 60:198-207, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.22657
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Re: Bias in the proportionate mortality ratio analysis of small study populations: A case on analyses of radiation and mesothelioma.

    Hein, Misty J / Schubauer-Berigan, Mary K

    International journal of radiation biology

    2015  Volume 91, Issue 11, Page(s) 908–910

    MeSH term(s) Humans ; Mesothelioma/etiology ; Neoplasms, Radiation-Induced/etiology
    Language English
    Publishing date 2015
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.3109/09553002.2015.1075179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Mortality of lead smelter workers: A follow-up study with exposure assessment.

    Bertke, Stephen J / Lehman, Everett J / Wurzelbacher, Steven J / Hein, Misty J

    American journal of industrial medicine

    2016  Volume 59, Issue 11, Page(s) 979–986

    Abstract: Background: Lead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS) ...

    Abstract Background: Lead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS).
    Methods: We extended vital status follow-up on a cohort of 1,990 lead smelter workers by 25 years and computed standardized mortality ratios and rate ratios (RR) stratified by cumulative lead exposure.
    Results: The update added 13,823 person-years at risk and 721 deaths. Increased risk of mortality was observed for the a priori outcomes of lung cancer, cardiovascular disease (including cerebrovascular disease), chronic kidney disease, and ALS. However, of these outcomes, only cardiovascular, cerebrovascular, and chronic kidney diseases were associated with a positive exposure-response in RR analyses.
    Conclusions: This study reaffirms the association of lead exposure with cardiovascular and kidney diseases; however, increased mortality observed for certain cancers is not likely to be due to lead exposure. Am. J. Ind. Med. 59:979-986, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/mortality ; Cause of Death ; Female ; Follow-Up Studies ; Humans ; Kidney Diseases/chemically induced ; Kidney Diseases/mortality ; Lead ; Lead Poisoning/complications ; Lead Poisoning/mortality ; Lung Neoplasms/mortality ; Male ; Metallurgy ; Middle Aged ; Occupational Diseases/chemically induced ; Occupational Diseases/mortality ; Occupational Exposure/adverse effects ; Occupational Exposure/statistics & numerical data ; United States/epidemiology
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2016-06-28
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.22618
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Mortality from neurodegenerative diseases in a cohort of US flight attendants.

    Pinkerton, Lynne E / Hein, Misty J / Grajewski, Barbara / Kamel, Freya

    American journal of industrial medicine

    2016  Volume 59, Issue 7, Page(s) 532–537

    Abstract: Background: Concern exists about the potential chronic neurological effects among aircrew of exposure to chemical contaminants from engine oil in aircraft cabin air. We evaluated mortality from neurodegenerative diseases among 11,311 former US flight ... ...

    Abstract Background: Concern exists about the potential chronic neurological effects among aircrew of exposure to chemical contaminants from engine oil in aircraft cabin air. We evaluated mortality from neurodegenerative diseases among 11,311 former US flight attendants.
    Methods: Vital status was ascertained through 2007, and life table analyses were conducted to obtain standardized mortality ratios (SMRs).
    Results: Amyotrophic lateral sclerosis (ALS) mortality was over twice as high in the cohort as in the US general population, based on nine observed ALS deaths. There was no clear pattern in risk when SMRs for ALS were stratified by exposure duration. Mortality from other neurodegenerative diseases was not elevated.
    Conclusions: Our findings are limited due to small numbers of observed deaths and reliance on mortality data, but suggest that flight attendants may have an increased risk of ALS. Additional research is needed. Am. J. Ind. Med. 59:532-537, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
    MeSH term(s) Aerospace Medicine ; Aged ; Aircraft ; Amyotrophic Lateral Sclerosis/mortality ; Cohort Studies ; Female ; Fuel Oils/adverse effects ; Humans ; Male ; Middle Aged ; Neurodegenerative Diseases/mortality ; Occupational Diseases/mortality ; Occupational Exposure/adverse effects ; United States/epidemiology
    Chemical Substances Fuel Oils
    Language English
    Publishing date 2016-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.22608
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Participation in a US community-based cardiovascular health study: investigating nonrandom selection effects related to employment, perceived stress, work-related stress, and family caregiving.

    MacDonald, Leslie A / Fujishiro, Kaori / Howard, Virginia J / Landsbergis, Paul / Hein, Misty J

    Annals of epidemiology

    2017  Volume 27, Issue 9, Page(s) 545–552.e2

    Abstract: Purpose: Participation in health studies may be inversely associated with employment and stress. We investigated whether employment, perceived stress, work-related stress, and family caregiving were related to participation in a longitudinal US ... ...

    Abstract Purpose: Participation in health studies may be inversely associated with employment and stress. We investigated whether employment, perceived stress, work-related stress, and family caregiving were related to participation in a longitudinal US community-based health study of black and white men and women aged ≥45 years.
    Methods: Prevalence ratios and confidence intervals were estimated for completion of the second stage (S2) of a two-stage enrollment process by employment (status, type), and stress (perceived stress, work-related stress, caregiving), adjusting for age, sex, race, region, income, and education. Eligibility and consent for a follow-up occupational survey were similarly evaluated.
    Results: Wage- but not self-employed participants were less likely than the unemployed to complete S2. Among the employed, S2 completion did not vary by stress; however, family caregivers with a short time burden of care (<2 hour/d) were more likely to complete S2, compared to noncaregivers. Eligibility and participation in the follow-up occupational survey were higher among those employed (vs. unemployed) at enrollment but were not associated with enrollment stress levels.
    Conclusions: Limited evidence of selection bias was seen by employment and stress within a large US community-based cohort, but findings suggest the need for enrollment procedures to consider possible barriers to participation among wage-employed individuals.
    MeSH term(s) African Continental Ancestry Group/psychology ; African Continental Ancestry Group/statistics & numerical data ; Aged ; Aged, 80 and over ; Caregivers/psychology ; Employment/psychology ; Employment/statistics & numerical data ; European Continental Ancestry Group/psychology ; European Continental Ancestry Group/statistics & numerical data ; Family ; Female ; Humans ; Income ; Longitudinal Studies ; Male ; Middle Aged ; Occupational Stress/psychology ; Public Health ; Salaries and Fringe Benefits ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Surveys and Questionnaires ; United States
    Language English
    Publishing date 2017-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1074355-8
    ISSN 1873-2585 ; 1047-2797
    ISSN (online) 1873-2585
    ISSN 1047-2797
    DOI 10.1016/j.annepidem.2017.08.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Cohort mortality study of garment industry workers exposed to formaldehyde: update and internal comparisons.

    Meyers, Alysha R / Pinkerton, Lynne E / Hein, Misty J

    American journal of industrial medicine

    2013  Volume 56, Issue 9, Page(s) 1027–1039

    Abstract: Background: To further evaluate the association between formaldehyde and leukemia, we extended follow-up through 2008 for a cohort mortality study of 11,043 US formaldehyde-exposed garment workers.: Methods: We computed standardized mortality ratios ... ...

    Abstract Background: To further evaluate the association between formaldehyde and leukemia, we extended follow-up through 2008 for a cohort mortality study of 11,043 US formaldehyde-exposed garment workers.
    Methods: We computed standardized mortality ratios and standardized rate ratios stratified by year of first exposure, exposure duration, and time since first exposure. Associations between exposure duration and rates of leukemia and myeloid leukemia were further examined using Poisson regression models.
    Results: Compared to the US population, myeloid leukemia mortality was elevated but overall leukemia mortality was not. In internal analyses, overall leukemia mortality increased with increasing exposure duration and this trend was statistically significant.
    Conclusions: We continue to see limited evidence of an association between formaldehyde and leukemia. However, the extended follow-up did not strengthen previously observed associations. In addition to continued epidemiologic research, we recommend further research to evaluate the biological plausibility of a causal relation between formaldehyde and leukemia.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Formaldehyde/adverse effects ; Georgia/epidemiology ; Humans ; Leukemia/chemically induced ; Leukemia/mortality ; Leukemia, Myeloid/chemically induced ; Leukemia, Myeloid/mortality ; Life Tables ; Male ; Middle Aged ; Models, Statistical ; Occupational Diseases/chemically induced ; Occupational Diseases/mortality ; Occupational Exposure/adverse effects ; Occupational Exposure/statistics & numerical data ; Pennsylvania/epidemiology ; Poisson Distribution ; Regression Analysis ; Retrospective Studies ; Textile Industry ; Time Factors
    Chemical Substances Formaldehyde (1HG84L3525)
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.22199
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Melanoma, thyroid cancer, and gynecologic cancers in a cohort of female flight attendants.

    Pinkerton, Lynne E / Hein, Misty J / Anderson, Jeri L / Christianson, Annette / Little, Mark P / Sigurdson, Alice J / Schubauer-Berigan, Mary K

    American journal of industrial medicine

    2018  Volume 61, Issue 7, Page(s) 572–581

    Abstract: Background: Flight attendants may have an increased risk of some cancers from occupational exposure to cosmic radiation and circadian disruption.: Methods: The incidence of thyroid, ovarian, and uterine cancer among ∼6000 female flight attendants ... ...

    Abstract Background: Flight attendants may have an increased risk of some cancers from occupational exposure to cosmic radiation and circadian disruption.
    Methods: The incidence of thyroid, ovarian, and uterine cancer among ∼6000 female flight attendants compared to the US population was evaluated via life table analyses. Associations of these cancers, melanoma, and cervical cancer with cumulative cosmic radiation dose and metrics of circadian disruption were evaluated using Cox regression.
    Results: Incidence of thyroid, ovarian, and uterine cancer was not elevated. No significant, positive exposure-response relations were observed. Weak, non-significant, positive relations were observed for thyroid cancer with cosmic radiation and time zones crossed and for melanoma with another metric of circadian disruption.
    Conclusions: We found little evidence of increased risk of these cancers from occupational cosmic radiation or circadian disruption in female flight attendants. Limitations include few observed cases of some cancers, limited data on risk factors, and misclassification of exposures.
    MeSH term(s) Adult ; Aerospace Medicine ; Chronobiology Disorders ; Circadian Rhythm ; Cosmic Radiation ; Female ; Genital Neoplasms, Female/epidemiology ; Humans ; Incidence ; Life Tables ; Melanoma/epidemiology ; Middle Aged ; Occupational Exposure/statistics & numerical data ; Ovarian Neoplasms/epidemiology ; Risk Factors ; Skin Neoplasms/epidemiology ; Thyroid Neoplasms/epidemiology ; United States ; Uterine Cervical Neoplasms/epidemiology ; Uterine Neoplasms/epidemiology
    Language English
    Publishing date 2018-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 604538-8
    ISSN 1097-0274 ; 0271-3586
    ISSN (online) 1097-0274
    ISSN 0271-3586
    DOI 10.1002/ajim.22854
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Author response.

    Lehman, Everett J / Hein, Misty J / Baron, Sherry L / Gersic, Christine M

    Neurology

    2013  Volume 80, Issue 13, Page(s) 1266–1267

    MeSH term(s) Athletic Injuries ; Cause of Death ; Football ; Humans ; Male ; Neurodegenerative Diseases ; Retirement
    Language English
    Publishing date 2013-03-26
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Assessment of ALS mortality in a cohort of formaldehyde-exposed garment workers.

    Pinkerton, Lynne E / Hein, Misty J / Meyers, Alysha / Kamel, Freya

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2013  Volume 14, Issue 5-6, Page(s) 353–355

    MeSH term(s) Amyotrophic Lateral Sclerosis/mortality ; Cohort Studies ; Female ; Fixatives ; Formaldehyde ; Humans ; Male ; Occupational Diseases/mortality ; Occupational Exposure/statistics & numerical data ; Textile Industry
    Chemical Substances Fixatives ; Formaldehyde (1HG84L3525)
    Language English
    Publishing date 2013-04-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.3109/21678421.2013.778284
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top