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  1. Book ; Thesis: Analysis of inverse agonism at and binding to alpha 1 B-adrenoceptors

    Hein, Peter

    2002  

    Author's details vorgelegt von Peter Hein
    Language English
    Size 54 Bl.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Essen, Univ., Diss., 2003
    HBZ-ID HT013634607
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 E 1736 order for loan Magazin

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  2. Book ; Thesis: Die mikrobiologische Besiedlung zahnmedizinischer Einheiten und MöglichKeiten ihrer Beeinflussung

    Hein, Peter

    1985  

    Size 66 S. : Ill., zahlr. graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1986
    HBZ-ID HT002831886
    Database Catalogue ZB MED Medicine, Health

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    87 D 3724 order for loan Magazin

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  3. Article ; Online: A Systematic Review of Inverse Agonism at Adrenoceptor Subtypes.

    Michel, Martin C / Michel-Reher, Martina B / Hein, Peter

    Cells

    2020  Volume 9, Issue 9

    Abstract: As many, if not most, ligands at G protein-coupled receptor antagonists are inverse agonists, we systematically reviewed inverse agonism at the nine adrenoceptor subtypes. Except for ... ...

    Abstract As many, if not most, ligands at G protein-coupled receptor antagonists are inverse agonists, we systematically reviewed inverse agonism at the nine adrenoceptor subtypes. Except for β
    MeSH term(s) Drug Development/methods ; Drug Inverse Agonism ; Humans ; Receptors, Adrenergic, beta-2/therapeutic use
    Chemical Substances Receptors, Adrenergic, beta-2
    Language English
    Publishing date 2020-08-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9091923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Drug discovery and development in idiopathic pulmonary fibrosis: challenges and opportunities.

    Cruwys, Simon / Hein, Peter / Humphries, Bob / Black, Darcey

    Drug discovery today

    2020  Volume 25, Issue 12, Page(s) 2277–2283

    Abstract: The pharmacological and adverse effect profiles of the two approved therapies for IPF make the development of new therapies challenging. Considering the similarity of the characteristics of drug candidates to Standard of Care is important in defining ... ...

    Abstract The pharmacological and adverse effect profiles of the two approved therapies for IPF make the development of new therapies challenging. Considering the similarity of the characteristics of drug candidates to Standard of Care is important in defining positioning and development strategies for this disease.
    MeSH term(s) Animals ; Drug Combinations ; Drug Development ; Drug Discovery ; Drug Therapy, Combination ; Humans ; Idiopathic Pulmonary Fibrosis/drug therapy
    Chemical Substances Drug Combinations
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2020.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book: DIE GRAFT-VERSUS-HOST-REAKTION BEI DER RATTENNIERENALLOTRANSPLANTATION

    Kuhl, Hein-Peter

    1977  

    Title variant GRAFT-VERSUS-HOST-REAKTION BEI DER RATTENNIERENALLOTRANSPLANTATION
    Size 34 S.
    Document type Book
    Note BONN, UNIV., MED. FAK., DISS., 1977
    HBZ-ID HT000230245
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    78 D 495 order for loan Magazin

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  6. Book: In-Situ-Abreinigung von Trichlorethen (TCE) im GW mit regenerierbarem Fe(0)-Reaktor in horizontaler Anordnung am Standort der ehemaligen WGT-Kaserne Bernau (Land Brandenburg)

    Hein, Peter

    Schlussbericht zum BMBF-Forschungsvorhaben ... "Reaktive Wände"

    2006  

    Title variant In-situ remediation of TCE contaminated groundwater, design and construction of a horizontal zero valent iron (ZVI) based permeable reactive barrier (PRB) system for the in-situ-treatment of halogenated VOC in groundwater at the Bernau site near Berlin
    Institution Brandenburgische Boden, Gesellschaft für Grundstücksverwaltung und -Verwertung
    INGAAS Ingenieurgesellschaft für Wasserwirtschaft und Umwelttechnik
    Author's details Zuwendungsempfänger: Land Brandenburg "Grundstücksfond Brandenburg", vertreten durch Brandenburgische Boden Gesellschaft für Grundstücksverwaltung und -verwertung mbH (BBG). Projektsteuerung: INGAAS GmbH, Berlin. Verf.: P. Hein
    Language German
    Size 355 S., Ill., graph. Darst., Kt.
    Publishing place Berlin
    Document type Book
    Note Förderkennzeichen BMBF 0251 231. - Verbund-Nr. 01018594. - Engl. Berichtsbl.: In-situ remediation of TCE contaminated groundwater, design and construction of a horizontal zero valent iron (ZVI) based permeable reactive barrier (PRB) system for the in-situ-treatment of halogenated VOC in groundwater at the Bernau site near Berlin ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book ; Online: In-Situ-Abreinigung von Trichlorethen (TCE) im GW mit regenerierbarem Fe(0)-Reaktor in horizontaler Anordnung am Standort der ehemaligen WGT-Kaserne Bernau (Land Brandenburg)

    Hein, Peter

    Schlussbericht zum BMBF-Forschungsvorhaben 0251 231 "Reaktive Wände"

    2006  

    Title variant In-situ remediation of TCE contaminated groundwater
    Institution Brandenburgische Boden, Gesellschaft für Grundstücksverwaltung und -Verwertung
    Author's details Zuwendungsempfänger: Land Brandenburg "Grundstücksfond Brandenburg", vertreten durch Brandenburgische Boden Gesellschaft für Grundstücksverwaltung und -Verwertung mbH (BBG). Projektsteuerung: INGAAS GmbH. Verf.: P. Hein
    Language German
    Size Online-Ressource (355 S., 11,30 MB), Ill., graph. Darst., Kt.
    Edition Stand: 04.10.2006
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek
    Publishing place Hannover ; Berlin
    Document type Book ; Online
    Note IMD-Felder maschinell generiert ; Unterschiede zwischen dem gedruckten Dokument und der elektronische Ressource können nicht ausgeschlossen werden ; Verbund-Nr. 01018594. - Engl. Titel: In-situ remediation of TCE contaminated groundwater
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Article ; Online: Validity of the cold pressor test and pain sensitivity questionnaire via online self-administration.

    McIntyre, Matthew H / Kless, Achim / Hein, Peter / Field, Mark / Tung, Joyce Y

    PloS one

    2020  Volume 15, Issue 4, Page(s) e0231697

    Abstract: To determine the feasibility of complex home-based phenotyping, 1,876 research participants from the customer base of 23andMe completed an online version of a Pain Sensitivity Questionnaire (PSQ) as well as a cold pressor test (CPT) which is used in ... ...

    Abstract To determine the feasibility of complex home-based phenotyping, 1,876 research participants from the customer base of 23andMe completed an online version of a Pain Sensitivity Questionnaire (PSQ) as well as a cold pressor test (CPT) which is used in clinical assessments of pain. Overall our online version of the PSQ performed similarly to the original pen-and-paper version. Construct validity of the PSQ total was demonstrated by internal consistency and consistent discrimination between more and less painful items. Criterion validity was demonstrated by correlation with pain sensitivity as measured by the CPT. Within the same cohort we performed a cold pressor test using a layperson description and household equipment. Comparison with published reports from controlled studies revealed similar distributions of cold pain tolerance times (i.e., time elapsed before removing the hand from the water). Of those who elected to participate in the CPT, a large majority of participants did not report issues with the test procedure or noncompliance with the instructions (97%). We confirmed a large sex difference in CPT thresholds in line with published data, such that women removed their hands from the water at a median of 54.2 seconds, with men lasting for a median time of 82.7 seconds (Kruskal-Wallis statistic, p < 0.0001), but other factors like age or current pain treatment were at most weakly associated, and inconsistently between men and women. We introduce a new paradigm for performing pain testing, called testing@home, that, in the case of cold nociception, showed comparable results to studies conducted under controlled conditions and supervision of a health care professional.
    MeSH term(s) Adult ; Aged ; Cold Temperature/adverse effects ; Female ; Humans ; Male ; Middle Aged ; Pain/etiology ; Pain Measurement/methods ; Pain Threshold ; Sex Characteristics ; Sex Factors ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2020-04-16
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0231697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Enabling scalable clinical interpretation of ML-based phenotypes using real world data

    Parsons, Owen / Barlow, Nathan E / Baxter, Janie / Paraschin, Karen / Derix, Andrea / Hein, Peter / Dürichen, Robert

    2022  

    Abstract: The availability of large and deep electronic healthcare records (EHR) datasets has the potential to enable a better understanding of real-world patient journeys, and to identify novel subgroups of patients. ML-based aggregation of EHR data is mostly ... ...

    Abstract The availability of large and deep electronic healthcare records (EHR) datasets has the potential to enable a better understanding of real-world patient journeys, and to identify novel subgroups of patients. ML-based aggregation of EHR data is mostly tool-driven, i.e., building on available or newly developed methods. However, these methods, their input requirements, and, importantly, resulting output are frequently difficult to interpret, especially without in-depth data science or statistical training. This endangers the final step of analysis where an actionable and clinically meaningful interpretation is needed.This study investigates approaches to perform patient stratification analysis at scale using large EHR datasets and multiple clustering methods for clinical research. We have developed several tools to facilitate the clinical evaluation and interpretation of unsupervised patient stratification results, namely pattern screening, meta clustering, surrogate modeling, and curation. These tools can be used at different stages within the analysis. As compared to a standard analysis approach, we demonstrate the ability to condense results and optimize analysis time. In the case of meta clustering, we demonstrate that the number of patient clusters can be reduced from 72 to 3 in one example. In another stratification result, by using surrogate models, we could quickly identify that heart failure patients were stratified if blood sodium measurements were available. As this is a routine measurement performed for all patients with heart failure, this indicated a data bias. By using further cohort and feature curation, these patients and other irrelevant features could be removed to increase the clinical meaningfulness. These examples show the effectiveness of the proposed methods and we hope to encourage further research in this field.

    Comment: 27 pages, 14 figures
    Keywords Computer Science - Machine Learning ; Computer Science - Information Retrieval ; 92C50 ; 92C60 ; 68T09 ; 62H30 ; J.3 ; I.5 ; I.2
    Subject code 006
    Publishing date 2022-08-02
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The future R&D landscape in non-alcoholic steatohepatitis (NASH).

    Black, Darcey / Brockbank, Sarah / Cruwys, Simon / Goldenstein, Kim / Hein, Peter / Humphries, Bob

    Drug discovery today

    2018  Volume 24, Issue 2, Page(s) 560–566

    Abstract: Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue for the 21st century and is associated with significant liver-related morbidity and mortality. At present, there are no approved drug therapies for NASH. Consequently, NASH ... ...

    Abstract Nonalcoholic steatohepatitis (NASH) is emerging as a major public health issue for the 21st century and is associated with significant liver-related morbidity and mortality. At present, there are no approved drug therapies for NASH. Consequently, NASH has become the focus of significant public and private research and development. In this review, we highlight the research and development (R&D) challenges and opportunities in this emerging therapeutic area. In particular, we consider the impact of the development of new biomarker strategies on clinical trial execution and design, and the positioning of single and combination therapies in future approaches to the treatment of NASH.
    MeSH term(s) Biomarkers ; Biomedical Research ; Drug Development ; Drug Therapy, Combination ; Humans ; Non-alcoholic Fatty Liver Disease/drug therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2018-10-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2018.09.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4725: Show issues Location:
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