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  1. Book ; Thesis: Früh- und Spätkomplikationen nach Implantation eines venösen Dauerkatheters bei Kindern

    Heinrich, Jacqueline

    eine retrospektive Analyse über 5 Jahre

    2017  

    Author's details vorgelegt von Jacqueline Heinrich
    Language German
    Size III, 110 Seiten, Illustrationen, Diagramme, 21 cm
    Publishing place Würzburg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Julius-Maximilians-Universität Würzburg, 2018
    HBZ-ID HT019982763
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 202 order for loan Magazin

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  2. Book: Soilless culture

    Raviv, Michael / Lieth, Heinrich J. / Bar-Tal, Asher

    theory and practice

    2019  

    Author's details edited by Michael Raviv, J. Heinrich Lieth, Asher Bar-Tal
    Keywords Gartenbau ; Erdlose Kultur
    Subject Erdelose Kultur ; Erdeloser Pflanzenbau ; Soilless culture ; Erdlose Pflanzkultur ; Erdlose Pflanzenkultur ; Hortikultur
    Language English
    Size xx,691 Seiten
    Edition second edition
    Publisher Elsevier
    Publishing place London ; San Diego, CA ; Cambridge, MA ; Kidlington
    Publishing country Great Britain
    Document type Book
    Note Literaturangaben und Index
    HBZ-ID HT020199398
    ISBN 978-0-444-63696-6 ; 0-444-63696-X
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    198/411 available for loan (reading room) Freihandmagazin (U1)

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  3. Article: Epilepsy.

    Heinrich, Joseph

    Hall's journal of health

    2022  Volume 40, Issue 7, Page(s) 148–150

    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Characterization of the two neuronal motor proteins Kif26b and Myo16 and their association with the postsynaptic protein Abi-1

    Heinrich, Jutta

    2012  

    Author's details Jutta Heinrich
    Language English
    Size V, 98 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Diss., 2012
    HBZ-ID HT018533895
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 E 206 order for loan Magazin

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  5. Article: Es ist kompliziert

    Heinrich, Jörg

    CNE Pflegemanagement

    2023  Volume 10, Issue S 01, Page(s) 11–13

    Abstract: Auch für die Pädiatrie ist die PPR 2.0 ein großer Fortschritt und wird zukünftig den Personalbedarf realistischer abbilden. Beim Start in die Testphase haperte es aber schon mal gewaltig am Zeitplan, an den Materialien und an der Unterstützung. ...

    Abstract Auch für die Pädiatrie ist die PPR 2.0 ein großer Fortschritt und wird zukünftig den Personalbedarf realistischer abbilden. Beim Start in die Testphase haperte es aber schon mal gewaltig am Zeitplan, an den Materialien und an der Unterstützung.
    Language German
    Publishing date 2023-11-29
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ISSN 2626-6229 ; 2196-9310
    ISSN (online) 2626-6229
    ISSN 2196-9310
    DOI 10.1055/a-2184-8778
    Database Thieme publisher's database

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  6. Article: Dietary Fatty Acids and Changes in Blood Lipids during Adolescence: The Role of Substituting Nutrient Intakes

    Harris, Carla / Heinrich, Joachim

    Nutrients, 9(2):127

    2017  

    Abstract: The relevance of dietary fatty acids (FA) for blood lipids should be assessed in the context of substituting nutrients. Such evidence is lacking for adolescents. This study describes prospective associations of dietary FA with changes in serum lipids ... ...

    Institution Leibniz-Institut für Umweltmedizinische Forschung
    Abstract The relevance of dietary fatty acids (FA) for blood lipids should be assessed in the context of substituting nutrients. Such evidence is lacking for adolescents. This study describes prospective associations of dietary FA with changes in serum lipids during adolescence, and considers the theoretical isocaloric replacements of saturated FA (SFA) with other FA or carbohydrates (CHO). Children from the GINIplus and LISAplus birth cohorts, with data on FA intakes (at age 10 years) and serum lipids (at age 10 and 15 years), were included (n = 1398). Associations of SFA, monounsaturated FA (MUFA), n-3 polyunsaturated FA (n-3 PUFA) and n-6 PUFA, with changes in low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TAG), and total cholesterol to HDL ratio (TOTAL:HDL), were assessed by linear regression. Substitution models assessed isocaloric replacements of SFA with MUFA, n-3 PUFA, n-6 PUFA or CHO. Higher SFA intakes were associated with decreasing TAG. No associations were observed for fatty acid intakes with LDL, HDL or TOTAL:HDL. In females, replacing SFA with CHO was associated with increasing LDL, TAG and TOTAL:HDL. Our findings confirm observations in adults, although sex-specific determinants seem relevant in our adolescent population. Overlooking the nutrient context when limiting SFA intakes might have detrimental consequences appreciable as early as adolescence.
    Keywords carbohydrates ; adolescence ; diet ; epidemiology ; fatty acids ; isocaloric substitution ; lipids
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

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  7. Book: Qualitätsmonitor / 2020 / F. Dormann, J. Klauber, R. Kuhlen (Hrsg.). Mit Beiträgen von H. J. Audebert [und 34 anderen]

    Dormann, Franz / Klauber, Jürgen / Kuhlen, Ralf / Audebert, Heinrich

    2021  

    Author's details Gesundheitsstadt Berlin, Initiative Qualitätsmedizin (IQM), WIdO Wissenschaftliches Institut der AOK
    Collection Qualitätsmonitor ...
    Language German
    Size XII, 412 Seiten, Illustrationen, Diagramme, Karten
    Publishing country Germany
    Document type Book
    HBZ-ID HT020703829
    ISBN 978-3-95466-511-2 ; 3-95466-511-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 93 available for loan (reading room) Lesesaal EG

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  8. Article: Erratum zu "Luftschadstoffe und primäre Prävention von Allergien" [Allergo J 2019;28:20-30]. Correction to: Air pollutants and primary allergy prevention [Allergo J Int 2019;28:5-15]. Allergo J Int 2019;28:165

    Heinrich, J.

    Allergo-Journal

    2019  Volume 28, Issue 5, Page(s) 18

    Language German
    Document type Article
    ZDB-ID 1136943-7
    ISSN 0941-8849
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3566: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Explaining in-vitro to in-vivo efficacy correlations in oncology pre-clinical development via a semi-mechanistic mathematical model.

    Huber, Heinrich J / Mistry, Hitesh B

    Journal of pharmacokinetics and pharmacodynamics

    2023  Volume 51, Issue 2, Page(s) 169–185

    Abstract: In-vitro to in-vivo correlations (IVIVC), relating in-vitro parameters like IC50 to in-vivo drug exposure in plasma and tumour growth, are widely used in oncology for experimental design and dose decisions. However, they lack a deeper understanding of ... ...

    Abstract In-vitro to in-vivo correlations (IVIVC), relating in-vitro parameters like IC50 to in-vivo drug exposure in plasma and tumour growth, are widely used in oncology for experimental design and dose decisions. However, they lack a deeper understanding of the underlying mechanisms. Our paper therefore focuses on linking empirical IVIVC relations for small-molecule kinase inhibitors with a semi-mechanistic tumour-growth model. We develop an approach incorporating parameters like the compound's peak-trough ratio (PTR), Hill coefficient of in-vitro dose-response curves, and xenograft-specific properties. This leads to formulas for determining efficacious doses for tumor stasis under linear pharmacokinetics equivalent to traditional empirical IVIVC relations, but enabling more systematic analysis. Our findings reveal that in-vivo xenograft-specific parameters, specifically the growth rate (g) and decay rate (d), along with the average exposure, are generally more significant determinants of tumor stasis and effective dose than the compound's peak-trough ratio. However, as the Hill coefficient increases, the dependency of tumor stasis on the PTR becomes more pronounced, indicating that the compound is more influenced by its maximum or trough values rather than the average exposure. Furthermore, we discuss the translation of our method to predict population dose ranges in clinical studies and propose a resistance mechanism that solely relies on specific in-vivo xenograft parameters instead of IC50 exposure coverage. In summary, our study aims to provide a more mechanistic understanding of IVIVC relations, emphasizing the importance of xenograft-specific parameters and PTR on tumor stasis.
    MeSH term(s) Humans ; Models, Theoretical ; Neoplasms/drug therapy
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2041601-5
    ISSN 1573-8744 ; 1567-567X
    ISSN (online) 1573-8744
    ISSN 1567-567X
    DOI 10.1007/s10928-023-09891-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 980: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Editorial: Feinstaub, Stickoxide, Ozon: Darf man in Großstädten noch atmen?

    Heinrich, J.

    Der Pneumologe

    2018  Volume 15, Issue 4, Page(s) 263

    Language German
    Document type Article
    ZDB-ID 2179408-X
    ISSN 1613-5636
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6467: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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