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  1. Article ; Online: Characteristics of pediatric recurrent erythema multiforme.

    Heinze, Adam / Tollefson, Megha / Holland, Kristen E / Chiu, Yvonne E

    Pediatric dermatology

    2018  Volume 35, Issue 1, Page(s) 97–103

    Abstract: Background: Erythema multiforme (EM) is an acute condition characterized by distinctive target lesions of the skin often accompanied by mucosal ulcers. A subset of individuals experience frequent episodes of recurrent EM, which is rare and poorly ... ...

    Abstract Background: Erythema multiforme (EM) is an acute condition characterized by distinctive target lesions of the skin often accompanied by mucosal ulcers. A subset of individuals experience frequent episodes of recurrent EM, which is rare and poorly understood, especially in children.
    Objective: To characterize clinical features, laboratory findings, and treatment responses of pediatric recurrent EM.
    Methods: A retrospective chart review was conducted at the Children's Hospital of Wisconsin in Milwaukee, Wisconsin (2000-2015) and the Mayo Clinic in Rochester, Minnesota (1990-2015). Inclusion criterion was a diagnosis before age 18 years with recurrent EM, defined as a symmetrically distributed, fixed eruption, including target lesions, with or without mucous membrane involvement, occurring on at least three occasions. A literature review was conducted to include individuals who met the inclusion criterion.
    Results: Twenty-six patients were included, of whom 16 (62%) were male. The median age of onset was 9.1 years (range 0-15.7 years). Nine patients (35%) required hospitalization. Herpes simplex virus testing was positive in 9 of 17 (65%) patients. Remission was achieved in 5 of 16 (31%) patients while taking suppressive antivirals. Eight patients received continuous anti-inflammatory treatment, two (25%) of whom experienced remission.
    Conclusion: This study of pediatric recurrent EM found a greater male predominance, more hospitalizations, fewer cases caused by herpes simplex virus, and a lower response to immunosuppression in children than in the general population.
    MeSH term(s) Adolescent ; Anti-Infective Agents/therapeutic use ; Child ; Child, Preschool ; Cohort Studies ; Erythema Multiforme/diagnosis ; Erythema Multiforme/drug therapy ; Erythema Multiforme/epidemiology ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Infant ; Male ; Minnesota ; Recurrence ; Retrospective Studies ; Treatment Outcome ; Wisconsin
    Chemical Substances Anti-Infective Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2018-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.13357
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Longitudinal Study of Pediatric Urticaria Pigmentosa.

    Heinze, Adam / Kuemmet, Travis J / Chiu, Yvonne E / Galbraith, Sheila S

    Pediatric dermatology

    2017  Volume 34, Issue 2, Page(s) 144–149

    Abstract: Background/objectives: Urticaria pigmentosa (UP) is the most common form of mastocytosis in children and is associated with systemic signs, symptoms, and triggers. To our knowledge, the effect of UP on children's quality of life has not been studied. ... ...

    Abstract Background/objectives: Urticaria pigmentosa (UP) is the most common form of mastocytosis in children and is associated with systemic signs, symptoms, and triggers. To our knowledge, the effect of UP on children's quality of life has not been studied. The objective of the current study was to characterize the natural history, triggers, and complications of pediatric UP, identify prognostic indicators, and determine its effect on quality of life.
    Methods: Between 2002 and 2007, children with three or more mastocytomas diagnosed by a pediatric dermatologist were recruited during visits at the Children's Hospital of Wisconsin Dermatology Clinic (Milwaukee, WI). Research visits were conducted every 3 years and telephone interviews yearly. The Children's Dermatology Life Quality Index was administered to subjects 4 years of age and older at enrollment. Laboratory test results were collected for subjects younger than 4 years at enrollment. Subjects were followed until UP resolution or study end in August 2015.
    Results: The final cohort size was 43 subjects followed for a median of 8.1 years. Twenty-six subjects were followed through study completion. At age 12 years, 6 patients had disease resolution and 14 remained active. Patients who had disease resolution before age 12 years were more likely to be male and had fewer years of age and smaller lesions, fewer affected areas, and earlier onset. Common medications and anesthetics resulted in no serious reactions. Hymenoptera stings occurred in 51%, with no reports of anaphylaxis. No patient reported a severe effect on quality of life, with most indicating mild to no effect.
    Conclusion: Severe complications are not common with historically identified triggers. Disease does not resolve before adolescence in most children. UP has a minimal effect on quality of life for most children.
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.13066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Thesis ; Online: The role of temperature in the distribution of mixotrophic protists of the genus Dinobryon

    Heinze, Adam Wesley

    2009  

    Abstract: Mixotrophic organisms utilize both photosynthetic and phagotrophic nutritional modes and are increasingly recognized as important contributors to aquatic food webs. Dinobryon, a widespread freshwater genus of mixotrophs had dramatic seasonal and annual ... ...

    Abstract Mixotrophic organisms utilize both photosynthetic and phagotrophic nutritional modes and are increasingly recognized as important contributors to aquatic food webs. Dinobryon, a widespread freshwater genus of mixotrophs had dramatic seasonal and annual variation in Lake Lacawac, a mesotrophic kettle lake in northeastern Pennsylvania. Although light is required for population growth in Dinobryon, it does not appear to control vertical distribution patterns observed during a 3-year survey. One year, the maximum annual abundance was observed close to the surface, while the following year the maximum annual abundance occurred at 4 m depth where light levels were <2% of surface irradiance. The depth of maximum Dinobryon abundance during the second year overlapped with an oxygen maximum at 4 m, which strongly suggests effective photosynthesis at a relatively low light level. Analysis of the distribution data suggests that temperature may be a primary driver of Dinobryon spp. distribution in the water column of this lake. Although annual variability in absolute abundance was high, peak Dinobryon biomass always occurred within a narrow range of temperature (10°-16°C). This distributional study was validated by an early spring field experiment where temperature was raised with water heater to 16°C. The abundance of Dinobryon increased two-fold at the higher temperature. A novel laboratory instrument was developed and constructed that established a vertical temperature gradient with even lighting to test the ability of Dinobryon to congregate within that specific temperature range independent of light intensity. Dinobryon abundance in the column was maximum within the same range of water temperatures observed in the field study. Because lighting was even across the vertical water column, any effect of light attenuation in the lake distribution was eliminated and accumulation due to temperature effects was confirmed. With climate change becoming more apparent, it is clear that understanding temperatures role in the distribution of the aquatic food web is timely and important.
    Keywords Ecology|Limnology
    Subject code 551
    Language ENG
    Publishing date 2009-01-01 00:00:01.0
    Publisher Temple University
    Publishing country us
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Preliminary summary and reclassification of cases from the Pediatric Research of Management in Stevens-Johnson syndrome and Epidermonecrolysis (PROMISE) study: A North American, multisite retrospective cohort.

    Martinez-Cabriales, Sylvia / Coulombe, Jerome / Aaron, Michelle / Hussain, Sadaf H / Linggonegoro, Danny / Lara-Corrales, Irene / Barootes, Hailey / Brandling-Bennett, Heather / Covelli, Isabela / Kirkorian, Anna Yasmine / Shah, Nidhi / Castelo-Soccio, Leslie / McKenzie, Paige / Arkin, Lisa M / Heinze, Adam / Liy-Wong, Carmen / Travis, Nicole / Rieder, Michael / Del Pozzo-Magana, Blanca R /
    Schoch, Jennifer J / Monir, Reesa / Glick, Sharon A / Uwakwe, Laura / Skillman, Sarah / Hekman, Dan P / Lethebe, Brendan C / Ramien, Michele L

    Journal of the American Academy of Dermatology

    2023  Volume 90, Issue 3, Page(s) 635–637

    MeSH term(s) Child ; Humans ; Retrospective Studies ; Stevens-Johnson Syndrome/therapy ; Research ; North America
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.08.112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
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