Article ; Online: Resveratrol intervention attenuates chylomicron secretion via repressing intestinal FXR-induced expression of scavenger receptor SR-B1.
2023 Volume 14, Issue 1, Page(s) 2656
Abstract: Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) in high-fat ... ...
| Abstract | Two common features of dietary polyphenols have hampered our mechanistic understanding of their beneficial effects for decades: targeting multiple organs and extremely low bioavailability. We show here that resveratrol intervention (REV-I) in high-fat diet (HFD)-challenged male mice inhibits chylomicron secretion, associated with reduced expression of jejunal but not hepatic scavenger receptor class B type 1 (SR-B1). Intestinal mucosa-specific SR-B1 |
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| MeSH term(s) | Male ; Animals ; Mice ; Humans ; Chylomicrons ; Resveratrol/pharmacology ; Caco-2 Cells ; Polyphenols ; Receptors, Scavenger |
| Chemical Substances | Chylomicrons ; Resveratrol (Q369O8926L) ; Polyphenols ; Receptors, Scavenger |
| Language | English |
| Publishing date | 2023-05-09 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-023-38259-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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