Article ; Online: Impact of DAXX and ATRX expression on telomere length and prognosis of breast cancer patients.
Journal of the Egyptian National Cancer Institute
2020 Volume 32, Issue 1, Page(s) 34
Abstract: Background: Telomere stability is one of the hallmarks of cancer that promotes cellular longevity, the accumulation of genetic alterations, and tumorigenesis. The loss of death domain-associated protein (DAXX) and α-thalassemia/mental retardation X- ... ...
Abstract | Background: Telomere stability is one of the hallmarks of cancer that promotes cellular longevity, the accumulation of genetic alterations, and tumorigenesis. The loss of death domain-associated protein (DAXX) and α-thalassemia/mental retardation X-linked protein (ATRX) plays a role in telomere lengthening and stability. This study aims to evaluate the prognostic significance of telomere length (TL) and its association with DAXX and ATRX proteins in breast cancer (BC). Our study used the FISH technique to detect peptide nucleic acid (PNA) in the peripheral blood cells of a cohort of BC patients (n = 220) and a control group of apparently healthy individuals (n = 100). Expression of DAXX and ATRX proteins was evaluated using immunohistochemistry (IHC) in all BC tissues. Results: Patients with a shorter TL had worse disease-free survival (DFS) and overall survival (OS). There were significant associations between shorter TL and advanced disease stages, lymph node metastasis, and positive HER2/neu expression. DAXX protein expression was significantly correlated with TL. Lower DAXX expression was significantly with shorter DFS. Conclusion: Assessing TL can be used as a worthy prognostic indicator in BC patients. Specifically, short TL had a poor impact on the prognosis of BC patients. Low DAXX expression is associated with poor outcomes in BC. Further mechanistic studies are warranted to reveal the underlying mechanisms of these associations. |
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MeSH term(s) | Adaptor Proteins, Signal Transducing/genetics ; Breast Neoplasms ; Co-Repressor Proteins/metabolism ; Female ; Humans ; Molecular Chaperones/metabolism ; Nuclear Proteins/genetics ; Pancreatic Neoplasms ; Prognosis ; Telomere ; X-linked Nuclear Protein/metabolism |
Chemical Substances | Adaptor Proteins, Signal Transducing ; Co-Repressor Proteins ; DAXX protein, human ; Molecular Chaperones ; Nuclear Proteins ; ATRX protein, human (EC 3.6.4.12) ; X-linked Nuclear Protein (EC 3.6.4.12) |
Language | English |
Publishing date | 2020-08-28 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1176790-x |
ISSN | 2589-0409 ; 1110-0362 |
ISSN (online) | 2589-0409 |
ISSN | 1110-0362 |
DOI | 10.1186/s43046-020-00045-1 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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