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  1. Book ; Thesis: Einfluss der konstitutiven Aktivierung von STAT3 auf die Induktion und Aufrechterhaltung der leukämischen Stammzelle in der akuten myeloischen Leukämie

    Held, Hannelore

    2016  

    Author's details vorgelegt von Hannelore Held
    Language German
    Size 194 Seiten, Illustrationen, Diagramme
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2017
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT019625858
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 D 301 order for loan Magazin

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  2. Article ; Online: Intensivmedizinisches Management akuter Aortenerkrankungen.

    Rand, A / Busch, A / Held, H / Reeps, C / Koch, T

    Die Anaesthesiologie

    2023  Volume 72, Issue 4, Page(s) 275–281

    Abstract: Acute aortic diseases represent a group of complex severe and often fatal medical conditions. Although they are significantly rarer than cardiac or thromboembolic events, they are an important differential diagnosis to be ruled out, e.g., in the clinical ...

    Title translation Intensive care management of acute diseases of the aorta.
    Abstract Acute aortic diseases represent a group of complex severe and often fatal medical conditions. Although they are significantly rarer than cardiac or thromboembolic events, they are an important differential diagnosis to be ruled out, e.g., in the clinical work-up of acute chest pain.Treatment, especially surgical interventions, depends on the progression, extent and size of the pathology and whenever possible should be performed in specialized centers with the appropriate experience.Intensive care monitoring is advisable as a range of peracute complications can occur even in initially stable patients. Depending on the clinical presentation and affected structures, a number of severe complications need to be anticipated by critical care physicians. Additionally, a notable symptom is severe and refractory hypertension, especially in the acute phase. This article provides a summary of the most frequent clinical pictures and corresponding treatment options. Furthermore, the principles of initial patient stabilization and treatment as well as the perioperative management of complex surgical procedures on the aorta are discussed.
    MeSH term(s) Humans ; Acute Disease ; Aortic Dissection ; Aorta/pathology ; Aortic Diseases/diagnosis ; Critical Care
    Language German
    Publishing date 2023-02-03
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-6866
    ISSN (online) 2731-6866
    DOI 10.1007/s00101-023-01253-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Climate targets and cost-effective climate stabilization pathways

    Held H.

    EPJ Web of Conferences, Vol 98, p

    2015  Volume 06002

    Abstract: Climate economics has developed two main tools to derive an economically adequate response to the climate problem. Cost benefit analysis weighs in any available information on mitigation costs and benefits and thereby derives an “optimal” global mean ... ...

    Abstract Climate economics has developed two main tools to derive an economically adequate response to the climate problem. Cost benefit analysis weighs in any available information on mitigation costs and benefits and thereby derives an “optimal” global mean temperature. Quite the contrary, cost effectiveness analysis allows deriving costs of potential policy targets and the corresponding cost- minimizing investment paths. The article highlights pros and cons of both approaches and then focusses on the implications of a policy that strives at limiting global warming to 2 °C compared to pre-industrial values. The related mitigation costs and changes in the energy sector are summarized according to the IPCC report of 2014. The article then points to conceptual difficulties when internalizing uncertainty in these types of analyses and suggests pragmatic solutions. Key statements on mitigation economics remain valid under uncertainty when being given the adequate interpretation. Furthermore, the expected economic value of perfect climate information is found to be on the order of hundreds of billions of Euro per year if a 2°-policy were requested. Finally, the prospects of climate policy are sketched.
    Keywords Science ; Q ; Physics ; QC1-999
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Cost Risk Analysis: Dynamically Consistent Decision-Making under Climate Targets

    Held, Hermann

    Environmental and resource economics. 2019 Jan., v. 72, no. 1

    2019  

    Abstract: Cost risk analysis (CRA) is currently emerging as a noticed decision-analytic framework within the field of climate economics. It combines the expected utility-based structure of cost–benefit analysis with the target-based approach of cost effectiveness ... ...

    Abstract Cost risk analysis (CRA) is currently emerging as a noticed decision-analytic framework within the field of climate economics. It combines the expected utility-based structure of cost–benefit analysis with the target-based approach of cost effectiveness analysis (CEA). As such, it offers a promising candidate for those decision-makers who would like to express their precautionary attitude in view of deeply uncertain global warming impacts through a temperature target, yet who would like to avoid the dynamic inconsistencies of CEA. We review both its rationale and key results derived from it. (1) Without a delay in mitigation policy as against the CRA-optimal solution, CRA produces solutions resembling those obtained by means of cost effectiveness analysis, thereby retroactively justifying the approach underlying the nearly 1000 scenarios gathered in IPCC AR5. (2) With an increasing delay, however, CRA would result in decreasing mitigation costs, contrary to CEA. (3) CRA has demonstrated that it is possible to determine the economic value of climate information, unlike CEA. Here, for the first time, a complete list of the assumptions on which CRA is based is presented, including a missing proof. In closing, we explain finding (1) and thereby also show that, without a delay, CRA-based solutions are universal in that they essentially do not depend on the choice of a ‘risk function.’
    Keywords climate ; cost benefit analysis ; cost effectiveness ; decision making ; economic valuation ; environmental economics ; environmental policy ; global warming ; risk ; risk analysis ; temperature
    Language English
    Dates of publication 2019-01
    Size p. 247-261.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 1479788-4
    ISSN 1573-1502 ; 0924-6460
    ISSN (online) 1573-1502
    ISSN 0924-6460
    DOI 10.1007/s10640-018-0288-y
    Database NAL-Catalogue (AGRICOLA)

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  5. Book ; Thesis: Detektion von einem differentiell exprimierten Gen in der Ovarialkarzinomzellinie NIH:OVCAR-3

    Held, Holger

    1998  

    Author's details vorgelegt von Holger Held
    Language German
    Size 57 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1998
    HBZ-ID HT008877638
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  6. Article ; Online: Climate policy options and the transformation of the energy system

    Held H.

    EPJ Web of Conferences, Vol 54, p

    2013  Volume 01002

    Abstract: The key lines of argument to estimate a meaningful degree of efforts to mitigate global warming are outlined. Potential implementations of a policy that strives to limit global warming to 2°C compared to pre-industrial values are discussed. A recent ... ...

    Abstract The key lines of argument to estimate a meaningful degree of efforts to mitigate global warming are outlined. Potential implementations of a policy that strives to limit global warming to 2°C compared to pre-industrial values are discussed. A recent model intercomparison study on mitigation costs is summarized. Conceptual difficulties when internalizing uncertainty in these types of analyses are highlighted and first attempts to overcome them are outlined. For the mitigation technology “carbon capture and storage” it is illustrated that mitigation technologies also require a proper treatment of their side-effects rather than just focusing on their cost-reduction potential in the context of mitigation. Finally, the prospects of climate policy are sketched.
    Keywords Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
    Language English
    Publishing date 2013-06-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: Die Kosten des 2°-Ziels und seine klimapolitischen Herausforderungen

    Held, Hermann

    Die Nutzung von Ressourcen - mehr als eine ökonomische Fragestellung : vierte wissenschaftliche Tagung Economic Governance und Ordonomik : Beiträge zur Tagung 2016 im Festsaal des Siedehauses des Technischen Halloren- und Salinemuseums , p. 177-188

    2017  , Page(s) 177–188

    Author's details Hermann Held
    Keywords Klimaschutz ; Nachhaltige Energieversorgung ; Kosteneffizienz
    Language German
    Publisher Lehrstuhl für Wirtschaftspolitik und Wirtschaftsforschung, Martin-Luther-Universität Halle-Wittenberg
    Publishing place Halle (Saale)
    Document type Article
    ISBN 978-3-86829-870-3 ; 3-86829-870-3
    Database ECONomics Information System

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  8. Article: Schockraummanagement

    Mibelli, Nicolas / Kamin, Konrad / Gondert, Markus M. / Held, Hanns-Christoph

    Allgemein- und Viszeralchirurgie up2date

    2023  Volume 17, Issue 05, Page(s) 385–405

    Keywords Notfallmedizin ; Polytrauma ; ABCDE-Schema ; Blutungskontrolle ; Verbrennung
    Language German
    Publishing date 2023-09-29
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2317051-7
    ISSN 1611-6461 ; 1611-6437
    ISSN (online) 1611-6461
    ISSN 1611-6437
    DOI 10.1055/a-2099-3327
    Database Thieme publisher's database

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    Zs.A 6570: Show issues Location:
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  9. Article ; Online: Optimal temperature overshoot profile found by limiting global sea level rise as a lower-cost climate target.

    Li, Chao / Held, Hermann / Hokamp, Sascha / Marotzke, Jochem

    Science advances

    2020  Volume 6, Issue 2, Page(s) eaaw9490

    Abstract: The global temperature targets of limiting surface warming to below 2.0°C or even to 1.5°C have been widely accepted through the Paris Agreement. However, limiting surface warming has previously been proven insufficient to control sea level rise (SLR). ... ...

    Abstract The global temperature targets of limiting surface warming to below 2.0°C or even to 1.5°C have been widely accepted through the Paris Agreement. However, limiting surface warming has previously been proven insufficient to control sea level rise (SLR). Here, we explore a sea level target that is closer to coastal planning and associated adaptation measures than a temperature target. We find that a sea level target provides an optimal temperature overshoot profile through a physical constraint of SLR. The allowable temperature overshoot leads to lower mitigation costs and more effective long-term sea level stabilization compared to a temperature target leading to the same SLR by 2200. With the same mitigation cost as the temperature target, a SLR target could bring surface warming back to the targeted temperatures within this century, lead to a reduction of surface warming of the next century, and reduce and slow down SLR in the centuries thereafter.
    Language English
    Publishing date 2020-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aaw9490
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Giftige Verwandtschaft. Versuch der Herbeiführung einer Boraxintoxikation? Toxic relatives. Attempted poisoning with borax?

    Plenzig, S. / Held, H. / Verhoff, M. A.

    Rechtsmedizin

    2019  Volume 29, Issue 3, Page(s) 209

    Language German
    Document type Article
    ZDB-ID 1064911-6
    ISSN 0937-9819
    Database Current Contents Medicine

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    Zs.A 3169: Show issues Location:
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